Research

Publications

Below you can find a list of our published research.

6131 results

Cited 10 times since 2010 (0.7 per year) source: EuropePMC

International journal of cardiology, Volume 152, Issue 2, 9 2 2010, Pages 237-241 Rehabilitation: Periodic somatosensory stimulation increases arterial baroreflex sensitivity in chronic heart failure patients. Gademan MG, Sun Y, Han L, Valk VJ, Schalij MJ, van Exel HJ, Lucas CM, Maan AC, Verwey HF, van de Vooren H, Pinna GD, Maestri R, La Rovere MT, van der Wall EE, Swenne CA

Background: One of the beneficial effects of exercise training in chronic heart failure (CHF) is an improvement in baroreflex sensitivity (BRS), a prognostic index in CHF. In our hypothesis-generating study we propose that at least part of this effect is mediated by neural afferent information, and more specifically, by exercise-induced somatosensory nerve traffic. Objective: To compare the effects of periodic electrical somatosensory stimulation on BRS in patients with CHF with the effects of e... Abstract

Cited 47 times since 2010 (3.2 per year) source: EuropePMC

European heart journal, Volume 31, Issue 22, 7 1 2010, Pages 2783-2790 Morbidity and mortality in heart failure patients treated with cardiac resynchronization therapy: influence of pre-implantation characteristics on long-term outcome. van Bommel RJ, Borleffs CJ, Ypenburg C, Marsan NA, Delgado V, Bertini M, van der Wall EE, Schalij MJ, Bax JJ

Aims: Cardiac resynchronization therapy (CRT) improves cardiac function, heart failure symptoms, and prognosis in selected patients. Many baseline characteristics associated with heart failure may influence prognosis after CRT. The objective of this study was to evaluate the effect of several baseline characteristics in relation to long-term prognosis in heart failure patients treated with CRT. Methods and results: A total of 716 consecutive heart failure patients treated with CRT were included... Abstract

Cited 5 times since 2010 (0.3 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 17, Issue 6, 6 1 2010, Pages 1034-1040 Incremental prognostic value of left ventricular function analysis over non-invasive coronary angiography with multidetector computed tomography. de Graaf FR, van Werkhoven JM, van Velzen JE, Antoni ML, Boogers MJ, Kroft LJ, de Roos A, Schalij MJ, Jukema JW, van der Wall EE, Schuijf JD, Bax JJ

Background: The purpose of this study was to determine the prognostic value of computed tomography coronary angiography (CTA)-derived left ventricular (LV) function analysis and to assess its incremental prognostic value over the detection of significant stenosis using CTA. Methods: In 728 patients (400 males, mean age 55 ± 12 years) with known or suspected CAD, the presence of significant stenosis (≥ 50% stenosis) and LV function were assessed using CTA. LV end-systolic volume (LVESV), LV end-d... Abstract

Cited 47 times since 2010 (3.2 per year) source: EuropePMC

QJM : monthly journal of the Association of Physicians, Volume 103, Issue 10, 4 1 2010, Pages 727-739 Barriers to cardiovascular disease risk scoring and primary prevention in Europe. Hobbs FD, Jukema JW, Da Silva PM, McCormack T, Catapano AL

The prevalence and burden of cardiovascular disease (CVD) is high, and it remains the leading cause of death worldwide. Unfortunately, many individuals who are at high risk for CVD are not recognized and/or treated. Therefore, programs are available to ensure individuals at risk for CVD are identified through appropriate risk classification and offered optimal preventative interventions. The use of algorithms to determine a global risk score may help to achieve these goals. Such global risk-scor... Abstract

Cited 7 times since 2010 (0.5 per year) source: EuropePMC

The Journal of surgical research, Volume 164, Issue 1, 2 1 2010, Pages e91-7 Impact of complications after surgery for colorectal liver metastasis on patient survival. Schepers A, Mieog S, van de Burg BB, van Schaik J, Liefers GJ, Marang-van de Mheen PJ

