Research

Publications

Below you can find a list of our published research.

8094 results

Cited 32 times since 2020 (5.9 per year) source: EuropePMC

Nucleic acids research, Volume 48, Issue 4, 1 1 2020, Pages 2156-2172 Structural basis for osmotic regulation of the DNA binding properties of H-NS proteins. Qin L, Bdira FB, Sterckx YGJ, Volkov AN, Vreede J, Giachin G, van Schaik P, Ubbink M, Dame RT

H-NS proteins act as osmotic sensors translating changes in osmolarity into altered DNA binding properties, thus, regulating enterobacterial genome organization and genes transcription. The molecular mechanism underlying the switching process and its conservation among H-NS family members remains elusive. Here, we focus on the H-NS family protein MvaT from Pseudomonas aeruginosa and demonstrate experimentally that its protomer exists in two different conformations, corresponding to two different... Abstract

Cited 9 times since 2020 (1.7 per year) source: EuropePMC

Academic medicine : journal of the Association of American Medical Colleges, Volume 95, Issue 2, 1 1 2020, Pages 293-300 "A Friendly Place to Grow as an Educator": A Qualitative Study of Community and Relationships Among Medical Student Coaches. Sheu L, Hauer KE, Schreiner K, van Schaik SM, Chang A, O'Brien BC

Purpose: The rise of coaching programs in medical education sparks questions about ways to support physician coaches in learning new educational practices specific to coaching. How coaches learn from one another is of particular interest considering the potential value of social learning. Using communities of practice as a conceptual framework, the authors examine the sense of community and relationships among coaches in a new medical student coaching program, the value of this community, and th... Abstract

Cited 12 times since 2020 (2.2 per year) source: EuropePMC

Pharmacogenomics, Volume 21, Issue 3, 1 1 2020, Pages 181-193 <i>OPRM1</i> and <i>COMT</i> polymorphisms: implications on postoperative acute, chronic and experimental pain after cardiac surgery. Matic M, Matic M, de Hoogd S, de Wildt SN, Tibboel D, Knibbe CA, van Schaik RH

Aim: Investigate the potential role of OPRM1 (mu-opioid receptor) and COMT (catechol-O-methyltransferase enzyme) polymorphisms in postoperative acute, chronic and experimental thermal pain. Methods: A secondary analysis of 125 adult cardiac surgery patients that were randomized between fentanyl and remifentanil during surgery and genotyped. Results: Patients in the fentanyl group with the COMT high-pain sensitivity haplotype required less postoperative morphine compared with the average-pain sen... Abstract

Cited 12 times since 2020 (2.2 per year) source: EuropePMC

The Journal of antimicrobial chemotherapy, Volume 75, Issue 2, 1 1 2020, Pages 283-291 Tandem amplification of the vanM gene cluster drives vancomycin resistance in vancomycin-variable enterococci. Sun L, Chen Y, Hua X, Chen Y, Hong J, Wu X, Jiang Y, van Schaik W, Qu T, Yu Y

Background: Vancomycin-variable enterococci (VVE) are a potential risk factor for vancomycin resistance gene dissemination and clinical treatment failure. vanM has emerged as a new prevalent resistance determinant among clinical enterococci in China. A total of 54 vancomycin-susceptible enterococci (VSE) isolates carrying incomplete vanM gene clusters were isolated in our previous study. Objectives: To determine the potential of vanM-carrying VSE to develop vancomycin resistance and investigate... Abstract

Cited 6 times since 2020 (1.1 per year) source: EuropePMC

European heart journal, Volume 41, Issue 6, 1 1 2020, Pages 739-747 The year in cardiology: imaging. Pennell D, Delgado V, Knuuti J, Maurovich-Horvat P, Bax JJ

Abstract

Cited 151 times since 2020 (27.9 per year) source: EuropePMC

Current opinion in microbiology, Volume 53, 1 1 2020, Pages 35-43 Horizontal transfer of antibiotic resistance genes in the human gut microbiome. McInnes RS, McCallum GE, Lamberte LE, van Schaik W

