8327 results
Cited 8 times since 2018 (1.2 per year)
source: EuropePMC
Human pathology,
Volume 81, 25 4 2018, Pages 245-254
The theranostic target prostate-specific membrane antigen is expressed in medullary thyroid cancer.
Lodewijk L, Willems SM, Dreijerink KMA, de Keizer B, van Diest PJ, Schepers A, Morreau H, Bonenkamp HJ, Van Engen-van Grunsven IACH, Kruijff S, van Hemel BM, Links TP, Nieveen van Dijkum E, van Eeden S, Valk GD, Borel Rinkes IHM, Vriens MR
Abstract
Cited 2 times since 2018 (0.3 per year)
source: EuropePMC
International journal of cardiology,
Volume 273, 24 4 2018, Pages 203-206
ECG derived ventricular gradient exceeds echocardiography in the early detection of pulmonary hypertension in scleroderma patients.
Meijer FMM, Kies P, Jongbloed MRM, van Wijngaarden SE, Swenne CA, Man S, Schalij MJ, de Vries-Bouwstra JK, Vliegen HW
Background: Patients with systemic sclerosis (SSc) are at risk for developing pulmonary hypertension (PH) which is a major cause of death in this population. Echocardiographic (TTE) derived pulmonary arterial pressure (PAP) can be unreliable for the early detection of PH. Previous studies demonstrate that the ECG derived ventricular gradient optimized for right ventricular pressure overload (VG-RVPO) can detect PH in a heterogeneous population suspected of PH. The aim of this study is to assess...
Abstract
Cited 31 times since 2018 (4.7 per year)
source: EuropePMC
PLoS medicine,
Volume 15, Issue 7, 24 4 2018, Pages e1002614
High levels of sewage contamination released from urban areas after storm events: A quantitative survey with sewage specific bacterial indicators.
Olds HT, Corsi SR, Dila DK, Halmo KM, Bootsma MJ, McLellan SL
Background: Past studies have demonstrated an association between waterborne disease and heavy precipitation, and climate change is predicted to increase the frequency of these types of intense storm events in some parts of the United States. In this study, we examined the linkage between rainfall and sewage contamination of urban waterways and quantified the amount of sewage released from a major urban area under different hydrologic conditions to identify conditions that increase human risk of...
Abstract
Cited 6 times since 2018 (0.9 per year)
source: EuropePMC
European journal of preventive cardiology,
Volume 25, Issue 14, 23 4 2018, Pages 1523-1531
Combined use of polypill components in patients with type 2 diabetes mellitus.
Janssen VE, Visseren FL, de Boer A, Grobbee DE, Westerink J, van der Graaf Y, Lafeber M, SMART Study Group
Objectives A polypill containing aspirin, a statin and blood pressure (BP)-lowering agents has been proposed for the prevention of cardiovascular disease. To increase adherence and reduce the gaps between indicated and used therapy, a polypill might be of interest for patients with type 2 diabetes (T2DM). Our aim was to assess the prevalence of the combined use of polypill components in patients with T2DM over time. Methods The combined use of polypill components was assessed between 1996 and 20...
Abstract
Cited 11 times since 2018 (1.7 per year)
source: EuropePMC
BMJ quality & safety,
Volume 28, Issue 3, 21 3 2018, Pages 180-189
Connecting perspectives on quality and safety: patient-level linkage of incident, adverse event and complaint data.
de Vos MS, Hamming JF, Chua-Hendriks JJC, Marang-van de Mheen PJ
Background and objective: Incident, adverse event (AE) and complaint data are typically used separately, but may be related at the patient level with one event triggering a cascade of events, ultimately resulting in a complaint. This study examined relations between incidents, AEs and complaints that co-occurred in admissions. Methods: Independently and routinely collected incident, AE and complaint data were retrospectively linked for surgical admissions in an academic centre (2008-2014). Two i...
Abstract
Cited 8 times since 2018 (1.2 per year)
source: EuropePMC
Clinical and experimental rheumatology,
Volume 36 Suppl 113, Issue 4, 18 3 2018, Pages 109-117
To what extent do autoantibodies help to identify high-risk patients in systemic sclerosis?
