9618 results
Cited 19 times since 2016 (2 per year)
source: EuropePMC
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group,
Volume 32, Issue 4, 20 3 2016, Pages 434-445
Effects of hyperthermia in neutralising mechanisms of drug resistance in non-muscle-invasive bladder cancer.
van der Heijden AG, Dewhirst MW
Non-muscle-invasive bladder cancer is a challenging disease, even given its superficial nature. It is prone to multiple recurrences and progression to muscle-invasive cancer. These features of this disease contribute significantly to reduced quality of life as well as creating significant morbidity and even mortality. Randomised trials demonstrate that when hyperthermia is added to conventional mitomycin-C treatment that local control rates and progression-free survival are substantially improve...
Abstract
Cited 4 times since 2016 (0.4 per year)
source: EuropePMC
Omics : a journal of integrative biology,
Volume 20, Issue 5, 20 3 2016, Pages 274-282
An Alternative Methodological Approach for Cost-Effectiveness Analysis and Decision Making in Genomic Medicine.
Fragoulakis V, Mitropoulou C, van Schaik RH, Maniadakis N, Patrinos GP
Genomic Medicine aims to improve therapeutic interventions and diagnostics, the quality of life of patients, but also to rationalize healthcare costs. To reach this goal, careful assessment and identification of evidence gaps for public health genomics priorities are required so that a more efficient healthcare environment is created. Here, we propose a public health genomics-driven approach to adjust the classical healthcare decision making process with an alternative methodological approach of...
Abstract
Cited 14 times since 2016 (1.5 per year)
source: Scopus
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
Volume 42, Issue 8, 19 3 2016, Pages 1183-1190
Delaying surgery after neoadjuvant chemoradiotherapy does not significantly influence postoperative morbidity or oncological outcome in patients with oesophageal adenocarcinoma.
Kathiravetpillai N, Koëter M, van der Sangen MJ, Creemers GJ, Luyer MD, Rutten HJ, Nieuwenhuijzen GA
Background: Patients with resectable oesophageal cancer are treated with neoadjuvant chemoradiotherapy (nCRT) followed by surgery within 3-8 weeks. In practice, surgery is often delayed for various reasons. The aim of this study was to evaluate whether delaying surgery beyond 8 weeks has an effect on postoperative morbidity, long-term survival, and pathologic response in patients treated for oesophageal ADC. Methods: Patients who underwent nCRT followed by surgery, for cT1-3, N0-3, M0 ADC betwee...
Abstract
Cited 12 times since 2016 (1.3 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 3, Issue 2, 15 3 2016, Pages E16
Postnatal Cardiac Autonomic Nervous Control in Pediatric Congenital Heart Disease.
Nederend I, Jongbloed MRM, de Geus EJC, Blom NA, Ten Harkel ADJ
Congenital heart disease is the most common congenital defect. During childhood, survival is generally good but, in adulthood, late complications are not uncommon. Abnormal autonomic control in children with congenital heart disease may contribute considerably to the pathophysiology of these long term sequelae. This narrative review of 34 studies aims to summarize current knowledge on function of the autonomic nervous system in children with a congenital heart defect. Large scale studies that me...
Abstract
Cited 44 times since 2016 (4.7 per year)
source: EuropePMC
Scientific reports,
Volume 6, 14 2 2016, Pages 24528
Manipulation complexity in primates coevolved with brain size and terrestriality.
Heldstab SA, Kosonen ZK, Koski SE, Burkart JM, van Schaik CP, Isler K
Humans occupy by far the most complex foraging niche of all mammals, built around sophisticated technology, and at the same time exhibit unusually large brains. To examine the evolutionary processes underlying these features, we investigated how manipulation complexity is related to brain size, cognitive test performance, terrestriality, and diet quality in a sample of 36 non-human primate species. We categorized manipulation bouts in food-related contexts into unimanual and bimanual actions, an...
Abstract
PloS one,
Volume 11, Issue 4, 14 2 2016, Pages e0153366
The Bayesian Decoding of Force Stimuli from Slowly Adapting Type I Fibers in Humans.
