8684 results
Cited 95 times since 2021 (22.8 per year)
source: EuropePMC
Therapeutic drug monitoring,
Volume 43, Issue 2, 1 1 2021, Pages 150-200
Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology.
Bergan S, Brunet M, Hesselink DA, Johnson-Davis KL, Kunicki PK, Lemaitre F, Marquet P, Molinaro M, Noceti O, Pattanaik S, Pawinski T, Seger C, Shipkova M, Swen JJ, van Gelder T, Venkataramanan R, Wieland E, Woillard JB, Zwart TC, Barten MJ, Budde K, Dieterlen MT, Elens L, Haufroid V, Masuda S, Millan O, Mizuno T, Moes DJAR, Oellerich M, Picard N, Salzmann L, Tönshoff B, van Schaik RHN, Vethe NT, Vinks AA, Wallemacq P, Åsberg A, Langman LJ
Abstract: When mycophenolic acid (MPA) was originally marketed for immunosuppressive therapy, fixed doses were recommended by the manufacturer. Awareness of the potential for a more personalized dosing has led to development of methods to estimate MPA area under the curve based on the measurement of drug concentrations in only a few samples. This approach is feasible in the clinical routine and has proven successful in terms of correlation with outcome. However, the search for superior correlate...
Abstract
Cited 26 times since 2021 (6.2 per year)
source: EuropePMC
Rheumatology (Oxford, England),
Volume 60, Issue 4, 1 1 2021, Pages 1784-1792
Intravenous immunoglobulins as first-line treatment in idiopathic inflammatory myopathies: a pilot study.
Lim J, Eftimov F, Verhamme C, Brusse E, Hoogendijk JE, Saris CGJ, Raaphorst J, De Haan RJ, van Schaik IN, Aronica E, de Visser M, van der Kooi AJ
Objectives: We explored efficacy and safety of IVIg as first-line treatment in patients with an idiopathic inflammatory myopathy. Methods: In this investigator-initiated phase 2 open-label study, we included 20 adults with a newly diagnosed, biopsy-proven idiopathic inflammatory myopathy, and a disease duration of less than 9 months. Patients with IBM and prior use of immunosuppressants were excluded. The standard treatment regimen consisted of IVIg (Privigen) monotherapy for 9 weeks: a loading...
Abstract
Cited 8 times since 2021 (1.9 per year)
source: EuropePMC
Academic medicine : journal of the Association of American Medical Colleges,
Volume 96, Issue 4, 1 1 2021, Pages 495-500
Accessible and Adaptable Faculty Development to Support Curriculum Reform in Medical Education.
van Schaik SM
Contemporary curricular reform in medical education focuses on areas that current physician-educators were likely not exposed to during medical school, such as interprofessional teamwork; informatics; health care systems improvement; and diversity, equity, and inclusion. Thus, faculty may not be ready to support the planned curricular reform without adequate faculty development to acquire the necessary knowledge and skills. In an era with increasing demands on faculty, new approaches that are fl...
Abstract
Cited 24 times since 2021 (5.7 per year)
source: EuropePMC
The Journal of antimicrobial chemotherapy,
Volume 76, Issue 5, 1 1 2021, Pages 1130-1134
Transferable Acinetobacter baumannii plasmid pDETAB2 encodes OXA-58 and NDM-1 and represents a new class of antibiotic resistance plasmids.
Liu H, Moran RA, Chen Y, Doughty EL, Hua X, Jiang Y, Xu Q, Zhang L, Blair JMA, McNally A, van Schaik W, Yu Y
Objectives: To characterize a blaOXA-58- and blaNDM-1-containing MDR plasmid from a rare Acinetobacter baumannii lineage and compare it with related plasmids to explore the distribution and evolution of a new plasmid group. Methods: A. baumannii DETAB-P2 was isolated from a rectal swab of an intensive care patient. Antibiotic susceptibility was determined using broth microdilution. DETAB-P2 was mated with A. baumannii ATCC 17978 and putative transconjugants were characterized by S1/PFGE and Sout...
Abstract
Cited 13 times since 2021 (3.1 per year)
source: EuropePMC
Journal of patient safety,
Volume 17, Issue 3, 1 1 2021, Pages 157-165
Preoperative Anticoagulation Management in Everyday Clinical Practice: An International Comparative Analysis of Work-as-Done Using the Functional Resonance Analysis Method.
