Research

Publications

Below you can find a list of our published research.

9618 results

Cited 125 times since 2015 (12.3 per year) source: EuropePMC

Nature, Volume 523, Issue 7561, 1 1 2015, Pages 459-462 Directional dominance on stature and cognition in diverse human populations. Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C, Smith AV, Zhang W, Okada Y, Stančáková A, Faul JD, Zhao W, Bartz TM, Concas MP, Franceschini N, Enroth S, Vitart V, Trompet S, Guo X, Chasman DI, O'Connel JR, Corre T, Nongmaithem SS, Chen Y, Mangino M, Ruggiero D, Traglia M, Farmaki AE, Kacprowski T, Bjonnes A, van der Spek A, Wu Y, Giri AK, Yanek LR, Wang L, Hofer E, Rietveld CA, McLeod O, Cornelis MC, Pattaro C, Verweij N, Baumbach C, Abdellaoui A, Warren HR, Vuckovic D, Mei H, Bouchard C, Perry JRB, Cappellani S, Mirza SS, Benton MC, Broeckel U, Medland SE, Lind PA, Malerba G, Drong A, Yengo L, Bielak LF, Zhi D, van der Most PJ, Shriner D, Mägi R, Hemani G, Karaderi T, Wang Z, Liu T, Demuth I, Zhao JH, Meng W, Lataniotis L, van der Laan SW, Bradfield JP, Wood AR, Bonnefond A, Ahluwalia TS, Hall LM, Salvi E, Yazar S, Carstensen L, de Haan HG, Abney M, Afzal U, Allison MA, Amin N, Asselbergs FW, Bakker SJL, Barr RG, Baumeister SE, Benjamin DJ, Bergmann S, Boerwinkle E, Bott

Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferr... Abstract

Cited 1 times since 2015 (0.1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 23, Issue 7-8, 1 1 2015, Pages 366-367 Acute pontine infarction after percutaneous coronary intervention: a very rare but devastating complication. Arslan F, Mair J, Franz WM, Otten M, van Lelyveld L

A 64-year-old man suffering from an acute posterior wall myocardial infarction underwent primary percutaneous coronary intervention. After several aspiration attempts, tirofiban infusion and pre- and post-dilatation, a bare-metal stent was successfully implanted in the culprit right coronary artery. While the patient did not show any neurological symptoms before or during the procedure, he exhibited hemiplegia and loss of spontaneous speech. Additional magnetic resonance imaging showed an extens... Abstract

Cited 17 times since 2015 (1.7 per year) source: EuropePMC

PloS one, Volume 10, Issue 6, 26 4 2015, Pages e0129899 Assessment of Myocardial Fibrosis in Mice Using a T2*-Weighted 3D Radial Magnetic Resonance Imaging Sequence. van Nierop BJ, Bax NA, Nelissen JL, Arslan F, Motaal AG, de Graaf L, Zwanenburg JJ, Luijten PR, Nicolay K, Strijkers GJ

Background: Myocardial fibrosis is a common hallmark of many diseases of the heart. Late gadolinium enhanced MRI is a powerful tool to image replacement fibrosis after myocardial infarction (MI). Interstitial fibrosis can be assessed indirectly from an extracellular volume fraction measurement using contrast-enhanced T1 mapping. Detection of short T2* species resulting from fibrotic tissue may provide an attractive non-contrast-enhanced alternative to directly visualize the presence of both repl... Abstract

Cited 39 times since 2015 (3.8 per year) source: EuropePMC

American journal of primatology, Volume 77, Issue 10, 26 4 2015, Pages 1109-1121 Contrasting responses to novelty by wild and captive orangutans. Forss SI, Schuppli C, Haiden D, Zweifel N, van Schaik CP

Several studies have suggested that wild primates tend to behave with caution toward novelty, whereas captive primates are thought to be less neophobic, more exploratory, and more innovative. However, few studies have systematically compared captive and wild individuals of the same species to document this "captivity effect" in greater detail. Here we report the responses of both wild and captive orangutans to the same novel items. Novel objects were presented to wild orangutans on mul... Abstract

Cited 54 times since 2015 (5.3 per year) source: EuropePMC

Clinical immunology (Orlando, Fla.), Volume 161, Issue 2, 25 4 2015, Pages 316-323 STK4 (MST1) deficiency in two siblings with autoimmune cytopenias: A novel mutation. Halacli SO, Ayvaz DC, Sun-Tan C, Erman B, Uz E, Yilmaz DY, Ozgul K, Tezcan İ, Sanal O

