7503 results
The British journal of surgery,
Volume 112, Issue 11, 1 1 2025, Pages znaf189
Colorectal-vaginal fistula after rectal cancer resection: international comparative cohort study of characteristics and treatment.
van Lieshout ML, Lemmens JMG, Greijdanus NG, Wienholts K, Ubels S, Talboom K, Hannink G, Wolthuis A, de Lacy FB, Lefevre JH, Solomon M, Frasson M, Rotholtz N, Denost Q, Perez RO, Konishi T, Panis Y, Rutegård M, Hompes R, van Workum F, Tanis PJ, de Wilt JHW, TENTACLE–Rectum Collaborative Group
Abstract
Journal of Crohn's & colitis,
Volume 19, Issue 10, 1 1 2025, Pages jjaf176
How long is long enough? Timing of pre-conceptional remission predicts relapse risk during pregnancy in IBD.
Bouwknegt DG, Hoekstra B, Donker HC, van Es B, Groen H, Dijkstra G, van Dop WA, Tauber T, van der Woude CJ, Visschedijk MC, Dutch Initiative on Crohn and Colitis (ICC)
Background and aims: Inflammatory bowel disease (IBD) often coincides with pregnancy, and disease activity during pregnancy increases the risk of adverse outcomes. We aimed to determine how disease course before conception influences relapse risk during pregnancy, adjusting for established risk factors. Methods: In this multicenter, retrospective cohort study, we included adult women with IBD who were pregnant during treatment at one of three university hospitals between 2017 and 2022. Using gen...
Abstract
Inflammatory bowel diseases,
Volume 31, Issue 11, 1 1 2025, Pages 3051-3059
Food Compounds Associated With Disease Activity in Inflammatory Bowel Disease.
Meima M, Westerhout J, Meijerink M, Bijlsma S, van Schaik F, Oldenburg B, Houben G
Background: Diet plays a modulatory role in inflammatory bowel disease (IBD), but specific relevant dietary factors have yet to be identified. To advance our understanding, we performed multivariate analyses of food compound intakes using dietary data from an IBD cohort. Methods: We used dietary and disease status data from IBD patients at the University Medical Center Utrecht, The Netherlands. Intake levels for 768 compounds from 135 patients were calculated. Using random forest analyses, we ex...
Abstract
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology,
Volume 80, 31 5 2025, Pages 107789
Aortic wall lamellar structure in phylogeny and in humans: insights from bicuspid and tricuspid aortic valve morphology.
Bacour N, Zafar M, Kargin N, Zinganshin B, Poelmann R, Klautz RJM, Elefteriades J, Grewal N
Objective: Despite a voluminous literature on aortopathy, comparatively little attention has been paid to the lamellar architecture of the aortic wall, including the number and distribution of these layers. This study compares the lamellar organization of the developing aorta in individuals with a bicuspid (BAV) versus tricuspid aortic valve (TAV) and includes a literature review on aortic lamellae in mammals and adult humans. Methods: Non-dilated ascending aortic wall samples (n = 83) were anal...
Abstract
American heart journal,
Volume 293, 31 5 2025, Pages 107296
Routine versus selective protamine administration to reduce bleeding after TAVI: Rationale and design of the POPular ACE TAVI trial.
Overduin DC, van Ginkel DJ, Dubois C, Lesizza P, Broeze GM, Montero-Cabezas JM, Rosseel L, van der Kley F, van Nuland PJ, Smits TP, Hemelrijk KI, Aarts HM, Rensing BJWM, Timmers L, Swaans MJ, Sonker U, Veenstra L, van 't Hof AWJ, Peper J, Tijssen JGP, Delewi R, Vriesendorp PA, Ten Berg JM
Background: Unfractionated heparin is routinely used during transcatheter aortic valve implantation (TAVI) to reduce catheter thrombosis and thromboembolism. Protamine reverses the effect of heparin and may lower bleeding risk, but it can also trigger severe allergic reactions. Robust data on the safety and efficacy of routine protamine administration after TAVI is lacking. Methods: The ``routine versus selective protamine administration to reduce bleeding complications after transcatheter aorti...
Abstract
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
31 5 2025, Pages S0894-7317(25)00608-X
Authors' Reply.