Boonstra M, Mertens BJA, Bakker JA, Ninaber MK, Ajmone Marsan N, van der Helm-van Mil AHM, Scherer HU, Huizinga TWJ, de Vries-Bouwstra JK
Objectives: To evaluate the additive value of autoantibodies in identifying systemic sclerosis (SSc) patients with high complication risk. Methods: Patients entering the Combined Care In SSc cohort, Leiden University Medical Centre between April 2009 and May 2016 were included. Subgroups of patients were determined using hierarchical clustering, performed on Principal Component Analysis scores, 1) using baseline data of demographic and clinical variables only and 2) with additional use of antibo...
Abstract
Cited 15 times since 2018 (2.3 per year)
source: EuropePMC
PLoS genetics,
Volume 14, Issue 7, 18 3 2018, Pages e1007527
Bacterial sensing: A putative amphipathic helix in RsiV is the switch for activating σV in response to lysozyme.
Lewerke LT, Kies PJ, Müh U, Ellermeier CD
Extra Cytoplasmic Function (ECF) σ factors are a diverse group of alternate σ factors bacteria use to respond to changes in the environment. The Bacillus subtilis ECF σ factor σV responds to lysozyme. In the absence of lysozyme, σV is held inactive by the anti-σ factor, RsiV. In the presence of lysozyme RsiV is degraded via regulated intramembrane proteolysis, which results in the release of σV and thus activation of lysozyme resistance genes. Signal peptidase is required to initiate degradation...
Abstract
Cited 30 times since 2018 (4.5 per year)
source: EuropePMC
Genome biology,
Volume 19, Issue 1, 17 3 2018, Pages 87
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.
Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J, Cappellani S, Van Duijvenboden S, Klena NT, Gabriel GC, Liu X, Gulec C, Grarup N, Haessler J, Hall LM, Iorio A, Isaacs A, Li-Gao R, Lin H, Liu CT, Lyytikäinen LP, Marten J, Mei H, Müller-Nurasyid M, Orini M, Padmanabhan S, Radmanesh F, Ramirez J, Robino A, Schwartz M, van Setten J, Smith AV, Verweij N, Warren HR, Weiss S, Alonso A, Arnar DO, Bots ML, de Boer RA, Dominiczak AF, Eijgelsheim M, Ellinor PT, Guo X, Felix SB, Harris TB, Hayward C, Heckbert SR, Huang PL, Jukema JW, Kähönen M, Kors JA, Lambiase PD, Launer LJ, Li M, Linneberg A, Nelson CP, Pedersen O, Perez M, Peters A, Polasek O, Psaty BM, Raitakari OT, Rice KM, Rotter JI, Sinner MF, Soliman EZ, Spector TD, Strauch K, Thorsteinsdottir U, Tinker A, Trompet S, Uitterlinden A, Vaartjes I, van der Meer P, Völker U, Völzke H, Waldenberger M, Wilson JG, Xie Z, Asselbergs FW, Dörr M, van Duijn CM, Gasparini P, Gudbjartsson DF, Gudnason V, Hansen T, Kääb S,
Background: Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. However, the variants identified fall predominantly in non-coding regions and their underlying mechanisms remain unclear. Results: Here, we identify putative functional coding variation associated with changes in the QRS interval duration by combining Illumina HumanExome Bead...
Abstract
Cited 4 times since 2018 (0.6 per year)
source: EuropePMC
Heart rhythm,
Volume 15, Issue 12, 12 2 2018, Pages 1816-1822
Impact of atrial fibrillation on improvement of functional mitral regurgitation in cardiac resynchronization therapy.
van der Bijl P, Vo NM, Leung M, Ajmone Marsan N, Delgado V, Stone GW, Bax JJ
Background: Functional mitral regurgitation (FMR) and atrial fibrillation (AF) are frequent heart failure (HF) complications. Cardiac resynchronization therapy (CRT) can improve FMR; however, little is known about the influence of AF on FMR improvement. Objective: The purpose of this study was to investigate the mechanisms and impact of baseline AF on FMR improvement after CRT. Methods: CRT recipients with HF, AF, or sinus rhythm (SR) at baseline with moderate or severe FMR, were included from a...
Abstract
Cited 2 times since 2018 (0.3 per year)
source: EuropePMC
Pharmacogenomics,
Volume 19, Issue 11, 11 2 2018, Pages 895-903
CYP3A5 and ABCB1 polymorphisms in living donors do not impact clinical outcome after kidney transplantation.
