Research

Publications

Below you can find a list of our published research.

6173 results

Cited 10 times since 2023 (4.7 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 16, Issue 3, 1 1 2023, Pages 332-341 Prognostic Value of Preprocedural LV Global Longitudinal Strain for Post-TAVR-Related Morbidity and Mortality: A Meta-Analysis. Stens NA, van Iersel O, Rooijakkers MJP, van Wely MH, Nijveldt R, Bakker EA, Rodwell L, Pedersen ALD, Poulsen SH, Kjønås D, Stassen J, Bax JJ, Tanner FC, Lerakis S, Shimoni S, Poulin F, Ferreira V, Reskovic Luksic V, van Royen N, Thijssen DHJ

Background: Left ventricular ejection fraction (LVEF) demonstrates limited prognostic value for post-transcatheter aortic valve replacement (TAVR) outcomes. Evidence regarding the potential role of left ventricular global longitudinal strain (LV-GLS) in this setting is inconsistent. Objectives: The aim of this systematic review and meta-analysis of aggregated data was to evaluate the prognostic value of preprocedural LV-GLS for post-TAVR-related morbidity and mortality. Methods: The authors sear... Abstract

Cited 2 times since 2023 (0.9 per year) source: EuropePMC

Human molecular genetics, Volume 32, Issue 7, 1 1 2023, Pages 1072-1082 Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance. Copier JS, Bootsma M, Ng CA, Wilde AAM, Bertels RA, Bikker H, Christiaans I, van der Crabben SN, Hol JA, Koopmann TT, Knijnenburg J, Lommerse AAJ, van der Smagt JJ, Bezzina CR, Vandenberg JI, Verkerk AO, Barge-Schaapveld DQCM, Lodder EM

Background: Variants in KCNH2, encoding the human ether a-go-go (hERG) channel that is responsible for the rapid component of the cardiac delayed rectifier K+ current (IKr), are causal to long QT syndrome type 2 (LQTS2). We identified eight index patients with a new variant of unknown significance (VUS), KCNH2:c.2717C > T:p.(Ser906Leu). We aimed to elucidate the biophysiological effect of this variant, to enable reclassification and consequent clinical decision-making. Methods: A genotype-phe... Abstract

Cited 8 times since 2023 (3.7 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 24, Issue 4, 1 1 2023, Pages 542-551 Comparative analysis of right ventricular strain in Fabry cardiomyopathy and sarcomeric hypertrophic cardiomyopathy. Meucci MC, Lillo R, Lombardo A, Lanza GA, Bootsma M, Butcher SC, Massetti M, Manna R, Bax JJ, Crea F, Ajmone Marsan N, Graziani F

Aims: To perform a comparative analysis of right ventricle (RV) myocardial mechanics, assessed by 2D speckle-tracking echocardiography (2D-STE), between patients with Fabry disease and patients with sarcomeric disease. Methods and results: Patients with Fabry cardiomyopathy (FC) (n = 28) were compared with patients with sarcomeric hypertrophic cardiomyopathy (HCM), matched for degree of left ventricle hypertrophy (LVH) and demographic characteristics (n = 112). In addition, patients with Fabry d... Abstract

Cited 3 times since 2023 (1.4 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 24, Issue 4, 1 1 2023, Pages 532-541 Interaction between secondary mitral regurgitation and left atrial function and their prognostic implications after cardiac resynchronization therapy. Stassen J, Galloo X, Hirasawa K, Hirasawa K, van der Bijl P, Leon MB, Marsan NA, Bax JJ

Aims: Left atrial (LA) function is a strong prognostic marker in patients with heart failure and functional mitral regurgitation (MR). Although cardiac resynchronization therapy (CRT) has shown to improve MR severity, the interaction between a reduction in MR severity and an increase in LA function, as well as its association with outcomes, has not been investigated. Methods and results: LA reservoir strain (RS) was evaluated with speckle tracking echocardiography in patients with at least moder... Abstract

Cited 3 times since 2023 (1.4 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 25, Issue 3, 1 1 2023, Pages 1035-1040 Unipolar voltage mapping in right ventricular cardiomyopathy: pitfalls, solutions and advantages. Hoogendoorn JC, Venlet J, de Riva M, Wijnmaalen AP, Piers SRD, Zeppenfeld K, Zeppenfeld K