Chua AP, Marsan NA
Abstract
Inflammatory bowel diseases,
31 5 2025, Pages izaf240
Implementation of a Capillary Blood Self-Sampling Technique at Home for Monitoring of Patients With IBD.
Schuurman GS, Tiel Groenestege W, Hirdes MMC, Fidder HH, Oldenburg B, de Roock S, van Schaik FDM
Background: Remote healthcare aims to improve the management of inflammatory bowel disease (IBD) patients by reducing hospital visits. This is the first study to assess capillary blood sampling at home for routine measurement of chemistry parameters and complete blood count parameters at several time points for disease monitoring in IBD patients. Methods: In this prospective, single-center proof-of-concept study, 27 patients with Crohn's disease or ulcerative colitis and an indication for f...
Abstract
Scientific reports,
Volume 15, Issue 1, 30 5 2025, Pages 38074
Safety trial assessing 1.77 cm<sup>2</sup> H<sub>2</sub>O<sub>2</sub> producing electrochemical bandages on healthy human skin.
Kies PJ, Kim WJ, Fleming D, Bozyel I, Holtegaard S, Shrivastava S, Schwartz K, Schwieder S, Beyenal H, Patel R
Mammalian skin maintains complex repair mechanisms after barrier disruption. Chronic wounds develop when these events are not efficiently completed, increasing infection risk. With ~2% of the population afflicted yearly, chronic wound care needs new technologies. Here, a Phase 0/1 study of one such therapeutic intervention is presented- H2O2 (hydrogen peroxide)-producing electrochemical bandages (e-bandages) controlled by wearable micropotentiostats. The e-bandages generate H2O2 in precise, micr...
Abstract
JACC. Cardiovascular imaging,
30 5 2025, Pages S1936-878X(25)00549-2
Can Cardiac Computed Tomography Refine Prognosis in Tricuspid Regurgitation?
Ajmone Marsan N
Abstract
Journal of cardiovascular translational research,
Volume 18, Issue 6, 30 5 2025, Pages 1540-1554
RNA Therapeutics in Heart Failure.
Deiman FE, de Graaf MM, Sillje HHW, Grote Beverborg N, Bomer N, van der Meer P
RNA-based therapeutics, such as small interfering RNAs (siRNAs), antisense oligonucleotides (ASOs) and messenger RNAs (mRNAs) are promising therapeutics that offer new avenues for targeting molecular pathways underlying heart failure (HF) pathogenesis. This review provides an overview of RNA therapeutics, detailing their mechanisms and potential applications in the treatment of HF. Key pathological processes in HF, including dysregulated calcium handling, myocardial fibrosis, oxidative stress, i...
Abstract
International journal of cardiology. Congenital heart disease,
Volume 22, 30 5 2025, Pages 100636
Cardiac autonomic function in patients with single ventricle physiology after Fontan palliation: A literature review.
Polyakova E, Nederend M, Kies P, Egorova AD, Jongbloed MRM
Background: The Fontan operation has significantly improved survival in patients with single ventricle physiology. This comes at a price of highly prevalent long-term complications. Autonomic dysfunction has been documented in patients after Fontan palliation. Although autonomic dysfunction is associated with a range of adverse outcomes, the exact clinical implications in patients with a Fontan circulation remain unclear. Aims: The aims of this review are to address (1) the extent and characteri...
Abstract
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance,
Volume 27, Issue 2, 29 5 2025, Pages 101975
Three-dimensional distensibility of the aorta derived from four-dimensional cardiovascular magnetic resonance in young and middle-aged adults with Marfan syndrome.
Bosshardt D, Merton R, Schreurs BA, van Kimmenade RRJ, Nederveen AJ, Cox MGPJ, Scholte AJHA, Schrauben EM, Strijkers GJ, de Waard V, Robbers-Visser D, Groenink M, van Ooij P
Background: Acute aortic syndromes in Marfan syndrome (MFS) often occur before reaching the surgical diameter threshold, highlighting the need for new imaging biomarkers. Objectives: Aim was to compare cardiovascular magnetic resonance (CMR)-derived aortic three-dimensional (3D) distensibility and displacement in MFS patients with or without a history of aortic root surgery (RR or native) and healthy volunteers. Methods: The participants underwent 3T CMR of the thoracic aorta using an accelerate...
