Research

Publications

Below you can find a list of our published research.

8684 results

Cited 16 times since 2016 (1.7 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 9, Issue 4, 1 1 2016, Pages e003439 Allosteric Modulation of Kv11.1 (hERG) Channels Protects Against Drug-Induced Ventricular Arrhythmias. Yu Z, Liu J, van Veldhoven JP, IJzerman AP, Schalij MJ, Pijnappels DA, Heitman LH, de Vries AA

Background: Ventricular arrhythmias as a result of unintentional blockade of the Kv11.1 (hERG [human ether-à-go-go-related gene]) channel are a major safety concern in drug development. In past years, several highly prescribed drugs have been withdrawn for their ability to cause such proarrhythmia. Here, we investigated whether the proarrhythmic risk of existing drugs could be reduced by Kv11.1 allosteric modulators. Methods and results: Using [(3)H]dofetilide-binding assays with membranes of hu... Abstract

Cited 1 times since 2016 (0.1 per year) source: EuropePMC

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, Volume 20, Issue 4, 31 5 2016, Pages 611-615 Increased insulin-like growth factor-1 levels in cerebrospinal fluid of advanced subacute sclerosing panencephalitis patients. Yılmaz D, Yüksel D, Gökkurt D, Oguz H, Anlar B

Purpose: Subacute sclerosing panencephalitis (SSPE) is a progressive, lethal disease. Brain histopathology in certain SSPE patients shows, neurofibrillary tangles composed of abnormally phosphorylated, microtubule-associated protein tau (PHF-tau). Because the, phosphorylation of tau is inhibited by insulin and insulin-like growth factor-1 (IGF-1), we investigated cerebrospinal fluid (CSF) insulin and IGF-1 levels in SSPE patients. Methods and results: In this study CSF IGF-1 and insulin levels o... Abstract

Cited 83 times since 2016 (9 per year) source: EuropePMC

Nature communications, Volume 7, 31 5 2016, Pages 10846 Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression. de Bruin RG, Shiue L, Prins J, de Boer HC, Singh A, Fagg WS, van Gils JM, Duijs JM, Katzman S, Kraaijeveld AO, Böhringer S, Leung WY, Kielbasa SM, Donahue JP, van der Zande PH, Sijbom R, van Alem CM, Bot I, van Kooten C, Jukema JW, Van Esch H, Rabelink TJ, Kazan H, Biessen EA, Ares M, van Zonneveld AJ, van der Veer EP

A hallmark of inflammatory diseases is the excessive recruitment and influx of monocytes to sites of tissue damage and their ensuing differentiation into macrophages. Numerous stimuli are known to induce transcriptional changes associated with macrophage phenotype, but posttranscriptional control of human macrophage differentiation is less well understood. Here we show that expression levels of the RNA-binding protein Quaking (QKI) are low in monocytes and early human atherosclerotic lesions, bu... Abstract

Revista espanola de cardiologia (English ed.), Volume 69, Issue 5, 30 5 2016, Pages 533 Evidence From Pacing in Obstructive Hypertrophic Cardiomyopathy. Response. Jurado Román A, Montero Cabezas JM, Tascón Pérez JC

Abstract

Cited 18 times since 2016 (2 per year) source: EuropePMC

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, Volume 21, Issue 5, 28 4 2016, Pages 526-528 De Winter Electrocardiographic Pattern Related with a Non-Left Anterior Descending Coronary Artery Occlusion. Montero Cabezas JM, Karalis I, Schalij MJ

The electrocardiographic pattern consisting of ST-segment depression and hyperacute T waves in patients with acute chest pain, known as "De Winter pattern," has been related with the occlusion of the proximal left anterior descending artery (LAD). The association of these findings with the involvement of a different coronary artery has not been described. We present a 53-year-old patient with an occlusion of the first diagonal branch and an electrocardiogram showing a "De Winter p... Abstract

Cited 6 times since 2016 (0.7 per year) source: EuropePMC

Diabetic medicine : a journal of the British Diabetic Association, Volume 33, Issue 6, 25 4 2016, Pages 794-802 Effectiveness of insulin therapy in people with Type 2 diabetes in the Hoorn Diabetes Care System. Mast MR, Walraven I, Hoekstra T, Jansen AP, van der Heijden AA, Elders PJ, Heine RJ, Dekker JM, Nijpels G, Hugtenburg JG

Aims: To identify HbA1c trajectories after the start of insulin treatment and to identify clinically applicable predictors of the response to insulin therapy. Methods: The study population comprised 1203 people with Type 2 diabetes included in the Hoorn Diabetes Care System (n = 9849). Inclusion criteria were: age ≥ 40 years; initiation of insulin during follow-up after failure to reach HbA1c levels ≤ 53 mmol/mol (7%) with oral glucose-lowering agents; and a follow up ≥ 2 years after initiating... Abstract

