9618 results
Cited 1 times since 2015 (0.1 per year)
source: EuropePMC
BMC genomics,
Volume 16, Issue 1, 15 3 2015, Pages 689
Erratum to: Investigating the mobilome in clinically important lineages of Enterococcus faecium and Enterococcus faecalis.
Mikalsen T, Pedersen T, Willems R, Coque TM, Werner G, Sadowy E, van Schaik W, Jensen LB, Francia MV, Sundsfjord A, Hegstad K
Abstract
The Journal of hand surgery, European volume,
Volume 41, Issue 7, 14 2 2015, Pages 776-777
The use of single photon emission computed tomography/computed tomography to differentiate between pain arising from trapeziometacarpal joint and scaphotrapeziotrapezoid joint osteoarthritis.
van Rijn SF, de Vries MR, Kraan GA
Abstract
Cited 10 times since 2015 (1 per year)
source: EuropePMC
PloS one,
Volume 10, Issue 9, 14 2 2015, Pages e0136699
Surfactant Protein D Binds to Coxiella burnetii and Results in a Decrease in Interactions with Murine Alveolar Macrophages.
Soltysiak KA, van Schaik EJ, Samuel JE
Coxiella burnetii is a Gram-negative, obligate intracellular bacterium and the causative agent of Q fever. Infections are usually acquired after inhalation of contaminated particles, where C. burnetii infects its cellular target cells, alveolar macrophages. Respiratory pathogens encounter the C-type lectin surfactant protein D (SP-D) during the course of natural infection. SP-D is a component of the innate immune response in the lungs and other mucosal surfaces. Many Gram-negative pulmonary path...
Abstract
Cited 13 times since 2015 (1.3 per year)
source: EuropePMC
International journal of cardiology,
Volume 202, 14 2 2015, Pages 246-251
Release of growth-differentiation factor 15 and associations with cardiac function in adult patients with congenital heart disease.
Eindhoven JA, van den Bosch AE, Oemrawsingh RM, Baggen VJ, Kardys I, Cuypers JA, Witsenburg M, van Schaik RH, Roos-Hesselink JW, Boersma E
Background: Growth-differentiation factor-15 (GDF-15), a cytokine with broad cardiac and non-cardiac activity, has diagnostic and prognostic value in various diseases, including heart failure. We aimed to investigate the release of GDF-15 in adults with congenital heart disease (ConHD), and assess the association with cardiac function and functional capacity. Methods: A total of 587 consecutive adults with ConHD (median age 33 [IQR 25-41] years, 59% men, and 90% NYHA I) underwent electrocardiogr...
Abstract
Cited 21 times since 2015 (2.1 per year)
source: EuropePMC
Journal of dairy science,
Volume 98, Issue 11, 9 2 2015, Pages 7699-7716
Evaluation of the epidemiological and economic consequences of control scenarios for bovine viral diarrhea virus in dairy herds.
Santman-Berends IM, Mars MH, van Duijn L, van Schaik G
Bovine viral diarrhea virus (BVDV) is an important endemic infection. However, no information was available on whether it would be economically beneficial to implement a national control program in the Netherlands. Therefore, a stochastic simulation model was developed in which control scenarios were added to compare the epidemiological and economic consequences of BVDV control in Dutch dairy herds in the next 10 yr. In the epidemiological part of the model, herds could be classified as suscepti...
Abstract
Cited 13 times since 2015 (1.3 per year)
source: EuropePMC
Chemistry (Weinheim an der Bergstrasse, Germany),
Volume 21, Issue 44, 8 2 2015, Pages 15676-15685
Ring-Closing and Cross-Metathesis with Artificial Metalloenzymes Created by Covalent Active Site-Directed Hybridization of a Lipase.
Basauri-Molina M, Verhoeven DG, van Schaik AJ, Kleijn H, Klein Gebbink RJ
A series of Grubbs-type catalysts that contain lipase-inhibiting phosphoester functionalities have been synthesized and reacted with the lipase cutinase, which leads to artificial metalloenzymes for olefin metathesis. The resulting hybrids comprise the organometallic fragment that is covalently bound to the active amino acid residue of the enzyme host in an orthogonal orientation. Differences in reactivity as well as accessibility of the active site by the functionalized inhibitor became evident...