Combined immunodeficiencies (CIDs) are heterogeneous group of disorders characterized by abrogated/impaired T cell development and/or functions that resulted from diverse genetic defects. In addition to the susceptibility to infections with various microorganisms, the patients may have lymphoproliferation, autoimmunity, inflammation, allergy and malignancy. Recently, three groups have independently reported patients having mutations in STK4 gene that cause a novel autosomal recessive (AR) CID. W... Abstract

Cited 2 times since 2015 (0.2 per year) source: EuropePMC

Cardiovascular and interventional radiology, Volume 38, Issue 6, 24 4 2015, Pages 1674-1675 Testicular Embolism After Endovascular Aneurysm Repair: A Rare Complication of Endovascular Repair of Abdominal Aortic Aneurysms. Vervoort M, Hoencamp R, Eefting D

Abstract

Cited 11 times since 2015 (1.1 per year) source: EuropePMC

Diabetic medicine : a journal of the British Diabetic Association, Volume 32, Issue 12, 15 3 2015, Pages 1580-1587 Policy evaluation in diabetes prevention and treatment using a population-based macro simulation model: the MICADO model. van der Heijden AA, Feenstra TL, Hoogenveen RT, Niessen LW, de Bruijne MC, Dekker JM, Baan CA, Nijpels G

Aims: To test a simulation model, the MICADO model, for estimating the long-term effects of interventions in people with and without diabetes. Methods: The MICADO model includes micro- and macrovascular diseases in relation to their risk factors. The strengths of this model are its population scope and the possibility to assess parameter uncertainty using probabilistic sensitivity analyses. Outcomes include incidence and prevalence of complications, quality of life, costs and cost-effectiveness.... Abstract

Cited 30 times since 2015 (2.9 per year) source: EuropePMC

Immunobiology, Volume 220, Issue 11, 10 2 2015, Pages 1219-1226 Overexpressions of hBD-2, hBD-3, and hCAP18/LL-37 in Gingiva of Diabetics with Periodontitis. Yılmaz D, Güncü GN, Könönen E, Barış E, Çağlayan F, Gursoy UK

Antimicrobial peptides of the epithelium play a significant role in the innate immune response in the oral cavity, which is constantly exposed to microbes. Type 2 diabetes mellitus (T2DM) is a highly prevalent metabolic disease which is related to periodontal disease. To date, little is known about expressions of antimicrobial peptides in gingival epithelia of diabetics. Our aim was to examine the expression and localization of human beta-defensins (hBD)-2 and -3 and cathelicidin (hCAP18/LL-37)... Abstract

Cited 50 times since 2015 (4.9 per year) source: EuropePMC

PloS one, Volume 10, Issue 6, 10 2 2015, Pages e0126946 A Paleolatitude Calculator for Paleoclimate Studies. van Hinsbergen DJ, de Groot LV, van Schaik SJ, Spakman W, Bijl PK, Sluijs A, Langereis CG, Brinkhuis H

Realistic appraisal of paleoclimatic information obtained from a particular location requires accurate knowledge of its paleolatitude defined relative to the Earth's spin-axis. This is crucial to, among others, correctly assess the amount of solar energy received at a location at the moment of sediment deposition. The paleolatitude of an arbitrary location can in principle be reconstructed from tectonic plate reconstructions that (1) restore the relative motions between plates based on (mar... Abstract

Cited 37 times since 2015 (3.6 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 17, Issue 1, 9 2 2015, Pages 96-105 Tricuspid valve remodelling in functional tricuspid regurgitation: multidetector row computed tomography insights. van Rosendael PJ, Joyce E, Katsanos S, Debonnaire P, Kamperidis V, van der Kley F, Schalij MJ, Bax JJ, Ajmone Marsan N, Delgado V

Aims: Multidetector row computed tomography (MDCT) may help to understand the underlying mechanisms of functional tricuspid regurgitation (TR), a highly prevalent valve disease with novel transcatheter therapies under development. The purpose of the present study was to assess the geometrical changes of the tricuspid valve in patients with functional TR using MDCT and to correlate these changes with the TR grade assessed with echocardiography. Methods and results: In 114 patients undergoing tran... Abstract