Damen NL, de Vos MS, Moesker MJ, Braithwaite J, de Lind van Wijngaarden RAF, Kaplan J, Hamming JF, Clay-Williams R
Objectives: Preoperative anticoagulation management (PAM) is a complex, multidisciplinary process important to patient safety. The Functional Resonance Analysis Method (FRAM) is a novel method to study how complex processes usually go right at the frontline (labeled Safety-II) and how this relates to predefined procedures. This study aimed to assess PAM in everyday practice and explore the usability and utility of FRAM. Methods: The study was conducted at an Australian and European Cardiothoraci...
Abstract
Cited 8 times since 2021 (1.9 per year)
source: EuropePMC
Journal of patient safety,
Volume 17, Issue 3, 1 1 2021, Pages 231-238
Learning From Morbidity and Mortality Conferences: Focus and Sustainability of Lessons for Patient Care.
de Vos MS, Hamming JF, Marang-van de Mheen PJ
Objective: It remains unclear to what extent the morbidity and mortality conference (M&M) meets the objective of improving quality and safety of patient care. It has been suggested that M&M may be too focused on individual performance, hampering system-level improvement. The aim of this study was to assess focus and sustainability of lessons for patient care that were derived from M&M. Methods: This is an observational study of routinely collected data on evaluated complications and...
Abstract
Cited 17 times since 2021 (4.1 per year)
source: EuropePMC
Cells,
Volume 10, Issue 4, 26 4 2021, Pages 737
The Inflammatory Profile of CTEPH-Derived Endothelial Cells Is a Possible Driver of Disease Progression.
Smolders VFED, Lodder K, Rodríguez C, Tura-Ceide O, Barberà JA, Jukema JW, Quax PHA, Goumans MJ, Kurakula K
Chronic thromboembolic pulmonary hypertension (CTEPH) is a form of pulmonary hypertension characterized by the presence of fibrotic intraluminal thrombi and causing obliteration of the pulmonary arteries. Although both endothelial cell (EC) dysfunction and inflammation are linked to CTEPH pathogenesis, regulation of the basal inflammatory response of ECs in CTEPH is not fully understood. Therefore, in the present study, we investigated the role of the nuclear factor (NF)-κB pro-inflammatory sign...
Abstract
Cited 56 times since 2021 (13.3 per year)
source: EuropePMC
Biomedicines,
Volume 9, Issue 4, 24 4 2021, Pages 328
Endothelial Barrier Function and Leukocyte Transmigration in Atherosclerosis.
Sluiter TJ, van Buul JD, Huveneers S, Quax PHA, de Vries MR
The vascular endothelium is a highly specialized barrier that controls passage of fluids and migration of cells from the lumen into the vessel wall. Endothelial cells assist leukocytes to extravasate and despite the variety in the specific mechanisms utilized by different leukocytes to cross different vascular beds, there is a general principle of capture, rolling, slow rolling, arrest, crawling, and ultimately diapedesis via a paracellular or transcellular route. In atherosclerosis, the barrier...
Abstract
Cited 27 times since 2021 (6.4 per year)
source: EuropePMC
Thorax,
Volume 76, Issue 10, 23 4 2021, Pages 1002-1009
Non-invasive early exclusion of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: the InShape II study.
Boon GJAM, Ende-Verhaar YM, Bavalia R, El Bouazzaoui LH, Delcroix M, Dzikowska-Diduch O, Huisman MV, Kurnicka K, Mairuhu ATA, Middeldorp S, Pruszczyk P, Ruigrok D, Verhamme P, Vliegen HW, Vonk Noordegraaf A, Vriend JWJ, Klok FA, InShape II study group
Background: The current diagnostic delay of chronic thromboembolic pulmonary hypertension (CTEPH) after pulmonary embolism (PE) is unacceptably long, causing loss of quality-adjusted life years and excess mortality. Validated screening strategies for early CTEPH diagnosis are lacking. Echocardiographic screening among all PE survivors is associated with overdiagnosis and cost-ineffectiveness. We aimed to validate a simple screening strategy for excluding CTEPH early after acute PE, limiting the...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
BMC medical education,
Volume 21, Issue 1, 22 4 2021, Pages 177
Talking the talk in junior interprofessional education: is healthcare terminology a barrier or facilitator?
Nadarajah S, Azim A, Yılmaz DU, Sibbald M
Background: Use of healthcare terminology is a potential barrier to interprofessional education (IPE). This study describes how junior learners perceive and classify healthcare terminology in IPE settings. Methods: We conducted a mixed methods study involving 29 medical, 14 nursing, and 2 physician assistant students who had previously attended or were registered to participate in educational activities at McMaster University's Centre for Simulation-Based Learning. 23 participants identifie...
