8684 results
Cited 9 times since 2016 (1 per year)
source: EuropePMC
Journal of applied clinical medical physics,
Volume 17, Issue 2, 8 2 2016, Pages 291-303
Diamond detector in absorbed dose measurements in high-energy linear accelerator photon and electron beams.
Ravichandran R, Binukumar JP, Al Amri I, Davis CA
Diamond detectors (DD) are preferred in small field dosimetry of radiation beams because of small dose profile penumbras, better spatial resolution, and tissue-equivalent properties. We investigated a commercially available 'microdiamond' detector in realizing absorbed dose from first principles. A microdiamond detector, type TM 60019 with tandem electrometer is used to measure absorbed doses in water, nylon, and PMMA phantoms. With sensitive volume 0.004 mm3, radius 1.1mm, thickness 1...
Abstract
Cited 5 times since 2016 (0.5 per year)
source: EuropePMC
Frontiers in psychology,
Volume 7, 8 2 2016, Pages 321
Young Children's Motor Interference Is Influenced by Novel Group Membership.
van Schaik JE, Endedijk HM, Stapel JC, Hunnius S
From early childhood onward, individuals use behavior copying to communicate liking and belonging. This non-verbal signal of affiliation is especially relevant in the context of social groups and indeed both children and adults copy in-group more than out-group members. Given the societal importance of inter-group interactions, it is imperative to understand the mechanistic level at which group modulations of copying occur early in development. The current study was designed to investigate the e...
Abstract
Cited 1 times since 2016 (0.1 per year)
source: EuropePMC
Clinical and experimental rheumatology,
Volume 34, Issue 3 Suppl 97, 7 1 2016, Pages S146
Azathioprine-induced eosinophilic myocarditis in a patient with ANCA-associated vasculitis.
Berden AE, Beeres SL, Crobach S, Schalij MJ, Rabelink TJ, Teng YK
Abstract
Cited 54 times since 2016 (5.8 per year)
source: EuropePMC
PloS one,
Volume 11, Issue 3, 7 1 2016, Pages e0144997
Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium.
Dehghan A, Bis JC, White CC, Smith AV, Morrison AC, Cupples LA, Trompet S, Chasman DI, Lumley T, Völker U, Buckley BM, Ding J, Jensen MK, Folsom AR, Kritchevsky SB, Girman CJ, Ford I, Dörr M, Salomaa V, Uitterlinden AG, Eiriksdottir G, Vasan RS, Franceschini N, Carty CL, Virtamo J, Demissie S, Amouyel P, Arveiler D, Heckbert SR, Ferrières J, Ducimetière P, Smith NL, Wang YA, Siscovick DS, Rice KM, Wiklund PG, Taylor KD, Evans A, Kee F, Rotter JI, Karvanen J, Kuulasmaa K, Heiss G, Kraft P, Launer LJ, Hofman A, Markus MR, Rose LM, Silander K, Wagner P, Benjamin EJ, Lohman K, Stott DJ, Rivadeneira F, Harris TB, Levy D, Liu Y, Rimm EB, Jukema JW, Völzke H, Ridker PM, Blankenberg S, Franco OH, Gudnason V, Psaty BM, Boerwinkle E, O'Donnell CJ
Background: Data are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a prospective setting. Methods: We performed a two-stage GWAS analysis of incident myocardial infarction (MI) and CHD in a total of 64,297 individuals (including 3898 MI cases, 5465 CHD cases). SNPs that passed an arbitrary threshold of 5×10-6 in Stage I were taken to Stage II for...
Abstract
Cited 12 times since 2016 (1.3 per year)
source: EuropePMC
The journal of vascular access,
Volume 17 Suppl 1, 6 1 2016, Pages S16-22
The pros and cons of preserving a functioning arteriovenous fistula after kidney transplantation.
Voorzaat BM, van Schaik J, Siebelink HM, Tordoir JH, Rotmans JI
The autologous arteriovenous fistula (AVF) for hemodialysis burdens the cardiovascular system with increased cardiac output and pulmonary artery pressure, increasing cardiovascular risk. This article reviews literature on the benefits and drawbacks of a functioning AVF after kidney transplantation and discusses the cardiovascular effects of AVF closure. Several cohort studies demonstrate a significant cardiac burden of an AVF and improvement of cardiac dimensions after AVF ligation. However, no...
Abstract
Cited 10 times since 2016 (1.1 per year)
source: EuropePMC
Journal of neurology,
Volume 263, Issue 4, 5 1 2016, Pages 807-813
Association between i.v. thrombolysis volume and door-to-needle times in acute ischemic stroke.
