Research

Publications

Below you can find a list of our published research.

6125 results

Cited 21 times since 2005 (1.1 per year) source: EuropePMC

Cardiovascular research, Volume 68, Issue 1, 1 1 2005, Pages 136-143 Involvement of furin-like proprotein convertases in the arterial response to injury. Sluijter JP, Verloop RE, Pulskens WP, Velema E, Grimbergen JM, Quax PH, Goumans MJ, Pasterkamp G, de Kleijn DP

Background: Furin-like proprotein convertases (PCs) are proteolytic activators of proproteins, like membrane type 1-matrix metalloproteinase (MT1-MMP) and transforming growth factor beta (TGF-beta), that are described in the arterial response to injury. However, the involvement of furin-like PCs in the arterial response to injury has not been studied yet. We studied furin, MT1-MMP, MMP levels and TGF-beta signaling after arterial injury. We also investigated the effect of an inhibitor of furin-l... Abstract

Cited 14 times since 2005 (0.7 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 16, Issue 10, 1 1 2005, Pages 1049-1056 Determinants of recurrent ventricular arrhythmia or death in 300 consecutive patients with ischemic heart disease who experienced aborted sudden death: data from the Leiden out-of-hospital cardiac arrest study. Kiès P, Boersma E, Bax JJ, van der Burg AE, Bootsma M, van Erven L, van der Wall EE, Schalij MJ

Objective: Evaluation of the relation between clinical characteristics and incidence of recurrent ventricular arrhythmias (VAs) or death during long-term follow-up in a cohort of 300 consecutive ischemic heart disease (IHD) patients who had survived an episode of sudden cardiac arrest (SCA). Background: Survivors of life-threatening VA are at high risk for recurrent events. Methods: A total of 300 consecutive survivors of SCA with IHD were included in a standardized screening and evaluation prot... Abstract

Cited 126 times since 2005 (6.5 per year) source: EuropePMC

Heart rhythm, Volume 2, Issue 10, 1 1 2005, Pages 1076-1081 Fusion of multislice computed tomography imaging with three-dimensional electroanatomic mapping to guide radiofrequency catheter ablation procedures. Tops LF, Bax JJ, Zeppenfeld K, Jongbloed MR, Lamb HJ, van der Wall EE, Schalij MJ

Background: The outcome of catheter ablation procedures of cardiac arrhythmias depends on the ability to evaluate the underlying mechanism and to depict target sites for ablation. Fusion of different imaging modalities within one system may improve electroanatomic modeling and facilitate ablation procedures. Objectives: The purpose of this study was to study the feasibility of fusion of multislice computed tomography (MSCT) with electroanatomic mapping to guide radiofrequency catheter ablation o... Abstract

Cited 35 times since 2005 (1.8 per year) source: EuropePMC

The American journal of cardiology, Volume 96, Issue 7, 1 1 2005, Pages 996-1001 Role of disease status and type D personality in outcomes in patients with peripheral arterial disease. Aquarius AE, Denollet J, Hamming JF, De Vries J

Patients with peripheral arterial disease (PAD) often experience diminishing quality of life (QOL) in many domains of their lives. However, factors associated with impaired QOL and perceived stress in these patients are not completely understood. The relative effects of disease status and type D ("distressed") personality (tendencies to experience negative emotions and be socially inhibited) on these patient-based outcomes were examined. It has been argued that type D personality might... Abstract

Cited 16 times since 2005 (0.8 per year) source: EuropePMC

The journals of gerontology. Series A, Biological sciences and medical sciences, Volume 60, Issue 10, 1 1 2005, Pages 1333-1338 Long-term prediction of mortality in elderly persons by dobutamine stress echocardiography. Biagini E, Elhendy A, Schinkel AF, Rizzello V, Bax JJ, Sozzi FB, Kertai MD, van Domburg RT, Krenning BJ, Branzi A, Rapezzi C, Simoons ML, Poldermans D

