6190 results
Clinical science (London, England : 1979),
Volume 91 Suppl, 1 1 1996, Pages 113-115
Heart rate variability, baroreflex sensitivity, and cardiac vagal tone.
Swenne CA, Bootsma M, Hyndman BW, Voogd J, Bruschke AV
Abstract
Cited 6 times since 1995 (0.2 per year)
source: EuropePMC
European heart journal,
Volume 16, Issue 12, 1 1 1995, Pages 1860-1871
Comparison between regional myocardial perfusion reserve and coronary flow reserve in the canine heart.
Geldof MJ, Schalij MJ, Manger Cats V, van der Zwet PM, Steendijk P, van der Velde ET, Nagtegaal EM, Reiber JH, Bruschke AV
Diameter stenosis and flow reserve are indices of morphological and functional severity of coronary artery stenosis. Flow reserve can be determined at coronary arterial or at myocardial level. In the presence of functional collateral circulation, coronary flow reserve and myocardial perfusion reserve may differ. We studied coronary flow, coronary flow reserve and myocardial perfusion reserve in an open chest dog model with intact collateral circulation, before and after induction of coronary art...
Abstract
Cited 5 times since 1995 (0.2 per year)
source: EuropePMC
Cell calcium,
Volume 18, Issue 6, 1 1 1995, Pages 515-525
Alpha-adrenergic agonist and endothelin-1 induced intracellular Ca2+ response in the presence of a Ca2+ entry blocker in cultured rat ventricular myocytes.
De Jonge HW, Atsma DE, van der Valk-Kokshoorn EJ, van Heugten HA, van der Laarse A, Lamers JM
Previously we demonstrated that stimulation of cultured neonatal rat ventricular myocytes by either alpha 1-adrenergic agonist or endothelin-1 resulted in a rapid formation of total inositolphosphates, although the levels of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate did not rise significantly. The aim of this study was to examine whether stimulation by alpha 1-adrenergic agonist and endothelin-1 could still elicit phosphatidylinositol cycle mediated intracellular Ca2+ m...
Abstract
Cited 5 times since 1995 (0.2 per year)
source: EuropePMC
American heart journal,
Volume 130, Issue 5, 1 1 1995, Pages 1020-1025
Heart rate variability profiles in symptomatic coronary artery disease and preserved left ventricular function: relation to ventricular tachycardia and transient myocardial ischemia. Regression Growth Evaluation Statin Study (REGRESS).
van Boven AJ, Jukema JW, Crijns HJ, Lie KI
We studied heart rate variability in ambulatory electrocardiographic recordings from 312 patients with significant coronary artery disease and a left ventricular ejection fraction of > or = 30%. Only those patients who had both episodes of ischemia and nonsustained ventricular arrhythmias showed diminished values for parasympathetic nonspectral and spectral heart rate (HR) variability parameters. The root mean square of difference of successive R-R intervals (RMSSD) and high-frequency (HF) po...
Abstract
Cited 151 times since 1995 (5.1 per year)
source: EuropePMC
Circulation,
Volume 92, Issue 9, 1 1 1995, Pages 2419-2425
Reduction in cardiovascular events during pravastatin therapy. Pooled analysis of clinical events of the Pravastatin Atherosclerosis Intervention Program.
Byington RP, Jukema JW, Salonen JT, Pitt B, Bruschke AV, Hoen H, Furberg CD, Mancini GB
Background: It has been documented that the HMG coenzyme A reductase inhibitors, or statins, can decrease cardiovascular events and mortality in patients with clinical coronary disease and moderately to severely elevated lipid levels. Additional data are required to demonstrate a reduction of vascular events in coronary patients with less than severely elevated lipid levels and in subgroups of this population. Methods and results: Clinical data from four atherosclerosis regression trials that ev...