Infections caused by antibiotic-resistant bacteria are a major threat to public health. The pathogens causing these infections can acquire antibiotic resistance genes in a process termed horizontal gene transfer (HGT). HGT is a common event in the human gut microbiome, that is, the microbial ecosystem of the human intestinal tract. HGT in the gut microbiome can occur via different mechanisms of which transduction and conjugation have been best characterised. Novel bioinformatic tools and experim... Abstract

Cited 5 times since 2020 (0.9 per year) source: EuropePMC

Psychiatric genetics, Volume 30, Issue 1, 1 1 2020, Pages 19-29 Modification of the association between paroxetine serum concentration and SERT-occupancy by ABCB1 (P-glycoprotein) polymorphisms in major depressive disorder. Simoons M, Mulder H, Appeldoorn JTY, Risselada AJ, Schene AH, van Schaik RHN, van Roon EN, Ruhé EG

Background: Selective serotonin reuptake inhibitors (SSRIs) exert substantial variability in effectiveness in patients with major depressive disorder (MDD), with up to 50-60% not achieving adequate response. Elucidating pharmacokinetic factors that explain this variability is important to increase treatment effectiveness. Objectives: To examine potential modification of the relationship between paroxetine serum concentration (PSC) and serotonin transporter (SERT)-occupancy by single nucleotide p... Abstract

Cited 25 times since 2020 (4.6 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 21, Issue 2, 1 1 2020, Pages 119-123 EACVI survey on standardization of cardiac chambers quantification by transthoracic echocardiography. Ajmone Marsan N, Michalski B, Cameli M, Podlesnikar T, Manka R, Sitges M, Dweck MR, Haugaa KH

Aims: To evaluate standard reporting of cardiac chambers size and function by transthoracic echocardiography (TTE), the EACVI Scientific Initiatives Committee performed a survey across European centres. In particular, the routine use of three-dimensional echocardiography (3DE) and speckle tracking-derived myocardial deformation imaging (STE) was explored. Methods and results: A total of 96 European Echocardiography Laboratories from 22 different countries responded to the survey, which consisted... Abstract

Cited 7 times since 2020 (1.3 per year) source: EuropePMC

Cells, Volume 9, Issue 2, 1 1 2020, Pages E336 Prolonged Hyperoxygenation Treatment Improves Vein Graft Patency and Decreases Macrophage Content in Atherosclerotic Lesions in ApoE3*Leiden Mice. Parma L, Peters HAB, Baganha F, Sluimer JC, de Vries MR, Quax PHA

Unstable atherosclerotic plaques frequently show plaque angiogenesis which increases the chance of rupture and thrombus formation leading to infarctions. Hypoxia plays a role in angiogenesis and inflammation, two processes involved in the pathogenesis of atherosclerosis. We aim to study the effect of resolution of hypoxia using carbogen gas (95% O2, 5% CO2) on the remodeling of vein graft accelerated atherosclerotic lesions in ApoE3*Leiden mice which harbor plaque angiogenesis. Single treatment... Abstract

Cited 20 times since 2020 (3.7 per year) source: EuropePMC

Cardiovascular research, Volume 116, Issue 2, 1 1 2020, Pages 416-428 Short-term preoperative protein restriction attenuates vein graft disease via induction of cystathionine γ-lyase. Trocha KM, Kip P, Tao M, MacArthur MR, Treviño-Villarreal JH, Longchamp A, Toussaint W, Lambrecht BN, de Vries MR, Quax PHA, Mitchell JR, Ozaki CK

Aims: Therapies to prevent vein graft disease, a major problem in cardiovascular and lower extremity bypass surgeries, are currently lacking. Short-term preoperative protein restriction holds promise as an effective preconditioning method against surgical stress in rodent models, but whether it can improve vein graft patency after bypass surgery is undetermined. Here, we hypothesized that short-term protein restriction would limit vein graft disease via up-regulation of cystathionine γ-lyase and... Abstract