Abstract
Cited 9 times since 2015 (0.9 per year)
source: EuropePMC
Injury,
Volume 47, Issue 1, 8 2 2015, Pages 94-98
Combat related vascular injuries: Dutch experiences from a role 2 MTF in Afghanistan.
van Dongen TT, Idenburg FJ, Tan EC, Rasmussen TE, Hamming JF, Leenen LP, Hoencamp R
Background: In a combat environment, major vascular trauma endures as the leading cause of death. The Dutch role 2 Medical Treatment Facility (MTF), provided supportive care during the mission in Uruzgan, Afghanistan. Aim of this study was to conduct detailed analysis of the admitted major haemorrhages (vascular injuries) and to compare our findings with NATO coalition partners. Methods: Retrospective, descriptive study. Participants eligible for this study came from the role 2 MTF admission dat...
Abstract
Cited 12 times since 2015 (1.2 per year)
source: EuropePMC
The pharmacogenomics journal,
Volume 16, Issue 6, 8 2 2015, Pages 519-524
Role of genetic variation in docetaxel-induced neutropenia and pharmacokinetics.
Nieuweboer AJ, Smid M, de Graan AM, Elbouazzaoui S, de Bruijn P, Eskens FA, Hamberg P, Martens JW, Sparreboom A, de Wit R, van Schaik RH, Mathijssen RH
Docetaxel is used for treatment of several solid malignancies. In this study, we aimed for predicting docetaxel clearance and docetaxel-induced neutropenia by developing several genetic models. Therefore, pharmacokinetic data and absolute neutrophil counts (ANCs) of 213 docetaxel-treated cancer patients were collected. Next, patients were genotyped for 1936 single nucleotide polymorphisms (SNPs) in 225 genes using the drug-metabolizing enzymes and transporters platform and thereafter split into...
Abstract
Cited 1759 times since 2015 (176.8 per year)
source: EuropePMC
Nature genetics,
Volume 47, Issue 10, 7 1 2015, Pages 1121-1130
A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
Nikpay M, Goel A, Won HH, Hall LM, Willenborg C, Kanoni S, Saleheen D, Kyriakou T, Nelson CP, Hopewell JC, Webb TR, Zeng L, Dehghan A, Alver M, Armasu SM, Auro K, Bjonnes A, Chasman DI, Chen S, Ford I, Franceschini N, Gieger C, Grace C, Gustafsson S, Huang J, Hwang SJ, Kim YK, Kleber ME, Lau KW, Lu X, Lu Y, Lyytikäinen LP, Mihailov E, Morrison AC, Pervjakova N, Qu L, Rose LM, Salfati E, Saxena R, Scholz M, Smith AV, Tikkanen E, Uitterlinden A, Yang X, Zhang W, Zhao W, de Andrade M, de Vries PS, van Zuydam NR, Anand SS, Bertram L, Beutner F, Dedoussis G, Frossard P, Gauguier D, Goodall AH, Gottesman O, Haber M, Han BG, Huang J, Jalilzadeh S, Kessler T, König IR, Lannfelt L, Lieb W, Lind L, Lindgren CM, Lokki ML, Magnusson PK, Mallick NH, Mehra N, Meitinger T, Memon FU, Morris AP, Nieminen MS, Pedersen NL, Peters A, Rallidis LS, Rasheed A, Samuel M, Shah SH, Sinisalo J, Stirrups KE, Trompet S, Wang L, Zaman KS, Ardissino D, Boerwinkle E, Borecki IB, Bottinger EP, Buring JE, Chambers JC, Collins R, Cupples LA, D
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of ∼185,000 CAD cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 million low-frequency (0.005 < MAF < 0.05) variants. In addition to confirming most known CAD-associated loci, we id...
Abstract
Cited 70 times since 2015 (7 per year)
source: EuropePMC
American journal of physiology. Heart and circulatory physiology,
Volume 309, Issue 9, 4 1 2015, Pages H1407-18
A porcine model of hypertensive cardiomyopathy: implications for heart failure with preserved ejection fraction.
Schwarzl M, Hamdani N, Seiler S, Alogna A, Manninger M, Reilly S, Zirngast B, Kirsch A, Steendijk P, Verderber J, Zweiker D, Eller P, Höfler G, Schauer S, Eller K, Maechler H, Pieske BM, Linke WA, Casadei B, Post H
Heart failure with preserved ejection fraction (HFPEF) evolves with the accumulation of risk factors. Relevant animal models to identify potential therapeutic targets and to test novel therapies for HFPEF are missing. We induced hypertension and hyperlipidemia in landrace pigs (n = 8) by deoxycorticosteroneacetate (DOCA, 100 mg/kg, 90-day-release subcutaneous depot) and a Western diet (WD) containing high amounts of salt, fat, cholesterol, and sugar for 12 wk. Compared with weight-matched contro...
