6190 results
Cited 166 times since 2002 (7.3 per year)
source: EuropePMC
Circulation,
Volume 106, Issue 15, 1 1 2002, Pages 1985-1990
In vivo evidence for a role of toll-like receptor 4 in the development of intimal lesions.
Vink A, Schoneveld AH, van der Meer JJ, van Middelaar BJ, Sluijter JP, Smeets MB, Quax PH, Lim SK, Borst C, Pasterkamp G, de Kleijn DP
Background: Inflammation plays an important role in atherogenesis. The toll-like receptor 4 (TLR4) is the receptor for bacterial lipopolysaccharides and also recognizes cellular fibronectin and heat shock protein 60, endogenous peptides that are produced in response to tissue injury. To explore a possible role for this receptor in arterial obstructive disease, we determined the expression of TLR4 in the atherosclerotic arterial wall, including adventitia, and studied the effect of adventitial TL...
Abstract
The international journal of cardiovascular imaging,
Volume 18, Issue 5, 1 1 2002, Pages 353-355
The cavity-to-myocardial count ratio as a marker of left ventricular function.
Bax JJ, Lamb HJ, van der Wall EE
Abstract
Cited 3 times since 2002 (0.1 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 15, Issue 10 Pt 2, 1 1 2002, Pages 1285-1289
Stress echocardiography for risk stratification of patients with chest pain and normal or slightly narrowed coronary arteries.
Bigi R, Cortigiani L, Bax JJ, Colombo P, Desideri A, Sponzilli C, Fiorentini C
One hundred twenty-five patients (60 +/- 10 years old, 60 women) with known (35, previous myocardial infarction) or suspected (90) coronary artery disease (CAD) and no more than 50% coronary stenoses underwent pharmacologic (48 dipyridamole and 77 dobutamine) stress echocardiography (SE) and prospective follow-up (36 +/- 22 months) for cardiac death, nonfatal infarction, and unstable angina. The ability of clinical and SE variables to predict the outcome was assessed by the Cox model. A signific...
Abstract
Cited 96 times since 2002 (4.2 per year)
source: EuropePMC
Blood,
Volume 101, Issue 5, 19 3 2002, Pages 1810-1817
Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix.
Collen A, Hanemaaijer R, Lupu F, Quax PH, van Lent N, Grimbergen J, Peters E, Koolwijk P, van Hinsbergh VW
Adult angiogenesis, associated with pathologic conditions, is often accompanied by the formation of a fibrinous exudate. This temporary matrix consists mainly of fibrin but is intermingled with plasma proteins and collagen fibers. The formation of capillary structures in a fibrinous matrix in vivo was mimicked by an in vitro model, in which human microvascular endothelial cells (hMVECs) seeded on top of a fibrin-10% collagen matrix form capillarylike tubular structures after stimulation with bas...
Abstract
Cited 31 times since 2002 (1.4 per year)
source: EuropePMC
American journal of physiology. Heart and circulatory physiology,
Volume 284, Issue 1, 12 2 2002, Pages H350-7
Impact of pericardial restraint on right atrial mechanics during acute right ventricular pressure load.
Maniar HS, Prasad SM, Gaynor SL, Chu CM, Steendijk P, Moon MR
Optimization of right atrial (RA) mechanics is important for maintaining right ventricular (RV) filling and global cardiac output. However, the impact of pericardial restraint on RA function and the compensatory role of the right atrium to changes in RV afterload remain poorly characterized. In eight open-chest sheep, RA elastance (contractility) and chamber stiffness were measured (RA pressure-volume relations) at baseline and during partial pulmonary artery (PA) occlusion. Data were collected...
Abstract
Cited 17 times since 2002 (0.7 per year)
source: EuropePMC
Atherosclerosis,
Volume 164, Issue 1, 1 1 2002, Pages 65-71
Raman spectroscopic investigation of atorvastatin, amlodipine, and both on atherosclerotic plaque development in APOE*3 Leiden transgenic mice.
van de Poll SW, Delsing DJ, Jukema JW, Princen HM, Havekes LM, Puppels GJ, van der Laarse A
Raman spectroscopy allows quantitative, non-destructive evaluation of entire, intact atherosclerotic plaques. We quantified the anti-atherosclerotic effects of atorvastatin and amlodipine on progression of atherosclerosis using post-mortem Raman spectroscopic plaque imaging in 28 APOE*3 Leiden transgenic mice who were fed a high fat/high cholesterol diet for 28 weeks. Mice were assigned to a control group receiving the diet alone or to groups that received the diet with either 0.01% w/w atorvast...
Abstract
Cited 36 times since 2002 (1.6 per year)
source: EuropePMC
Cardiovascular research,
Volume 55, Issue 4, 1 1 2002, Pages 768-777
Angiogenesis-independent cardioprotection in FGF-1 transgenic mice.