Abstract
Cited 81 times since 1995 (2.7 per year)
source: EuropePMC
Circulation,
Volume 92, Issue 9, 1 1 1995, Pages 2723-2739
Magnetic resonance imaging in coronary artery disease.
van der Wall EE, Vliegen HW, de Roos A, Bruschke AV
The cardiovascular applications of nuclear magnetic resonance (MR) techniques in coronary artery disease have increased considerably in recent years. Technical advantages of MR imaging in comparison with other techniques are the excellent spatial resolution, the characterization of myocardial tissue, and the potential for three-dimensional imaging. This allows the accurate assessment of left ventricular mass and volume, the differentiation of infarcted tissue from normal myocardial tissue, and t...
Abstract
Cited 2 times since 1995 (0.1 per year)
source: EuropePMC
The American journal of cardiology,
Volume 76, Issue 12, 1 1 1995, Pages 922-927
Similar orthostatic defense in active, healthy young adult and late middle-aged men.
Bootsma M, Swenne CA, Bruschke AV
Orthostatic defense is commonly validated with a 60 degrees to 80 degrees head-up tilt test, addressing the step response rather than the response to permanent orthostatis. During the initial phase of tilt, neural factors predominate, while later, the slower humoral factors fade in. It has been demonstrated that, during adaptation of the circulatory system to the standing conditions, overshoot and undershoot occur. These oscillations hamper straight-forward interpretation of a tilt test, and may...
Abstract
Cited 10 times since 1995 (0.3 per year)
source: EuropePMC
Magnetic resonance in medicine,
Volume 34, Issue 5, 1 1 1995, Pages 728-737
Magnetic resonance imaging analysis of left ventricular pressure-volume relations: validation with the conductance method at rest and during dobutamine stress.
Pattynama PM, de Roos A, Van der Velde ET, Lamb HJ, Steendijk P, Hermans J, Baan J
The accuracy of magnetic resonance (MR) imaging was assessed for in vivo measurement of the ventricular end-systolic pressure-volume relation (ESPVR) and preload recruitable stroke work (PRSW). The conductance catheter was used as reference. In 10 pigs, ventricular volumes were measured with both methods under different loading conditions at two levels of contractility. Increased contractility resulted in a significant leftward shift of the ESPVR and PRSW for both methods. The magnitude of these...
Abstract
Cited 3 times since 1995 (0.1 per year)
source: EuropePMC
Laboratory animals,
Volume 29, Issue 4, 1 1 1995, Pages 459-463
Spleen pigmentation in young C57BL mice is caused by accumulation of melanin.
van der Heijden A, van Dijk JE, Lemmens AG, Beynen AC
It has been previously reported that in 2 C57BL mouse sublines a dark pigmentation of the cranial part of the spleen occurs in up to 30% of the animals within the populations. It was not clear whether this discoloration is caused by melanosis, lipofuscinosis or haemosiderosis. With the use of light and electron microscopy of stained spleen sections, we identified the pigment in 14 out of 60 C57BL mice aged 8-10 wks. In the mice with pigmented spleens there was accumulation of melanin, predominan...
Abstract
Cited 54 times since 1995 (1.8 per year)
source: EuropePMC
The American journal of cardiology,
Volume 76, Issue 9, 1 1 1995, Pages 40C-46C
Effect of pravastatin on progression and regression of coronary atherosclerosis and vessel wall changes in carotid and femoral arteries: a report from the Regression Growth Evaluation Statin Study.
de Groot E, Jukema JW, van Boven AJ, Reiber JH, Zwinderman AH, Lie KI, Ackerstaff RA, Bruschke AV
Few data are available about the potential benefit of serum cholesterol reduction in the broad range of patients with coronary atherosclerosis and normal to moderately elevated serum cholesterol levels. REGRESS is a double-blind, placebo-controlled, multicenter study to assess the effect of a 2-year treatment with the 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor pravastatin on progression and regression of coronary atherosclerosis using quantitative coronary arteriography in 885 ma...
Abstract
Cited 53 times since 1995 (1.8 per year)
source: EuropePMC
The Journal of general virology,
Volume 76 ( Pt 9), 1 1 1995, Pages 2223-2233
Comparison of equine arteritis virus isolates using neutralizing monoclonal antibodies and identification of sequence changes in GL associated with neutralization resistance.