Aims: Endocardial unipolar and bipolar voltage mapping (UVM/BVM) of the right ventricle (RV) are used for transmural substrate delineation. However, far-field electrograms (EGMs) and EGM changes due to injury current may influence automatically generated UVM. Epicardial BVM is considered less accurate due to the impact of fat thickness (FT). Data on epicardial UVM are sparse. The aim of the study is two-fold: to assess the influence of the manually corrected window-of-interest on UVM and the pot... Abstract

Cited 23 times since 2023 (10.7 per year) source: EuropePMC

The New England journal of medicine, Volume 388, Issue 12, 1 1 2023, Pages 1092-1100 Acute Effects of Coffee Consumption on Health among Ambulatory Adults. Marcus GM, Rosenthal DG, Nah G, Vittinghoff E, Fang C, Ogomori K, Joyce S, Yilmaz D, Yang V, Kessedjian T, Wilson E, Yang M, Chang K, Wall G, Olgin JE

Background: Coffee is one of the most commonly consumed beverages in the world, but the acute health effects of coffee consumption remain uncertain. Methods: We conducted a prospective, randomized, case-crossover trial to examine the effects of caffeinated coffee on cardiac ectopy and arrhythmias, daily step counts, sleep minutes, and serum glucose levels. A total of 100 adults were fitted with a continuously recording electrocardiogram device, a wrist-worn accelerometer, and a continuous glucos... Abstract

Cited 7 times since 2023 (3.3 per year) source: EuropePMC

European heart journal, Volume 44, Issue 10, 1 1 2023, Pages 871-881 Factors influencing post-surgical survival in degenerative mitral regurgitation. Butcher SC, Essayagh B, Steyerberg EW, Benfari G, Antoine C, Grigioni F, Le Tourneau T, Roussel JC, van Wijngaarden A, Marsan NA, Tribouilloy C, Rusinaru D, Hochstadt A, Topilsky Y, Michelena HI, Delgado V, Bax JJ, Enriquez-Sarano M

Aims: Indications for surgery in patients with degenerative mitral regurgitation (DMR) are increasingly liberal in all clinical guidelines but the role of secondary outcome determinants (left atrial volume index ≥60 mL/m2, atrial fibrillation, pulmonary artery systolic pressure ≥50 mmHg and moderate to severe tricuspid regurgitation) and their impact on post-operative outcome remain disputed. Whether these secondary outcome markers are just reflective of the DMR severity or intrinsically affect... Abstract

European heart journal. Cardiovascular Imaging, Volume 24, Issue 4, 1 1 2023, Pages 424-425 The importance of big databases in understanding valvular heart disease. Galloo X, Bax JJ

Abstract

Cited 12 times since 2023 (5.6 per year) source: EuropePMC

Journal of medical virology, Volume 95, Issue 3, 1 1 2023, Pages e28628 The diversity in the clinical features of children hospitalized with COVID-19 during the nonvariant, Alpha (B.1.1.7), Delta (B.1.617.2), and Omicron (B.1.1.529) variant periods of SARS CoV-2: Caution for neurological symptoms in Omicron variant. Sahin A, Karadag-Oncel E, Buyuksen O, Ekemen-Keles Y, Ustundag G, Elvan-Tuz A, Tasar S, Didinmez-Taskirdi E, Baykan M, Kara-Aksay A, Yilmaz N, Olgac-Dundar N, Yilmaz D

Since the COVID-19 pandemic began, various severe acute respiratory syndrome coronavirus 2 variants have been identified with different characteristics than the nonvariant strain. We retrospectively evaluated the demographic and clinical differences in the cohort of hospitalized COVID-19 children (1 month-18 years old) between March 11, 2020, and September 31, 2022, by the time the variants identified in our country predominate. Bonferroni post hoc analysis was performed to compare the differenc... Abstract

Cited 3 times since 2023 (1.4 per year) source: EuropePMC

Ocular immunology and inflammation, Volume 32, Issue 7, 28 4 2023, Pages 1150-1154 Non-Infectious Uveitis Secondary to Dupilumab Treatment in Atopic Dermatitis Patients Shows a Pro-Inflammatory Molecular Profile. Achten R, van Luijk C, Thijs J, Drylewicz J, Delemarre E, Nierkens S, Bakker D, van Wijk F, de Graaf M, de Bruin-Weller M, de Boer J, Kuiper J

Severe uveitis is a rare complication of interleukin-4 receptor alpha blocking by dupilumab in topic dermatitis (AD) patients. The aim of this study was to describe five moderate-to-severe AD patients who developed uveitis during dupilumab treatment and to compare the proteomic profile of aqueous humor (AqH) of dupilumab-associated uveitis (n=3/5 available samples) with non-infectious uveitis (n=27) and cataract controls (n=11). Included patients were treated at the University Medical Center Utr... Abstract