Buehler A, Martire A, Strohm C, Wolfram S, Fernandez B, Palmen M, Wehrens XH, Doevendans PA, Franz WM, Schaper W, Zimmermann R
Objective: This study was performed to evaluate the cardioprotective role of acidic fibroblast growth factor-1 (FGF-1) in transgenic mice with cardiac-specific overexpression of human FGF-1. Methods: Mice were subjected to coronary artery occlusion for 15-75 min with a continuously recorded 3-lead electrocardiogram (ECG). Infarct size was measured and ERK-1 and -2 activity was assessed by Western blot analysis. Creatine kinase and lactate dehydrogenase activity as marker for cell viability were...
Abstract
Cited 26 times since 2002 (1.1 per year)
source: EuropePMC
Arteriosclerosis, thrombosis, and vascular biology,
Volume 22, Issue 9, 1 1 2002, Pages 1433-1438
Inhibition of accelerated atherosclerosis in vein grafts by placement of external stent in apoE*3-Leiden transgenic mice.
Lardenoye JH, De Vries MR, Grimbergen JM, Havekes LM, Knaapen MW, Kockx MM, van Hinsbergh VW, van Bockel JH, Quax PH
Objective: Vein grafts fail because of the development of intimal hyperplasia and accelerated atherosclerosis. Placement of an external stent around vein grafts resulted in an inhibition of intimal hyperplasia in several animal studies. Here, we assess the effects of external stenting on accelerated atherosclerosis in early vein grafts in carotid arteries in hypercholesterolemic apolipoprotein E*3-Leiden transgenic mice. Methods and results: Venous interposition grafting was performed in apolipo...
Abstract
Cited 20 times since 2002 (0.9 per year)
source: EuropePMC
Diabetes care,
Volume 25, Issue 9, 1 1 2002, Pages 1637-1643
Prognostic value of dobutamine-atropine stress myocardial perfusion imaging in patients with diabetes.
Schinkel AF, Elhendy A, van Domburg RT, Bax JJ, Vourvouri EC, Sozzi FB, Valkema R, Roelandt JR, Poldermans D
Objective: Exercise tolerance in patients with diabetes is frequently impaired due to noncardiac disease such as claudication and polyneuropathy. This study assesses the prognostic value of dobutamine stress myocardial perfusion imaging in patients with diabetes. Research design and methods: A total of 207 consecutive diabetic patients who were unable to undergo exercise stress testing underwent dobutamine-atropine stress myocardial perfusion imaging. Follow-up was successful in 206 of 207 (99.5...
Abstract
Cited 232 times since 2002 (10.2 per year)
source: EuropePMC
Circulation,
Volume 106, Issue 13, 1 1 2002, Pages 1703-1707
Magnetic resonance imaging to assess the hemodynamic effects of pulmonary valve replacement in adults late after repair of tetralogy of fallot.
Vliegen HW, van Straten A, de Roos A, Roest AA, Schoof PH, Zwinderman AH, Ottenkamp J, van der Wall EE, Hazekamp MG
Background: Pulmonary regurgitation (PR) late after total correction for tetralogy of Fallot may lead to progressive right ventricular (RV) dilatation and an increased incidence of severe arrhythmias and sudden death. Timing of pulmonary valve replacement (PVR) is subject to discussion, because the effect of PVR on RV function in adults is unclear. In this study, MRI was used to assess the effect of PVR on RV function and PR. Clinical improvement was established by means of the NYHA classificati...
Abstract
Cited 19 times since 2002 (0.8 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 22, Issue 3, 1 1 2002, Pages 426-430
The beneficial effect of revascularization on jeopardized myocardium: reverse remodeling and improved long-term prognosis.
Mule JD, Bax JJ, Zingone B, Martinelli F, Burelli C, Stefania A, DiSipio L, Soravia G
Objectives: To evaluate the impact of viability/ischemia before revascularization on improvement in systolic performance, reverse remodeling, symptoms and long-term prognosis post-revascularization. Methods: Fifty patients underwent thallium-201 imaging before revascularization to assess stress-induced ischemia and viability ('jeopardized myocardium'). Left ventricular (LV) ejection fraction (EF), LV end-systolic volume index (LVESVI) and LV end-diastolic volume index (LVEDVI) were det...
Abstract
Cited 1 times since 2002 (0 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 10, Issue 9, 1 1 2002, Pages 345-348
Adults with congenital heart disease: a growing population.
Vriend JW, van der Velde ET, Mulder BJ
Abstract
Cited 7 times since 2002 (0.3 per year)
source: EuropePMC
Circulation,
Volume 106, Issue 12 Suppl 1, 1 1 2002, Pages I14-8
Perfusion and contractile reserve in chronic dysfunctional myocardium: relation to functional outcome after surgical revascularization.
