Research

Publications

Below you can find a list of our published research.

9618 results

Cited 11 times since 2015 (1.1 per year) source: EuropePMC

European heart journal. Cardiovascular pharmacotherapy, Volume 1, Issue 4, 12 2 2015, Pages 232-244 Contemporary registries on P2Y12 inhibitors in patients with acute coronary syndromes in Europe: overview and methodological considerations. Jukema JW, Lettino M, Widimský P, Danchin N, Bardaji A, Barrabes JA, Cequier A, Claeys MJ, De Luca L, Dörler J, Erlinge D, Erne P, Goldstein P, Koul SM, Lemesle G, Lüscher TF, Matter CM, Montalescot G, Radovanovic D, Lopez-Sendón J, Tousek P, Weidinger F, Weston CF, Zaman A, Zeymer U, PIRAEUS group

Patient registries that document real-world clinical experience play an important role in cardiology as they complement the data from randomized controlled trials, provide valuable information on drug use and clinical outcomes, and evaluate to what extent guidelines are followed in practice. The Platelet Inhibition Registry in ACS EvalUation Study (PIRAEUS) project is an initiative of registry holders who are managing national or international registries observing patients with acute coronary sy... Abstract

Cited 60 times since 2015 (5.8 per year) source: EuropePMC

Nature communications, Volume 6, 8 2 2015, Pages 7030 Expression of the vault RNA protects cells from undergoing apoptosis. Amort M, Nachbauer B, Tuzlak S, Kieser A, Schepers A, Villunger A, Polacek N

Non-protein-coding RNAs are a functionally versatile class of transcripts exerting their biological roles on the RNA level. Recently, we demonstrated that the vault complex-associated RNAs (vtRNAs) are significantly upregulated in Epstein-Barr virus (EBV)-infected human B cells. Very little is known about the function(s) of the vtRNAs or the vault complex. Here, we individually express latent EBV-encoded proteins in B cells and identify the latent membrane protein 1 (LMP1) as trigger for vtRNA u... Abstract

Cited 25 times since 2015 (2.4 per year) source: EuropePMC

Journal of electrocardiology, Volume 48, Issue 4, 8 2 2015, Pages 463-475 Vectorcardiographic diagnostic & prognostic information derived from the 12-lead electrocardiogram: Historical review and clinical perspective. Man S, Maan AC, Schalij MJ, Swenne CA

In the course of time, electrocardiography has assumed several modalities with varying electrode numbers, electrode positions and lead systems. 12-lead electrocardiography and 3-lead vectorcardiography have become particularly popular. These modalities developed in parallel through the mid-twentieth century. In the same time interval, the physical concepts underlying electrocardiography were defined and worked out. In particular, the vector concept (heart vector, lead vector, volume conductor) a... Abstract

Cited 4 times since 2015 (0.4 per year) source: EuropePMC

Revista espanola de cardiologia (English ed.), Volume 68, Issue 6, 7 1 2015, Pages 541-543 Proximal Left Anterior Descending Artery Acute Occlusion With an Unusual Electrocardiographic Pattern: Not Everything Is ST Elevation. Montero-Cabezas JM, van-der-Kley F, Karalis I, Schalij MJ

Abstract

Cited 50 times since 2015 (4.9 per year) source: EuropePMC

Surgery, Volume 158, Issue 5, 6 1 2015, Pages 1323-1330 Intraoperative guidance in parathyroid surgery using near-infrared fluorescence imaging and low-dose Methylene Blue. Tummers QR, Schepers A, Hamming JF, Kievit J, Frangioni JV, van de Velde CJ, Vahrmeijer AL

Background: Identification of diseased and normal parathyroid glands during parathyroid surgery can be challenging. The aim of this study was to assess whether near-infrared (NIR) fluorescence imaging using administration of a low-dose Methylene Blue (MB) at the start of the operation could provide optical guidance during parathyroid surgery and assist in the detection of parathyroid adenomas. Methods: Patients diagnosed with primary hyperparathyroidism planned for parathyroidectomy were include... Abstract

Cited 40 times since 2015 (3.9 per year) source: EuropePMC

Clinical and vaccine immunology : CVI, Volume 22, Issue 7, 6 1 2015, Pages 778-788 Mycobacterium bovis BCG Vaccination Induces Divergent Proinflammatory or Regulatory T Cell Responses in Adults. Boer MC, Prins C, van Meijgaarden KE, van Dissel JT, Ottenhoff TH, Joosten SA

