9618 results
Cited 344 times since 2016 (36.3 per year)
source: EuropePMC
The New England journal of medicine,
Volume 374, Issue 12, 2 1 2016, Pages 1134-1144
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.
Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, Stitziel NO, Stirrups KE, Masca NG, Erdmann J, Ferrario PG, König IR, Weeke PE, Webb TR, Auer PL, Schick UM, Lu Y, Zhang H, Dube MP, Goel A, Farrall M, Peloso GM, Won HH, Do R, van Iperen E, Kanoni S, Kruppa J, Mahajan A, Scott RA, Willenberg C, Braund PS, van Capelleveen JC, Doney AS, Donnelly LA, Asselta R, Merlini PA, Duga S, Marziliano N, Denny JC, Shaffer CM, El-Mokhtari NE, Franke A, Gottesman O, Heilmann S, Hengstenberg C, Hoffman P, Holmen OL, Hveem K, Jansson JH, Jöckel KH, Kessler T, Kriebel J, Laugwitz KL, Marouli E, Martinelli N, McCarthy MI, Van Zuydam NR, Meisinger C, Esko T, Mihailov E, Escher SA, Alver M, Moebus S, Morris AD, Müller-Nurasyid M, Nikpay M, Olivieri O, Lemieux Perreault LP, AlQarawi A, Robertson NR, Akinsanya KO, Reilly DF, Vogt TF, Yin W, Asselbergs FW, Kooperberg C, Jackson RD, Stahl E, Strauch K, Varga TV, Waldenberger M, Zeng L, Kraja AT, Liu C, Ehret GB, Newton-Cheh C, Chasman DI, Chowdhury R, Ferra
Background: The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets. Methods: Through DNA genotyping, we tested 54,003 coding-sequence variants covering 13,715 human genes in up to 72,868 patients with coronary artery disease and 120,770 controls who did not have coronary artery disease. Through DNA sequencing, we studied the effects of loss-of-function mutations in selected genes. Results: We confirme...
Abstract
Cited 98 times since 2016 (10.3 per year)
source: EuropePMC
European heart journal,
Volume 37, Issue 37, 2 1 2016, Pages 2823-2829
Happy heart syndrome: role of positive emotional stress in takotsubo syndrome.
Ghadri JR, Sarcon A, Diekmann J, Bataiosu DR, Cammann VL, Jurisic S, Napp LC, Jaguszewski M, Scherff F, Brugger P, Jäncke L, Seifert B, Bax JJ, Ruschitzka F, Lüscher TF, Templin C, InterTAK Co-investigators:
Aims: Takotsubo syndrome (TTS) is typically provoked by negative stressors such as grief, anger, or fear leading to the popular term 'broken heart syndrome'. However, the role of positive emotions triggering TTS remains unclear. The aim of the present study was to analyse the prevalence and characteristics of patients with TTS following pleasant events, which are distinct from the stressful or undesirable episodes commonly triggering TTS. Methods and results: Takotsubo syndrome patient...
Abstract
Cited 35 times since 2016 (3.7 per year)
source: EuropePMC
Philosophical transactions of the Royal Society of London. Series B, Biological sciences,
Volume 371, Issue 1690, 1 1 2016, Pages 20150183
The reluctant innovator: orangutans and the phylogeny of creativity.
van Schaik CP, Burkart J, Damerius L, Forss SI, Koops K, van Noordwijk MA, Schuppli C
Young orangutans are highly neophobic, avoid independent exploration and show a preference for social learning. Accordingly, they acquire virtually all their learned skills through exploration that is socially induced. Adult exploration rates are also low. Comparisons strongly suggest that major innovations, i.e. behaviours that have originally been brought into the population through individual invention, are made where ecological opportunities to do so are propitious. Most populations nonethel...
Abstract
Cited 10 times since 2016 (1.1 per year)
source: EuropePMC
Saudi medical journal,
Volume 37, Issue 3, 1 1 2016, Pages 304-308
The effect of air-lock technique on pain at the site of intramuscular injection.
Yılmaz DK, Dikmen Y, Köktürk F, Dedeoğlu Y
Objectives: To investigate the effects of air-lock technique (ALT) on pain of intramuscular (IM) injection delivered to the ventrogluteal and dorsogluteal site (DS). Methods: A randomized controlled trial design was used to assess the pain intensity associated with IM injections administered using 2 different methods and injection sites. Recruitment of patients was carried out between April and August 2013 at the Department of Brain Surgery, Cekirge State Hospital, Bursa, Turkey. The sample comp...