Kasi P, Wright J, Khamis H, Birznieks I, van Schaik A
It is well known that signals encoded by mechanoreceptors facilitate precise object manipulation in humans. It is therefore of interest to study signals encoded by the mechanoreceptors because this will contribute further towards the understanding of fundamental sensory mechanisms that are responsible for coordinating force components during object manipulation. From a practical point of view, this may suggest strategies for designing sensory-controlled biomedical devices and robotic manipulator...
Abstract
Cited 17 times since 2016 (1.8 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 102, Issue 14, 13 2 2016, Pages 1127-1133
Surgical options after Fontan failure.
van Melle JP, Wolff D, Hörer J, Belli E, Meyns B, Padalino M, Lindberg H, Jacobs JP, Mattila IP, Berggren H, Berger RM, Prêtre R, Hazekamp MG, Helvind M, Nosál M, Tlaskal T, Rubay J, Lazarov S, Kadner A, Hraska V, Fragata J, Pozzi M, Sarris G, Michielon G, di Carlo D, Ebels T
Objective: The objective of this European multicenter study was to report surgical outcomes of Fontan takedown, Fontan conversion and heart transplantation (HTX) for failing Fontan patients in terms of all-cause mortality and (re-)HTX. Methods: A retrospective international study was conducted by the European Congenital Heart Surgeons Association among 22 member centres. Outcome of surgery to address failing Fontan was collected in 225 patients among which were patients with Fontan takedown (n=3...
Abstract
Cited 19 times since 2016 (2 per year)
source: EuropePMC
Scientific reports,
Volume 6, 13 2 2016, Pages 24334
Islands of spatially discordant APD alternans underlie arrhythmogenesis by promoting electrotonic dyssynchrony in models of fibrotic rat ventricular myocardium.
Majumder R, Engels MC, de Vries AA, Panfilov AV, Pijnappels DA
Fibrosis and altered gap junctional coupling are key features of ventricular remodelling and are associated with abnormal electrical impulse generation and propagation. Such abnormalities predispose to reentrant electrical activity in the heart. In the absence of tissue heterogeneity, high-frequency impulse generation can also induce dynamic electrical instabilities leading to reentrant arrhythmias. However, because of the complexity and stochastic nature of such arrhythmias, the combined effect...
Abstract
Cited 61 times since 2016 (6.5 per year)
source: EuropePMC
European journal of heart failure,
Volume 18, Issue 5, 12 2 2016, Pages 482-489
Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency.
Anker SD, Schroeder S, Atar D, Bax JJ, Ceconi C, Cowie MR, Crisp A, Dominjon F, Ford I, Ghofrani HA, Gropper S, Hindricks G, Hlatky MA, Holcomb R, Honarpour N, Jukema JW, Kim AM, Kunz M, Lefkowitz M, Le Floch C, Landmesser U, McDonagh TA, McMurray JJ, Merkely B, Packer M, Prasad K, Revkin J, Rosano GM, Somaratne R, Stough WG, Voors AA, Ruschitzka F
Composite endpoints are commonly used as the primary measure of efficacy in heart failure clinical trials to assess the overall treatment effect and to increase the efficiency of trials. Clinical trials still must enrol large numbers of patients to accrue a sufficient number of outcome events and have adequate power to draw conclusions about the efficacy and safety of new treatments for heart failure. Additionally, the societal and health system perspectives on heart failure have raised interest...
Abstract
Cited 17 times since 2016 (1.8 per year)
source: EuropePMC
Pharmacological research,
Volume 107, 8 2 2016, Pages 398-406
Pharmacogenetics of CYP2D6 and tamoxifen therapy: Light at the end of the tunnel?
Del Re M, Citi V, Crucitta S, Rofi E, Belcari F, van Schaik RH, Danesi R
The clinical usefulness of assessing the enzymatic activity of CYPD6 in patients taking tamoxifen had been longly debated. In favour of preemptive evaluation of phenotypic profile of patients is the strong pharmacologic rationale, being that the formation of endoxifen, the major and clinically most important metabolite of tamoxifen, is largely dependent on the activity of CYP2D6. This enzyme is highly polymorphic for which the activity is largely depending on genetics, but that can also be inhib...