Cited 22 times since 2015 (2.2 per year) source: EuropePMC

Breast cancer research and treatment, Volume 152, Issue 1, 7 1 2015, Pages 119-128 Circadian variation in tamoxifen pharmacokinetics in mice and breast cancer patients. Binkhorst L, Kloth JSL, de Wit AS, de Bruijn P, Lam MH, Chaves I, Burger H, van Alphen RJ, Hamberg P, van Schaik RHN, Jager A, Koch BCP, Wiemer EAC, van Gelder T, van der Horst GTJ, Mathijssen RHJ

The anti-estrogen tamoxifen is characterized by a large variability in response, partly due to pharmacokinetic differences. We examined circadian variation in tamoxifen pharmacokinetics in mice and breast cancer patients. Pharmacokinetic analysis was performed in mice, dosed at six different times (24-h period). Tissue samples were used for mRNA expression analysis of drug-metabolizing enzymes. In patients, a cross-over study was performed. During three 24-h periods, after tamoxifen dosing at 8... Abstract

Cited 18 times since 2015 (1.8 per year) source: EuropePMC

European journal of heart failure, Volume 17, Issue 10, 4 1 2015, Pages 1042-1049 Anaemia in patients with aortic stenosis: influence on long-term prognosis. Ng AC, Kong WK, Kamperidis V, Bertini M, Antoni ML, Leung DY, Marsan NA, Delgado V, Bax JJ

Aims: The prognostic implications of anaemia in patients with aortic stenosis (AS) remain unclear. Accordingly, the present study aimed to evaluate the prognostic implications of anaemia in AS patients before and after aortic valve replacement (AVR). Methods and results: A total of 856 AS patients (age 71 ± 12 years, 60.2% male, 47.4% severe AS) were included. The mean haemoglobin (Hb) level was 13.2 ± 1.8 g/dL, and the prevalence of anaemia (Hb Abstract

Cited 45 times since 2015 (4.4 per year) source: EuropePMC

Atherosclerosis, Volume 241, Issue 2, 3 1 2015, Pages 289-296 Mast cells mediate neutrophil recruitment during atherosclerotic plaque progression. Wezel A, Lagraauw HM, van der Velden D, de Jager SC, Quax PH, Kuiper J, Bot I

Aims: Activated mast cells have been identified in the intima and perivascular tissue of human atherosclerotic plaques. As mast cells have been described to release a number of chemokines that mediate leukocyte fluxes, we propose that activated mast cells may play a pivotal role in leukocyte recruitment during atherosclerotic plaque progression. Methods and results: Systemic IgE-mediated mast cell activation in apoE(-/-)μMT mice resulted in an increase in atherosclerotic lesion size as compared... Abstract

Cited 35 times since 2015 (3.4 per year) source: EuropePMC

Atherosclerosis, Volume 241, Issue 2, 3 1 2015, Pages 547-554 Individual contributions of visceral fat and total body fat to subclinical atherosclerosis: The NEO study. Gast KB, den Heijer M, Smit JW, Widya RL, Lamb HJ, de Roos A, Jukema JW, Rosendaal FR, de Mutsert R, NEO study group

Background: Both overall and abdominal adiposity are established risk factors for cardiovascular disease. Visceral adipose tissue (VAT) and total body fat (TBF) are strongly correlated and previous studies did not make this distinction. Objective: We aimed to distinguish individual contributions of TBF, VAT, and the ratio of VAT to abdominal subcutaneous adipose tissue (VAT/SAT) to subclinical atherosclerosis in men and women. Methods: In this cross-sectional analysis of the Netherlands Epidemio... Abstract

Cited 435 times since 2015 (42.6 per year) source: EuropePMC

Clinical pharmacology and therapeutics, Volume 98, Issue 1, 3 1 2015, Pages 19-24 Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing. Birdwell KA, Decker B, Barbarino JM, Peterson JF, Stein CM, Sadee W, Wang D, Vinks AA, He Y, Swen JJ, Leeder JS, van Schaik R, Thummel KE, Klein TE, Caudle KE, MacPhee IA

Tacrolimus is the mainstay immunosuppressant drug used after solid organ and hematopoietic stem cell transplantation. Individuals who express CYP3A5 (extensive and intermediate metabolizers) generally have decreased dose-adjusted trough concentrations of tacrolimus as compared with those who are CYP3A5 nonexpressers (poor metabolizers), possibly delaying achievement of target blood concentrations. We summarize evidence from the published literature supporting this association and provide dosing... Abstract