Abstract
Cited 19 times since 2016 (2 per year)
source: EuropePMC
Critical care medicine,
Volume 44, Issue 3, 1 1 2016, Pages e158-67
Inotropic Effects of Experimental Hyperthermia and Hypothermia on Left Ventricular Function in Pigs-Comparison With Dobutamine.
Alogna A, Manninger M, Schwarzl M, Zirngast B, Steendijk P, Verderber J, Zweiker D, Maechler H, Pieske BM, Post H
Objectives: The results from the recent Targeted Temperature Management trial raised the question whether cooling or merely the avoidance of fever mediates better neurologic outcome in resuscitated patients. As temperature per se is a major determinant of cardiac function, we characterized the effects of hyperthermia (40.5°C), normothermia (38.0°C), and mild hypothermia (33.0°C) on left ventricular contractile function in healthy pigs and compared them with dobutamine infusion. Design: Animal st...
Abstract
The Journal of craniofacial surgery,
Volume 27, Issue 2, 1 1 2016, Pages e175-6
Atypical Carcinoid Tumor and Chondroid and Glandular Hamartoma of the Arythenoid Region.
Sarioglu S, Akturk G, Aslier NG, Yilmaz DB, Dogan E
Neuroendocrine tumors of the head and neck are rare. Laryngeal hamartomas are even rarer especially in adult patients. Here in a 69-year-old male patient is presented who had atypical carcinoid tumor and chondroid and glandular hamartoma of the medial mucosa of the left arythenoid. To the best of our knowledge, this is the first case presenting the association of these 2 rare lesions.
Abstract
Annals of surgery,
Volume 263, Issue 3, 1 1 2016, Pages e41
Comment on "Trainee Participation Is Associated With Adverse Outcomes in Emergency General Surgery: An Analysis of the National Surgical Quality Improvement Program Database".
Graat LJ, Roukema JA, Hamming JF
Abstract
Cited 14 times since 2016 (1.5 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 67, Issue 9, 1 1 2016, Pages 1123-1124
Pulmonary Valve Replacement After Repair of Pulmonary Stenosis Compared With Tetralogy of Fallot.
Bokma JP, Winter MM, Oosterhof T, Vliegen HW, van Dijk AP, Pieper PG, Meijboom FJ, Groenink M, Mulder BJM, Bouma BJ
Abstract
Cited 360 times since 2016 (38 per year)
source: EuropePMC
Science (New York, N.Y.),
Volume 351, Issue 6278, 1 1 2016, Pages 1166-1171
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.
Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M, DerOhannessian S, Kontush A, Surendran P, Saleheen D, Trompet S, Jukema JW, De Craen A, Deloukas P, Sattar N, Ford I, Packard C, Majumder Aa, Alam DS, Di Angelantonio E, Abecasis G, Chowdhury R, Erdmann J, Nordestgaard BG, Nielsen SF, Tybjærg-Hansen A, Schmidt RF, Kuulasmaa K, Liu DJ, Perola M, Blankenberg S, Salomaa V, Männistö S, Amouyel P, Arveiler D, Ferrieres J, Müller-Nurasyid M, Ferrario M, Kee F, Willer CJ, Samani N, Schunkert H, Butterworth AS, Howson JM, Peloso GM, Stitziel NO, Danesh J, Kathiresan S, Rader DJ, CHD Exome+ Consortium, CARDIoGRAM Exome Consortium, Global Lipids Genetics Consortium
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary heart disease (CHD). Mice that have depleted Scarb1 (SR-BI knockout mice) have markedly elevated HDL-C levels but, paradoxically, increased atherosclerosis. The impact of SR-BI on HDL metabolism and CHD risk in humans remains unclear. Through targeted sequencing of coding regions of lipid-modifying gene...
Abstract
Cited 4 times since 2016 (0.4 per year)
source: EuropePMC
Journal of atrial fibrillation,
Volume 8, Issue 5, 29 5 2016, Pages 1362
Cardiac Resynchronization Therapy in Non-Ischemic Cardiomyopathy.
