Research

Publications

Below you can find a list of our published research.

6190 results

Cited 8 times since 2003 (0.4 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 24, Issue 1, 1 1 2003, Pages 98-104 Reproducible model of post-infarction left ventricular dysfunction: haemodynamic characterization by conductance catheter. Hasnat AK, van der Velde ET, Hon JK, Yacoub MH

Objective: The understanding of pathophysiology and cellular mechanisms of chronic heart failure requires the creation of appropriate and accurately characterized animal models, thus enabling meaningful evaluation of evolving medical and surgical therapies. Methods: The left anterior descending and its diagonal branch were ligated in 12 sheep to induce left ventricular dysfunction. Results: Study of left ventricular pressure-volume loops 3 months post-operatively showed a significant deteriorati... Abstract

Cited 39 times since 2003 (1.8 per year) source: EuropePMC

Medicine, Volume 82, Issue 4, 1 1 2003, Pages 251-256 Myocardial infarction in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Lesnik Oberstein SA, Jukema JW, Van Duinen SG, Macfarlane PW, van Houwelingen HC, Breuning MH, Ferrari MD, Haan J

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an angiopathy caused by mutations in the NOTCH3 gene. Typical microvascular changes are found throughout the arterial tree, but the documented disease expression is confined to the central nervous system. In an ongoing CADASIL study, we noted a number of patients with early acute myocardial infarction (before the age of 50 years), as well as patients with electrocardiogram (ECG) abnormalities.... Abstract

Cited 11 times since 2003 (0.5 per year) source: EuropePMC

Biological trace element research, Volume 94, Issue 1, 1 1 2003, Pages 79-86 Effects of iron(II) salts and iron(III) complexes on trace element status in children with iron-deficiency anemia. Sözmen EY, Kavakli K, Cetinkaya B, Akçay YD, Yilmaz D, Aydinok Y

Iron-deficiency anemia (IDA) is the most common nutritional deficiency in childhood throughout the world. Although it has been shown that IRA is associated with elevated plasma copper and depleted zinc levels in children, there are conflicting results on the effect of iron supplementation on the absorption of these elements. The aim of this study was to investigate the effects of ferrous and ferric iron supplementation on the trace element status in children (n=25, aged 8-168 mo) with IDA. Fourt... Abstract

Cited 36 times since 2003 (1.6 per year) source: EuropePMC

Journal of cardiovascular pharmacology, Volume 42, Issue 1, 1 1 2003, Pages 63-70 Differential effects of amlodipine and atorvastatin treatment and their combination on atherosclerosis in ApoE*3-Leiden transgenic mice. Delsing DJ, Jukema JW, van de Wiel MA, Emeis JJ, van der Laarse A, Havekes LM, Princen HM

This study was designed to investigate the potential antiatherosclerotic effects of the calcium antagonist amlodipine as compared with the HMG-CoA reductase inhibitor atorvastatin and the combination of both in ApoE*3-Leiden transgenic mice. Four groups of 15 ApoE*3-Leiden mice were put on a high-cholesterol diet. One group received 0.002% (wt/wt) amlodipine in the diet, which had no effect on plasma cholesterol levels. Another group received 0.01% (wt/wt) atorvastatin, resulting in a decrease o... Abstract

Cited 2 times since 2003 (0.1 per year) source: EuropePMC

International journal of cardiology, Volume 90, Issue 1, 1 1 2003, Pages 15-21 Secondary prevention in coronary heart disease patients with low HDL: which options do we have? Liem AH, Jukema JW, van Veldhuisen DJ

Low levels of high-density lipoprotein cholesterol (HDL-C) are frequently encountered in patients with coronary artery disease (CAD), most often in combination with elevated triglycerides as part of a dysmetabolic syndrome. Although no large secondary prevention trials with statin therapy with special emphasis on low HDL-C have been performed, some guidance can be extracted from a number of post-hoc analyses on how to treat patients with low levels of HDL-C. In terms of risk reduction, statin th... Abstract

Cited 5 times since 2003 (0.2 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 89, Issue 7, 1 1 2003, Pages 703 Area ablation of ventricular tachycardia in a patient with arrhythmogenic right ventricular cardiomyopathy. de Groot NM, Schalij MJ, van der Wall EE

Abstract

Cited 81 times since 2003 (3.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 41, Issue 12, 1 1 2003, Pages 2105-2113 Secondary prevention with folic acid: effects on clinical outcomes. Liem A, Reynierse-Buitenwerf GH, Zwinderman AH, Jukema JW, van Veldhuisen DJ

Objectives: We sought to conduct a randomized trial with folic acid 0.5 mg/day in a patient population with stable coronary artery disease (CAD). Background: Folic acid has favorable effects on vascular endothelium and lowers plasma homocysteine levels. In addition, homocysteine appears to be an independent risk factor for atherosclerotic disease. However, the value of folic acid in secondary prevention had seldom been tested. Methods: In this open-label study, 593 patients were included; 300 we... Abstract

