8900 results
European journal of pediatrics,
Volume 184, Issue 8, 14 2 2025, Pages 481
''Unraveling the effects of smoking in asthmatic adolescents: clinical outcomes, spirometry findings, and risk analysis''.
Genis C, Tas D, Yılmaz D, Kuzucu FN, Selmanoglu A, Sengul Emeksiz Z, Dibek Mısırlıoglu E
Adolescent smoking and asthma are major global public health concerns. This study aims to comprehensively assess the impact of smoking on asthma control, pulmonary function, and risk factors for uncontrolled asthma in adolescents. A total of 126 adolescents aged 10 to 18 years were categorized into three groups: (1) smoking asthmatics, (2) non-smoking asthmatics, and (3) smoking non-asthmatics. Asthma symptom control was determined according to the Global Initiative for Asthma (GINA). Demographi...
Abstract
JBMR plus,
Volume 9, Issue 10, 13 2 2025, Pages ziaf118
Comparison between dietary, parenteral, and genetic iron overload on bone health reveals secondary iron overload as a driver of cortical bone loss and fracture risk in mice.
Steele-Perkins P, Yilmaz D, Walther Y, Wagner A, Paganoni R, Rauner M, Baschant U, Vujić Spasić M
More than 18% of the global population suffers from osteoporosis and its associated fracture risk each year. Among the many factors implicated in osteoporosis development, high iron levels have been implicated in bone loss in mice and patients. Here, we performed a comparative analysis of the effect of iron overload induced via diet, injections, or genetic factors, on overall bone health and mechanical bone strength. We used female mice, given the higher risk of osteoporosis and associated fract...
Abstract
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
12 2 2025, Pages S1078-5884(25)00678-1
Factors Influencing Vascular Surgeons' Compliance with Elective Repair Guidelines for Abdominal Aortic Aneurysm: A Qualitative Study.
Brust M, van Gestel LC, Vriens PWHE, Hamming JF, Adriaanse MA, Lindeman JH
Objective: Despite guideline recommendations to delay elective abdominal aortic aneurysm (AAA) repair until the diameter exceeds the intervention threshold, a notable proportion of repairs occur earlier. This study aimed to explore factors influencing vascular surgeons' compliance with the intervention threshold regarding AAA repair, adopting a behavioural science perspective. Methods: This qualitative study employed semi-structured interviews with vascular surgeons. Twelve vascular surgeon...
Abstract
Scientific reports,
Volume 15, Issue 1, 11 2 2025, Pages 25022
Joint contact forces during barefoot, minimal and conventional shod running are highly individual.
Kloock L, Arensmann A, de Graaf ML, Gerlach M, Boström KJ, Wagner H
The supposed benefits of barefoot running are an often debated topic, with many studies investigating footwear influences on the kinematics and kinetics of running. Few studies, however, have analysed the effect on joint contact forces (JCFs). In this study, we investigated the influence of different footwear on the JCFs of the hip, knee, and ankle during running using a 3D musculoskeletal model. Kinematics were recorded from 16 volunteers while running on a treadmill at two speeds (2.0 m/s and...
Abstract
Cited 1 times since 2025 (3.5 per year)
source: EuropePMC
Royal Society open science,
Volume 12, Issue 7, 9 2 2025, Pages 241754
An integrated baseline assessment of reef-associated sharks around Saba (Dutch Caribbean), combining three methods: stereo-BRUVs, telemetry and citizen science.
Leurs G, de Graaf M, Hassell-Knijff D, Izioka LAK, van Looijengoed W, Meijer Zu Schlochtern MP, Bervoets T, Nagelkerke LAJ, Winter HV
The Exclusive Economic Zone of Saba (Dutch Windward Islands) has been designated Yarari Marine Mammal and Shark Sanctuary. However, to effectively conserve sharks, a baseline on their diversity and spatiotemporal distribution is required. We used three methods: telemetry, stereo-baited remote underwater video systems (stereo-BRUVs) and a citizen science program to study reef-associated sharks, mainly Caribbean reef sharks (Carcharhinus perezi) and nurse sharks (Ginglymostoma cirratum) around Sab...