Yang L, de Winter BC, van Schaik RH, Xie RX, Li Y, Andrews LM, Shuker N, Bahmany S, Koch B, van Gelder T, Hesselink DA
Aim: To investigate the association between donor CYP3A5 and ABCB1 polymorphisms and tacrolimus (Tac)-induced nephrotoxicity and renal function in kidney transplant recipients. Methods: The CYP3A5 6986A>G and ABCB1 3435C>T polymorphisms were determined in 237 recipients and donors. Results: There was no significant association between Tac-related nephrotoxicity and donor CYP3A5 and ABCB1 genotype. The donor ABCB1 3435C>T polymorphism was associated with estimated glomerular filtration r...
Abstract
Cited 24 times since 2018 (3.6 per year)
source: EuropePMC
The Lancet. Neurology,
Volume 17, Issue 8, 9 2 2018, Pages 689-698
Oral fingolimod for chronic inflammatory demyelinating polyradiculoneuropathy (FORCIDP Trial): a double-blind, multicentre, randomised controlled trial.
Hughes R, Dalakas MC, Merkies I, Latov N, Léger JM, Nobile-Orazio E, Sobue G, Genge A, Cornblath D, Merschhemke M, Ervin CM, Agoropoulou C, Hartung HP, FORCIDP Trial Investigators
Background: Fingolimod is approved for the treatment of relapsing-remitting multiple sclerosis and was effective in experimental autoimmune neuritis in rats, a possible model for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We aimed to evaluate the efficacy of fingolimod in delaying disability progression in patients with CIDP who withdrew from currently effective treatments (intravenous immunoglobulin [IVIg] or corticosteroids). Methods: This double-blind, multicentre, rand...
Abstract
Cited 8 times since 2018 (1.2 per year)
source: EuropePMC
Pharmacology research & perspectives,
Volume 6, Issue 4, 5 1 2018, Pages e00419
Enantioselective pharmacokinetics of tramadol and its three main metabolites; impact of <i>CYP2D6</i>, <i>CYP2B6</i>, and <i>CYP3A4</i> genotype.
Haage P, Kronstrand R, Josefsson M, Calistri S, van Schaik RHN, Green H, Kugelberg FC
Tramadol is a complex drug, being metabolized by polymorphic enzymes and administered as a racemate with the (+)- and (-)-enantiomers of the parent compound and metabolites showing different pharmacological effects. The study aimed to simultaneously determine the enantiomer concentrations of tramadol, O-desmethyltramadol, N-desmethyltramadol, and N,O-didesmethyltramadol following a single dose, and elucidate if enantioselective pharmacokinetics is associated with the time following drug intake a...
Abstract
Cited 6 times since 2018 (0.9 per year)
source: EuropePMC
Journal of periodontal research,
Volume 53, Issue 5, 4 1 2018, Pages 916-923
Matrix metalloproteinase-7 in periodontitis with type 2 diabetes mellitus.
Zeidán-Chuliá F, Yilmaz D, Häkkinen L, Könönen E, Neves de Oliveira BH, Güncü G, Uitto VJ, Caglayan F, Gürsoy UK
Background and objective: Elevated levels of matrix metalloproteinase-7 (MMP7) have been observed in serum samples of subjects with type 2 diabetes mellitus (T2DM) and in gingival tissues of subjects with periodontitis. The aim of the present study was to collect in vivo and in silico evidence on the role of MMP7 in the interplay between T2DM and generalized periodontitis (GP). Material and methods: The extent of MMP7 expression and localization were immunohistochemically analyzed in gingival ti...
Abstract
Cited 33 times since 2018 (4.9 per year)
source: EuropePMC
Applied and environmental microbiology,
Volume 84, Issue 14, 2 1 2018, Pages e00309-18
Human-Associated Lachnospiraceae Genetic Markers Improve Detection of Fecal Pollution Sources in Urban Waters.
Feng S, Bootsma M, McLellan SL
The human microbiome contains many organisms that could potentially be used as indicators of human fecal pollution. Here we report the development of two novel human-associated genetic marker assays that target organisms within the family Lachnospiraceae Next-generation sequencing of the V6 region of the 16S rRNA gene from sewage and animal stool samples identified 40 human-associated marker candidates with a robust signal in sewage and low or no occurrence in samples from nonhuman hosts. Two we...