Abstract
Cited 84 times since 2016 (9 per year)
source: EuropePMC
Expert opinion on drug metabolism & toxicology,
Volume 12, Issue 5, 7 1 2016, Pages 555-565
Pharmacogenetic aspects of the use of tacrolimus in renal transplantation: recent developments and ethnic considerations.
Tang JT, Andrews LM, van Gelder T, Shi YY, van Schaik RH, Wang LL, Hesselink DA
Introduction: Tacrolimus (Tac) is effective in preventing acute rejection but has considerable toxicity and inter-individual variability in pharmacokinetics and pharmacodynamics. Part of this is explained by polymorphisms in genes encoding Tac-metabolizing enzymes and transporters. A better understanding of Tac pharmacokinetics and pharmacodynamics may help to minimize different outcomes amongst transplant recipients by personalizing immunosuppression. Areas covered: The pharmacogenetic contribu...
Abstract
Cited 4 times since 2016 (0.4 per year)
source: EuropePMC
The American journal of emergency medicine,
Volume 34, Issue 8, 7 1 2016, Pages 1364-1368
Comparison of near-infrared spectroscopy and head CT interpretations of the ED patients with minor head injury.
Akyol PY, Bayram B, Acerer A, Girgin MC, Yılmaz DÇ, Men S, Atilla R
Abstract
Cited 14 times since 2016 (1.5 per year)
source: EuropePMC
Scientific reports,
Volume 6, 7 1 2016, Pages 24248
Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response.
Wezel A, de Vries MR, Maassen JM, Kip P, Peters EA, Karper JC, Kuiper J, Bot I, Quax PHA
Venous grafts are often used to bypass occlusive atherosclerotic lesions; however, poor patency leads to vein graft disease. Deficiency of TLR4, an inflammatory regulator, reduces vein graft disease. Here, we investigate the effects of the accessory molecule and TLR4 analogue RadioProtective 105 (RP105) on vein graft disease. RP105 deficiency resulted in a 90% increase in vein graft lesion area compared to controls. In a hypercholesterolemic setting (LDLr(-/-)/RP105(-/-) versus LDLr(-/-) mice),...
Abstract
Cited 103 times since 2016 (11 per year)
source: EuropePMC
The Lancet. Neurology,
Volume 15, Issue 7, 7 1 2016, Pages 695-707
Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies.
Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, the Stroke Genetics Network (SiGN), and the International Stroke Genetics Consortium (ISGC)
Background: Genetic determinants of stroke, the leading neurological cause of death and disability, are poorly understood and have seldom been explored in the general population. Our aim was to identify additional loci for stroke by doing a meta-analysis of genome-wide association studies. Methods: For the discovery sample, we did a genome-wide analysis of common genetic variants associated with incident stroke risk in 18 population-based cohorts comprising 84 961 participants, of whom 4348 had...
Abstract
Cited 6 times since 2016 (0.6 per year)
source: EuropePMC
Applied neuropsychology. Child,
Volume 6, Issue 2, 6 1 2016, Pages 145-157
Neuropsychological presentation and adaptive skills in high-functioning adolescents with visual impairment: A preliminary investigation.
Greenaway R, Pring L, Schepers A, Isaacs DP, Dale NJ
Studies in infants and young children with congenital visual impairment (VI) have indicated early developmental vulnerabilities, conversely research with older children and adults have highlighted areas of cognitive strength. A minimal amount is known, however, about the possible combination of strengths and weaknesses in adolescence, and this present study therefore aims to explore the neuropsychological presentation and adaptive behavior profile in high-functioning adolescents with congenital...
Abstract
Cited 17 times since 2016 (1.8 per year)
source: EuropePMC
Journal of experimental child psychology,
Volume 147, 6 1 2016, Pages 71-81
Little chameleons: The development of social mimicry during early childhood.
van Schaik JE, Hunnius S
Adults use behavioral mimicry to blend in with (or stand out from) their social environment. Adopting another's mannerisms and behaviors, or "mimicking", communicates liking and similarity between interaction partners and has been shown to serve as an implicit affiliation mechanism. Given this important social function, it is surprising that so little is known about the development of mimicry. In two studies, we investigated mimicry and its social sensitivity during early childhoo...