Glaser AL, de Vries AA, Dubovi EJ
Three murine monoclonal antibodies (MAbs) that neutralize equine arteritis virus (EAV) infectivity were identified and characterized. The antibodies, 93B, 74D(B) and 38F, recognized the major envelope glycoprotein (GL) encoded by open reading frame (ORF) 5 in immunoblots and by immunoprecipitation. All three MAbs were used to compare the Bucyrus isolate of EAV and MAb neutralization-resistant (NR) escape mutants with the vaccine virus and 19 independent field isolates of EAV by virus neutralizat...
Abstract
Cited 13 times since 1995 (0.4 per year)
source: EuropePMC
German journal of ophthalmology,
Volume 4, Issue 5, 1 1 1995, Pages 311-314
Microperimetry in patients with central serous retinopathy.
Toonen F, Remky A, Janssen V, Wolf S, Reim M
In patients with acute central serous retinopathy (CSR), evaluation of visual acuity alone may not represent visual function. In patients with acute CSR, visual function may be disturbed by localized scotomas, distortion, and waviness. For the assessment of localized light sensitivity and stability of fixation, patients with CSR were evaluated by fundus perimetry with a scanning laser ophthalmoscope (SLO 101, Rodenstock Instruments). In all, 21 patients with acute CSR and 19 healthy volunteers w...
Abstract
Cited 14 times since 1995 (0.5 per year)
source: EuropePMC
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
Volume 10, Issue 9, 1 1 1995, Pages 1374-1384
Regulation of plasminogen activation, matrix metalloproteinases and urokinase-type plasminogen activator-mediated extracellular matrix degradation in human osteosarcoma cell line MG63 by interleukin-1 alpha.
de Bart AC, Quax PH, Löwik CW, Verheijen JH
Plasmin-mediated extracellular proteolysis has been implicated in the degradation of bone in normal and pathological conditions. Normal and malignant osteoblasts can produce both tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). We have used the osteosarcoma cell line MG63 to address the question of whether the enhanced bone turnover in osteosarcomas is mediated by t-PA or by u-PAA and to study the effect of the cytokine interleukin-1 alpha (IL-1 alpha), k...
Abstract
Cited 50 times since 1995 (1.7 per year)
source: EuropePMC
Journal of virology,
Volume 69, Issue 8, 1 1 1995, Pages 4668-4674
The two major envelope proteins of equine arteritis virus associate into disulfide-linked heterodimers.
de Vries AA, Post SM, Raamsman MJ, Horzinek MC, Rottier PJ
In a coimmunoprecipitation assay with monospecific antisera, the two major envelope proteins GL and M of equine arteritis virus were found to occur in heteromeric complexes in virions and infected cells. While the GL protein associated with M rapidly and efficiently, newly synthesized M protein was incorporated into complexes at a slower rate, which implies that it interacts with GL molecules synthesized earlier. Analysis under nonreducing conditions revealed that the GL/M complexes consist of d...
Abstract
Cited 35 times since 1995 (1.2 per year)
source: EuropePMC
Magnetic resonance in medicine,
Volume 34, Issue 2, 1 1 1995, Pages 161-169
Quantitative analysis of regional left ventricular function after myocardial infarction in the pig assessed with cine magnetic resonance imaging.
Holman ER, Vliegen HW, van der Geest RJ, Reiber JH, van Dijkman PR, van der Laarse A, de Roos A, van der Wall EE
To assess the accuracy of quantitative analysis of global and regional wall motion and wall thickening of the left ventricle with cine magnetic resonance (MR), images obtained in eight pigs before and after myocardial infarction were compared with those obtained using gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA)-enhanced multislice spin-echo MR imaging and determination of pathology. The region with abnormal wall motion and wall thickening, as determined with cine MR imaging, identifi...
Abstract
Cited 45 times since 1995 (1.5 per year)
source: EuropePMC
The Journal of general virology,
Volume 76 ( Pt 8), 1 1 1995, Pages 1989-1998
Equine arteritis virus-neutralizing antibody in the horse is induced by a determinant on the large envelope glycoprotein GL.