Background: In some patients with colorectal liver metastases it is not clear whether liver resection or isolated liver perfusion is the best treatment option. For instance, the risk of complications after surgery may be so substantial and affect subsequent survival. Aim of the present study is to compare complication occurrence and its effect on survival after liver resection and perfusion. Methods: Patient records of all 225 patients with colorectal liver metastases treated with liver resectio... Abstract

Cited 52 times since 2010 (3.6 per year) source: EuropePMC

International journal of cardiology, Volume 147, Issue 1, 2 1 2010, Pages 13-24 Normal and abnormal development of pulmonary veins: state of the art and correlation with clinical entities. Douglas YL, Jongbloed MR, Deruiter MC, Gittenberger-de Groot AC

Interest for the pulmonary veins has increased in the past decade after the potential arrhythmogenicity of the myocardial sleeve surrounding these structures has been recognized. Furthermore, there are several clinical entities, such as anomalous connection pattern and pulmonary vein stenosis, that are related to abnormal pulmonary vein development. In this review, we will describe current literature and aim to elucidate and reorganize current opinions on normal and abnormal pulmonary vein devel... Abstract

Cited 18 times since 2010 (1.2 per year) source: EuropePMC

Tissue engineering. Part C, Methods, Volume 16, Issue 4, 1 1 2010, Pages 597-607 Intravital molecular imaging of small-diameter tissue-engineered vascular grafts in mice: a feasibility study. Hjortnaes J, Gottlieb D, Figueiredo JL, Melero-Martin J, Kohler RH, Bischoff J, Weissleder R, Mayer JE, Aikawa E

Objectives: Creating functional small-diameter tissue-engineered blood vessels has not been successful to date. Moreover, the processes underlying the in vivo remodeling of these grafts and the fate of cells seeded onto scaffolds remain unclear. Here we addressed these unmet scientific needs by using intravital molecular imaging to monitor the development of tissue-engineered vascular grafts (TEVG) implanted in mouse carotid artery. Methods and results: Green fluorescent protein-labeled human bo... Abstract

Cited 1 times since 2010 (0.1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 18, Issue 7-8, 1 1 2010, Pages 381 Giant pseudoaneurysm after aortic root replacement. van de Wetering ML, Wagenaar LJ, Bouma BJ, Koolbergen DR

Abstract

Cited 20 times since 2010 (1.4 per year) source: EuropePMC

International journal of cardiology, Volume 152, Issue 2, 1 1 2010, Pages 212-217 Mortality in adult congenital heart disease: are national registries reliable for cause of death? Zomer AC, Uiterwaal CS, van der Velde ET, Tijssen JG, Mariman EC, Verheugt CL, Vaartjes I, Pieper PG, Meijboom FJ, Grobbee DE, Mulder BJ

Background: Statistics on cause-specific mortality are important for prognostic research. The aim of this study was to assess the utility of the national mortality registry in research on causes of death in adult patients with congenital heart disease (CHD). Methods: The CONCOR registry of over 10,000 adults with CHD was used to verify the causes of death provided by the WHO guidelines based national mortality registry, by linkage. Results: Of 7277 patients linked to the national mortality regis... Abstract

Cited 43 times since 2010 (2.9 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 12, Issue 8, 1 1 2010, Pages 1176-1177 Deactivation of implanted cardioverter-defibrillators at the end of life: results of the EHRA survey. Marinskis G, van Erven L, EHRA Scientific Initiatives Committee

This survey assesses the current opinion on and practice of the management of terminally ill patients with implanted cardioverter-defibrillators (ICDs) in 47 large European centres. The principal findings of this survey were that most physicians (62%) from European centres who responded to this survey would consider deactivating ICDs at the patient's end of life. In these circumstances, multiple appropriate ICD shocks may be an indication to deactivate an ICD (83% positive answers). Remote... Abstract

Cited 91 times since 2010 (6.2 per year) source: EuropePMC

The American journal of cardiology, Volume 106, Issue 3, 1 1 2010, Pages 395-401 Predictors of mitral regurgitation recurrence in patients with heart failure undergoing mitral valve annuloplasty. Ciarka A, Braun J, Delgado V, Versteegh M, Boersma E, Klautz R, Dion R, Bax JJ, Van de Veire N