Shanks M, Delgado V, Bax JJ
Cardiac resynchronization therapy (CRT) is an established therapy for heart failure patients who remain symptomatic despite optimal medical therapy, have reduced left ventricular ejection fraction (120 ms), preferably with left bundle branch block morphology. The response to CRT depends on the cardiac substrate: presence of correctable left ventricular mechanical dyssynchrony, presence of myocardial fibrosis (scar) and position of the left ventricular pacing lead. Patients with non-ischemic card...
Abstract
Cited 104 times since 2016 (11 per year)
source: EuropePMC
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
Volume 16, Issue 7, 26 4 2016, Pages 2085-2096
A Randomized Controlled Trial Comparing the Efficacy of Cyp3a5 Genotype-Based With Body-Weight-Based Tacrolimus Dosing After Living Donor Kidney Transplantation.
Shuker N, Bouamar R, van Schaik RH, Clahsen-van Groningen MC, Damman J, Baan CC, van de Wetering J, Rowshani AT, Weimar W, van Gelder T, Hesselink DA
Patients expressing the cytochrome P450 (CYP) 3A5 gene require a higher tacrolimus dose to achieve therapeutic exposure compared with nonexpressers. This randomized-controlled study investigated whether adaptation of the tacrolimus starting dose according to CYP3A5 genotype increases the proportion of kidney transplant recipients being within the target tacrolimus predose concentration range (10-15 ng/mL) at first steady-state. Two hundred forty living-donor, renal transplant recipients were ass...
Abstract
Cited 16 times since 2016 (1.7 per year)
source: EuropePMC
Interactive cardiovascular and thoracic surgery,
Volume 22, Issue 6, 25 4 2016, Pages 817-825
Is the Lecompte technique the last word on transposition of the great arteries repair for all patients? A magnetic resonance imaging study including a spiral technique two decades postoperatively.
Rickers C, Kheradvar A, Sievers HH, Falahatpisheh A, Wegner P, Gabbert D, Jerosch-Herold M, Hart C, Voges I, Putman LM, Kristo I, Fischer G, Scheewe J, Kramer HH
Objectives: To compare the Lecompte technique and the spiral anastomosis (complete anatomic correction) two decades after arterial switch operation (ASO). Methods: Nine patients after primary ASO with Lecompte and 6 selected patients after spiral anastomosis were evaluated 20.8 ± 2.1 years after ASO versus matched controls. Blood flow dynamics and flow profiles (e.g. vorticity, helicity) in the great arteries were quantified from time-resolved 3D magnetic resonance imaging (MRI) phase contrast f...
Abstract
Cited 57 times since 2016 (6 per year)
source: EuropePMC
Genome research,
Volume 26, Issue 4, 25 4 2016, Pages 417-426
Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck.
Li M, Rothwell R, Vermaat M, Wachsmuth M, Schröder R, Laros JF, van Oven M, de Bakker PI, Bovenberg JA, van Duijn CM, van Ommen GJ, Slagboom PE, Swertz MA, Wijmenga C, Genome of Netherlands Consortium, Kayser M, Boomsma DI, Zöllner S, de Knijff P, Stoneking M
Although previous studies have documented a bottleneck in the transmission of mtDNA genomes from mothers to offspring, several aspects remain unclear, including the size and nature of the bottleneck. Here, we analyze the dynamics of mtDNA heteroplasmy transmission in the Genomes of the Netherlands (GoNL) data, which consists of complete mtDNA genome sequences from 228 trios, eight dizygotic (DZ) twin quartets, and 10 monozygotic (MZ) twin quartets. Using a minor allele frequency (MAF) threshold...
Abstract
Cited 25 times since 2016 (2.6 per year)
source: EuropePMC
Journal of human evolution,
Volume 92, 24 4 2016, Pages 91-100
Life history, cognition and the evolution of complex foraging niches.
Schuppli C, Graber SM, Isler K, van Schaik CP
Animal species that live in complex foraging niches have, in general, improved access to energy-rich and seasonally stable food sources. Because human food procurement is uniquely complex, we ask here which conditions may have allowed species to evolve into such complex foraging niches, and also how niche complexity is related to relative brain size. To do so, we divided niche complexity into a knowledge-learning and a motor-learning dimension. Using a sample of 78 primate and 65 carnivoran spec...