International journal of epidemiology, Volume 49, Issue 1, 1 1 2020, Pages 357 Corrigendum to: Cohort Profile: The Hoorn Studies. Rutters F, Nijpels G, Elders P, Stehouwer CDA, van der Heijden AA, Groeneveld L, 't Hart LM, Dekker JM, Beulens JWJ

Abstract

Cited 22 times since 2020 (4.1 per year) source: EuropePMC

Journal of cardiovascular computed tomography, Volume 14, Issue 5, 30 5 2020, Pages 400-406 Percent atheroma volume: Optimal variable to report whole-heart atherosclerotic plaque burden with coronary CTA, the PARADIGM study. van Rosendael AR, Lin FY, Ma X, van den Hoogen IJ, Gianni U, Al Hussein O, Al'Aref SJ, Peña JM, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Conte E, Marques H, de Araújo Gonçalves P, Gottlieb I, Hadamitzky M, Leipsic JA, Maffei E, Pontone G, Raff GL, Shin S, Kim YJ, Lee BK, Chun EJ, Sung JM, Lee SE, Berman DS, Virmani R, Samady H, Stone PH, Narula J, Bax JJ, Shaw LJ, Min JK, Chang HJ

Background and aims: Different methodologies to report whole-heart atherosclerotic plaque on coronary computed tomography angiography (CCTA) have been utilized. We examined which of the three commonly used plaque burden definitions was least affected by differences in body surface area (BSA) and sex. Methods: The PARADIGM study includes symptomatic patients with suspected coronary atherosclerosis who underwent serial CCTA >2 years apart. Coronary lumen, vessel, and plaque were quantified from... Abstract

Cited 4 times since 2020 (0.7 per year) source: EuropePMC

Journal of applied physiology (Bethesda, Md. : 1985), Volume 128, Issue 3, 30 5 2020, Pages 545-553 The proarrhythmic features of pathological cardiac hypertrophy in neonatal rat ventricular cardiomyocyte cultures. Neshati Z, Schalij MJ, de Vries AAF

Different factors may trigger arrhythmias in diseased hearts, including fibrosis, cardiomyocyte hypertrophy, hypoxia, and inflammation. This makes it difficult to establish the relative contribution of each of them to the occurrence of arrhythmias. Accordingly, in this study, we used an in vitro model of pathological cardiac hypertrophy (PCH) to investigate its proarrhythmic features and the underlying mechanisms independent of fibrosis or other PCH-related processes. Neonatal rat ventricular ca... Abstract

Cited 8 times since 2020 (1.5 per year) source: EuropePMC

Trials, Volume 21, Issue 1, 28 4 2020, Pages 112 Pelvic floor rehabilitation to improve functional outcome and quality of life after surgery for rectal cancer: study protocol for a randomized controlled trial (FORCE trial). Kalkdijk-Dijkstra AJ, van der Heijden JAG, van Westreenen HL, Broens PMA, Trzpis M, Pierie JPEN, Klarenbeek BR, FORCE Trial Group

Background: After low anterior resection (LAR), up to 90% of patients develop anorectal dysfunction. Especially fecal incontinence has a major impact on the physical, psychological, social, and emotional functioning of the patient but also on the Dutch National Healthcare budget with more than €2000 spent per patient per year. No standardized treatment is available to help these patients. Common treatment nowadays is focused on symptom relief, consisting of lifestyle advices and pharmacotherapy... Abstract

Cited 21 times since 2020 (3.9 per year) source: EuropePMC

Orphanet journal of rare diseases, Volume 15, Issue 1, 28 4 2020, Pages 28 Depressive symptoms in Fabry disease: the importance of coping, subjective health perception and pain. Körver S, Geurtsen GJ, Hollak CEM, van Schaik IN, Longo MGF, Lima MR, Vedolin L, Dijkgraaf MGW, Langeveld M

Background: Despite the high prevalence of depressive symptoms in Fabry disease (FD), it is unclear which patient characteristics are important in relation to these symptoms. Additionally, the impact of coping styles in relation to depressive symptoms in FD has been unexplored. Determining the impact of different factors relating to depressive symptoms in FD can guide both prevention and treatment of these symptoms. Methods: Depressive symptoms (Center for Epidemiologic Studies Depression scale... Abstract

