Research

Publications

Below you can find a list of our published research.

9618 results

Cited 24 times since 2015 (2.3 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 56 Suppl 4, 1 1 2015, Pages 25S-30S 123I-MIBG SPECT for Evaluation of Patients with Heart Failure. Dimitriu-Leen AC, Scholte AJ, Jacobson AF

Heart failure (HF) is characterized by activation of the sympathetic cardiac nerves. The condition of cardiac sympathetic nerves can be evaluated by (123)I-metaiodobenzylguanidine ((123)I-MIBG) imaging. Most cardiac (123)I-MIBG studies have relied on measurements from anterior planar images of the chest. However, it has become progressively more common to include SPECT imaging in clinical and research protocols. This review examines recent trends in (123)I-MIBG SPECT imaging and evidence that pr... Abstract

Cited 7 times since 2015 (0.7 per year) source: EuropePMC

The International journal of angiology : official publication of the International College of Angiology, Inc, Volume 24, Issue 2, 1 1 2015, Pages 127-132 Blood Leukocyte Count on Admission Predicts Cardiovascular Events in Patients with Acute Non-ST Elevation Myocardial Infarction. Dharma S, Hapsari R, Siswanto BB, van der Laarse A, Jukema JW

We aim to test the hypothesis that blood leukocyte count adds prognostic information in patients with acute non-ST-elevation myocardial infarction (non-STEMI). A total of 585 patients with acute non-STEMI (thrombolysis in myocardial infarction risk score ≥ 3) were enrolled in this cohort retrospective study. Blood leukocyte count was measured immediately after admission in the emergency department. The composite of death, reinfarction, urgent revascularization, and stroke during hospitalization... Abstract

Cited 212 times since 2015 (20.7 per year) source: EuropePMC

Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Volume 370, Issue 1670, 1 1 2015, Pages 20140087 The human gut resistome. van Schaik W

In recent decades, the emergence and spread of antibiotic resistance among bacterial pathogens has become a major threat to public health. Bacteria can acquire antibiotic resistance genes by the mobilization and transfer of resistance genes from a donor strain. The human gut contains a densely populated microbial ecosystem, termed the gut microbiota, which offers ample opportunities for the horizontal transfer of genetic material, including antibiotic resistance genes. Recent technological advan... Abstract

Cited 1 times since 2015 (0.1 per year) source: EuropePMC

Acta orthopaedica Belgica, Volume 81, Issue 2, 1 1 2015, Pages 321-326 Evaluation of current treatment techniques for distal radius fractures amongst Belgian orthopaedic surgeons. van Schaik DE, Goorens CK, Wernaers P, Hendrickx B, Scheerlinck T, Goubau JF

This online questionnaire was initiated to investigate if a consensus on the treatment of distal radius fractures amongst orthopaedic surgeons in Belgium exist. Two cases were presented: an extra-articular fracture, with dorsal displacement (Frykman type I) and a displaced intra-articular fracture (Frykman type VII). Treatment of choice and rationale of choice were investigated. 158 responses were collected. In case of a Frykman type I, the majority of surgeons would have performed a closed redu... Abstract

Cited 9 times since 2015 (0.9 per year) source: EuropePMC

Clinical chemistry and laboratory medicine, Volume 53, Issue 7, 1 1 2015, Pages 981-988 Is laboratory medicine ready for the era of personalized medicine? A survey addressed to laboratory directors of hospitals/academic schools of medicine in Europe. Malentacchi F, Mancini I, Brandslund I, Vermeersch P, Schwab M, Marc J, van Schaik RH, Siest G, Theodorsson E, Pazzagli M, Di Resta C, European Federation of Clinical Chemistry and Laboratory Medicine (EFLM), European Society of Pharmacogenomics and Personalised Therapy (ESPT) Joint Working Group on Personalized Laboratory Medicine (WG-PLM)