Cited 12 times since 2016 (1.3 per year) source: EuropePMC

Langenbeck's archives of surgery, Volume 401, Issue 3, 24 4 2016, Pages 365-373 Characteristics of contralateral carcinomas in patients with differentiated thyroid cancer larger than 1 cm. Lodewijk L, Kluijfhout WP, Kist JW, Stegeman I, Plukker JT, Nieveen van Dijkum EJ, Bonjer HJ, Bouvy ND, Schepers A, de Wilt JH, Netea-Maier RT, van der Hage JA, Burger JW, Ho G, Lee WS, Shen WT, Aronova A, Zarnegar R, Benay C, Mitmaker EJ, Sywak MS, Aniss AM, Kruijff S, James B, Grogan RH, Brunaud L, Hoch G, Pandolfi C, Ruan DT, Jones MD, Guerrero MA, Valk GD, Borel Rinkes IH, Vriens MR

Purpose: Traditionally, total thyroidectomy has been advocated for patients with tumors larger than 1 cm. However, according to the ATA and NCCN guidelines (2015, USA), patients with tumors up to 4 cm are now eligible for lobectomy. A rationale for adhering to total thyroidectomy might be the presence of contralateral carcinomas. The purpose of this study was to describe the characteristics of contralateral carcinomas in patients with differentiated thyroid cancer (DTC) larger than 1 cm. Methods... Abstract

Cited 6 times since 2016 (0.7 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 18, Issue 2, 24 4 2016, Pages 203-211 The influence of clinical and acquisition parameters on the interpretability of adenosine stress myocardial computed tomography perfusion. van Rosendael AR, de Graaf MA, Dimitriu-Leen AC, van Zwet EW, van den Hoogen IJ, Kharbanda RK, Bax JJ, Kroft LJ, Scholte AJ

Aims: The interpretation of adenosine stress myocardial computed tomography perfusion (CTP) is often hampered by image artefacts caused by cardiac motion, beam hardening, and cone beam. The aim of the present analysis was to assess the influence of the heart-rate response during adenosine infusion, patient characteristics, and medication use on the interpretability of stress myocardial CTP examinations. Methods and results: Interpretability of stress myocardial CTP examinations was evaluated in... Abstract

Cited 5 times since 2016 (0.5 per year) source: EuropePMC

Journal of vascular surgery, Volume 63, Issue 6, 19 3 2016, Pages 1428-1433.e1 Predicting reinterventions after open and endovascular aneurysm repair using the St George's Vascular Institute score. de Bruin JL, Karthikesalingam A, Holt PJ, Prinssen M, Thompson MM, Blankensteijn JD, Dutch Randomised Endovascular Aneurysm Management (DREAM) Study Group

Background: Identifying patients at risk for aneurysm rupture and sac expansion after open and endovascular abdominal aortic aneurysm (AAA) repair (EVAR) may help to attenuate this risk by intensifying follow-up and early detection of problems. The goal of this study was to validate the St George's Vascular Institute (SGVI) score to identify patients at risk for a secondary intervention after elective aneurysm repair. Methods: A post hoc on-treatment analysis of a randomized trial comparing... Abstract

Cited 1 times since 2016 (0.1 per year) source: EuropePMC

The Canadian journal of cardiology, Volume 32, Issue 12, 19 3 2016, Pages 1576.e7-1576.e9 Prosthesis Dislocation After Transapical Valve-In-Valve Mitral Valve Implantation. Tomšič A, Palmen M, Versteegh MI, van der Kley F, Siebelink HJ, Berendsen RR, Schalij MJ

Transapical valve-in-valve mitral valve implantation (TA-MVI) has been described as an alternative treatment option in patients with degenerated bioprostheses in the mitral position. We report the first case of prosthesis dislocation and migration into the left atrium after TA-MVI. A new prosthesis was implanted using the same approach. The dislocated prosthesis was successfully removed through the left atrial appendage through an extended anterolateral thoracotomy without the use of cardiopulmo... Abstract

Cited 6 times since 2016 (0.7 per year) source: EuropePMC

Frontiers in neuroscience, Volume 10, 18 3 2016, Pages 104 Bayesian Estimation and Inference Using Stochastic Electronics. Thakur CS, Afshar S, Wang RM, Hamilton TJ, Tapson J, van Schaik A

In this paper, we present the implementation of two types of Bayesian inference problems to demonstrate the potential of building probabilistic algorithms in hardware using single set of building blocks with the ability to perform these computations in real time. The first implementation, referred to as the BEAST (Bayesian Estimation and Stochastic Tracker), demonstrates a simple problem where an observer uses an underlying Hidden Markov Model (HMM) to track a target in one dimension. In this im... Abstract