Background: Dobutamine stress echocardiography (DSE) was shown to provide incremental prognostic information. However, its role in the prediction of mortality in elderly persons is not well defined. We assessed the value of DSE in the prediction of mortality and hard cardiac events during long-term follow-up in patients older than 65 years. Methods: We studied 1434 patients >65 years old (mean age 72 +/- 3 years) who underwent DSE for evaluation of coronary artery disease. Ischemia was define... Abstract

Cited 51 times since 2005 (2.6 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 46, Issue 7, 1 1 2005, Pages 1264-1269 The extent of perfusion-F18-fluorodeoxyglucose positron emission tomography mismatch determines mortality in medically treated patients with chronic ischemic left ventricular dysfunction. Desideri A, Cortigiani L, Christen AI, Coscarelli S, Gregori D, Zanco P, Komorovsky R, Bax JJ

Objectives: The purpose of this study was to assess the determinants of mortality in a large group of patients with ischemic cardiomyopathy who are treated medically and the impact of the extent of viable tissue on prognosis. Background: Whether the presence of viability drives mortality in patients with ischemic cardiomyopathy who are treated medically and whether the extent of viability is important are issues that are currently unclear. Methods: Two hundred sixty-one patients with ischemic ca... Abstract

Cited 172 times since 2005 (8.9 per year) source: EuropePMC

The American journal of medicine, Volume 118, Issue 10, 1 1 2005, Pages 1134-1141 Perioperative cardiovascular mortality in noncardiac surgery: validation of the Lee cardiac risk index. Boersma E, Kertai MD, Schouten O, Bax JJ, Noordzij P, Steyerberg EW, Schinkel AF, van Santen M, Simoons ML, Thomson IR, Klein J, van Urk H, Poldermans D

Purpose: The Lee risk index was developed to predict major cardiac complications in noncardiac surgery. We retrospectively evaluated its ability to predict cardiovascular death in the large cohort of patients who recently underwent noncardiac surgery in our institution. Methods: The administrative database of the Erasmus MC, Rotterdam, The Netherlands, contains information on 108 593 noncardiac surgical procedures performed from 1991 to 2000. The Lee index assigns 1 point to each of the followin... Abstract

Cited 12 times since 2005 (0.6 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 21, Issue 5, 1 1 2005, Pages 519-529 Evaluation of the Quantitative Gated SPECT (QGS) software program in the presence of large perfusion defects. America YG, Bax JJ, Dibbets-Schneider P, Pauwels EK, Van der Wall EE

Objectives: To evaluate the reproducibility and operator dependence for the quantitative regional left ventricular functional parameters (LVFP) assessed by Cedars-Sinai's Quantitative automated gated SPECT (QGS) software. Methods: The QGS algorithm was reviewed in detail and potential operator dependencies were defined. Series of prototypes were selected, consisting of (a) normal perfusion, (b) perfusion defects in all perfusion regions, (c) perfusion studies of patients with angiographic c... Abstract

Cited 9 times since 2005 (0.5 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 46, Issue 10, 1 1 2005, Pages 1589-1595 Association of ischemia on stress (99m)Tc-tetrofosmin myocardial perfusion imaging with all-cause mortality in patients with diabetes mellitus. Elhendy A, Huurman A, Schinkel AF, Bax JJ, van Domburg RT, Valkema R, Biagini E, Poldermans D

Unlabelled: Stress myocardial perfusion imaging is a useful method for evaluation of coronary artery disease (CAD) in patients with diabetes mellitus. However, its role in predicting all-cause mortality is not well defined. The aim of this study was to determine whether myocardial ischemia on stress myocardial perfusion imaging can predict all causes of death in patients with diabetes mellitus. Methods: We studied 297 patients with diabetes mellitus and known or suspected CAD by exercise or dobu... Abstract

Cited 1 times since 2005 (0.1 per year) source: EuropePMC

Journal of vascular surgery, Volume 42, Issue 4, 1 1 2005, Pages 825; author reply 826 Regarding "Perioperative beta-blockade (POBBLE) for patients undergoing infrarenal vascular surgery: results of a randomized double-blind controlled trial". Schouten O, van Urk H, Feringa HH, Bax JJ, Poldermans D