Abstract
Cited 24 times since 2015 (2.4 per year)
source: EuropePMC
Journal of lipid research,
Volume 56, Issue 11, 4 1 2015, Pages 2085-2093
Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9.
van der Tuin SJ, Kühnast S, Berbée JF, Verschuren L, Pieterman EJ, Havekes LM, van der Hoorn JW, Rensen PC, Jukema JW, Princen HM, Willems van Dijk K, Wang Y
Recently, we showed in APOE*3-Leiden cholesteryl ester transfer protein (E3L.CETP) mice that anacetrapib attenuated atherosclerosis development by reducing (V)LDL cholesterol [(V)LDL-C] rather than by raising HDL cholesterol. Here, we investigated the mechanism by which anacetrapib reduces (V)LDL-C and whether this effect was dependent on the inhibition of CETP. E3L.CETP mice were fed a Western-type diet alone or supplemented with anacetrapib (30 mg/kg body weight per day). Microarray analyses o...
Abstract
Cited 18 times since 2015 (1.8 per year)
source: EuropePMC
PloS one,
Volume 10, Issue 9, 2 1 2015, Pages e0137035
Circulating MicroRNAs Characterizing Patients with Insufficient Coronary Collateral Artery Function.
Hakimzadeh N, Nossent AY, van der Laan AM, Schirmer SH, de Ronde MW, Pinto-Sietsma SJ, van Royen N, Quax PH, Hoefer IE, Piek JJ
Background: Coronary collateral arteries function as natural bypasses in the event of coronary obstruction. The degree of collateral network development significantly impacts the outcome of patients after an acute myocardial infarction (AMI). MicroRNAs (miRNAs, miRs) have arisen as biomarkers to identify heterogeneous patients, as well as new therapeutic targets in cardiovascular disease. We sought to identify miRNAs that are differentially expressed in chronic total occlusion (CTO) patients wit...
Abstract
Cited 6 times since 2015 (0.6 per year)
source: EuropePMC
Frontiers in neuroscience,
Volume 9, 2 1 2015, Pages 309
Sound stream segregation: a neuromorphic approach to solve the "cocktail party problem" in real-time.
Thakur CS, Wang RM, Afshar S, Hamilton TJ, Tapson JC, Shamma SA, van Schaik A
The human auditory system has the ability to segregate complex auditory scenes into a foreground component and a background, allowing us to listen to specific speech sounds from a mixture of sounds. Selective attention plays a crucial role in this process, colloquially known as the "cocktail party effect." It has not been possible to build a machine that can emulate this human ability in real-time. Here, we have developed a framework for the implementation of a neuromorphic sound segre...
Abstract
Cited 7 times since 2015 (0.7 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 23, Issue 10, 1 1 2015, Pages 493-501
Coupling between MRI-assessed regional aortic pulse wave velocity and diameters in patients with thoracic aortic aneurysm: a feasibility study.
Kröner ESJ, Westenberg JJM, Kroft LJM, Brouwer NJ, van den Boogaard PJ, Scholte AJHA
Aims: Thoracic aortic aneurysm (TAA) is potentially life-threatening and requires close follow-up to prevent aortic dissection. Aortic stiffness and size are considered to be coupled. Regional aortic stiffness in patients with TAA is unknown. We aimed to evaluate coupling between regional pulse wave velocity (PWV), a marker of vascular stiffness, and aortic diameter in TAA patients. Methods: In 40 TAA patients (59 ± 13 years, 28 male), regional aortic diameters and regional PWV were assessed by...
Abstract
Cited 11 times since 2015 (1.1 per year)
source: EuropePMC
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
Volume 26, Issue 6, 1 1 2015, Pages 613-620
Fibrinogen reduction and coagulation in cardiac surgery: an investigational study.
Gielen CL, Grimbergen J, Klautz RJ, Koopman J, Quax PH
Fibrinogen as precursor of fibrin plays an essential role in clot formation. There are three main mechanisms associated with a reduction in fibrinogen concentration during cardiac surgery: hemodilution, consumption, and degradation. Moreover, early fibrinogen degradation products (FgDPs) can interfere with normal fibrin formation of intact fibrinogen. The aim of this study was to determine the relative contributions of hemodilution, consumption, and degradation to fibrinogen loss in cardiac surg...
Abstract
Cited 13 times since 2015 (1.3 per year)
source: EuropePMC
Journal of orthopaedic trauma,
Volume 29, Issue 9, 1 1 2015, Pages e285-92
Implant Removal After Internal Fixation of a Femoral Neck Fracture: Effects on Physical Functioning.