Abstract
Heart (British Cardiac Society),
8 2 2025, Pages heartjnl-2025-326162
Representativeness of surgical controls in aortic valve replacement trials: comparison with routine surgical cohorts.
Tomsic A, Velders BJJ, Kawczynski MJ, Schoones JW, Klautz RJM, Palmen M, Sardari Nia P, Owais T, Girdauskas E, Heuts S
Background: Randomised controlled trials (RCTs) comparing transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) have significantly influenced treatment guidelines for aortic stenosis, expanding the use of TAVI into lower risk populations. However, the patients enrolled in the SAVR arms of these trials may differ from those typically undergoing SAVR in routine clinical practice. This study aims to critically assess the representativeness of SAVR patients in t...
Abstract
The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland,
8 2 2025, Pages S1479-666X(25)00123-4
Bridging generational gaps in Surgery: A narrative review on values, well-being, and training preferences.
Huizing F, Sier VQ, Sark AD, Snijders HS, van der Vorst JR, Schmitz RF, Schepers A, Blok JJ, Future Surgeon Initiative
Background and purpose: Intergenerational differences in surgery create both challenges and opportunities. While differening perspectives and expectations may deter younger generations from pursuing surgical careers, it is crucial to balance these with the core values that define the surgical profession. This narrative review was conducted to better understand how the profession needs to evolve. Methods: A structured literature search on generational changes in surgery was conducted using PubMed...
Abstract
The international journal of cardiovascular imaging,
Volume 41, Issue 8, 5 1 2025, Pages 1577-1587
Incremental prognostic value of left atrial reservoir strain after ST-segment elevation myocardial infarction for the prediction of new-onset atrial fibrillation.
Caunite L, Myagmardorj R, Galloo X, Laenens D, Stassen J, Nabeta T, Yedidya I, Meucci MC, Kuneman JH, van den Hoogen IJ, van Rosendael SE, Wu HW, van den Brand VM, Giuca A, Trusinskis K, Marsan NA, Bax JJ, van der Bijl P
New-onset atrial fibrillation (AF) affects up to 21% of ST-segment elevation myocardial infarction (STEMI) patients. The value of LA reservoir strain to predict new-onset AF in a STEMI population has not been thoroughly investigated. We aimed to explore the incremental value of LA reservoir strain for predicting new-onset AF post-STEMI. Data were analyzed retrospectively from an ongoing STEMI registry. LA reservoir strain
Abstract
Waste management (New York, N.Y.),
Volume 205, 4 1 2025, Pages 115003
Coupling of chemical deconstruction and pyrolysis to upcycle metallized multilayer plastic films.
Kulas D, Aloba S, Noecker A, Putman L, Meinholz C, Garland K, Henry J, Flores H, Chipkar S, Zolghadr A, Techtmann S, Ong R, Shonnard D
Multilayer metallized plastic films are popular packaging materials that are not currently recycled due to their complex multi-material make-up. In this study, a sequential pathway combining chemical, thermal and biological techniques was introduced to recycle military multilayer packaging made up of Polyethylene Terephthalate (PET), Polyethylene (PE), and aluminum. Chemical deconstruction using 10 wt% aqueous ammonia was able to selectively depolymerize the PET layer at a conversion close to 10...
Abstract
EClinicalMedicine,
Volume 85, 4 1 2025, Pages 103342
Intravascular lithotripsy for the treatment of calcified coronary lesions in individuals of advanced age: a post-hoc analysis of the multicentre, prospective BENELUX-IVL study.
Oliveri F, García PV, van Oort MJH, Phagu A, Al Amri I, Bingen BO, Paradies V, Mincione G, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Mandurino-Mirizzi A, Van der Kley F, Jukema JW, Montero-Cabezas JM
Background: Patients of advanced age are frequently underrepresented or excluded from major clinical trials, leading to limited evidence in this population and a reliance on data extrapolated from younger populations. The present study aims to compare and evaluate the safety and efficacy of intravascular lithotripsy (IVL) for the treatment of calcified coronary lesions in individuals of advanced age and in younger populations. Methods: In this post-hoc analysis, from the ongoing prospective, mul...