Cited 4 times since 2003 (0.2 per year) source: EuropePMC

European journal of heart failure, Volume 5, Issue 3, 1 1 2003, Pages 315-317 Eligibility for biventricular pacing in patients with an implantable cardioverter defibrillator. Molhoek SG, Bax JJ, van Erven L, Steendijk P, van der Wall EE, Schalij MJ

Implantable cardioverter defibrillator (ICD)-therapy prevents sudden death in patients at high risk, but incidence of death due to heart failure remains unaltered. Recent data suggest that biventricular (BV) pacing is useful in patients with heart failure. It is unclear, how many patients with an ICD indication may have an indication for BV pacing. Therefore all patients who received an ICD were analyzed for eligibility of BV pacing using the following criteria: NYHA class III or IV, QRS duratio... Abstract

Cited 41 times since 2003 (1.9 per year) source: EuropePMC

Journal of virology, Volume 77, Issue 11, 1 1 2003, Pages 6216-6226 Formation of disulfide-linked complexes between the three minor envelope glycoproteins (GP2b, GP3, and GP4) of equine arteritis virus. Wieringa R, de Vries AA, Rottier PJ

Equine arteritis virus (EAV) is an enveloped, positive-stranded RNA virus belonging to the family Arteriviridae of the order NIDOVIRALES: Six transmembrane proteins have been identified in EAV particles: the nonglycosylated membrane protein M and the glycoprotein GP(5) (previously named G(L)), which occur as disulfide-bonded heterodimers and are the major viral envelope proteins; the unglycosylated small envelope protein E; and the minor glycoproteins GP(2b) (formerly designated G(S)), GP(3), an... Abstract

Cited 9 times since 2003 (0.4 per year) source: EuropePMC

The American journal of cardiology, Volume 91, Issue 12, 1 1 2003, Pages 1406-1409 Individual prediction of functional recovery after coronary revascularization in patients with ischemic cardiomyopathy: the scar-to-biphasic model. Rizzello V, Schinkel AF, Bax JJ, Boersma E, Bountioukos M, Vourvouri EC, Krenning B, Agricola E, Roelandt JR, Poldermans D

Currently, the prediction of improvement of left ventricular (LV) ejection fraction (EF) after revascularization in patients with ischemic cardiomyopathy relies only on viable myocardium extent, whereas both the amount of viable and scar tissue may be important. A model was developed, based on the amount of viable and nonviable myocardium, to predict functional recovery. Viable and scarred myocardium was defined by dobutamine stress echocardiography (DSE) in 108 consecutive patients. LVEF before... Abstract

Cited 21 times since 2003 (1 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 44, Issue 6, 1 1 2003, Pages 877-883 Effect of diabetes mellitus on myocardial 18F-FDG SPECT using acipimox for the assessment of myocardial viability. Schinkel AF, Bax JJ, Valkema R, Elhendy A, van Domburg RT, Vourvouri EC, Bountioukos MA, Krenning EP, Roelandt JR, Poldermans D

Unlabelled: During the noninvasive assessment of myocardial viability with (18)F-FDG metabolic imaging, adequate regulation of metabolic conditions is needed to ensure optimal image quality. The aim of this study was to compare the feasibility and image quality of cardiac (18)F-FDG SPECT imaging using acipimox in patients with diabetes and patients without diabetes. Methods: Seventy patients with ischemic cardiomyopathy underwent (18)F-FDG SPECT using acipimox for the assessment of myocardial vi... Abstract

Cited 9 times since 2003 (0.4 per year) source: EuropePMC

Biochemical pharmacology, Volume 65, Issue 11, 1 1 2003, Pages 1875-1881 Cytosolic beta-glycosidases for activation of glycoside prodrugs of daunorubicin. de Graaf M, Pinedo HM, Quadir R, Haisma HJ, Boven E

Human cytosolic beta-glycosidase is a small monomeric enzyme that is active under physiological conditions, which might be ideal for enzyme-prodrug therapy. We have previously reported the synthesis of a galactoside (DNR-GlA3) and a glucoside (DNR-GsA3) prodrug of daunorubicin. In the present study, we established that cellular uptake of DNR-GlA3 and DNR-GsA3 was low in contrast to that of daunorubicin. Recombinant human beta-glycosidase converted both prodrugs to daunorubicin as shown by liquid... Abstract

Cited 11 times since 2003 (0.5 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 11, Issue 6, 1 1 2003, Pages 250-259 Heart rate variability and sympathovagal balance: pharmacological validation. Bootsma M, Swenne CA, Janssen MJ, Cats VM, Schalij MJ

Rationale: We validated heart rate (HR) and six time and six frequency domain measures of heart rate variability (HRV) as estimators of autonomic outflow in 44 young healthy male subjects. Gold standards for autonomic outflow were the Rosenblueth-Simeone factors m (sympathetic tone) and n (vagal tone), and the sympathovagal balance m·n, determined by two-stage complete autonomic blockade. Methods: Rank correlations were computed between HR and the HRV measures obtained before autonomic blockade,... Abstract

Cited 150 times since 2003 (6.8 per year) source: EuropePMC

Circulation, Volume 107, Issue 19, 12 2 2003, Pages 2416-2421 Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events. Boekholdt SM, Agema WR, Peters RJ, Zwinderman AH, van der Wall EE, Reitsma PH, Kastelein JJ, Jukema JW, REgression GRowth Evaluation Statin Study Group