Cited 2 times since 2023 (0.9 per year) source: EuropePMC

Research and practice in thrombosis and haemostasis, Volume 7, Issue 2, 27 4 2023, Pages 100096 Atrial fibrillation in cancer: thromboembolism and bleeding in daily practice. Chu G, Seelig J, Cannegieter SC, Gelderblom H, Hovens MMC, Huisman MV, van der Hulle T, Trines SA, Vlot AJ, Versteeg HH, Hemels MEW, Klok FA

Background: Cancer is suggested to confer thromboembolic and bleeding risk in patients with atrial fibrillation (AF). Objectives: We aimed to describe current anticoagulant practice in patients with AF and active cancer, present incidences of thromboembolic and bleeding complications, and evaluate the association between cancer type or anticoagulant management strategy with AF-related complications. Methods: This retrospective study identified patients with AF and active cancer in 2 hospitals be... Abstract

Cited 1 times since 2023 (0.5 per year) source: EuropePMC

Internet interventions, Volume 31, 26 4 2023, Pages 100610 Put your money where your feet are: The real-world effects of StepBet gamified deposit contracts for physical activity. de Buisonjé DR, Brosig F, Breeman LD, Bloom EL, Reijnders T, Janssen VR, Kraaijenhagen RA, Kemps HMC, Evers AWM

Background: Gamification and deposit contracts (a financial incentive in which participants pledge their own money) can enhance effectiveness of mobile behavior change interventions. However, to assess their potential for improving population health, research should investigate implementation of gamified deposit contracts outside the research setting. Therefore, we analyzed data from StepBet, a smartphone application originally developed by WayBetter, Inc. Objective: To perform a naturalistic ev... Abstract

Cited 2 times since 2023 (0.9 per year) source: EuropePMC

Genes, Volume 14, Issue 3, 25 4 2023, Pages 578 Feasibility of Community Pharmacist-Initiated and Point-of-Care <i>CYP2C19</i> Genotype-Guided De-Escalation of Oral P2Y12 Inhibitors. Levens AD, den Haan MC, Jukema JW, Heringa M, van den Hout WB, Moes DJAR, Swen JJ

Tailoring antiplatelet therapy based on CYP2C19 pharmacogenetic (PGx) testing can improve cardiovascular outcomes and potentially reduce healthcare costs in patients on a P2Y12-inhibitor regime with prasugrel or ticagrelor. However, ubiquitous adoption-particularly in an outpatient setting-remains limited. We conducted a proof-of-concept study to evaluate the feasibility of CYP2C19-guided de-escalation of prasugrel/ticagrelor to clopidogrel through point-of-care (POC) PGx testing in the communit... Abstract

Cited 1 times since 2023 (0.5 per year) source: EuropePMC

The International journal of angiology : official publication of the International College of Angiology, Inc, Volume 33, Issue 3, 25 4 2023, Pages 148-155 Validity of Routinely Reported Rutherford Scores Reported by Clinicians as Part of Daily Clinical Practice. van der Heijden LLM, Marang-van de Mheen PJ, Thielman L, Stijnen P, Hamming JF, Fourneau I

Routinely reported structured data from the electronic health record (EHR) are frequently used for secondary purposes. However, it is unknown how valid routinely reported data are for reuse. This study aimed to assess the validity of routinely reported Rutherford scores by clinicians as an indicator for the validity of structured data in the EHR. This observational study compared clinician-reported Rutherford scores with medical record review Rutherford scores for all visits at the vascular surg... Abstract

Cited 1 times since 2023 (0.5 per year) source: EuropePMC

Nutrition, metabolism, and cardiovascular diseases : NMCD, Volume 33, Issue 5, 23 4 2023, Pages 1077-1086 The association between leptin and subclinical cardiovascular disease explained by body fat: Observational and Mendelian randomization analyses. Christen T, de Mutsert R, Smit RA, Willems van Dijk K, Lamb HJ, Rosendaal FR, Jukema JW, Trompet S

Background and aims: Leptin has been associated with adverse effects on cardiovascular disease, but the effect of confounding by body fat in these associations remains unclear. To investigate associations between leptin and heart function and subclinical cardiovascular disease adjusted for total body fat, and to investigate the causal relation between leptin and cardiovascular disease using Mendelian randomisation. Methods and results: Leptin concentrations, total body fat and diverse measures o... Abstract