Abstract
International journal of radiation oncology, biology, physics,
Volume 123, Issue 4, 3 1 2025, Pages 1004-1017
Health-Related Quality of Life in Patients Treated for Nonmetastatic Muscle-Invasive Bladder Cancer: Radical Cystectomy Versus Bladder-Preserving Therapy.
Brück K, Atema V, Leliveld AM, Franckena M, Meijer RP, van der Heijden MS, Donders AR, Witjes JA, Uyl-de Groot CA, van Hoogstraten LMC, Kiemeney LA, Boormans JL, Aben KKH, Hulshof MCCM, CRAC study group and the BlaZIB study group
Purpose: Patients with nonmetastatic muscle-invasive bladder cancer (MIBC) can be treated with either radical cystectomy (RC) or bladder-preserving therapy (BPT). Contemporary data on the impact of these treatments on health-related quality of life (HRQOL) are lacking. Methods and materials: In our prospective national cohort study, patients were invited to complete HRQOL questionnaires at baseline, 12 and 24 months after diagnosis. We included patients with nonmetastatic MIBC, treated with eith...
Abstract
The Prostate,
Volume 85, Issue 13, 2 1 2025, Pages 1168-1180
Transcriptomic Signatures of Monocyte-Derived Macrophages Associate With Androgen Receptor Pathway Inhibitor Progression in Prostate Cancer.
Sharifi MN, Heninger E, Bootsma ML, Recchia EE, Breneman MT, Taylor AK, Zhao SG, LeBeau AM, Kosoff D
Background: Androgen receptor pathway inhibitors (ARPIs) have significantly improved clinical outcomes for patients with metastatic prostate cancer (PC) but acquired ARPI resistance remains universal. Maximizing ARPI treatment duration is crucial to optimal clinical outcomes, but current clinical tools to detect acquired ARPI resistance, including serum Prostate Specific Antigen (PSA) and radiographic disease monitoring, are limited in both sensitivity and specificity. Since prostate cancer dise...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 26, Issue 8, 1 1 2025, Pages 1466-1474
Left ventricular dilatation in patients with significant aortic regurgitation: association with outcome.
Lopez Santi P, Bernard J, Fortuni F, Butcher SC, Meucci MC, Sarrazyn C, Chua AP, Nabeta T, Zhang J, Popescu BA, Tay ELW, Yiu KH, Clavel MA, Pibarot P, Bax JJ, Ajmone Marsan N
Aims: Left ventricular (LV) dilatation is an important prognostic factor in patients with aortic regurgitation (AR). Although current guidelines recommend the use of LV end-systolic diameter index (LVESDi) to indicate the need for intervention, recent studies suggested that LV end-systolic volume index (LVESVi) may more accurately characterize LV remodelling.The present study aims to evaluate, in a multi-centre setting, whether combining LV linear and volumetric measures could improve risk strat...
Abstract
Cited 4 times since 2025 (13.1 per year)
source: EuropePMC
Cardiovascular research,
Volume 121, Issue 8, 1 1 2025, Pages 1215-1227
Sex and sex hormonal regulation of the atrial inward rectifier potassium current (IK1): insights into potential pro-arrhythmic mechanisms.
Giammarino L, Matas L, Alerni N, Horváth A, Vashanthakumar V, Nimani S, Barbieri M, Bains S, Lopez R, Louradour J, Ördög B, Hof T, Maguy A, Conte G, Auricchio A, Schotten U, Odening KE
Aims: Pronounced sex-differences are known in the incidence of atrial fibrillation (AF). In this study, we aimed to investigate the atrial electrophysiological properties that may underlie sex-differences in AF incidence in the younger population, focusing on IK1, a cardiac ion current important for action potential (AP) stability and triggered activity. Methods and results: We assessed sex-differences in P-wave morphology in 12-lead ECG in healthy young New Zealand White rabbits. Males presente...