Bax JJ, Poldermans D, Schinkel AF, Boersma E, Elhendy A, Maat A, Valkema R, Krenning EP, Roelandt JR
Background: Chronic dysfunctional but viable myocardium may exhibit contractile reserve and/or intact perfusion. Segments with intact perfusion without contractile reserve are frequently observed inpatients with ischemic cardiomyopathy. The clinical relevance of this observation is unclear; in particular, the functional outcome after revascularization is unknown. Thus, contractile reserve (using low-dose dobutamine echocardiography) and perfusion (using resting (99m)Tc tetrofosmin) were evaluate...
Abstract
Cited 25 times since 2002 (1.1 per year)
source: EuropePMC
British journal of cancer,
Volume 87, Issue 6, 1 1 2002, Pages 659-664
Secreted and tumour targeted human carboxylesterase for activation of irinotecan.
Oosterhoff D, Pinedo HM, van der Meulen IH, de Graaf M, Sone T, Kruyt FA, van Beusechem VW, Haisma HJ, Gerritsen WR
Irinotecan (CPT-11) is an anticancer agent for the treatment of colon cancer. CPT-11 can be considered as a prodrug, since it needs to be activated into the toxic drug SN-38 by the enzyme carboxylesterase. An approach to achieve tumour specific activation of CPT-11 is to transduce the cDNA encoding carboxylesterase into tumour cells. A secreted form of carboxylesterase may diffuse through a tumour mass and may activate CPT-11 extracellularly. This could enhance the antitumour efficacy by exertin...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 10, Issue 7-8, 1 1 2002, Pages 329-330
Contrast medium echocardiography-assisted pericardiocentesis of loculated pericardial fluid.
van Houwelingen KG, Bax JJ, Jukema JW, van der Wall EE
Abstract
Cited 1 times since 2002 (0 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 10, Issue 7-8, 1 1 2002, Pages 301-303
100 years of electrocardiography; who was Willem Einthoven? (1860-1927).
Schalij MJ, van der Wall EE
Abstract
Cited 42 times since 2002 (1.8 per year)
source: EuropePMC
The American journal of cardiology,
Volume 90, Issue 4, 1 1 2002, Pages 379-383
Effectiveness of resynchronization therapy in patients with end-stage heart failure.
Molhoek SG, Bax JJ, van Erven L, Bootsma M, Boersma E, Steendijk P, van der Wall EE, Schalij MJ
Biventricular pacing has been introduced to treat patients with end-stage heart failure, and short-term results of this technique are promising. Because data on longer follow-up are limited to 3-month follow-up, the sustained effect of biventricular pacing is unclear and long-term survival is unknown. Forty patients with end-stage heart failure in New York Heart Association (NYHA) functional class III or IV with left ventricular (LV) ejection fraction (EF) 120 ms, and left bundle branch block mo...
Abstract
Cited 61 times since 2002 (2.7 per year)
source: EuropePMC
American heart journal,
Volume 144, Issue 2, 1 1 2002, Pages 198-205
Assessment of diastolic function by cardiovascular magnetic resonance.
Paelinck BP, Lamb HJ, Bax JJ, Van der Wall EE, de Roos A
Background: The assessment of diastolic heart function has been hampered by multiple difficulties. Cardiovascular magnetic resonance (CMR) is a new, noninvasive technique to study cardiac function. Methods: The literature on CMR for the analysis of diastolic function and its clinical applications is extensively reviewed. Results: Analysis of ventricular filling velocity and volume flow, volumetric assessment of ventricular chamber volume, analysis of 3-dimensional myocardial strains, and assessm...
Abstract
Cited 40 times since 2002 (1.8 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 29, Issue 9, 11 2 2002, Pages 1257-1266
The need for standardisation of cardiac FDG PET imaging in the evaluation of myocardial viability in patients with chronic ischaemic left ventricular dysfunction.
Knuuti J, Schelbert HR, Bax JJ
The evaluation of myocardial glucose utilisation with fluorine-18 fluorodeoxyglucose (FDG) and positron emission tomography is currently considered the most reliable tool for the identification of myocardial viability. However, the investigations using FDG imaging to predict improvement in left ventricular (LV) function after revascularisation have reported wide ranges for sensitivity (71%-100%) and, in particular, for specificity (33%-91%). The variable results may be related to differences in...
Abstract
Cited 48 times since 2002 (2.1 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 36, Issue 1, 1 1 2002, Pages 94-99
The impact of walking impairment, cardiovascular risk factors, and comorbidity on quality of life in patients with intermittent claudication.
Breek JC, Hamming JF, De Vries J, van Berge Henegouwen DP, van Heck GL
Objective: The objective of this study was to assess the impact of walking impairment, cardiovascular risk factors, and comorbidity on quality of life (QOL) in patients with intermittent claudication (IC). Material and methods: The prospective observational study was conducted in the setting of a vascular outpatient department of a teaching hospital. QOL was assessed in 200 consecutive patients with IC, with a reduced version of the World Health Organization Quality of Life Assessment Instrument...
Abstract