Cited 10 times since 2020 (1.8 per year) source: EuropePMC

The British journal of surgery, Volume 107, Issue 5, 24 4 2020, Pages 552-559 Safety of hospital discharge before return of bowel function after elective colorectal surgery. EuroSurg Collaborative

Background: Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function. Methods: A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between... Abstract

Cited 18 times since 2020 (3.3 per year) source: EuropePMC

Acta odontologica Scandinavica, Volume 78, Issue 5, 24 4 2020, Pages 327-331 Salivary human beta-defensins and cathelicidin levels in relation to periodontitis and type 2 diabetes mellitus. Yilmaz D, Topcu AO, Akcay EU, Altındis M, Gursoy UK

Objective: Type 2 diabetes mellitus (T2DM) is a well-defined risk factor of periodontitis and it can affect expression of human beta-defensins (hBDs) and cathelicidin (LL-37) as well. The aim of the present study was to evaluate the impact of periodontitis and T2DM on salivary concentrations of these antimicrobial peptides.Material and methods: Unstimulated saliva samples, together with full-mouth periodontal recordings were collected from 92 individuals with periodontitis (63 with T2DM and 21 s... Abstract

Cited 7 times since 2020 (1.3 per year) source: EuropePMC

Frontiers in oncology, Volume 9, 22 4 2020, Pages 1521 Implementation of Novel Molecular Biomarkers for Non-small Cell Lung Cancer in the Netherlands: How to Deal With Increasing Complexity. van den Broek D, Hiltermann TJN, Biesma B, Dinjens WNM, 't Hart NA, Hinrichs JWJ, Leers MPG, Monkhorst K, van Oosterhout M, Scharnhorst V, Schuuring E, Speel EM, van den Heuvel MM, van Schaik RHN, von der Thüsen J, Willems SM, de Visser L, Ligtenberg MJL

The diagnostic landscape of non-small cell lung cancer (NSCLC) is changing rapidly with the availability of novel treatments. Despite high-level healthcare in the Netherlands, not all patients with NSCLC are tested with the currently relevant predictive tumor markers that are necessary for optimal decision-making for today's available targeted or immunotherapy. An expert workshop on the molecular diagnosis of NSCLC involving pulmonary oncologists, clinical chemists, pathologists, and clinic... Abstract

Cited 6 times since 2020 (1.1 per year) source: EuropePMC

Thrombosis research, Volume 188, 21 3 2020, Pages 44-48 The association between leptin concentration and blood coagulation: Results from the NEO study. Buis DTP, Christen T, Smit RAJ, de Mutsert R, Jukema JW, Cannegieter SC, Lijfering WM, Rosendaal FR

Background: The adipocyte-derived hormone leptin has been associated with altered blood coagulation in in vitro studies. However, it is unclear whether this association is relevant in vivo and to what extent this association is influenced by total body fat. Therefore, we aimed to examine the association between serum leptin and blood coagulation while taking total body fat into account in a population-based cohort study. Methods: We performed a cross-sectional analysis with baseline measurements... Abstract

Cited 7 times since 2020 (1.3 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 110, Issue 3, 18 3 2020, Pages 956-961 Mitral Valve Replacement With the 15-mm Mechanical Valve: A 20-Year Multicenter Experience. IJsselhof RJ, Slieker MG, Hazekamp MG, Accord R, van Wetten H, Haas F, Schoof PH

Background: The aim of this study was to evaluate early and long-term outcomes (mortality and prosthetic valve replacement) after mitral valve replacement with the 15-mm St Jude Medical prosthesis (St Jude Medical, St Paul, MN). Methods: A multicenter, retrospective cohort study was performed among patients who underwent mitral valve replacement with a 15-mm St Jude Medical Masters prosthesis at 4 congenital cardiac centers in The Netherlands. Operative results were evaluated and echocardiograph... Abstract