Cited 2355 times since 2015 (230.6 per year) source: EuropePMC

The New England journal of medicine, Volume 372, Issue 25, 3 1 2015, Pages 2387-2397 Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes. Cannon CP, Blazing MA, Giugliano RP, McCagg A, White JA, Theroux P, Darius H, Lewis BS, Ophuis TO, Jukema JW, De Ferrari GM, Ruzyllo W, De Lucca P, Im K, Bohula EA, Reist C, Wiviott SD, Tershakovec AM, Musliner TA, Braunwald E, Califf RM, IMPROVE-IT Investigators

Background: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. Methods: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to... Abstract

Cited 12 times since 2015 (1.2 per year) source: EuropePMC

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, Volume 43, Issue 7, 2 1 2015, Pages 1059-1064 Do altitude and climate affect paranasal sinus volume? Selcuk OT, Erol B, Renda L, Osma U, Eyigor H, Gunsoy B, Yagci B, Yılmaz D

Objective: The aim of this study was to evaluate the effect of climate and altitude differences on the volume of paranasal sinuses and on the frequency of anatomic variations by comparing the paranasal sinus tomograms (PNSCT) of patients who were born and living in a cold, dry climate at high altitude with those of patients who were born and living on the coast at sea level in a temperate climate. We also aimed to determine differences relating to gender. Material and methods: A total of 55 PNSC... Abstract

Guang pu xue yu guang pu fen xi = Guang pu, Volume 35, Issue 6, 1 1 2015, Pages 1501-1505 Radiation Parameters of Some Potential Bioactive Compounds. Gedik Z, Tugrak M, Dastan A, Gul HI, Yilmaz D

In this study, we aimed to determine the radiation parameters of some potential bioactive compounds. 1-Aryl-3-dibenzylamino-propane-1-on hydrochloride type Mannich bases were synthesized via classical conventional heating method. Aryl part was changed as phenyl (C6H5), 4-methylphenyl (4-CH3C6H4), 4-fluorophenyl ( 4-FC6H4), 4-nitrophenyl (4-NO2C6H4), 4-chlorophenyl (4-ClC6H4), 4-bromophenyl (4-BrC6H4), and 2-thienyl (C4H3S-2-yl). Mass attenuation coefficient (μm), effective atomic number (Z(eff))... Abstract

Cited 65 times since 2015 (6.4 per year) source: EuropePMC

European heart journal, Volume 36, Issue 31, 1 1 2015, Pages 2087-2096 Low gradient severe aortic stenosis with preserved ejection fraction: reclassification of severity by fusion of Doppler and computed tomographic data. Kamperidis V, van Rosendael PJ, Katsanos S, van der Kley F, Regeer M, Al Amri I, Sianos G, Marsan NA, Delgado V, Bax JJ

Aims: Low gradient severe aortic stenosis (AS) with preserved left ventricular ejection fraction (LVEF) may be attributed to aortic valve area index (AVAi) underestimation due to the assumption of a circular shape of the left ventricular outflow tract (LVOT) with 2-dimensional echocardiography. The current study evaluated whether fusing Doppler and multidetector computed tomography (MDCT) data to calculate AVAi results in significant reclassification of inconsistently graded severe AS. Methods a... Abstract

Cited 11 times since 2015 (1.1 per year) source: EuropePMC

Journal of cardiovascular medicine (Hagerstown, Md.), Volume 16, Issue 6, 1 1 2015, Pages 465-471 B-type natriuretic peptide vs. cardiac risk scores for prediction of outcome following major orthopedic surgery. Katsanos S, Babalis D, Kafkas N, Mavrogenis A, Leong D, Parissis J, Varounis C, Makris K, van der Heijden A, Anastasiou-Nana M, Filippatos G

Aims: The clinical role of B-type natriuretic peptide (BNP) in preoperative evaluation is not clear. We designed a prospective study to investigate the predictive value of BNP in comparison with established clinical risk scores for the outcome of major orthopedic surgery. Methods: Overall 242 elderly patients [80 (74-85) years] undergoing orthopedic surgery were included. Inhospital cardiovascular events and 1-year mortality were the main endpoints. Results: In total 20 (8.3%) patients had major... Abstract