Cited 12 times since 2016 (1.3 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 43, Issue 8, 18 3 2016, Pages 1522-1529 Segmental quantitative myocardial perfusion with PET for the detection of significant coronary artery disease in patients with stable angina. Berti V, Sciagrà R, Neglia D, Pietilä M, Scholte AJ, Nekolla S, Rouzet F, Pupi A, Knuuti J

Purpose: The goal of this study is to determine the technical accuracy of segmental perfusion parameters assessed with quantitative cardiac PET imaging in the evaluation of coronary artery disease (CAD) in patients with stable angina. Methods: A cohort of patients who participated in the EVINCI protocol underwent an evaluation of coronary anatomy by invasive coronary angiography (ICA) and/or coronary computed tomography angiography (CCTA) and PET myocardial perfusion imaging with H2 (15)O, (13)N... Abstract

Cited 52 times since 2016 (5.6 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 17, Issue 9, 18 3 2016, Pages 951-960 Multicentre multi-device hybrid imaging study of coronary artery disease: results from the EValuation of INtegrated Cardiac Imaging for the Detection and Characterization of Ischaemic Heart Disease (EVINCI) hybrid imaging population. Liga R, Vontobel J, Rovai D, Marinelli M, Caselli C, Pietila M, Teresinska A, Aguadé-Bruix S, Pizzi MN, Todiere G, Gimelli A, Chiappino D, Marraccini P, Schroeder S, Drosch T, Poddighe R, Casolo G, Anagnostopoulos C, Pugliese F, Rouzet F, Le Guludec D, Cappelli F, Valente S, Gensini GF, Zawaideh C, Capitanio S, Sambuceti G, Marsico F, Filardi PP, Fernández-Golfín C, Rincón LM, Graner FP, de Graaf MA, Stehli J, Reyes E, Nkomo S, Mäki M, Lorenzoni V, Turchetti G, Carpeggiani C, Puzzuoli S, Mangione M, Marcheschi P, Giannessi D, Nekolla S, Lombardi M, Sicari R, Scholte AJ, Zamorano JL, Underwood SR, Knuuti J, Kaufmann PA, Neglia D, Gaemperli O, EVINCI Study Investigators

Aims: Hybrid imaging provides a non-invasive assessment of coronary anatomy and myocardial perfusion. We sought to evaluate the added clinical value of hybrid imaging in a multi-centre multi-vendor setting. Methods and results: Fourteen centres enrolled 252 patients with stable angina and intermediate (20-90%) pre-test likelihood of coronary artery disease (CAD) who underwent myocardial perfusion scintigraphy (MPS), CT coronary angiography (CTCA), and quantitative coronary angiography (QCA) with... Abstract

Cited 55 times since 2016 (6 per year) source: EuropePMC

Journal of molecular and cellular cardiology, Volume 94, 17 3 2016, Pages 13-20 Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation. Hjortnaes J, Goettsch C, Hutcheson JD, Camci-Unal G, Lax L, Scherer K, Body S, Schoen FJ, Kluin J, Khademhosseini A, Khademhosseini A, Aikawa E

Purpose: Calcific aortic valve disease (CAVD) is the most prevalent valve disease in the Western world. Recent difficulty in translating experimental results on statins to beneficial clinical effects warrants the need for understanding the role of valvular interstitial cells (VICs) in CAVD. In two-dimensional culture conditions, VICs undergo spontaneous activation similar to pathological differentiation, which intrinsically limits the use of in vitro models to study CAVD. Here, we hypothesized t... Abstract

Cited 33 times since 2016 (3.6 per year) source: EuropePMC

BMJ open, Volume 6, Issue 3, 17 3 2016, Pages e009971 Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258: a systematic review and meta-analysis. Dautzenberg MJ, Haverkate MR, Bonten MJ, Bootsma MC

Objectives: Observational studies have suggested that Escherichia coli sequence type (ST) 131 and Klebsiella pneumoniae ST258 have hyperendemic properties. This would be obvious from continuously high incidence and/or prevalence of carriage or infection with these bacteria in specific patient populations. Hyperendemicity could result from increased transmissibility, longer duration of infectiousness, and/or higher pathogenic potential as compared with other lineages of the same species. The aim... Abstract

Cited 24 times since 2016 (2.6 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 50, Issue 3, 16 3 2016, Pages 456-463 Follow-up after tricuspid valve surgery in adult patients with systemic right ventricles. Koolbergen DR, Ahmed Y, Bouma BJ, Scherptong RW, Bruggemans EF, Vliegen HW, Holman ER, Mulder BJ, Hazekamp MG