Abstract

Cited 31 times since 2005 (1.6 per year) source: EuropePMC

Cancer research, Volume 65, Issue 20, 1 1 2005, Pages 9398-9405 Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma. Lamfers ML, Gianni D, Tung CH, Idema S, Schagen FH, Carette JE, Quax PH, Van Beusechem VW, Vandertop WP, Dirven CM, Chiocca EA, Gerritsen WR

Oncolytic adenoviruses exhibiting tumor-selective replication are promising anticancer agents. Insertion and expression of a transgene encoding tissue inhibitor of metalloproteinase-3 (TIMP-3), which has been reported to inhibit angiogenesis and tumor cell infiltration and induce apoptosis, may improve the antitumor activity of these agents. To assess the effects of TIMP-3 gene transfer to glioma cells, a replication-defective adenovirus encoding TIMP-3 (Ad.TIMP-3) was employed. Ad.TIMP-3 infect... Abstract

Cited 48 times since 2005 (2.5 per year) source: EuropePMC

American heart journal, Volume 150, Issue 4, 1 1 2005, Pages 775-781 Comprehensive assessment of patients after coronary artery bypass grafting by 16-detector-row computed tomography. Salm LP, Bax JJ, Jukema JW, Schuijf JD, Vliegen HW, Lamb HJ, van der Wall EE, de Roos A

Background: Multidetector-row computed tomography (MDCT) is a versatile modality to evaluate stenoses in native coronary arteries and bypass grafts. Acquired MDCT data can additionally be used to assess left ventricular ejection fraction (LVEF). The purpose was to use MDCT for the assessment of bypass graft and coronary artery disease combined with evaluation of LVEF. Methods: Twenty-five patients underwent 16-detector-row CT examination and coronary angiography. Bypass grafts and nongrafted cor... Abstract

Cited 1 times since 2005 (0.1 per year) source: EuropePMC

Thrombosis and haemostasis, Volume 94, Issue 4, 1 1 2005, Pages 892-894 Pre-procedural levels of erythrocyte sedimentation rate (ESR) and risk of clinical restenosis in patients with percutaneous coronary intervention and coronary stent placement. Rana JS, Monraats PS, Zwinderman AH, de Maat MP, Kastelein JJ, Agema WR, Doevendans PA, de Winter RJ, Tio RA, Waltenberger J, Frants RR, van der Laarse A, van der Wall EE, Jukema JW

Abstract

Cited 51 times since 2005 (2.6 per year) source: EuropePMC

Circulation, Volume 112, Issue 16, 1 1 2005, Pages 2417-2425 Genetic inflammatory factors predict restenosis after percutaneous coronary interventions. Monraats PS, Pires NM, Agema WR, Zwinderman AH, Schepers A, de Maat MP, Doevendans PA, de Winter RJ, Tio RA, Waltenberger J, Frants RR, Quax PH, van Vlijmen BJ, Atsma DE, van der Laarse A, van der Wall EE, Jukema JW

Background: Restenosis is a negative effect of percutaneous coronary intervention (PCI). No clinical factors are available that allow good risk stratification. However, evidence exists that genetic factors are important in the restenotic process as well as in the process of inflammation, a pivotal factor in restenosis. Association studies have identified genes that may predispose to restenosis, but confirmation by large prospective studies is lacking. Our aim was to identify polymorphisms and ha... Abstract

Neuropediatrics, Volume 36, Issue 5, 1 1 2005, Pages 324-327 An unexpected cause of a recurrent cerebral hemorrhage. Thijs RD, Hazekamp MG, Rijlaarsdam ME, Willems SM, Schutte PJ, Laan LA

A 4-year-old previously healthy boy presented with a non-traumatic right parietal hemorrhage. A second life-threatening left cerebral hemorrhage occurred three weeks later and was decompressed with a craniotomy. Transthoracic echocardiography revealed a hypermobile elongated tumor of the mitral valve. The cardiac tumor was successfully resected three weeks after the craniotomy. Histological examination of the cardiac tumor revealed a papillary lesion of spindle cells with smooth muscle cell diff... Abstract

Cited 30 times since 2005 (1.5 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 16, Issue 10, 1 1 2005, Pages 1097-1103 Validation of ECG indices of ventricular repolarization heterogeneity: a computer simulation study. Van Huysduynen BH, Swenne CA, Draisma HH, Antoni ML, Van De Vooren H, Van Der Wall EE, Schalij MJ