Abstract
Cited 14 times since 2018 (2.1 per year)
source: EuropePMC
Journal of neurology,
Volume 265, Issue 9, 2 1 2018, Pages 2052-2059
Corticosteroids in chronic inflammatory demyelinating polyneuropathy : A retrospective, multicentre study, comparing efficacy and safety of daily prednisolone, pulsed dexamethasone, and pulsed intravenous methylprednisolone.
van Lieverloo GGA, Peric S, Doneddu PE, Gallia F, Nikolic A, Wieske L, Verhamme C, van Schaik IN, Nobile-Orazio E, Basta I, Eftimov F
Background: Chronic inflammatory demyelinating polyneuropathy (CIDP) can be treated with corticosteroids or intravenous immunoglobulins. Various corticosteroid regimens are currently used in CIDP, but it is unknown whether they are equally efficacious. In this retrospective study, we compared efficacy and safety of three corticosteroid regimens in CIDP patients. Methods: We included treatment naïve patients that fulfilled the EFNS/PNS criteria for CIDP. Patients were treated with corticosteroids...
Abstract
Cited 221 times since 2018 (33 per year)
source: EuropePMC
JAMA cardiology,
Volume 3, Issue 7, 1 1 2018, Pages 619-627
Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis.
Burgess S, Ference BA, Staley JR, Freitag DF, Mason AM, Nielsen SF, Willeit P, Young R, Surendran P, Karthikeyan S, Bolton TR, Peters JE, Kamstrup PR, Tybjærg-Hansen A, Benn M, Langsted A, Schnohr P, Vedel-Krogh S, Kobylecki CJ, Ford I, Packard C, Trompet S, Jukema JW, Sattar N, Di Angelantonio E, Saleheen D, Howson JMM, Nordestgaard BG, Butterworth AS, Danesh J, European Prospective Investigation Into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD) Consortium
Importance: Human genetic studies have indicated that plasma lipoprotein(a) (Lp[a]) is causally associated with the risk of coronary heart disease (CHD), but randomized trials of several therapies that reduce Lp(a) levels by 25% to 35% have not provided any evidence that lowering Lp(a) level reduces CHD risk. Objective: To estimate the magnitude of the change in plasma Lp(a) levels needed to have the same evidence of an association with CHD risk as a 38.67-mg/dL (ie, 1-mmol/L) change in low-dens...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 54, Issue 1, 1 1 2018, Pages 199
Mitral valve infective endocarditis: putting the puzzle pieces together.
Tomšic A, Klautz RJM, Palmen M
Abstract
Heart, lung & circulation,
Volume 27, Issue 7, 1 1 2018, Pages 782-784
Lessons from an International Bicuspid Aortic Valve Disease Registry: the Raphe and Beyond.
Ng ACT, Delgado V, Kong WKF, Bax JJ
Abstract
Cited 43 times since 2018 (6.4 per year)
source: EuropePMC
Circulation. Cardiovascular imaging,
Volume 11, Issue 7, 1 1 2018, Pages e007562
Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease.
Lee SE, Sung JM, Rizvi A, Lin FY, Kumar A, Hadamitzky M, Kim YJ, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, Leipsic JA, Shin S, Hyun Choi J, Chinnaiyan K, Raff G, Virmani R, Samady H, Stone PH, Berman DS, Narula J, Shaw LJ, Bax JJ, Min JK, Chang HJ
Background: Diagnosis of coronary artery disease and management strategies have relied solely on the presence of diameter stenosis ≥50%. We assessed whether direct quantification of plaque burden (PB) and plaque characteristics assessed by coronary computed tomography angiography could provide additional value in terms of predicting rapid plaque progression. Methods and results: From a 13-center, 7-country prospective observational registry, 1345 patients (60.4±9.4 years old; 57.1% male) who und...
Abstract
JACC. Cardiovascular imaging,
Volume 11, Issue 7, 1 1 2018, Pages 984-986
Will Cardiac Magnetic Resonance Change the Management of Severe Aortic Stenosis Patients?
Delgado V, Bax JJ
Abstract