Abstract
Cited 27 times since 2016 (2.8 per year)
source: EuropePMC
BMC neurology,
Volume 16, 24 4 2016, Pages 25
Pain management strategies for neuropathic pain in Fabry disease--a systematic review.
Schuller Y, Linthorst GE, Hollak CE, Van Schaik IN, Biegstraaten M
Background: Neuropathic pain is one of the key features of (classical) Fabry disease (FD). No randomized clinical trials comparing effectiveness of different pain management strategies have been performed. This review aims to give an overview of existing pain management strategies. Methods: PubMed and Embase were searched up to September 2014 for relevant articles on treatment of neuropathic pain in FD. Results: Seven-hundred-thirty-one articles were identified of which 26 were included in the a...
Abstract
Cited 9 times since 2016 (0.9 per year)
source: EuropePMC
Journal of theoretical biology,
Volume 396, 23 4 2016, Pages 53-62
The impact of host metapopulation structure on the population genetics of colonizing bacteria.
Numminen E, Gutmann M, Shubin M, Marttinen P, Méric G, van Schaik W, Coque TM, Baquero F, Willems RJ, Sheppard SK, Feil EJ, Hanage WP, Corander J
Many key bacterial pathogens are frequently carried asymptomatically, and the emergence and spread of these opportunistic pathogens can be driven, or mitigated, via demographic changes within the host population. These inter-host transmission dynamics combine with basic evolutionary parameters such as rates of mutation and recombination, population size and selection, to shape the genetic diversity within bacterial populations. Whilst many studies have focused on how molecular processes underpin...
Abstract
Revista espanola de cardiologia (English ed.),
Volume 69, Issue 4, 23 4 2016, Pages 460-461
Could Descending Septal Artery Be Another Variant of the Dual Left Anterior Descending Artery? Response.
Montero-Cabezas JM, Delgado V, Karalis I, Schalij MJ
Abstract
Cited 10 times since 2016 (1.1 per year)
source: EuropePMC
Journal of internal medicine,
Volume 279, Issue 6, 23 4 2016, Pages 592-605
Heat-killed Staphylococcus aureus reduces atherosclerosis by inducing anti-inflammatory macrophages.
Frodermann V, van Duijn J, van Puijvelde GH, van Santbrink PJ, Lagraauw HM, de Vries MR, Quax PH, Bot I, Foks AC, de Jager SC, Kuiper J
Background: Staphylococcus aureus cell wall components can induce IL-10 responses by immune cells, which may be atheroprotective. Therefore, in this study, we investigated whether heat-killed S. aureus (HK-SA) could inhibit the development of atherosclerosis. Methods: Atherosclerosis-susceptible LDL receptor-deficient mice were administered intraperitoneal HK-SA twice weekly and fed a Western-type diet for 6 weeks. Results: HK-SA administration resulted in a 1.6-fold increase in IL-10 production...
Abstract
Cited 100 times since 2016 (10.5 per year)
source: EuropePMC
Cardiovascular research,
Volume 110, Issue 1, 23 4 2016, Pages 6-22
The multifactorial nature of microRNAs in vascular remodelling.
Welten SM, Goossens EA, Quax PH, Nossent AY
Vascular remodelling is a multifactorial process that involves both adaptive and maladaptive changes of the vessel wall through, among others, cell proliferation and migration, but also apoptosis and necrosis of the various cell types in the vessel wall. Vascular remodelling can be beneficial, e.g. during neovascularization after ischaemia, as well as pathological, e.g. during atherosclerosis and aneurysm formation. In recent years, it has become clear that microRNAs are able to target many gene...
Abstract
Cited 27 times since 2016 (2.8 per year)
source: EuropePMC
European heart journal,
Volume 37, Issue 47, 22 4 2016, Pages 3536-3543
The 200th anniversary of the stethoscope: Can this low-tech device survive in the high-tech 21st century?
Bank I, Vliegen HW, Bruschke AV
In 1816, Laennec discovered that auscultation of the heart and lungs could effectively be performed by placing a hollow cylinder (initially made of a roll of paper) between the chest of the patient and the ear of the examiner. This was the first step in the development of the stethoscope, which was a breakthrough in the diagnosis and management of cardiac and pulmonary patients. Technical improvements of the stethoscope followed and in cardiac patients auscultation soon became a major diagnostic...
Abstract