Developments in "-omics" are creating a paradigm shift in laboratory medicine leading to personalized medicine. This allows the increase in diagnostics and therapeutics focused on individuals rather than populations. In order to investigate whether laboratory medicine is ready to play a key role in the integration of personalized medicine in routine health care and set the state-of-the-art knowledge about personalized medicine and laboratory medicine in Europe, a questionnaire was cons... Abstract

Cited 3 times since 2015 (0.3 per year) source: EuropePMC

Drug metabolism and personalized therapy, Volume 30, Issue 2, 1 1 2015, Pages 121-128 Is laboratory medicine ready for the era of personalized medicine? A survey addressed to laboratory directors of hospitals/academic schools of medicine in Europe. Malentacchi F, Mancini I, Brandslund I, Vermeersch P, Schwab M, Marc J, van Schaik RH, Siest G, Theodorsson E, Pazzagli M, Di Resta C, European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) – European Society of Pharmacogenomics and Personalised Therapy (ESPT) Joint Working Group on Personalized Laboratory Medicine (WG-PLM)

Cited 10 times since 2015 (1 per year) source: EuropePMC

Neurocritical care, Volume 22, Issue 3, 1 1 2015, Pages 385-394 Feasibility and diagnostic accuracy of early electrophysiological recordings for ICU-acquired weakness: an observational cohort study. Wieske L, Verhamme C, Witteveen E, Bouwes A, Dettling-Ihnenfeldt DS, van der Schaaf M, Schultz MJ, van Schaik IN, Horn J

Background: An early diagnosis of ICU-acquired weakness (ICU-AW) is difficult because disorders of consciousness frequently preclude muscle strength assessment. In this study, we investigated feasibility and accuracy of electrophysiological recordings to diagnose ICU-AW early in non-awake critically ill patients. Methods: Newly admitted patients, mechanically ventilated ≥2 days and unreactive to verbal stimuli, were included in this study. Electrophysiological recordings comprised nerve conducti... Abstract

Cited 11 times since 2015 (1.1 per year) source: EuropePMC

Human nature (Hawthorne, N.Y.), Volume 26, Issue 2, 1 1 2015, Pages 143-160 Chimpanzees' Bystander Reactions to Infanticide: An Evolutionary Precursor of Social Norms? von Rohr CR, van Schaik CP, Kissling A, Burkart JM

Social norms-generalized expectations about how others should behave in a given context-implicitly guide human social life. However, their existence becomes explicit when they are violated because norm violations provoke negative reactions, even from personally uninvolved bystanders. To explore the evolutionary origin of human social norms, we presented chimpanzees with videos depicting a putative norm violation: unfamiliar conspecifics engaging in infanticidal attacks on an infant chimpanzee. T... Abstract

Cited 31 times since 2015 (3 per year) source: EuropePMC

Protein science : a publication of the Protein Society, Volume 24, Issue 8, 29 5 2015, Pages 1292-1300 Top-down mass spectrometry of intact membrane protein complexes reveals oligomeric state and sequence information in a single experiment. Konijnenberg A, Bannwarth L, Yilmaz D, Koçer A, Venien-Bryan C, Sobott F

Here we study the intact stoichiometry and top-down fragmentation behavior of three integral membrane proteins which were natively reconstituted into detergent micelles: the mechano-sensitive ion channel of large conductance (MscL), the Kirbac potassium channel and the p7 viroporin from the hepatitis C virus. By releasing the proteins under nondenaturing conditions inside the mass spectrometer, we obtained their oligomeric sizes. Increasing the ion activation (collision energy) causes unfolding... Abstract

Cited 39 times since 2015 (3.8 per year) source: EuropePMC

European heart journal, Volume 36, Issue 30, 25 4 2015, Pages 1983-1989 The effect of QRS duration on cardiac resynchronization therapy in patients with a narrow QRS complex: a subgroup analysis of the EchoCRT trial. Steffel J, Robertson M, Singh JP, Abraham WT, Bax JJ, Borer JS, Dickstein K, Ford I, Gorcsan J, Gras D, Krum H, Sogaard P, Holzmeister J, Brugada J, Ruschitzka F