Abstract
European journal of pediatrics,
Volume 184, Issue 11, 29 5 2025, Pages 719
Resurgent measles in Türkiye: predictors of severe disease in a nationwide paediatric cohort, 2023.
Bursal B, Çelik T, Bingöl İ, Tosun D, Tuncay SA, Dağtekin ZK, Kaçmaz BB, Somer A, Dinleyici EÇ, Tezer H, Kara A, Türkiye Measles Study Group
Measles remains among the most important global health threats worldwide. A global increase has been reported since 2022, peaking in 2024, which heightens the risk of imported infections, particularly from unvaccinated children and adults, and measles outbreaks persist where immunity gaps remain. The aim of this study was to assess the clinical severity, complications, and outcomes of measles in hospitalised children as well as the effect of vaccination status on measles in Türkiye in 2023. We p...
Abstract
Cited 2 times since 2025 (13.6 per year)
source: EuropePMC
Lancet (London, England),
Volume 406, Issue 10519, 27 4 2025, Pages 2541-2550
Percutaneous transcatheter valve replacement in individuals with mitral regurgitation unsuitable for surgery or transcatheter edge-to-edge repair: a prospective, multicountry, single-arm trial.
Guerrero ME, Daniels DV, Makkar RR, Thourani VH, Asch FM, Pham M, Muhammad KI, Greenbaum AB, Vasquez A, Oldemeyer JB, Dahle TG, Rihal C, Morse MA, Rodriguez E, O'Neill BP, Russo M, Whisenant B, Yadav P, Yu X, Wang DD, Makar M, Baran DA, Mahoney P, Reddy G, Blanke P, Webb J, ENCIRCLE Trial Executive Committee and Study Investigators
Background: Patients with severe mitral regurgitation are frequently not candidates for surgery or transcatheter edge-to-edge repair (TEER). We aimed to evaluate 1-year outcomes of a novel percutaneous transseptal transcatheter mitral valve replacement (TMVR) system in patients unsuitable for surgery or TEER. Methods: In this prospective, multicentre, single-arm, pivotal trial, adult patients (aged ≥18 years) with symptomatic moderate-to-severe or severe mitral regurgitation who were not suitabl...
Abstract
Biomedicines,
Volume 13, Issue 11, 26 4 2025, Pages 2619
Investigation of Serum Visfatin and Chemerin Levels in Type 2 Diabetes and Obesity Patients: Their Potential Role as Clinical and Biomarkers.
Yilmaz DT, Gul MA, Capraz M, Demir HD, Tekcan A
Background/Objectives: The global prevalence of obesity and type 2 diabetes mellitus (T2DM) has been steadily increasing, and these interrelated disorders share common pathophysiological mechanisms, including altered levels of adipokines secreted from adipose tissue. Among these, chemerin and visfatin have been suggested as potential biomarkers for obesity-related metabolic dysfunction. This study aimed to evaluate the relationship between serum chemerin and visfatin levels and obesity in patien...
Abstract
International journal of paediatric dentistry,
25 4 2025
Is Digital Anesthesia a Viable Alternative for Pain and Anxiety Control in Pediatric Dentistry?
Atesci AA, Korkut Isik B, Yılmaz DO, Gergit B, Kılıc MÇ, Oncag RO
Background: Pain and anxiety during dental procedures remain major challenges in pediatric dentistry, particularly during local anesthesia administration. Aim: This study compared the effectiveness of digital anesthesia systems versus conventional infiltration and mandibular block techniques in managing pain, anxiety, and behavioral responses in pediatric dental patients. Design: Seventy-nine children aged 6-12 were randomly assigned to receive anesthesia via digital anesthesia system (DAS), inf...
Abstract
JACC. Advances,
Volume 4, Issue 11 Pt 1, 24 4 2025, Pages 102250
Drug-Coated Balloon After Intravascular Lithotripsy: Procedural and Clinical Outcome of the "Crack and Drug" Strategy.
