8900 results
Cited 1 times since 2025 (3.3 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 7, 1 1 2025, Pages euaf122
Excellent interobserver agreement and steep learning curve for target volume delineation for stereotactic arrhythmia radioablation using a commercial software.
Rademaker R, Cirkel S, Omara S, Dankers FJWM, Sramko M, Solana Munoz J, Kaya YS, Ter Bekke RMA, Schiappacasse L, Teres C, Verhoeven K, Pruvot E, Rasch CRN, Zeppenfeld K
Aims: Stereotactic arrhythmia radioablation (STAR) has emerged as bail-out treatment for ventricular tachycardia (VT). Accurate, reproducible, and easy-to-use data transfer from electroanatomical mapping (EAM) systems to radiotherapy planning CT is desirable. We aim to evaluate interobserver variability, ease of use, and learning curve for EAM based target volume (CardTV-EPinv) creation and transfer using available software packages. Methods and results: In patients considered for STAR, CardTV-E...
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 7, 1 1 2025, Pages euaf134
Regionalization of the atria for 3D electroanatomical mapping, cardiac imaging, and computational modelling: a clinical consensus statement of the European Heart Rhythm Association and the European Association of Cardiovascular Imaging of the ESC.
Althoff TF, Anderson RH, Goetz C, Petersen SE, Díaz PM, Nijveldt R, Maurovich-Horvat P, Bax J, Hussain S, Schmidt C, Spicer DE, Sanchez-Quintana D, Corsi C, Dössel O, Climent AM, Rodriguez B, Schotten U, Loewe A, Guillem MS, Cabrera JÁ, Merino JL, Wijnmaalen AP, Bertrand PB, de Groot N, Derval N, Didenko M, Donal E, Dweck MR, Ho SY
This clinical consensus document proposes standardized atrial segments for 3D imaging, electroanatomical mapping and computational modelling, based on anatomical, electrophysiological and clinical considerations, with precise definitions of regional borders allowing for reproducible and automated regionalization. 3D imaging and high-resolution electroanatomical mapping have become an integral part of cardiac electrophysiology and the management of patients with arrhythmias. However, to perform r...
Abstract
Journal of magnetic resonance imaging : JMRI,
Volume 62, Issue 5, 30 5 2025, Pages 1412-1422
Aortic Function in a Longitudinal 4D Flow MRI Study in Marfan Syndrome Patients Receiving Resveratrol.
Bosshardt D, van Andel MM, Schrauben EM, van Kimmenade RRJ, Scholte AJ, Cox MGJP, Robbers-Visser D, Zwinderman AH, Mulder BJM, Nederveen AJ, de Waard V, Groenink M, van Ooij P
Background: New treatment strategies are required to reduce aortic events in Marfan syndrome (MFS). Resveratrol is a dietary supplement that intervenes in aortic wall cellular metabolism and may benefit MFS patients. Purpose: To evaluate whether treatment with Resveratrol affects aorta hemodynamics derived from 4D flow MRI in MFS. Study type: Prospective single-arm open-label multicenter trial. Population: 46 MFS patients (mean age 36 ± 9 years, 23 female), 20 with and 26 without a history of ao...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 169, 30 5 2025, Pages D8346
[Unfounded objections against the use of salbutamol/ipratropium].
Lucassen EA, Rood R, Tibboel J, Piers SRD
In acute bronchospasm due to asthma/COPD exacerbations two bronchodilators are frequently used: ipratropium, an acetylcholine antagonist, and salbutamol, a β2-agonist. The combination ipratropium/salbutamol gives more bronchodilation than ipratropium monotherapy in asthma/COPD exacerbations, but there are concerns about cardiac safety of salbutamol. Salbutamol in regular dosage does not affect heart rate in diverse populations (ED, ICU and children). Only a dosage 5-10x the standard dosage of 2,...
Abstract
mBio,
Volume 16, Issue 8, 30 5 2025, Pages e0035325
A redundant isoprenoid biosynthetic pathway supports <i>Staphylococcus aureus</i> metabolic versatility.