Objectives: In patients with congenitally corrected transposition of the great arteries (ccTGA) or after atrial (Mustard or Senning) correction for transposition of the great arteries (acTGA), the right ventricle (RV) supports the systemic circulation. The tricuspid valve (TV) (systemic atrioventricular valve) is prone to regurgitation in these patients and this is associated with impending RV failure and decreased survival. This study evaluates mid-term functional improvements, echocardiographi... Abstract

Cited 34 times since 2016 (3.7 per year) source: EuropePMC

The Journal of infectious diseases, Volume 214, Issue 2, 16 3 2016, Pages 189-195 Genome-wide Screening Identifies Phosphotransferase System Permease BepA to Be Involved in Enterococcus faecium Endocarditis and Biofilm Formation. Paganelli FL, Huebner J, Singh KV, Zhang X, van Schaik W, Wobser D, Braat JC, Murray BE, Bonten MJ, Willems RJ, Leavis HL

Enterococcus faecium is a common cause of nosocomial infections, of which infective endocarditis is associated with substantial mortality. In this study, we used a microarray-based transposon mapping (M-TraM) approach to evaluate a rat endocarditis model and identified a gene, originally annotated as "fruA" and renamed "bepA," putatively encoding a carbohydrate phosphotransferase system (PTS) permease (biofilm and endocarditis-associated permease A [BepA]), as important in in... Abstract

Cited 4704 times since 2016 (509.4 per year) source: EuropePMC

Scientific data, Volume 3, 15 3 2016, Pages 160018 The FAIR Guiding Principles for scientific data management and stewardship. Wilkinson MD, Dumontier M, Aalbersberg IJ, Appleton G, Axton M, Baak A, Blomberg N, Boiten JW, da Silva Santos LB, Bourne PE, Bouwman J, Brookes AJ, Clark T, Crosas M, Dillo I, Dumon O, Edmunds S, Evelo CT, Finkers R, Gonzalez-Beltran A, Gray AJ, Groth P, Goble C, Grethe JS, Heringa J, 't Hoen PA, Hooft R, Kuhn T, Kok R, Kok J, Lusher SJ, Martone ME, Mons A, Packer AL, Persson B, Rocca-Serra P, Roos M, van Schaik R, Sansone SA, Schultes E, Sengstag T, Slater T, Strawn G, Swertz MA, Thompson M, van der Lei J, van Mulligen E, Velterop J, Waagmeester A, Wittenburg P, Wolstencroft K, Zhao J, Mons B

There is an urgent need to improve the infrastructure supporting the reuse of scholarly data. A diverse set of stakeholders-representing academia, industry, funding agencies, and scholarly publishers-have come together to design and jointly endorse a concise and measureable set of principles that we refer to as the FAIR Data Principles. The intent is that these may act as a guideline for those wishing to enhance the reusability of their data holdings. Distinct from peer initiatives that focus on... Abstract

Cited 34 times since 2016 (3.7 per year) source: EuropePMC

RMD open, Volume 2, Issue 1, 15 3 2016, Pages e000159 Therapeutic and diagnostic outcomes of a standardised, comprehensive care pathway for patients with systemic sclerosis. Meijs J, Schouffoer AA, Ajmone Marsan N, Kroft LJ, Stijnen T, Ninaber MK, Huizinga TW, Vliet Vlieland TP, de Vries-Bouwstra JK

Objectives: To determine the outcomes, including number of medical interventions and initiation of immunosuppressive treatment of a standardised, comprehensive, diagnostic care pathway for patients with systemic sclerosis (SSc). Patient characteristics associated with need for medical interventions and with need for immunosuppressive treatment were determined. Methods: Data were routinely gathered in connection with a 2-day care pathway combining multidisciplinary care and complete diagnostic wo... Abstract

Cited 2 times since 2016 (0.2 per year) source: EuropePMC

European journal of pharmacology, Volume 779, 9 2 2016, Pages 91-101 Role of the dysfunctional ryanodine receptor - Na(+)-Ca(2+)exchanger axis in progression of cardiovascular diseases: What we can learn from pharmacological studies? Acsai K, Ördög B, Varró A, Nánási PP

Abnormal Ca(2+)homeostasis is often associated with chronic cardiovascular diseases, such as hypertension, heart failure or cardiac arrhythmias, and typically contributes to the basic ethiology of the disease. Pharmacological targeting of cardiac Ca(2+)handling has great therapeutic potential offering invaluable options for the prevention, slowing down the progression or suppression of the harmful outcomes like life threatening cardiac arrhythmias. In this review we outline the existing knowledg... Abstract