Abstract
Cited 7 times since 2021 (1.7 per year)
source: EuropePMC
Pediatric pulmonology,
Volume 56, Issue 6, 22 4 2021, Pages 1666-1672
Point of care diaphragm ultrasound: An objective tool to predict the severity of pneumonia and outcomes in children.
Şık N, Çitlenbik H, Öztürk A, Yılmaz D, Duman M
Background: Pneumonia is one of the most common serious infections in children. Scoring systems have been adopted to quantify the severity of the disease, but they were based on clinical findings that can vary according to the subjective assessment of the clinician. We hypothesized that diaphragm ultrasound (DUS) parameters may be a new useful tool to objectively score the severity of the disease and predict outcomes in children with pneumonia. Methods: Children diagnosed with pneumonia, aged be...
Abstract
Cited 8 times since 2021 (1.9 per year)
source: EuropePMC
Veterinary world,
Volume 14, Issue 3, 22 4 2021, Pages 709-720
Determination of residues of pesticides, anabolic steroids, antibiotics, and antibacterial compounds in meat products in Oman by liquid chromatography/mass spectrometry and enzyme-linked immunosorbent assay.
Al-Amri I, Kadim IT, AlKindi A, Hamaed A, Al-Magbali R, Khalaf S, Al-Hosni K, Mabood F
Background and aim: Meat is a rich source of many nutrients and plays a vital role in human life however, meat safety is one of the top priorities of great concern for consumers today. More than 90% of human exposure to harmful materials is due to consumption of contaminated meat products. This study was designed to compare four valid analytical methods for the determination of organochlorine pesticides 2,4 D (2,4-dichlorophenoxyacetic acid), dichlorodiphenyldichloroethylene/dichlorodiphenyltric...
Abstract
Cited 6 times since 2021 (1.4 per year)
source: EuropePMC
Scientific reports,
Volume 11, Issue 1, 22 4 2021, Pages 6507
Reduced scan time and superior image quality with 3D flow MRI compared to 4D flow MRI for hemodynamic evaluation of the Fontan pathway.
Rijnberg FM, van Assen HC, Juffermans JF, Kroft LJM, van den Boogaard PJ, de Koning PJH, Hazekamp MG, van der Woude SFS, Warmerdam EG, Leiner T, Grotenhuis HB, Goeman JJ, Lamb HJ, Roest AAW, Westenberg JJM
Long scan times prohibit a widespread clinical applicability of 4D flow MRI in Fontan patients. As pulsatility in the Fontan pathway is minimal during the cardiac cycle, acquiring non-ECG gated 3D flow MRI may result in a reduction of scan time while accurately obtaining time-averaged clinical parameters in comparison with 2D and 4D flow MRI. Thirty-two Fontan patients prospectively underwent 2D (reference), 3D and 4D flow MRI of the Fontan pathway. Multiple clinical parameters were assessed fro...
Abstract
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
Access microbiology,
Volume 3, Issue 3, 22 4 2021, Pages 000217
<i>Bartonella quintana</i> as a cause for prosthetic valve endocarditis and post-sternotomy mediastinitis.
Plantinga NL, Vos RJ, Georgieva L, Roescher N
An otherwise healthy patient, with minimal clinical, biochemical and peroperative signs of infection, was diagnosed with Bartonella quintana prosthetic valve endocarditis by 16S PCR. The patient subsequently developed a post-sternotomy mediastinitis and Bartonella quintana was the only detected pathogen. Bartonella quintana can cause severe infections in individuals not classically at risk, and may be missed in the routine diagnostic work-up of endocarditis.
Abstract
Endocrine,
Volume 73, Issue 1, 20 3 2021, Pages 226-229
No association between glucocorticoid receptor polymorphisms and long-term respiratory outcome after very preterm birth.
Baas EM, Romijn M, van der Pal SM, Vrijlandt EJLE, Rotteveel J, Finken MJJ, Dutch POPS-19 Collaborative Study Group
Abstract
Cited 6 times since 2021 (1.4 per year)
source: EuropePMC
Heart rhythm O2,
Volume 2, Issue 3, 19 3 2021, Pages 290-297
Predicting early reconnection after cryoballoon ablation with procedural and biophysical parameters.