Groot AE, van Schaik IN, Visser MC, Nederkoorn PJ, Limburg M, Aramideh M, de Beer F, Zwetsloot CP, Halkes P, de Kruijk J, Kruyt ND, van der Meulen W, Spaander F, van der Ree T, Kwa VI, Van den Berg-Vos RM, Roos YB, Coutinho JM
Centralization of intravenous thrombolysis (IVT) for acute ischemic stroke in high-volume centers is believed to improve the door-to-needle times (DNT), but limited data support this assumption. We examined the association between DNT and IVT volume in a large Dutch province. We identified consecutive patients treated with IVT between January 2009 and 2013. Based on annualized IVT volume, hospitals were categorized as low-volume (≤ 24), medium-volume (25-49) or high-volume (≥ 50). In logistic re...
Abstract
Cited 15 times since 2016 (1.6 per year)
source: EuropePMC
The Journal of steroid biochemistry and molecular biology,
Volume 165, Issue Pt A, 5 1 2016, Pages 57-63
Novel and prevalent CYP11B1 gene mutations in Turkish patients with 11-β hydroxylase deficiency.
Kandemir N, Yilmaz DY, Gonc EN, Ozon A, Alikasifoglu A, Dursun A, Ozgul RK
11β-Hydroxylase deficiency is the second most frequent type of congenital adrenal hyperplasia and is more common in those of Turkish descent than in other populations. The purpose of this study is to examine the spectrum of CYP11B1 gene mutations in Turkish patients with 11β-hydroxylase deficiency. Twenty-eight patients from 24 families, ages ranging from 0.1 to 7 years, were included in the study. Clinical diagnosis was based on virilization and high levels of 11-deoxycortisol. Twenty-six cases...
Abstract
Cited 41 times since 2016 (4.4 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 18, Issue 11, 3 1 2016, Pages 1740-1747
Combined leadless pacemaker and subcutaneous implantable defibrillator therapy: feasibility, safety, and performance.
Tjong FV, Brouwer TF, Smeding L, Kooiman KM, de Groot JR, Ligon D, Sanghera R, Schalij MJ, Wilde AA, Knops RE
Aims: The subcutaneous implantable cardioverter-defibrillator (S-ICD) and leadless pacemaker (LP) are evolving technologies that do not require intracardiac leads. However, interactions between these two devices are unexplored. We investigated the feasibility, safety, and performance of combined LP and S-ICD therapy, considering (i) simultaneous device-programmer communication, (ii) S-ICD rhythm discrimination during LP communication and pacing, and (iii) post-shock LP performance. Methods and r...
Abstract
Cited 37 times since 2016 (4 per year)
source: EuropePMC
European heart journal. Cardiovascular pharmacotherapy,
Volume 2, Issue 4, 2 1 2016, Pages 229-243
P2Y12 receptor inhibitors in patients with non-ST-elevation acute coronary syndrome in the real world: use, patient selection, and outcomes from contemporary European registries.
Zeymer U, Widimsky P, Danchin N, Lettino M, Bardaji A, Barrabes JA, Cequier A, Claeys MJ, De Luca L, Dörler J, Erlinge D, Erne P, Goldstein P, Koul SM, Lemesle G, Lüscher TF, Matter CM, Montalescot G, Radovanovic D, Sendón JL, Tousek P, Weidinger F, Weston CF, Zaman A, Andell P, Li J, Jukema JW, PIRAEUS group
Aims: Non-ST-elevation acute coronary syndrome (NSTE-ACS) is present in about 60-70% of patients admitted with acute coronary syndromes in clinical practice. This study provides a 'real-life' overview of NSTE-ACS patient characteristics, dual antiplatelet therapy clinical practice, and outcomes at both the time of discharge from hospital and up to 1-year post-discharge. Methods and results: A total of 10 registries (documenting 84 054 NSTE-ACS patients) provided data in a systematic ma...
Abstract
Cited 317 times since 2016 (34.2 per year)
source: EuropePMC
The New England journal of medicine,
Volume 374, Issue 12, 2 1 2016, Pages 1134-1144
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.
Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, Stitziel NO, Stirrups KE, Masca NG, Erdmann J, Ferrario PG, König IR, Weeke PE, Webb TR, Auer PL, Schick UM, Lu Y, Zhang H, Dube MP, Goel A, Farrall M, Peloso GM, Won HH, Do R, van Iperen E, Kanoni S, Kruppa J, Mahajan A, Scott RA, Willenberg C, Braund PS, van Capelleveen JC, Doney AS, Donnelly LA, Asselta R, Merlini PA, Duga S, Marziliano N, Denny JC, Shaffer CM, El-Mokhtari NE, Franke A, Gottesman O, Heilmann S, Hengstenberg C, Hoffman P, Holmen OL, Hveem K, Jansson JH, Jöckel KH, Kessler T, Kriebel J, Laugwitz KL, Marouli E, Martinelli N, McCarthy MI, Van Zuydam NR, Meisinger C, Esko T, Mihailov E, Escher SA, Alver M, Moebus S, Morris AD, Müller-Nurasyid M, Nikpay M, Olivieri O, Lemieux Perreault LP, AlQarawi A, Robertson NR, Akinsanya KO, Reilly DF, Vogt TF, Yin W, Asselbergs FW, Kooperberg C, Jackson RD, Stahl E, Strauch K, Varga TV, Waldenberger M, Zeng L, Kraja AT, Liu C, Ehret GB, Newton-Cheh C, Chasman DI, Chowdhury R, Ferra
Background: The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets. Methods: Through DNA genotyping, we tested 54,003 coding-sequence variants covering 13,715 human genes in up to 72,868 patients with coronary artery disease and 120,770 controls who did not have coronary artery disease. Through DNA sequencing, we studied the effects of loss-of-function mutations in selected genes. Results: We confirme...
Abstract
Cited 93 times since 2016 (10 per year)
source: EuropePMC
European heart journal,
Volume 37, Issue 37, 2 1 2016, Pages 2823-2829
Happy heart syndrome: role of positive emotional stress in takotsubo syndrome.
Ghadri JR, Sarcon A, Diekmann J, Bataiosu DR, Cammann VL, Jurisic S, Napp LC, Jaguszewski M, Scherff F, Brugger P, Jäncke L, Seifert B, Bax JJ, Ruschitzka F, Lüscher TF, Templin C, InterTAK Co-investigators:
Aims: Takotsubo syndrome (TTS) is typically provoked by negative stressors such as grief, anger, or fear leading to the popular term 'broken heart syndrome'. However, the role of positive emotions triggering TTS remains unclear. The aim of the present study was to analyse the prevalence and characteristics of patients with TTS following pleasant events, which are distinct from the stressful or undesirable episodes commonly triggering TTS. Methods and results: Takotsubo syndrome patient...
Abstract
Cited 31 times since 2016 (3.3 per year)
source: EuropePMC
Philosophical transactions of the Royal Society of London. Series B, Biological sciences,
Volume 371, Issue 1690, 1 1 2016, Pages 20150183
The reluctant innovator: orangutans and the phylogeny of creativity.
van Schaik CP, Burkart J, Damerius L, Forss SI, Koops K, van Noordwijk MA, Schuppli C
Young orangutans are highly neophobic, avoid independent exploration and show a preference for social learning. Accordingly, they acquire virtually all their learned skills through exploration that is socially induced. Adult exploration rates are also low. Comparisons strongly suggest that major innovations, i.e. behaviours that have originally been brought into the population through individual invention, are made where ecological opportunities to do so are propitious. Most populations nonethel...
Abstract
The Journal of craniofacial surgery,
Volume 27, Issue 2, 1 1 2016, Pages e175-6
Atypical Carcinoid Tumor and Chondroid and Glandular Hamartoma of the Arythenoid Region.
Sarioglu S, Akturk G, Aslier NG, Yilmaz DB, Dogan E
Neuroendocrine tumors of the head and neck are rare. Laryngeal hamartomas are even rarer especially in adult patients. Here in a 69-year-old male patient is presented who had atypical carcinoid tumor and chondroid and glandular hamartoma of the medial mucosa of the left arythenoid. To the best of our knowledge, this is the first case presenting the association of these 2 rare lesions.
Abstract
Cited 9 times since 2016 (1 per year)
source: EuropePMC
Saudi medical journal,
Volume 37, Issue 3, 1 1 2016, Pages 304-308
The effect of air-lock technique on pain at the site of intramuscular injection.
Yılmaz DK, Dikmen Y, Köktürk F, Dedeoğlu Y
Objectives: To investigate the effects of air-lock technique (ALT) on pain of intramuscular (IM) injection delivered to the ventrogluteal and dorsogluteal site (DS). Methods: A randomized controlled trial design was used to assess the pain intensity associated with IM injections administered using 2 different methods and injection sites. Recruitment of patients was carried out between April and August 2013 at the Department of Brain Surgery, Cekirge State Hospital, Bursa, Turkey. The sample comp...
Abstract
Cited 19 times since 2016 (2 per year)
source: EuropePMC
Critical care medicine,
Volume 44, Issue 3, 1 1 2016, Pages e158-67
Inotropic Effects of Experimental Hyperthermia and Hypothermia on Left Ventricular Function in Pigs-Comparison With Dobutamine.