Abstract
Cited 32 times since 2016 (3.4 per year)
source: EuropePMC
PloS one,
Volume 11, Issue 4, 6 1 2016, Pages e0151870
Measuring Hair Cortisol Concentrations to Assess the Effect of Anthropogenic Impacts on Wild Chimpanzees (Pan troglodytes).
Carlitz EH, Miller R, Kirschbaum C, Gao W, Hänni DC, van Schaik CP
Non-human primates face major environmental changes due to increased human impacts all over the world. Although some species are able to survive in certain landscapes with anthropogenic impact, their long-term viability and fitness may be decreased due to chronic stress. Here we assessed long-term stress levels through cortisol analysis in chimpanzee hair obtained from sleeping nests in northwestern Uganda, in order to estimate welfare in the context of ecotourism, forest fragmentation with huma...
Abstract
Cited 6 times since 2016 (0.6 per year)
source: EuropePMC
PloS one,
Volume 11, Issue 4, 6 1 2016, Pages e0152938
Discrepant Results of Experimental Human Mesenchymal Stromal Cell Therapy after Myocardial Infarction: Are Animal Models Robust Enough?
den Haan MC, van Zuylen VL, Pluijmert NJ, Schutte CI, Fibbe WE, Schalij MJ, Roelofs H, Atsma DE
Background: Human mesenchymal stromal cells (MSCs) have been reported to preserve cardiac function in myocardial infarction (MI) models. Previously, we found a beneficial effect of intramyocardial injection of unstimulated human MSCs (uMSCs) on cardiac function after permanent coronary artery ligation. In the present study we aimed to extend this research by investigating the effect of intramyocardial injection of human MSCs pre-stimulated with the pro-inflammatory cytokine interferon-gamma (iMS...
Abstract
Cited 2 times since 2016 (0.2 per year)
source: EuropePMC
Renal failure,
Volume 38, Issue 5, 6 1 2016, Pages 781-786
Comparison of serum paraoxonase and arylesterase activities between iron deficiency anemia patients and chronic kidney disease patients with anemia.
Okuturlar Y, Akalin N, Kaptanogullari OH, Guner NT, Yilmaz D, Gedikbasi A, Soyluk O, Mert M, Serin SO, Kocoglu H, Hursitoglu M, Kumbasar A
Objective: Altered paraoxonase (PON) and arylesterase (ARE) activities have been shown in anemic chronic kidney disease (CKD) patients and in iron deficiency anemia (IDA) patients. Whether accompanying anemia alone is responsible for this diminished PON and ARE activities in CKD patients or an additive factor for this is not well studied. Therefore, we tried to clarify this issue here. Methods: A total of 82 subjects that consisted of 19 patients with IDA (group 1), 23 anemic CKD patients (group...
Abstract
Cited 5 times since 2016 (0.5 per year)
source: EuropePMC
Neurourology and urodynamics,
Volume 36, Issue 3, 6 1 2016, Pages 597-603
Effects of silodosin, a selective alpha-1A adrenoceptor antagonist, on erectile function in a rat model of partial bladder outlet obstruction.
Bastaskın T, Kaya E, Ozakca I, Yilmaz D, Bayatlı N, Akdemir AO, Gur S
Aim: We investigated the effects of silodosin (selective α1A -adrenoceptor antagonist) on erectile dysfunction (ED) in a rat model of bladder outlet obstruction. Methods: Adult male Sprague-Dawley rats (n = 32) were divided into four groups: (i) sham-operated control; (ii) silodosin-treated (sham) control (0.1 mg/kg/day); (iii) partial bladder outlet obstruction (PBOO); and (iv) silodosin-treated with PBOO. PBOO was induced by ligation of the urethra for 6 weeks. In vivo, erectile responses were...
Abstract