Restrictive mitral annuloplasty is a surgical treatment option for patients with heart failure (HF) and functional mitral regurgitation (MR). However, recurrent MR has been reported at mid-term follow-up. The aim of the present study was to identify the echocardiographic predictors of recurrent MR in patients with HF undergoing mitral annuloplasty. During a mean follow-up of 2.6 +/- 1.6 years, 109 patients with HF (49% ischemic and 51% idiopathic dilated cardiomyopathy) who had undergone mitral... Abstract

Cited 46 times since 2010 (3.2 per year) source: EuropePMC

European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, Volume 17, Issue 4, 1 1 2010, Pages 455-461 KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER study. Iakoubova OA, Robertson M, Tong CH, Rowland CM, Catanese JJ, Blauw GJ, Jukema JW, Murphy MB, Devlin JJ, Ford I, Shepherd J

Background: Statin therapy has been found to substantially and significantly reduce coronary events in carriers of the KIF6 719Arg variant (rs20455) but not in noncarriers. We investigated whether, among the elderly, statin therapy also significantly reduced coronary events in carriers but not in noncarriers. Design and methods: Among 5,752 patients of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) study, we assessed the effect of pravastatin, compared with placebo, on cor... Abstract

Cited 10 times since 2010 (0.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 56, Issue 10, 1 1 2010, Pages 754-762 Critical appraisal of the use of cardiac resynchronization therapy beyond current guidelines. Van Bommel RJ, Delgado V, Schalij MJ, Bax JJ

Cardiac resynchronization therapy (CRT) is an effective treatment for patients with drug-refractory, chronic heart failure. Multiple single-center and multicenter studies have shown significant reductions in left ventricular (LV) volumes and an increase in LV systolic function. More importantly, CRT reduces mortality and morbidity during long-term follow-up. Current guidelines consider CRT as a Class I indication for heart failure patients in New York Heart Association (NYHA) functional class II... Abstract

Cited 25 times since 2010 (1.7 per year) source: EuropePMC

Molecular imaging, Volume 9, Issue 4, 1 1 2010, Pages 223-231 Novel intraoperative near-infrared fluorescence camera system for optical image-guided cancer surgery. Mieog JS, Vahrmeijer AL, Hutteman M, van der Vorst JR, Drijfhout van Hooff M, Dijkstra J, Kuppen PJ, Keijzer R, Kaijzel EL, Que I, van de Velde CJ, Löwik CW

Current methods of intraoperative tumor margin detection using palpation and visual inspection frequently result in incomplete resections, which is an important problem in surgical oncology. Therefore, real-time visualization of cancer cells is needed to increase the number of patients with a complete tumor resection. For this purpose, near-infrared fluorescence (NIRF) imaging is a promising technique. Here we describe a novel, handheld, intraoperative NIRF camera system equipped with a 690 nm l... Abstract

Cited 55 times since 2010 (3.8 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 96, Issue 16, 1 1 2010, Pages 1275-1280 Beneficial effects of catheter ablation on left ventricular and right ventricular function in patients with frequent premature ventricular contractions and preserved ejection fraction. Wijnmaalen AP, Delgado V, Schalij MJ, van Huls van Taxis CF, Holman ER, Bax JJ, Zeppenfeld K

Background: Improvement of left ventricular ejection fraction (LVEF) after radiofrequency catheter ablation (RFCA) of frequent premature ventricular contractions (PVCs) has been reported. However, most patients with frequent PVCs have a normal LVEF. In these patients subtle and early forms of PVC-induced left and right ventricular (RV) impairment may not be detected by standard echocardiographic techniques. Objective: To assess the effect of frequent PVCs on ventricular function in patients with... Abstract

Cited 3 times since 2010 (0.2 per year) source: EuropePMC

Minerva medica, Volume 101, Issue 4, 1 1 2010, Pages 255-270 Young at heart. An update on cardiac regeneration. Smits AM, Ramkisoensing AA, Atsma DE, Goumans MJ