Aims: In EchoCRT, a randomized trial evaluating the effect of cardiac resynchronization therapy (CRT) in patients with a QRS duration of Abstract

Cited 53 times since 2015 (5.2 per year) source: EuropePMC

Heart rhythm, Volume 12, Issue 10, 22 4 2015, Pages 2106-2114 Myocardial scar predicts monomorphic ventricular tachycardia but not polymorphic ventricular tachycardia or ventricular fibrillation in nonischemic dilated cardiomyopathy. Piers SR, Everaerts K, van der Geest RJ, Hazebroek MR, Siebelink HM, Pison LA, Schalij MJ, Bekkers SC, Heymans S, Zeppenfeld K

Background: The relation between myocardial scar and different types of ventricular arrhythmias in patients with nonischemic dilated cardiomyopathy (NIDCM) is unknown. Objectives: The purpose of this study was to analyze the effect of myocardial scar, assessed by late gadolinium enhancement cardiac magnetic resonance imaging (LGE-CMR), on the occurrence and type of ventricular arrhythmia in patients with NIDCM. Methods: Consecutive patients with NIDCM who underwent LGE-CMR and implantable cardio... Abstract

Cited 1 times since 2015 (0.1 per year) source: EuropePMC

World journal of experimental medicine, Volume 5, Issue 2, 20 3 2015, Pages 140-153 Barriers in contribution of human mesenchymal stem cells to murine muscle regeneration. de la Garza-Rodea AS, Boersma H, Dambrot C, de Vries AA, van Bekkum DW, Knaän-Shanzer S

Aim: To study regeneration of damaged human and murine muscle implants and the contribution of added xenogeneic mesenchymal stem cells (MSCs). Methods: Minced human or mouse skeletal muscle tissues were implanted together with human or mouse MSCs subcutaneously on the back of non-obese diabetic/severe combined immunodeficient mice. The muscle tissues (both human and murine) were minced with scalpels into small pieces (< 1 mm(3)) and aliquoted in portions of 200 mm(3). These portions were eith... Abstract

Cited 7 times since 2015 (0.7 per year) source: EuropePMC

Frontiers in neuroscience, Volume 9, 20 3 2015, Pages 180 A neuromorphic implementation of multiple spike-timing synaptic plasticity rules for large-scale neural networks. Wang RM, Hamilton TJ, Tapson JC, van Schaik A

We present a neuromorphic implementation of multiple synaptic plasticity learning rules, which include both Spike Timing Dependent Plasticity (STDP) and Spike Timing Dependent Delay Plasticity (STDDP). We present a fully digital implementation as well as a mixed-signal implementation, both of which use a novel dynamic-assignment time-multiplexing approach and support up to 2(26) (64M) synaptic plasticity elements. Rather than implementing dedicated synapses for particular types of synaptic plast... Abstract

Cited 3 times since 2015 (0.3 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 101, Issue 16, 18 3 2015, Pages 1263-1264 Diastolic dysfunction and atrial fibrillation. Delgado V, Bax JJ

Abstract

Cited 34 times since 2015 (3.3 per year) source: EuropePMC

European journal of pharmacology, Volume 763, Issue Pt A, 16 3 2015, Pages 48-63 Innovative pharmaceutical interventions in cardiovascular disease: Focusing on the contribution of non-HDL-C/LDL-C-lowering versus HDL-C-raising: A systematic review and meta-analysis of relevant preclinical studies and clinical trials. Kühnast S, Fiocco M, van der Hoorn JW, Princen HM, Jukema JW

Non-HDL-cholesterol is well recognised as a primary causal risk factor in cardiovascular disease. However, despite consistent epidemiological evidence for an inverse association between HDL-C and coronary heart disease, clinical trials aimed at raising HDL-C (AIM-HIGH, HPS2-THRIVE, dal-OUTCOMES) failed to meet their primary goals. This systematic review and meta-analysis investigated the effects of established and novel treatment strategies, specifically targeting HDL, on inhibition of atheroscl... Abstract