Burtchett TA, Ottosen EN, Jitsukawa T, Kaneko M, Yasui M, Lysne JA, Kies PJ, Bailey JA, Thomas SM, Fujisaki S, Hammer ND
Isoprenoids are ubiquitous molecules that serve as fundamental building blocks for life. In bacteria, isoprenoids are precursors for carotenoid pigments, respiratory cofactors, and essential sugar carrier lipids, such as lipid II. Isoprenoid synthesis initiates via condensation of the five-carbon (C5) precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). This initial reaction condenses one DMAPP and two IPPs, resulting in C15 farnesyl diphosphate (FPP), an intermediate...
Abstract
Cited 1 times since 2025 (3.3 per year)
source: EuropePMC
International journal of cancer,
Volume 157, Issue 10, 30 5 2025, Pages 2049-2060
Physical activity and risks of recurrence and progression among patients with non-muscle invasive bladder cancer.
Beeren I, Kiebach J, Hof JP, Buffart LM, Aben KKH, Witjes JA, van der Heijden AG, Kiemeney LALM, Vrieling A
Previous studies in solid tumors link high physical activity (PA) levels to lower cancer recurrence risk, but evidence is lacking for patients with non-muscle invasive bladder cancer (NMIBC). We evaluated the association between (changes in) PA (total, moderate-to-vigorous PA, leisure-time PA, and Dutch PA guideline adherence) and risks of NMIBC recurrence and progression. Patients diagnosed between 2014 and 2021 were recruited for the multi-center prospective cohort UroLife. Participants report...
Abstract
Clinical pharmacokinetics,
Volume 64, Issue 9, 30 5 2025, Pages 1379-1394
A Population Pharmacokinetic Model and Dosing Algorithm to Guide the Tacrolimus Starting and Follow-Up Dose in Living and Deceased Donor Kidney Transplant Recipients.
Francke MI, Sassen SDT, Lloberas N, Colom H, Elens L, Moudio S, de Vries APJ, Moes DJAR, van Schaik RHN, Hesselink DA, de Winter BCM
Introduction: Tacrolimus treatment is complicated by its narrow therapeutic range and large inter- and intra-patient variability. This study aimed to develop a population pharmacokinetic model and dosing algorithm to predict an individual's dose requirement following living and deceased donor kidney transplantation. Methods: In this international, multicenter, retrospective study, data was collected from patients who had received a living or a deceased donor kidney and received tacrolimus t...
Abstract
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
Volume 210, 27 4 2025, Pages 111004
Transfer of arrhythmia substrate targets from the cardiac electroanatomical and imaging modalities to the planning computed tomography scan for stereotactic arrhythmia radioablation for refractory ventricular tachycardia - a state-of-the-art review on software developments on behalf of the STOPSTORM.eu consortium.
Ter Bekke RMA, Hohmann S, Xie J, Grehn M, Verhoeven K, Volders PGA, Mihl C, Kaya YS, Manninger M, Scherr D, Corradini S, Schweikard A, Rademaker R, Hoeksema WF, Schiappacasse L, Knybel L, Pruvot E, Postema PG, Peichl P, Cvek J, Zeppenfeld K, Blanck O, Boda-Heggemann J
Stereotactic arrhythmia radioablation (STAR) for ventricular tachycardia (VT) is a non-invasive treatment modality to reduce the VT burden by delivering a single high radiation dose to the arrhythmogenic substrate. Identification and delineation of the arrhythmogenic substrate, definition of the radiation target, and transfer of this target across different imaging modalities from the invasive electroanatomic map (EAM) to the planning computed tomography (CT) scan are key to the success of thera...
Abstract
Physics in medicine and biology,
Volume 70, Issue 13, 27 4 2025
Analysis and generation of the fibrosis textures based on histology data of the human hearts with non-ischemic cardiomyopathy.
Okenov A, Nezlobinsky T, Glashan CA, Zeppenfeld K, Vandersickel N, Panfilov AV
Objective.Cardiac arrhythmias, marked by irregular and/or fast heartbeats, can severely compromise heart function and pose serious health risks. Fibrosis alters the propagation of electrical signals in the heart and plays a critical role in arrhythmogenesis. The impact of fibrosis depends not only on its amount, but also on its geometric features and spatial distribution. Therefore, understanding and replicating the structural characteristics of fibrotic tissue is essential for accurate arrhythm...