Background: Atherosclerosis is increasingly considered to be a chronic inflammatory process. We examined whether genetic variants of the toll-like receptor 4 (TLR4), which are correlated with impaired innate immunity and with progression of carotid atherosclerosis, are also associated with coronary atherosclerosis and predict the risk of cardiovascular events. Methods and results: Two polymorphisms of the TLR4 gene (Asp299Gly and Thr399Ile) were determined in 655 men with angiographically docume... Abstract

Cited 25 times since 2003 (1.1 per year) source: EuropePMC

Atherosclerosis, Volume 168, Issue 1, 1 1 2003, Pages 131-138 A novel functional polymorphism in the PECAM-1 gene (53G>A) is associated with progression of atherosclerosis in the LOCAT and REGRESS studies. Elrayess MA, Webb KE, Flavell DM, Syvänne M, Taskinen MR, Frick MH, Nieminen MS, Kesäniemi YA, Pasternack A, Jukema JW, Kastelein JJ, Zwinderman AH, Humphries SE

A 53G>A polymorphism identified in the 5' untranslated region (5'UTR) of the platelet endothelial cell adhesion molecule-1 (PECAM-1) gene alters a putative shear stress responsive element (SSRE). PECAM-1 was shown to be responsive to shear stress and transient transfection of human umbilical vein endothelial cell (HUVECs) with two luciferase reporter constructs driven by the PECAM-1 promoter and 5'UTR showed a response of the 53G allele, not the 53A allele, to shear stress. Ass... Abstract

Cited 7 times since 2003 (0.3 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 89, Issue 5, 1 1 2003, Pages 557-558 DD ACE gene polymorphism is associated with increased coronary artery endothelial dysfunction: the PREFACE trial. Mulder HJ, van Geel PP, Schalij MJ, van Gilst WH, Zwinderman AH, Bruschke AV, PREFACE trial

Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 11, Issue 5, 1 1 2003, Pages 203-209 Simultaneous measurement of right and left ventricular volume by the conductance catheter technique in the newborn lamb. Cardozo RH, de Vroomen M, van Bel F, Baan J, Steendijk P

Background: Measurement of absolute ventricular volume with the conductance catheter technique has been documented extensively for the left ventricle (LV). More recently, the same technique has been applied in studies of right ventricular (RV) performance. In the present study we performed simultaneous measurements of LV and RV volumes. Conversion of measured conductances to absolute volumes requires the assessment of slope factor alpha (α) and parallel conductance correction volume (Vc) for bot... Abstract

Cited 48 times since 2003 (2.2 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 10, Issue 3, 1 1 2003, Pages 261-266 Long-term prognosis after a normal exercise stress Tc-99m sestamibi SPECT study. Elhendy A, Schinkel A, Bax JJ, van Domburg RT, Poldermans D

Background: Patients with a normal stress technetium 99m sestamibi study were shown to have a favorable outcome at intermediate-term follow-up. However, long-term survival has not been studied. The aim of this study was to evaluate the incidence and predictors of mortality and cardiac events at long-term follow-up after a normal exercise stress sestamibi study. Methods and results We studied 218 patients (mean age, 53 +/- 10 years, 108 men) who had normal myocardial perfusion assessed by Tc-99m... Abstract

Cited 264 times since 2003 (12 per year) source: EuropePMC

Circulation, Volume 107, Issue 14, 14 2 2003, Pages 1848-1851 Statins are associated with a reduced incidence of perioperative mortality in patients undergoing major noncardiac vascular surgery. Poldermans D, Bax JJ, Kertai MD, Krenning B, Westerhout CM, Schinkel AF, Thomson IR, Lansberg PJ, Fleisher LA, Klein J, van Urk H, Roelandt JR, Boersma E

Background: Patients undergoing major vascular surgery are at increased risk of perioperative mortality due to underlying coronary artery disease. Inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A (statins) may reduce perioperative mortality through the improvement of lipid profile, but also through the stabilization of coronary plaques on the vascular wall. Methods and results: To evaluate the association between statin use and perioperative mortality, we performed a case-controlled study... Abstract

Cited 51 times since 2003 (2.3 per year) source: EuropePMC

The American journal of cardiology, Volume 91, Issue 7, 1 1 2003, Pages 785-789 Impact of percutaneous coronary intervention or coronary artery bypass grafting on outcome after nonfatal cardiac arrest outside the hospital. Borger van der Burg AE, Bax JJ, Boersma E, Bootsma M, van Erven L, van der Wall EE, Schalij MJ

Survivors of cardiac arrest due to ventricular arrhythmias are at risk for recurrent events. The role of revascularization in secondary prevention for survivors of cardiac arrest has been addressed in various studies with conflicting results. A total of 142 survivors of cardiac arrest with coronary artery disease were evaluated according to a standardized protocol, including 2-dimensional echocardiography, myocardial perfusion scintigraphy, coronary angiography, and electrophysiologic testing. R... Abstract