Introduction: Repolarization heterogeneity (RH) is functionally linked to dispersion in refractoriness and to arrhythmogenicity. In the current study, we validate several proposed electrocardiogram (ECG) indices for RH: T-wave amplitude, -area, -complexity, and -symmetry ratio, QT dispersion, and the Tapex-end interval (the latter being an index of transmural dispersion of the repolarization (TDR)). Methods and results: We used ECGSIM, a mathematical simulation model of ECG genesis in a human th... Abstract

Cited 2 times since 2005 (0.1 per year) source: EuropePMC

European journal of heart failure, Volume 8, Issue 3, 26 4 2005, Pages 314-320 Benefits of coronary revascularisation in diabetic and non-diabetic patients with ischaemic cardiomyopathy: role of myocardial viability. Rizzello V, Poldermans D, Biagini E, Schinkel AF, Boersma E, Elhendy A, Sozzi FB, Maat A, Roelandt JR, Bax JJ

Background: Diabetes mellitus in patients with coronary artery disease is associated with poor outcome. In this study, the relation between myocardial viability, diabetes, coronary revascularisation and outcome was evaluated. Methods: 129 patients (31 diabetic, 98 non-diabetic) with ischaemic cardiomyopathy underwent dobutamine stress echocardiography to assess myocardial viability. Patients with >or=4 viable segments were defined as viable and patients with or=5% in 44% of diabetic and in 40... Abstract

Cited 36 times since 2005 (1.9 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 46, Issue 8, 23 4 2005, Pages 1559-1564 Time course of diastolic and systolic function improvement after pulmonary valve replacement in adult patients with tetralogy of Fallot. van Straten A, Vliegen HW, Lamb HJ, Roes SD, van der Wall EE, Hazekamp MG, de Roos A

Objectives: The aim of this research was to assess right ventricular diastolic and systolic function before and after pulmonary valve replacement (PVR) in adult patients after repair of tetralogy of Fallot. Background: Pulmonary valve replacement (PVR) in adult patients late after repair of tetralogy of Fallot leads to rapid improvement of right ventricular (RV) systolic function. Methods: A total of 16 patients and 8 healthy subjects were included. Median age at initial repair was 4.9 (0.9 to 1... Abstract

Cited 16 times since 2005 (0.8 per year) source: EuropePMC

Intensive care medicine, Volume 31, Issue 10, 16 3 2005, Pages 1420-1426 Effect of dexamethasone on postoperative cardiac troponin T production in pediatric cardiac surgery. Malagon I, Hogenbirk K, van Pelt J, Hazekamp MG, Bovill JG

Objective: Pediatric cardiac surgery is associated with a temporary rise in cardiac troponin T (cTnT) during the postoperative period. We examined whether dexamethasone given before cardiopulmonary bypass has myocardial protective effects as assessed by the postoperative production of cTnT. Design and setting: Prospective randomized interventional study in the pediatric intensive care unit in a university hospital. Interventions: Patients were randomly allocated to act as controls or receive a s... Abstract

Cited 38 times since 2005 (2 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 92, Issue 4, 13 2 2005, Pages 490-494 Cardiac resynchronisation therapy in chronic atrial fibrillation: impact on left atrial size and reversal to sinus rhythm. Kiès P, Leclercq C, Bleeker GB, Crocq C, Molhoek SG, Poulain C, van Erven L, Bootsma M, Zeppenfeld K, van der Wall EE, Daubert JC, Schalij MJ, Bax JJ

Objective: To evaluate the impact of long term cardiac resynchronisation therapy (CRT) on left atrial and left ventricular (LV) reverse remodelling and reversal to sinus rhythm (SR) in patients with heart failure with atrial fibrillation (AF). Patients: 74 consecutive patients (age 68 (8) years; 67 men) with advanced heart failure and AF (20 persistent and 54 permanent) were implanted with a CRT device. Main outcome measures: Patients were evaluated clinically (New York Heart Association (NYHA)... Abstract