Cardiovascular disease remains one of the most important causes of mortality. Over the past decades important advances have been made in prevention and treatment of acute complications after myocardial infarction (MI). As a result, the number of patients that acutely die from MI has been reduced. Current treatments can not prevent the loss of cardiac contractility caused by cardiomyocyte death, and therefore patients that do survive MI are prone to develop progressive impaired cardiac function,... Abstract

Cited 35 times since 2010 (2.4 per year) source: EuropePMC

Magnetic resonance in medicine, Volume 64, Issue 2, 1 1 2010, Pages 586-594 Automated segmentation of myocardial scar in late enhancement MRI using combined intensity and spatial information. Tao Q, Milles J, Zeppenfeld K, Lamb HJ, Bax JJ, Reiber JH, van der Geest RJ

Accurate assessment of the size and distribution of a myocardial infarction (MI) from late gadolinium enhancement (LGE) MRI is of significant prognostic value for postinfarction patients. In this paper, an automatic MI identification method combining both intensity and spatial information is presented in a clear framework of (i) initialization, (ii) false acceptance removal, and (iii) false rejection removal. The method was validated on LGE MR images of 20 chronic postinfarction patients, using... Abstract

Cited 9 times since 2010 (0.6 per year) source: EuropePMC

European journal of trauma and emergency surgery : official publication of the European Trauma Society, Volume 36, Issue 6, 27 4 2010, Pages 579-585 Appendicular tuberculosis: review of 155 published cases and a report of two cases. Akbulut S, Yagmur Y, Bakir S, Sogutcu N, Yilmaz D, Senol A, Bahadir MV

Purpose: This paper provides an overview of the literature on appendicular tuberculosis (ATB) between 1909 and 2010. Methods: We present two cases of primary ATB and a literature review of studies on ATB published in English and accessed via the Pubmed and Google Scholar databases. Results: One hundred fifty-five published cases of ATB were reviewed, and two patients with primary ATB, treated and followed in our clinic, were reported. The age range of the patients (62 females, 60 males and 33 wi... Abstract

Cited 38 times since 2010 (2.6 per year) source: EuropePMC

The American journal of cardiology, Volume 106, Issue 5, 23 4 2010, Pages 723-729 Relation of left ventricular twist and global strain with right ventricular dysfunction in patients after operative "correction" of tetralogy of fallot. van der Hulst AE, Delgado V, Holman ER, Kroft LJ, de Roos A, Hazekamp MG, Blom NA, Bax JJ, Roest AA

In patients with corrected tetralogy of Fallot (cToF), left ventricular (LV) dysfunction is closely related to right ventricular (RV) dysfunction, indicating adverse ventricular-ventricular interactions. However, the mechanism that links RV dysfunction to LV dysfunction remains unclear. In this prospective study, 32 patients with cToF and 19 controls were enrolled. With cardiac magnetic resonance imaging, biventricular ejection fractions were assessed. Using 2-dimensional speckle tracking, globa... Abstract

Cited 8 times since 2010 (0.5 per year) source: EuropePMC

The American journal of cardiology, Volume 106, Issue 5, 23 4 2010, Pages 682-687 Effect of cardiac resynchronization therapy on subendo- and subepicardial left ventricular twist mechanics and relation to favorable outcome. Bertini M, Delgado V, Nucifora G, Marsan NA, Ng AC, Shanks M, Van Bommel RJ, Borleffs CJ, Ewe SH, Boriani G, Biffi M, Schalij MJ, Bax JJ

The analysis of left ventricular (LV) mechanics provides novel insights into the effects of cardiac resynchronization therapy (CRT) on LV performance. Currently, advances in speckle-tracking echocardiographic analysis have permitted the characterization of subendocardial and subepicardial LV twist. The aim of this study was to investigate the role of the acute changes in subendocardial and subepicardial LV twist for the prediction of midterm beneficial effects of CRT. A total of 84 patients with... Abstract