Abstract
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
26 4 2025
Measurement of Tralokinumab Concentrations in Serum and Tear Fluid of Atopic Dermatitis Patients and the Relationship With Treatment Response and Ocular Surface Disease.
Dekkers C, Smeijsters EH, El Amrani M, Jager CDH, van der Elst KCM, van Luin M, van Luijk C, Bakker DS, Huitema ADR, de Graaf M, van Wijk F, de Bruin-Weller MS
Abstract
Cited 3 times since 2025 (9.4 per year)
source: EuropePMC
Philosophical transactions of the Royal Society of London. Series B, Biological sciences,
Volume 380, Issue 1929, 26 4 2025, Pages 20240124
The fish challenge to vertebrate cognitive evolution.
Triki Z, van Schaik C, Bshary R
There is tremendous taxonomic variation in the size, shape and structure of vertebrate brains. While many studies use cross-species comparisons to aim at identifying the ecological factors (social and environmental) that explain what cognitive advantages larger brains confer, a more fundamental divide exists between endotherm and ectotherm vertebrates. Relative to body size, ectotherms have ten times smaller brains than endotherms. Existing ecological hypotheses cannot explain this divide, as so...
Abstract
Circulation. Arrhythmia and electrophysiology,
Volume 18, Issue 7, 25 4 2025, Pages e013670
Race Comparisons in Patients With Cardiac Sarcoidosis: Insights From the Cardiac Sarcoidosis Consortium.
Trongtorsak A, De La Rosa Martinez J, Crawford TC, Bogun FM, Gu X, Puroll E, Ellenbogen KA, Chicos AB, Roukoz H, Zimetbaum PJ, Kalbfleisch SJ, Murgatroyd FD, Steckman DA, Rosenfeld LE, Soejima K, Bhan AK, Vedantham V, Dickfeld TL, DeLurgio DB, Platonov PG, Zipse MM, Nishiuchi S, Ortman ML, Narasimhan C, Patton KK, Rosenthal DG, Mukerji SS, Hoogendoorn JC, Zeppenfeld K, Torosoff M, Judson MA, Martin K, Madias C, Hermel M, Nour K, Torbey E, Sauer WH, Kron J, Cardiac Sarcoidosis Consortium
Background: Differences in cardiac sarcoidosis between racial groups remain understudied. Therefore, this study aims to explore race differences in patients with cardiac sarcoidosis. Methods: We analyzed data from the Cardiac Sarcoidosis Consortium, an international registry including over 25 centers. The primary clinical outcome was a composite end point of all-cause mortality, left ventricular assist device implantation, heart transplantation, or implantable cardioverter defibrillator therapy....
Abstract
Cited 1 times since 2025 (3.1 per year)
source: EuropePMC
PloS one,
Volume 20, Issue 6, 25 4 2025, Pages e0327044
Exploring the potential of blood and urine protein electrophoresis in predicting 1-year mortality in acute kidney injury.
Yilmaz D, Sahin E, Batar G, Caglayan K, Gulturk E, Aydin Yoldemir S
This retrospective cohort study aimed to assess the predictive value of protein fractions obtained from blood and urine protein electrophoresis, along with various clinical and laboratory parameters, for 1-year all-cause mortality in acute kidney injury (AKI) patients. Data were collected from hospitalized patients who had been diagnosed with AKI. Demographics, smoking status, blood and urine electrophoresis results, serum gamma globulin levels, monoclonal gammopathy status, immunofixation resul...
Abstract
Science advances,
Volume 11, Issue 26, 25 4 2025, Pages eadt7718
The evolution of infant-directed communication: Comparing vocal input across all great apes.
Wegdell F, Fryns C, Schick J, Nellissen L, Laporte M, Surbeck M, van Noordwijk MA, Masi S, Hellwig B, Willems EP, Zuberbühler K, van Schaik CP, Stoll S, Townsend SW
Human language is unique among communication systems since many elements are learned and transmitted across generations. Previous research suggests that this process is best predicted by infant-directed communication, i.e., a mode of communication directed by caregivers to children. Despite its importance for language, whether infant-directed communication is unique to humans or rooted more deeply in the primate lineage remains unclear. To assess this, we investigated directed and surrounding vo...