Cited 5 times since 2023 (2.3 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 109, Issue 6, 23 4 2023, Pages 478-484 Prognostic impact of left ventricular global longitudinal strain in atrial mitral regurgitation. Meucci MC, Stassen J, Tomsic A, Palmen M, Crea F, Bax JJ, Ajmone Marsan N, Delgado V

Objective: Left atrial (LA) and left ventricular (LV) mechanics are impaired in patients with atrial functional mitral regurgitation (AFMR), but their prognostic value in this subset of patients remains unknown. The present study aimed to evaluate the association between LA and LV longitudinal strain and clinical outcomes in patients with AFMR. Methods: A total of 197 patients (mean age 73±10 years, 44% men) with at least moderate AFMR were retrospectively identified. LV global longitudinal stra... Abstract

Cited 2 times since 2023 (0.9 per year) source: EuropePMC

Magma (New York, N.Y.), Volume 36, Issue 5, 23 4 2023, Pages 701-709 A comparison of myocardial magnetic resonance extracellular volume mapping at 3 T against histology of tissue collagen in severe aortic valve stenosis and obstructive hypertrophic cardiomyopathy. Bakermans AJ, Kouwenhoven M, de Vos J, de Vries DK, Reckman YJ, Farag ES, Koolbergen DR, Kluin J, Nederveen AJ, Strijkers GJ, Boekholdt SM

Objective: Quantitative extracellular volume fraction (ECV) mapping with MRI is commonly used to investigate in vivo diffuse myocardial fibrosis. This study aimed to validate ECV measurements against ex vivo histology of myocardial tissue samples from patients with aortic valve stenosis or hypertrophic cardiomyopathy. Materials and methods: Sixteen patients underwent MRI examination at 3 T to acquire native T1 maps and post-contrast T1 maps after gadobutrol administration, from which hematocrit-... Abstract

Cited 3 times since 2023 (1.4 per year) source: EuropePMC

American heart journal plus : cardiology research and practice, Volume 27, 23 4 2023, Pages 100280 Coronary calcium score in COVID-19 survivors: Association with cardiac injury and cardiac function after 6 weeks. Groen RA, de Graaf MA, Stöger JL, van Dijkman PRM, Jukema JW, Schalij MJ, Geelhoed JJM, Antoni ML

Aims: Cardiac manifestations are common in COVID-19, often elevated serum troponin levels or myocardial dysfunction on trans-thoracic echocardiography (TTE) is observed. Both parameters are associated with increased in-hospital mortality. Possibly, subclinical coronary atherosclerosis plays a role, of which severity can be assessed by calculating the coronary artery calcium (CAC) score. This study aims to determine the relation between coronary atherosclerosis and cardiac manifestations in COVID... Abstract

Cited 11 times since 2023 (5.1 per year) source: EuropePMC

JACC. Clinical electrophysiology, Volume 9, Issue 5, 22 4 2023, Pages 715-728 Management of Ventricular Arrhythmias Worldwide: Comparison of the Latest ESC, AHA/ACC/HRS, and CCS/CHRS Guidelines. Könemann H, Ellermann C, Zeppenfeld K, Eckardt L

A new guideline for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death has been published by the European Society of Cardiology (ESC). Beside the 2017 American Heart Association/American College of Cardiology/Heart Rhythm Society (AHA/ACC/HRS) guideline and the 2020 Canadian Cardiovascular Society/Canadian Heart Rhythm Society (CCS/CHRS) position statement, this guideline provides evidence-based recommendations for clinical practice. As these recom... Abstract

Cited 5 times since 2023 (2.3 per year) source: EuropePMC

JACC. CardioOncology, Volume 5, Issue 1, 21 3 2023, Pages 117-127 Impact of Age at Diagnosis on Cardiotoxicity in High-Grade Osteosarcoma and Ewing Sarcoma Patients. Heemelaar JC, Speetjens FM, Al Jaff AAM, Evenhuis RE, Polomski EAS, Mertens BJA, Jukema JW, Gelderblom H, van de Sande MAJ, Antoni ML

Background: Osteosarcoma and Ewing sarcoma patients face a significant risk of cardiotoxicity as defined by left ventricular dysfunction and heart failure (HF). Objectives: This study sought to evaluate the association between age at sarcoma diagnosis and incident HF. Methods: A retrospective cohort study was performed at the largest sarcoma center in the Netherlands among patients with an osteosarcoma or Ewing sarcoma. All patients were diagnosed and treated over a 36-year period (1982-2018) an... Abstract