Zielinski SM, Heetveld MJ, Bhandari M, Patka P, Van Lieshout EM, FAITH Trial Investigators
Objectives: The effect of implant removal after internal fixation of a femoral neck fracture on physical functioning was analyzed. Characteristics of patients who had their implant removed were studied, as it is currently unknown from which type of patients implants are removed and what effect removal has on function. Design: Secondary cohort study alongside a randomized controlled trial. Setting: Multicenter study in 14 hospitals. Patients and intervention: Patients who had their implant remove...
Abstract
Cited 10 times since 2015 (1 per year)
source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
Volume 11 Suppl W, 1 1 2015, Pages W123-7
The tricuspid valve and the right heart: anatomical, pathological and imaging specifications.
van Rosendael PJ, Delgado V, Bax JJ
Transcatheter tricuspid valve repair/replacement is an emerging therapy for patients with symptomatic severe tricuspid regurgitation who are deemed inoperable. Accurate knowledge of the anatomy of the tricuspid valve and right ventricle is key to developing transcatheter techniques. In addition, it is important to understand the mechanistic concept of transcatheter tricuspid valve repair/replacement in order to select the patients who may benefit from it. The severity and mechanism of tricuspid...
Abstract
Cited 30 times since 2015 (3 per year)
source: EuropePMC
Journal of the peripheral nervous system : JPNS,
Volume 20, Issue 3, 1 1 2015, Pages 289-295
Impairment measures versus inflammatory RODS in GBS and CIDP: a responsiveness comparison.
Vanhoutte EK, Draak TH, Gorson KC, van Nes SI, Hoeijmakers JG, Van der Pol WL, Notermans NC, Lewis RA, Nobile-Orazio E, Léger JM, Van den Bergh PY, Lauria G, Bril V, Katzberg H, Lunn MP, Pouget J, van der Kooi AJ, Hahn AF, van Doorn PA, Cornblath DR, van den Berg LH, Faber CG, Merkies IS, PeriNomS Study Group
This study aimed to 'define responder' through the concept of minimum clinically important differences using the individually obtained standard errors (MCID-SE) and a heuristic 'external criterion' responsiveness method in patients with Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). One hundred and fourteen newly diagnosed or relapsing patients (GBS: 55, CIDP: 59) were serially examined (1-year follow-up). The inflammatory...
Abstract
Cited 7 times since 2015 (0.7 per year)
source: EuropePMC
Journal of the peripheral nervous system : JPNS,
Volume 20, Issue 3, 1 1 2015, Pages 306-318
Outcome measures in MMN revisited: further improvement needed.
Pruppers MH, Draak TH, Vanhoutte EK, Van der Pol WL, Gorson KC, Léger JM, Nobile-Orazio E, Lewis RA, van den Berg LH, Faber CG, Merkies IS, PeriNomS study group
The objectives of this study were to provide an overview of the outcome measures (OMs) applied in clinical trials in multifocal motor neuropathy (MMN) and to determine the responsiveness of a core set of selected OMs as part of the peripheral neuropathy outcome measures standardization (PeriNomS) study. The following OMs were serially applied in 26 patients with newly diagnosed or relapsing MMN, receiving intravenous immunoglobulin (assessments: T0/T3/T12 months): 14 muscle pairs MRC (Medical Re...
Abstract
Cited 25 times since 2015 (2.5 per year)
source: EuropePMC
Journal of the peripheral nervous system : JPNS,
Volume 20, Issue 3, 1 1 2015, Pages 269-276
Grip strength comparison in immune-mediated neuropathies: Vigorimeter vs. Jamar.
Draak TH, Pruppers MH, van Nes SI, Vanhoutte EK, Bakkers M, Gorson KC, Van der Pol WL, Lewis RA, Notermans NC, Nobile-Orazio E, Léger JM, Van den Bergh PY, Lauria G, Bril V, Katzberg H, Lunn MP, Pouget J, van der Kooi AJ, van den Berg LH, van Doorn PA, Cornblath DR, Hahn AF, Faber CG, Merkies IS, PeriNomS study group
The Jamar dynamometer and Vigorimeter have been used to assess grip strength in immune-mediated neuropathies, but have never been compared to each other. Therefore, we performed a comparison study between these two devices in patients with immune-mediated neuropathies. Grip strength data were collected in 102 cross-sectional stable and 163 longitudinal (new diagnoses or changing condition) patients with Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CID...
Abstract