Chirnside ED, de Vries AA, Mumford JA, Rottier PJ
Complementary DNAs encoding ORFs 2 to 7 equine arteritis virus (EAV) have been cloned into the expression vector pGEX to produce glutathione-S-transferase fusion proteins. Recombinant proteins were affinity purified and screened in ELISA with equine sera to identify immunoreactive polypeptides. The large envelope glycoprotein (GL) was identified as the most reactive to EAV-positive equine sera and an immuno-dominant epitope was mapped between amino acids 55 and 98 by subcloning and expression. A...
Abstract
Cited 10 times since 1995 (0.3 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 110, Issue 1, 1 1 1995, Pages 248-257
In situ hybridization: a new technique to determine the origin of fibroblasts in cryopreserved aortic homograft valve explants.
Hazekamp MG, Koolbergen DR, Braun J, Sugihara H, Cornelisse CJ, Goffin YA, Huysmans HA
Tissue degeneration reduces the durability of cryopreserved homografts. Earlier studies indicated that the presence of fibroblasts in homograft leaflets may contribute to increased valve longevity. These fibroblasts may be of recipient origin or represent surviving donor cells. We developed a method, based on in situ hybridization, to determine the origin of fibroblasts in homograft explants. In young pigs we performed aortic valve replacement with a cryopreserved porcine aortic homograft. A mal...
Abstract
Cited 32 times since 1995 (1.1 per year)
source: EuropePMC
Journal of virological methods,
Volume 54, Issue 1, 1 1 1995, Pages 1-13
Development and evaluation of an ELISA using recombinant fusion protein to detect the presence of host antibody to equine arteritis virus.
Chirnside ED, Francis PM, de Vries AA, Sinclair R, Mumford JA
A recombinant glutathione-S-transferase fusion protein expressing amino acids 55-98 of equine arteritis virus (EAV) GL (rGL 55-98) was tested in an ELISA for its ability to detect serum antibodies to EAV. Host antibodies induced following EAV infection bound the recombinant antigen by ELISA. The ELISA specificity and sensitivity were determined with a panel of equine sera including postinfection and postvaccination samples. A good correlation existed between EAV neutralizing antibody titers and...
Abstract
Cited 28 times since 1995 (0.9 per year)
source: EuropePMC
Journal of virology,
Volume 69, Issue 6, 1 1 1995, Pages 3441-3448
The small envelope glycoprotein (GS) of equine arteritis virus folds into three distinct monomers and a disulfide-linked dimer.
de Vries AA, Raamsman MJ, van Dijk HA, Horzinek MC, Rottier PJ
The small membrane glycoprotein (GS) of equine arteritis virus (EAV) is a minor virion component but is abundantly expressed in EAV-infected cells. In this study, we have analyzed its membrane topology, folding, oligomerization, and intracellular transport. We show that GS is a class I integral membrane protein with one functional N-glycosylation site. Gel electrophoresis under nonreducing conditions revealed that GS occurs in EAV-infected cells in four monomeric conformations and as disulfide-l...
Abstract
Cited 4 times since 1995 (0.1 per year)
source: EuropePMC
Archives of biochemistry and biophysics,
Volume 319, Issue 2, 1 1 1995, Pages 350-354
Metabolic inhibition of cardiomyocytes causes an increase in sarcolemmal fluidity which may be due to loss of cellular cholesterol.
Bastiaanse EM, Atsma DE, Van der Valk LJ, Van der Laarse A
We examined whether metabolic inhibition (5 mM NaCN + 10 mM 2-deoxyglucose) affects sarcolemmal fluidity in cultured neonatal cardiomyocytes. As a measure of sarcolemmal fluidity we determined the fluorescence steady-state anisotropy (rss, which is reciprocally related to membrane fluidity) of cardiomyocytes labeled with 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene, p-toluenesulfonate. During metabolic inhibition, membrane fluidity increased progressively: after 30 min rss had fallen...
Abstract