Oliveri F, van Oort MJH, Phagu AAS, Al Amri I, Bingen BO, Paradies V, Mincione G, Claessen BEPM, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Mandurino-Mirizzi A, Van der Kley F, Jukema JW, Montero-Cabezas J
Background: Drug-eluting stents (DESs) after intravascular lithotripsy (IVL) have proven effective in calcified coronary lesions. However, evidence supporting drug-coated balloons (DCBs) after IVL remains limited. Objectives: We aimed to compare the technical success and 1-year clinical outcomes of IVL + DES vs IVL + DCB strategies for the treatment of balloon-crossable calcified coronary lesions. Methods: Patients undergoing percutaneous coronary intervention with IVL from the prospective BENEL...
Abstract
Science advances,
Volume 11, Issue 43, 24 4 2025, Pages eadx3794
The designer cytokine IC7Fc attenuates atherosclerosis development by targeting hyperlipidemia in mice.
In Het Panhuis W, Thiemann E, van Dijk DMAH, Been B, Jarrett KE, Meurs A, Kooijman S, Hovingh MV, Modder M, van Os BW, Sluiter TJ, Blomberg N, Pronk ACM, Afkir S, Streefland TCM, Lalai RA, Taveras MO, Zhang S, Adams TE, Terry LV, Turpin-Nolan SM, de Vries MR, Giera M, Rose-John S, Zelcer N, de Boer JF, de Aguiar Vallim TQ, Febbraio MA, Rensen PCN, Schönke M
The chimeric cytokine IC7Fc conveys the metabolic signaling properties of the glycoprotein 130 receptor cytokines interleukin-6 and ciliary neurotrophic factor via membrane-bound signaling. IC7Fc was previously shown to slow the progression of type 2 diabetes mellitus, and here, we demonstrate its effect on atherosclerotic development. In APOE*3-Leiden.CETP mice, an atherosclerosis-prone model with a humanized lipoprotein metabolism, IC7Fc markedly lowered plasma triglyceride and total cholester...
Abstract
Langenbeck's archives of surgery,
Volume 410, Issue 1, 23 4 2025, Pages 309
Cut from the same cloth? investigating the personality of interventional and surgical cardiovascular specialists.
Sier VQ, Verhagen MJ, Zegel M, Schmitz RF, van Rijswijk CSP, van Schaik J, Schmidt EJET, Hamming JF, Schepers A, Wijdh-den Hamer IJ, Burgmans MC, Hjortnaes J, van der Vorst JR, SUPER Consortium
Purpose: Considering that the treatment of patients with complex vascular disease requires multidisciplinary collaboration in teams and personality traits can impact team dynamics, we investigated the personality structures of vascular surgeons, cardiothoracic surgeons, and interventional radiologists using the validated big five model. Methods: A cross-sectional study utilizing the validated Big Five Inventory-2 (BFI-2) questionnaire. Corrected one-way analyses of variance were performed to com...
Abstract
European heart journal,
23 4 2025, Pages ehaf835
Early outcomes of children with univentricular circulation undergoing Fontan surgery: the EuroFontan registry.
Padalino MA, Constantine A, Bergonzoni E, Cao I, Horer J, Ono M, Staehler H, Sames-Dolzer E, Gierlinger G, Hazekamp M, Rijnberg FM, Galletti L, Butera G, Panebianco M, Meyns B, Van Puyvelde J, Yemets I, Bairamov E, Kansy A, Nosal M, Lenoir M, Angeli E, Careddu L, Martens T, Bove T, Napoleone CP, Lo Rito M, Giamberti A, Montanaro C, Marianeschi S, Agati S, Sarris GK, Protopapas E, Rocafort AG, Scrascia G, Meliota G, Vairo U, Michielon G, Gozzi A, Biffanti R, Castaldi B, Gregori D, Vedovelli L, Di Salvo G, Vida V, Dimopoulos K
Background and aims: The Fontan operation and its modifications have transformed the management of children with functional single ventricle physiology. While outcomes have improved, peri-operative complications remain common. This study aimed to assess early outcomes and complications following Fontan completion in a large international European cohort. Methods: The EuroFontan registry is a multicentre retrospective study involving 21 congenital heart disease and transplant centres across Europ...
Abstract