Alogna A, Manninger M, Schwarzl M, Zirngast B, Steendijk P, Verderber J, Zweiker D, Maechler H, Pieske BM, Post H
Objectives: The results from the recent Targeted Temperature Management trial raised the question whether cooling or merely the avoidance of fever mediates better neurologic outcome in resuscitated patients. As temperature per se is a major determinant of cardiac function, we characterized the effects of hyperthermia (40.5°C), normothermia (38.0°C), and mild hypothermia (33.0°C) on left ventricular contractile function in healthy pigs and compared them with dobutamine infusion. Design: Animal st...
Abstract
Annals of surgery,
Volume 263, Issue 3, 1 1 2016, Pages e41
Comment on "Trainee Participation Is Associated With Adverse Outcomes in Emergency General Surgery: An Analysis of the National Surgical Quality Improvement Program Database".
Graat LJ, Roukema JA, Hamming JF
Abstract
Cited 13 times since 2016 (1.4 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 67, Issue 9, 1 1 2016, Pages 1123-1124
Pulmonary Valve Replacement After Repair of Pulmonary Stenosis Compared With Tetralogy of Fallot.
Bokma JP, Winter MM, Oosterhof T, Vliegen HW, van Dijk AP, Pieper PG, Meijboom FJ, Groenink M, Mulder BJM, Bouma BJ
Abstract
Cited 349 times since 2016 (37.7 per year)
source: EuropePMC
Science (New York, N.Y.),
Volume 351, Issue 6278, 1 1 2016, Pages 1166-1171
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.
Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M, DerOhannessian S, Kontush A, Surendran P, Saleheen D, Trompet S, Jukema JW, De Craen A, Deloukas P, Sattar N, Ford I, Packard C, Majumder Aa, Alam DS, Di Angelantonio E, Abecasis G, Chowdhury R, Erdmann J, Nordestgaard BG, Nielsen SF, Tybjærg-Hansen A, Schmidt RF, Kuulasmaa K, Liu DJ, Perola M, Blankenberg S, Salomaa V, Männistö S, Amouyel P, Arveiler D, Ferrieres J, Müller-Nurasyid M, Ferrario M, Kee F, Willer CJ, Samani N, Schunkert H, Butterworth AS, Howson JM, Peloso GM, Stitziel NO, Danesh J, Kathiresan S, Rader DJ, CHD Exome+ Consortium, CARDIoGRAM Exome Consortium, Global Lipids Genetics Consortium
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary heart disease (CHD). Mice that have depleted Scarb1 (SR-BI knockout mice) have markedly elevated HDL-C levels but, paradoxically, increased atherosclerosis. The impact of SR-BI on HDL metabolism and CHD risk in humans remains unclear. Through targeted sequencing of coding regions of lipid-modifying gene...
Abstract
Cited 4 times since 2016 (0.4 per year)
source: EuropePMC
Journal of atrial fibrillation,
Volume 8, Issue 5, 29 5 2016, Pages 1362
Cardiac Resynchronization Therapy in Non-Ischemic Cardiomyopathy.
Shanks M, Delgado V, Bax JJ
Cardiac resynchronization therapy (CRT) is an established therapy for heart failure patients who remain symptomatic despite optimal medical therapy, have reduced left ventricular ejection fraction (120 ms), preferably with left bundle branch block morphology. The response to CRT depends on the cardiac substrate: presence of correctable left ventricular mechanical dyssynchrony, presence of myocardial fibrosis (scar) and position of the left ventricular pacing lead. Patients with non-ischemic card...
Abstract
Cited 95 times since 2016 (10.2 per year)
source: EuropePMC
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
Volume 16, Issue 7, 26 4 2016, Pages 2085-2096
A Randomized Controlled Trial Comparing the Efficacy of Cyp3a5 Genotype-Based With Body-Weight-Based Tacrolimus Dosing After Living Donor Kidney Transplantation.
Shuker N, Bouamar R, van Schaik RH, Clahsen-van Groningen MC, Damman J, Baan CC, van de Wetering J, Rowshani AT, Weimar W, van Gelder T, Hesselink DA
Patients expressing the cytochrome P450 (CYP) 3A5 gene require a higher tacrolimus dose to achieve therapeutic exposure compared with nonexpressers. This randomized-controlled study investigated whether adaptation of the tacrolimus starting dose according to CYP3A5 genotype increases the proportion of kidney transplant recipients being within the target tacrolimus predose concentration range (10-15 ng/mL) at first steady-state. Two hundred forty living-donor, renal transplant recipients were ass...
Abstract