Cited 62 times since 2015 (6 per year) source: EuropePMC

International journal of cardiology, Volume 194, 15 3 2015, Pages 7-12 Increased aortic tortuosity indicates a more severe aortic phenotype in adults with Marfan syndrome. Franken R, El Morabit A, de Waard V, Timmermans J, Scholte AJ, van den Berg MP, Marquering H, Planken NR, Zwinderman AH, Mulder BJ, Groenink M

Background: Patients with Marfan syndrome (MFS) have a highly variable occurrence of aortic complications. Aortic tortuosity is often present in MFS and may help to identify patients at risk for aortic complications. Methods: 3D-visualization of the total aorta by MR imaging was performed in 211 adult MFS patients (28% with prior aortic root replacement) and 20 controls. A method to assess aortic tortuosity (aortic tortuosity index: ATI) was developed and reproducibility was tested. The relation... Abstract

Cited 33 times since 2015 (3.2 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 8, Issue 6, 14 2 2015, Pages 697-704 The Functional Effects of Intramural Course of Coronary Arteries and its Relation to Coronary Atherosclerosis. Uusitalo V, Saraste A, Pietilä M, Kajander S, Bax JJ, Knuuti J

Objectives: This study observed hemodynamic consequences of myocardial bridging and its relation to coronary atherosclerosis. Background: Myocardial bridging is seen as intramural course by computed tomography angiography (CTA) or systolic compression by invasive coronary angiography. Segments with myocardial bridging are in previous studies closely associated with proximal atherosclerotic plaques. Methods: We prospectively studied 100 patients 63 ± 7 years of age with intermediate likelihood of... Abstract

Cited 2 times since 2015 (0.2 per year) source: EuropePMC

Korean journal of radiology, Volume 16, Issue 3, 13 2 2015, Pages 668-672 Right ventricular cardiomyopathy meeting the arrhythmogenic right ventricular dysplasia revised criteria? Don't forget sarcoidosis! Vasaturo S, Ploeg DE, Buitrago G, Zeppenfeld K, Veselic-Charvat M, Kroft LJ

A 53-year-old woman was referred for ventricular fibrillation with resuscitation. A CT-angiography showed signs of a right ventricular enlargement without obvious cause. A cardiac MRI demonstrated a dilated and hypokinetic right ventricle with extensive late gadolinium enhancement. Arrhythmogenic right ventricular dysplasia (ARVD) was suspected according to the "revised ARVD task force criteria". An endomyocardial biopsy was inconclusive. The patient developed purulent pericarditis aft... Abstract

Cited 4 times since 2015 (0.4 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 21, Issue 2, 13 2 2015, Pages 157-162 In vitro evaluation of physiological spiral anastomoses for the arterial switch operation in simple transposition of the great arteries: a first step towards a surgical alternative? Sievers HH, Scharfschwerdt M, Putman LM

Objectives: The currently most frequently used technique for the arterial switch operation (ASO) in simple transposition of the great arteries (TGA) includes the transposition of the pulmonary artery anterior to the ascending aorta. This arterial arrangement is less anatomical, and although the initial results are excellent, some long-term data are indicating a certain risk of morbidity, encouraging the search for more physiological techniques. As a first step, we studied the feasibility of anat... Abstract

Cited 21 times since 2015 (2 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 8, Issue 4, 12 2 2015, Pages 853-862 Reassessing noninducibility as ablation endpoint of post-infarction ventricular tachycardia: the impact of left ventricular function. de Riva M, Piers SR, Kapel GF, Watanabe M, Venlet J, Trines SA, Schalij MJ, Zeppenfeld K

Background: Noninducibility is frequently used as procedural end point of ventricular tachycardia (VT) ablation after myocardial infarction. We investigated the influence of left ventricular (LV) function on the predictive value of noninducibility for VT recurrence and cardiac mortality. Methods and results: Ninety-one patients (82 men, 67±10 years) with post-myocardial infarction VT underwent ablation between 2009 and 2012. Fifty-nine (65%) had an LV ejection fraction (EF) >30% (mean 41±7) a... Abstract