7503 results
Cited 1 times since 2025 (3.3 per year)
source: EuropePMC
Nature structural & molecular biology,
Volume 32, Issue 11, 1 1 2025, Pages 2335-2348
Interactions between the genome and the nuclear lamina are multivalent and cooperative.
Dauban L, Eder M, de Haas M, Franceschini-Santos VH, Yañez-Cuna JO, Martinovic M, van Schaik T, Leemans C, Teunissen H, Rademaker K, Martinez Ara M, Verkuilen M, de Wit E, van Steensel B
Lamina-associated domains (LADs) are megabase-sized genomic regions that interact with the nuclear lamina (NL). It is not yet understood how their interactions with the NL are encoded in their DNA. Here we designed an efficient LAD 'scrambling' approach, based on transposon-mediated local hopping of loxP recombination sites, to generate series of large deletions and inversions that span LADs and flanking sequences. Mapping of NL interactions in these rearrangements revealed that, in mo...
Abstract
Nucleic acids research,
Volume 53, Issue 18, 1 1 2025, Pages gkaf964
Coordinated control of genome-nuclear lamina interactions by topoisomerase 2B and lamin B receptor.
van Schaik T, Magnitov M, de Haas M, Breda J, de Wit E, Manjon AG, Medema RH, Gothe HJ, Roukos V, Buckle AJ, Naughton C, Gilbert N, van Steensel B, Manzo SG
Lamina-associated domains (LADs) are megabase-sized genomic regions anchored to the nuclear lamina (NL). Factors controlling the interactions of the genome with the NL have largely remained elusive. Here, we identified DNA topoisomerase 2 beta (TOP2B) as a regulator of these interactions. TOP2B binds predominantly to inter-LAD (iLAD) chromatin and its depletion results in a partial loss of genomic partitioning between LADs and iLADs, suggesting that this enzyme might protect specific iLADs from...
Abstract
Cells,
Volume 14, Issue 17, 31 5 2025, Pages 1357
Heart Failure Impacts Endothelial Cell Responses to Cardiac Surgery on Cardiopulmonary Bypass.
Papazisi O, Postma RJ, Dirven RJ, Beeres SLMA, Berendsen RR, Arbous SM, Klautz RJM, van Vessem ME, Bijkerk R, Lindeman JHN, Palmen M, van Zonneveld AJ
Patients with heart failure with a reduced ejection fraction (HFrEF) are at an increased risk of developing postoperative hemodynamic instability and vasoplegia after surgery on cardiopulmonary bypass (CPB). Potentially pre-existing endothelial cell (EC) alterations due to chronic HF influence EC responses to cardiac surgery and might be responsible for the altered vascular responsiveness observed postoperatively. In this study, well-described EC activation markers were measured in blood samples...
Abstract
Cited 1 times since 2025 (3.3 per year)
source: EuropePMC
European journal of heart failure,
30 5 2025
Left ventricular ejection fraction and benefit of tricuspid valve interventions - insights from the international TRIGISTRY.
Heitzinger G, Dreyfus J, Dannenberg V, Topilsky Y, Benfari G, Marsan NA, Taramasso M, Russo G, Bohbot Y, Iliadis C, Weber M, Nombela-Franco L, Eixerés-Esteve A, Bazire B, Iung B, Obadia JF, Loureiro RE, Riant E, Donal E, Habib G, Lavie-Badie Y, Hausleiter J, Stolz L, Badano L, Le Tourneau T, Coisne A, Modine T, Praz F, Zamorano JL, von Bardeleben RS, Hahn RT, Fam N, Sievert H, Muraru D, Adamo M, Heuts S, Nejjari M, Chan V, De Bonis M, Carnero-Alcazar M, Rudolph V, Crestanello J, Lurz P, Bax J, Gauda R, Bernick J, Wells GA, Maisano F, Enriquez-Sarano M, Bartko P, Messika-Zeitoun D, TRIGISTRY Investigators
Aims: The impact of treatment for tricuspid regurgitation (TR) across different levels of left ventricular ejection fraction (LVEF) remains uncertain. This study aimed to compare the outcomes of surgical and transcatheter tricuspid valve interventions (TTVI) to conservative (medical) management across LVEF categories. Methods and results: Patients with severe isolated TR from the TRIGISTRY, a multicentre international registry, were categorized based on LVEF (preserved ejection fraction [pEF]: ≥...