Abstract
Frontiers in physiology,
Volume 16, 1 1 2025, Pages 1631426
Functional conduction system mapping in sheep reveals Purkinje spikes in the free wall of the right ventricular outflow tract.
Blok M, den Ouden BL, Kuiper M, Ophelders DRMG, Jongbloed MRM, Zeemering S, Jensen B, van Hunnik A, Boukens BJ
Ablation of sites displaying Purkinje activity is highly effective against idiopathic ventricular fibrillation which often originates in the right ventricular outflow tract. However, during endocardial mapping Purkinje potentials are rarely, if never, detected in the right ventricular outflow tract. In the present study, we aimed to determine whether the Purkinje system extends into the right ventricular outflow tract. Hearts of five female sheep were blood-perfused in a Langendorff setup in whi...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 67, Issue 7, 1 1 2025, Pages ezaf137
Reply to Xiao et al.
Sabik JF, Rao V, Dagenais F, Reardon MJ, PERIGON Investigators
Abstract
Scientific reports,
Volume 15, Issue 1, 1 1 2025, Pages 21482
Systematic assessment of bone and soft tissue tumors on whole-body CTs of 45 mummies from ancient Egypt.
Panzer S, Wörtler K, Paladin A, Zesch S, Rosendahl W, van Schaik KD, Sutherland ML, Sutherland JD, Hergan K, Thompson RC, Zink AR
There is a growing interest in the antiquity of cancer and ongoing discussion of the apparent scarcity of malignant tumors in ancient human remains, especially those of soft tissues. We systematically assessed bone and soft tissue tumors on 45 whole-body computed tomography (CT) scans of ancient Egyptian mummies. In one of 45 cases (2%), malignant skeletal disease (probably skeletal metastases) was detected. In five of 45 cases (11%), probably malignant soft tissue masses were identified. The so...
Abstract
Heart rhythm,
Volume 22, Issue 7, 1 1 2025, Pages 1877-1879
Top stories on proactive ventricular arrhythmia assessment in repaired tetralogy of Fallot.
Zeppenfeld K, Kimura Y
Abstract
Cited 1 times since 2025 (3.3 per year)
source: EuropePMC
Clinical cancer research : an official journal of the American Association for Cancer Research,
Volume 31, Issue 13, 1 1 2025, Pages 2793-2813
Antitumor Immunity Mediated by Engineered Stem Cells Exploiting TRAIL-Induced Cell Death and FLT3L Immunomodulation.
van Schaik TA, Chen KS, Kanaya N, Moreno-Lama L, Freeman NW, Wang M, Li W, Zhang YS, Vrbanac V, Huang R, Wakimoto H, Reardon D, Shah K
Purpose: Death receptor (DR)-targeted therapies offer a promising tumor cell-specific therapeutic strategy for highly malignant brain tumors, such as glioblastoma (GBM). However, whether DR-mediated cell death leads to activation of the adaptive immune system and impacts the tumor immune microenvironment (TIME) remains unknown. In this study, we explored the (i) immunomodulatory role of secretable human DR4/5 ligand, TNF-related apoptosis-inducing ligand (S-TRAIL) and (ii) the therapeutic potent...
Abstract
Current heart failure reports,
Volume 22, Issue 1, 1 1 2025, Pages 21
Impact of Multisensor CIED-based Heart Failure Monitoring on Mortality, Heart Failure Hospitalizations and Outpatient Visits: A Systematic Review.
Zwaenepoel BAC, Kluft A, Feijen M, Schoones JW, Heggermont WA, Egorova AD, Beeres SLMA
Purpose of review: Cardiac Implantable Electronic Device (CIED)-based remote monitoring has been proposed to improve heart failure (HF) management by enabling early detection of decompensation. This systematic review evaluates the effectiveness of multisensor CIED-based monitoring in reducing mortality, HF hospitalizations, and unplanned HF outpatient visits. Recent findings: Earlier CIED-based remote monitoring strategies were mainly based on single-sensor impedance-based algorithms, and showed...
Abstract