Abstract
JHEP reports : innovation in hepatology,
Volume 7, Issue 9, 24 4 2025, Pages 101490
Reply to: "Statins in MASLD: Challenges and future directions".
de Jong VD, Trompet S, Jukema JW, Grobbee DE, Cabezas MC
Abstract
Journal of cardiothoracic and vascular anesthesia,
Volume 39, Issue 10, 23 4 2025, Pages 2899-2900
Toward a Consensus for the Definition of Vasoplegia in Cardiac Surgery.
Papazisi O, Palmen M, Rao V, Billia F, de Waal EEC
Abstract
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 106, Issue 2, 23 4 2025, Pages 1489-1498
Intravascular Lithotripsy for Calcific Coronary Bifurcations: Procedural Success and 1-Year Clinical Outcomes.
Oliveri F, D'Acunto G, Oort MJHV, Phagu A, Amri IA, Bingen BO, Paradies V, Mincione G, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Van der Kley F, Jukema JW, Montero-Cabezas JM
Background: Intravascular lithotripsy (IVL) has emerged as a promising treatment for heavily calcified coronary lesions. However, evidence regarding its effectiveness in calcific bifurcation lesions remains limited. Objective: We aimed to evaluate the technical success and 1-year clinical outcomes of IVL in calcified coronary bifurcation lesions. Methods: Patients undergoing PCI with the use of IVL from the ongoing prospective BENELUX-IVL registry were included. Participants were stratified into...
Abstract
Cited 1 times since 2025 (3 per year)
source: EuropePMC
Gut microbes,
Volume 17, Issue 1, 22 4 2025, Pages 2519700
<i>Staphylococcus haemolyticus</i> is a reservoir of antibiotic resistance genes in the preterm infant gut.
Lamberte LE, Darby EM, Kiu R, Moran RA, Acuna-Gonzalez A, Sim K, Shaw AG, Kroll JS, Belteki G, Clarke P, Felgate H, Webber MA, Rowe W, Hall LJ, Van Schaik W
Staphylococcus haemolyticus is an important cause of sepsis in preterm infants, with gut colonization being recognized as a risk factor for infection. To better understand the diversity of S. haemolyticus among preterm infants, we generated genome sequences of S. haemolyticus strains (n = 140) from 44 stool samples of 22 preterm infants from four hospitals in England. Core genome phylogenetic analyses, incorporating 126 publicly available S. haemolyticus genome sequences, showed that 85/140 (60....
Abstract
Acta biomaterialia,
Volume 202, 21 3 2025, Pages 262-275
Multilayered trabecular meshwork for dynamic in vitro studies in glaucoma research.
Gładysz MZ, Fernandes M, Li X, Koch M, Marchena F, Hofman A, de Graaf M, Wolters JC, Kamperman M, Nagelkerke A, Włodarczyk-Biegun MK
Glaucoma, an eye disease causing incremental vision loss, currently has no cure. Its primary cause is the malfunction of the trabecular meshwork (TM), a multilayered tissue in the eye responsible for draining aqueous humor (AH) from the anterior chamber. TM clogging increases outflow resistance, elevates intraocular pressure (IOP), and damages optic nerves, leading to irreversible blindness. Existing in vitro TM models are suboptimal, as they lack the hierarchical structure of the TM. This artic...
Abstract
Cited 1 times since 2025 (3 per year)
source: EuropePMC
International journal of cardiology. Congenital heart disease,
Volume 21, 21 3 2025, Pages 100603
Echocardiographic effects of sodium-glucose cotransporter 2 inhibitors in single ventricle circulatory failure.
Neijenhuis RML, Regeer MV, Walker NL, Hunter A, Kiès P, Holman ER, Jukema JW, Jongbloed MRM, Veldtman GR, Egorova AD
Background: Single ventricle patients are at high risk of developing circulatory failure. There is limited evidence for pharmacological treatment. This study assessed the echocardiographic changes in ventricular function during sodium-glucose cotransporter 2 inhibitor (SGLT2i) therapy in patients with single ventricle failure (SVF). Methods: SVF patients with a baseline transthoracic echocardiogram within six months before starting SGLT2i and at least one echocardiographic examination within twe...
Abstract