Abstract
European heart journal,
30 5 2025, Pages ehaf660
AAV9-mediated KCNH2 suppression-replacement gene therapy in a transgenic rabbit model of type 1 short QT syndrome.
Nimani S, Bains S, Alerni N, Ördög B, Horváth A, Matas L, Louradour J, Giammarino L, Tester DJ, Beslac O, Lopez R, Meier S, Egle M, Christoforou N, Barbieri M, Vashanthakumar V, Perez-Feliz S, Parodi C, Garcia Casalta LG, Kim CSJ, Zhou W, Ye D, Jurgensen J, Barry MA, Bego M, Keyes L, Owens J, Pinkstaff J, Christoph J, Zehender M, Brunner M, Heijman J, Casoni D, Praz F, Haeberlin A, Brooks G, Ackerman MJ, Odening KE
Background and aims: Type 1 short QT syndrome (SQT1) is a genetic channelopathy caused by gain-of-function variants in KCNH2. This shortens cardiac repolarization and QT intervals, predisposing patients to ventricular arrhythmias and sudden cardiac death. This study aimed to investigate the therapeutic efficacy of KCNH2-specific suppression-and-replacement (KCNH2-SupRep) gene therapy in a transgenic rabbit model of SQT1. Methods: KCNH2-SupRep was developed by combining a KCNH2-shRNA with its cor...
Abstract
The Annals of thoracic surgery,
29 5 2025, Pages S0003-4975(25)00805-7
Mitral Valve Repair in Infective Endocarditis: A Patient-Tailored Approach.
Tomšič A, Palmen M
Abstract
Cited 1 times since 2025 (3.2 per year)
source: EuropePMC
European heart journal,
29 5 2025, Pages ehaf560
Surgical myectomy for hypertrophic cardiomyopathy: procedural volume and outcomes.
Heeringa TJP, Hegeman RMJJ, Koop Y, El Mathari S, Hoogewerf M, Roefs MM, Smits KC, Laenens D, De Zan G, Cramer MJ, Guglielmo M, van der Harst P, Vaartjes I, Mokhles MM, Klein P, van der Kaaij NP, SAM-Registry Study Investigators, Cardiothoracic Surgery Registration Committee of the Netherlands
Background and aims: Outcomes after surgical myectomy in hypertrophic obstructive cardiomyopathy (HOCM) patients have not been investigated in a multicentre registry with detailed clinical data. Hence, the objectives of this multicentre Dutch study are to describe the 30-day clinical outcomes after surgical myectomy, and to assess factors associated with increased 30-day complication rates. Methods: All HOCM patients (n = 335) who underwent surgery between 2012 and 2020 across 12 Dutch hospitals...
Abstract
Clinical genitourinary cancer,
Volume 23, Issue 6, 28 4 2025, Pages 102423
Addressing Uneven Treatment Discontinuation Rate in the Chemotherapy Arm of the EV-302 Phase 3 Randomized Clinical Trial: Implications for Outcome Interpretation.
Robesti D, Micheli F, Rai SN, Fallara G, Gallina A, Montorsi F, Briganti A, Fossati N, Grivas P, van der Heijden AG, Ploussard G, Malavaud B, Martini A
Introduction: The EV-302 trial demonstrated a very significant overall survival (OS) benefit for Enfortumab Vedotin plus Pembrolizumab (EVP) relative to standard chemotherapy (CHT) for patients with metastatic urothelial carcinoma. However, questions have been raised regarding the high rate of treatment discontinuation in the CHT arm for reasons unrelated to adverse events or progression (33% vs. 10% with EVP, P < .01), potentially resulting in loss of unaccounted information, or informative...
Abstract
Communications biology,
Volume 8, Issue 1, 28 4 2025, Pages 1293
Publisher Correction: Observational social learning of "know-how" and "know-what" in wild orangutans: evidence from nest-building skill acquisition.
Permana AL, Permana JJ, Nellissen L, Prayogi ES, Prasetyo D, Wich SA, van Schaik CP, Schuppli C
Abstract
Scientific reports,
Volume 15, Issue 1, 27 4 2025, Pages 31537
Perspectives of adults aged 55+ on plant-based diets rich in protein.
van Oppenraaij SL, Putker M, van Schaik A, Weijs PJM, Verlaan S
An increased protein intake is required during aging to preserve muscle mass. A predominantly plant-based diet is beneficial for the climate and may lower the risk of certain non-communicable diseases, but could also lead to protein below recommendations. This study seeks to elucidate facilitators and barriers in adults aged 55+ adopting a diet that is both predominantly plant-based and provides sufficient protein to preserve muscle mass. Three focus groups were conducted with 30 Dutch adults, a...