Keçe F, de Riva M, Alizadeh Dehnavi R, Wijnmaalen AP, Mertens BJ, Schalij MJ, Zeppenfeld K, Trines SA
Background: Predicting early reconnection/dormant conduction (ERC) immediately after pulmonary vein isolation (PVI) can avoid a waiting period with adenosine testing. Objective: To identify procedural and biophysical parameters predicting ERC. Methods: Consecutive atrial fibrillation (AF) patients undergoing a first cryoballoon ablation (Arctic Front Advance) between 2014 and 2017 were included. ERC was defined as manifest or dormant pulmonary vein (PV) reconnection with adenosine 30 minutes aft...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
Diagnostics (Basel, Switzerland),
Volume 11, Issue 3, 19 3 2021, Pages 553
Radioiodine in Differentiated Thyroid Carcinoma: Do We Need Diagnostic Pre-Ablation Iodine-123 Scintigraphy to Optimize Treatment?
de Koster EJ, Sulaiman T, Hamming JF, Schepers A, Snel M, van Velden FHP, de Geus-Oei LF, Vriens D
Changing insights regarding radioiodine (I-131) administration in differentiated thyroid carcinoma (DTC) stir up discussions on the utility of pre-ablation diagnostic scintigraphy (DxWBS). Our retrospective study qualitatively and semi-quantitatively assessed posttherapy I-131 whole-body scintigraphy (TxWBS) data for thyroid remnant size and metastasis. Findings were associated with initial treatment success after nine months, as well as clinical, histopathological, and surgical parameters. Poss...
Abstract
Cited 12 times since 2021 (2.8 per year)
source: EuropePMC
BMC medicine,
Volume 19, Issue 1, 18 3 2021, Pages 69
Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses.
Bos MM, Goulding NJ, Lee MA, Hofman A, Bot M, Pool R, Vijfhuizen LS, Zhang X, Li C, Mustafa R, Neville MJ, Li-Gao R, Trompet S, Beekman M, Biermasz NR, Boomsma DI, de Boer I, Christodoulides C, Dehghan A, van Dijk KW, Ford I, Ghanbari M, Heijmans BT, Ikram MA, Jukema JW, Mook-Kanamori DO, Karpe F, Luik AI, Lumey LH, van den Maagdenberg AMJM, Mooijaart SP, de Mutsert R, Penninx BWJH, Rensen PCN, Richmond RC, Rosendaal FR, Sattar N, Schoevers RA, Slagboom PE, Terwindt GM, Thesing CS, Wade KH, Wijsman CA, Willemsen G, Zwinderman AH, van Heemst D, Noordam R, Lawlor DA
Background: Sleep traits are associated with cardiometabolic disease risk, with evidence from Mendelian randomization (MR) suggesting that insomnia symptoms and shorter sleep duration increase coronary artery disease risk. We combined adjusted multivariable regression (AMV) and MR analyses of phenotypes of unfavourable sleep on 113 metabolomic traits to investigate possible biochemical mechanisms linking sleep to cardiovascular disease. Methods: We used AMV (N = 17,368) combined with two-sample...
Abstract
Cited 8 times since 2021 (1.9 per year)
source: EuropePMC
Cancers,
Volume 13, Issue 6, 18 3 2021, Pages 1370
Germline Variation in <i>PDCD1</i> Is Associated with Overall Survival in Patients with Metastatic Melanoma Treated with Anti-PD-1 Monotherapy.
de With M, Hurkmans DP, Oomen-de Hoop E, Lalouti A, Bins S, El Bouazzaoui S, van Brakel M, Debets R, Aerts JGJV, van Schaik RHN, Mathijssen RHJ, van der Veldt AAM
A substantial number of melanoma patients do not benefit from therapy with anti-PD-1. Therefore, we investigated the predictive value of single nucleotide polymorphisms (SNPs) in genes related to the PD-1 axis in patients with metastatic melanoma. From 119 consecutive melanoma patients who were treated with pembrolizumab or nivolumab monotherapy, blood samples were genotyped for 11 SNPs in nine genes. Associations between SNPs and OS were tested using Cox regression analysis and internally valid...
Abstract
Cited 6 times since 2021 (1.4 per year)
source: EuropePMC
Journal of molecular and cellular cardiology,
Volume 156, 18 3 2021, Pages 95-104
New calcification model for intact murine aortic valves.
Kruithof BPT, van de Pol V, Los T, Lodder K, Mousavi Gourabi B, DeRuiter MC, Goumans MJ, Ajmone Marsan N
Calcific aortic valve disease (CAVD) is a common progressive disease of the aortic valves, for which no medical treatment exists and surgery represents currently the only therapeutic solution. The development of novel pharmacological treatments for CAVD has been hampered by the lack of suitable test-systems, which require the preservation of the complex valve structure in a mechanically and biochemical controllable system. Therefore, we aimed at establishing a model which allows the study of cal...
Abstract