Abstract
Cited 1 times since 2025 (3.2 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 86, Issue 21, 27 4 2025, Pages 2071-2076
Lipoprotein(a) Levels and Time to Cardiovascular Benefit With Alirocumab in Patients With Recent Acute Coronary Syndrome.
Ray KK, Szarek M, Bhatt DL, Bittner VA, Fazio S, Goodman SG, Harrington RA, Jukema JW, White HD, Steg PG, Schwartz GG
Abstract
Open heart,
Volume 12, Issue 2, 27 4 2025, Pages e003534
Long-term clinical outcomes in adult congenital aortic stenosis: results from a national study.
Keuning ZA, Meccanici F, Schreurs BA, Veen K, Bouma BJ, Voskuil M, Jongbloed MRM, van Melle JP, van Kimmenade RRJ, Kapoor R, Bozkurt I, Hirsch A, Roos-Hesselink JW, van den Bosch AE
Background: Previous research on congenital aortic stenosis (AS) mainly focused on children, while data on long-term outcomes in adults is scarce. Therefore, this study aims to evaluate outcomes in adult patients with congenital AS and identify prognostic markers for aortic valve replacement (AVR). Methods: In this multicentre study, patients aged 18-55 years with congenital AS (peak velocity ≥2.5 m/s) registered in the Dutch CONCOR (Congential Cor Vitia) registry from expert centres for congeni...
Abstract
PharmacoEconomics,
Volume 43, Issue 12, 23 4 2025, Pages 1405-1417
Cost-Utility Analysis of Treatment Sequences for Moderate-to-Severe Crohn's Disease.
Versteegh MM, Huygens SA, Bermejo I, Grimm S, Pierik M, Römkens T, van Schaik F, Wahab P
Objectives: The clinical pathway for patients with moderate-to-severe Crohn's disease (CD) typically includes sequential pharmacologic treatment as well as surgery, but positioning of different therapies within these sequences remains challenging. Cost-utility analysis rarely captures these sequences and does not incorporate registry data on long-term effectiveness. In this study, we aim to overcome these limitations. Methods: We developed an individual state transition model with four heal...
Abstract
International journal of stroke : official journal of the International Stroke Society,
22 4 2025, Pages 17474930251372371
Interaction of CYP2C19 with the effect of clopidogrel in secondary prevention of major ischemic events: Systematic review and meta-analysis.
Kremers FC, van den Biggelaar J, Lingsma HF, van Schaik RH, Roozenbeek B, Dippel DW
Background and aims: Clopidogrel may be a less effective antiplatelet agent for secondary prevention after cardiovascular events in carriers of the CYP2C19 Loss of Function (LoF) allele. Randomized controlled trials (RCTs) of clopidogrel in patients with known CYP2C19 carrier status have provided inconsistent results. This meta-analysis aims to pool evidence on the effect of different antiplatelet strategies on outcomes according to CYP2C19 LoF status. Methods: We conducted a systematic review a...
Abstract
Scientific reports,
Volume 15, Issue 1, 21 3 2025, Pages 30672
Metagenomic analysis and genomic characterization of enterovirus A76 and Norovirus GI.6[P11] co-infection in a patient with acute gastroenteritis in Thailand.
Chuchaona W, Izquierdo-Lara RW, Schapendonk CME, Khongwichit S, Koopmans MPG, de Graaf M, Poovorawan Y
Acute gastroenteritis (AGE) remains a significant global health concern, with noroviruses among the most prevalent viral pathogens. However, other enteric viruses also contribute substantially to the public health burden. This study provides the first molecular characterization of a co-infection involving a rarely reported enterovirus A76 (EV-A76) and a norovirus GI.6[P11] in a patient from Thailand. Metagenomic sequencing successfully identified complete viral genomes, revealing unique genetic...
Abstract
Cited 1 times since 2025 (3 per year)
source: EuropePMC
JACC. Basic to translational science,
Volume 10, Issue 9, 21 3 2025, Pages 101359
Triglycerides and T Cells in Cardiovascular Risk: Inflammatory Transcriptomic Profile in Hypertriglyceridemia Patients' T Cells.
Reilly NA, Mulder JWCM, Dekkers KF, Kuipers TB, van Vark-van der Zee LC, Mulder MT, Roeters van Lennep JE, Jukema JW, Heijmans BT
Triglycerides and T cells play a key role in atherosclerosis, the leading cause of cardiovascular disease (CVD). Moderately elevated triglycerides have emerged as a causal risk factor, and T cells are a prominent component of atherosclerotic plaques. This cross-sectional study examined transcriptomic differences in T cells among patients with varying triglyceride levels via RNA sequencing. We analyzed CD4+ and CD8+ T cells from 49 participants, including those with primary (genetic) and secondar...
Abstract
European journal of cancer (Oxford, England : 1990),
Volume 229, 21 3 2025, Pages 115731
Final clinical analysis of pre-operative ipilimumab and nivolumab in locally advanced urothelial cancer and exploration of tumor-draining lymph node composition: The NABUCCO trial.
Stockem CF, van Dorp J, van Dijk N, Vis DJ, Harkes R, van den Broek B, Alkemade M, Broeks A, Hendricksen K, Boellaard TN, de Feijter JM, van Montfoort ML, Daletzakis A, van der Heijden AG, Meijer RP, Mehra N, Wessels LFA, van Rhijn BWG, Suelmann BBM, van der Heijden MS
Background: Pre-operative immune checkpoint blockade (ICB) with ipilimumab and nivolumab has shown encouraging pathological complete response (pCR) rates in stage III urothelial cancer (UC). A previous analysis of NABUCCO suggested that ipilimumab 3 mg/kg is more effective than ipilimumab 1 mg/kg. However, long-term progression-free and overall survival (PFS, OS) following pre-operative combination ICB are unknown. Methods: In NABUCCO, 54 patients received pre-operative ipilimumab plus nivolumab...
Abstract
Pediatric allergy, immunology, and pulmonology,
Volume 38, Issue 3, 21 3 2025, Pages 108-111
A Rare Clinical Course in Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome: Lung Involvement.
Yılmaz D, Emeksiz ZŞ, İclal G, Bilgiç I, Mısırlıoğlu ED
Background: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a rare, potentially life-threatening hypersensitivity reaction characterized by skin rash, fever, eosinophilia, and multi-organ involvement. Although pulmonary complications are uncommon, they can significantly impact prognosis. Case Presentation: Here, we present a 6-year-old male with antibiotic-induced DRESS syndrome complicated by pleural effusion and pneumonitis. The patient was treated successfully with s...
Abstract
Scientifica,
Volume 2025, 20 3 2025, Pages 4314722
The Effect of Nano-Fertilization With NPK and Spraying With Potassium Silicate on Improving the Physical Characteristics of Date Palm (<i>Phoenix dactylifera</i>) Fruits of Khastawi and Khadhrawi Cultivars.
Al-Khafaji ZAH, Al-Amri IAU
This study was conducted during the 2024 growing season at the Palm Research Station in Al-Zafaraniya, Baghdad, Iraq. A total of 54 uniform date palm trees (Khastawi and Khadhrawi cultivars), approximately 15 years old and planted at 10-m spacing, were selected for experimental treatments. The objective was to evaluate the effects of three concentrations of nano NPK fertilizer (0, 2, and 4 g·L-1), applied in six foliar doses, and three concentrations of potassium silicate (0, 2, and 4 mL·L-1), a...
Abstract
Molecular therapy : the journal of the American Society of Gene Therapy,
Volume 33, Issue 11, 20 3 2025, Pages 5373-5382
In vivo base editing reduces liver cysts in autosomal dominant polycystic kidney disease.
Ibel A, Bhardwaj R, Yilmaz DE, Kong S, Wendlinger S, Cordero C, Papaioannou D, Papazian M, Schönauer R, Meng Q, Eckardt KU, Hassan F, Volpe I, Klämbt V, Halbritter J, Fedeles S, Krappitz M, Kaminski MM
Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent genetic kidney disorder, affecting over 10 million individuals worldwide. Cystic expansion typically progresses to kidney failure and also involves the liver with limited treatment options. Pathogenic variants in PKD1 or PKD2 account for 85%-90% of cases. Genetic re-expression of Pkd1 or Pkd2 has been shown to partially reverse key characteristics of the disease phenotype in mice. Despite advancements in understanding the...
Abstract