Mycobacterium bovis bacillus Calmette-Guérin (BCG), the only currently available vaccine against tuberculosis, induces variable protection in adults. Immune correlates of protection are lacking, and analyses on cytokine-producing T cell subsets in protected versus unprotected cohorts have yielded inconsistent results. We studied the primary T cell response, both proinflammatory and regulatory T cell responses, induced by BCG vaccination in adults. Twelve healthy adult volunteers who were tubercu... Abstract

Cited 8 times since 2015 (0.8 per year) source: EuropePMC

Drug and chemical toxicology, Volume 39, Issue 2, 5 1 2015, Pages 119-123 Anti-genotoxic effect of naringin against bleomycin-induced genomic damage in human lymphocytes in vitro. Yilmaz D, Teksoy O, Bilaloglu R, Çinkilic N

Naringin is a flavonoid found in grapefruit and other citrus fruits that shows antioxidant activity. The aim of the present study was to determine the anti-genotoxic and protective effects of naringin on the chemotherapeutic/radiomimetic agent bleomycin (BLM) in human blood lymphocyte cultures in vitro using micronucleus test and chromosomal aberrations (CA) assay. We tested the three doses of naringin (1, 2, 3 µg/mL) and a single dose of BLM (20 µg/mL). BLM significantly increased the total CAs... Abstract

Cited 14 times since 2015 (1.4 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 17, Issue 9, 2 1 2015, Pages 1383-1390 Incidence and predictors of dormant conduction after cryoballoon ablation incorporating a 30-min waiting period. Compier MG, De Riva M, Dyrda K, Zeppenfeld K, Schalij MJ, Trines SA

Aims: Electrical reconnection after pulmonary vein (PV) isolation is associated with atrial fibrillation (AF) recurrence. Reconnection may already develop within a 30 min waiting period and may only occur as dormant conduction (DC) revealed by adenosine infusion. This study determines incidence and predictors of DC after cryoballoon ablation incorporating a 30 min waiting period and the effect of treating this 'late' DC on 1 year AF-recurrence. Methods and results: Consecutive patients... Abstract

Cited 8 times since 2015 (0.8 per year) source: EuropePMC

Journal of electrocardiology, Volume 48, Issue 4, 1 1 2015, Pages 498-504 Performance of ST and ventricular gradient difference vectors in electrocardiographic detection of acute myocardial ischemia. Treskes RW, Ter Haar CC, Man S, De Jongh MC, Maan AC, Wolterbeek R, Schalij MJ, Wagner GS, Swenne CA

Introduction: Serial analysis could improve ECG diagnosis of myocardial ischemia caused by acute coronary occlusion. Methods: We analyzed ECG pairs of 84 cases and 398 controls. In case-patients, who underwent elective percutaneous coronary intervention, ischemic ECGs during balloon occlusion were compared with preceding non-ischemic ECGs. In control-patients, two elective non-ischemic ECGs were compared. In each ECG the ST vector at the J point and the ventricular gradient (VG) vector was compu... Abstract

Cited 26 times since 2015 (2.5 per year) source: EuropePMC

Atherosclerosis, Volume 241, Issue 1, 1 1 2015, Pages 55-61 HDL cholesterol, leptin and interleukin-6 predict high risk coronary anatomy assessed by CT angiography in patients with stable chest pain. Caselli C, De Graaf MA, Lorenzoni V, Rovai D, Marinelli M, Del Ry S, Giannessi D, Bax JJ, Neglia D, Scholte AJ

Objectives: Coronary computed tomography angiography (CTA) describes several features of coronary plaques, i.e. location, severity, and composition. Integrated CTA scores are able to identify individual patterns of higher risk. We sought to test whether circulating biomarkers related with metabolism and inflammation could predict high risk coronary anatomy at CTA in patients with stable chest pain. Methods: We evaluated a panel of 17 biomarkers in 429 patients (60.3 ± 0.4 years, 268 males) with... Abstract

Cited 10 times since 2015 (1 per year) source: EuropePMC

The Journal of bone and joint surgery. American volume, Volume 97, Issue 9, 1 1 2015, Pages 751-757 Reliability, validity, and responsiveness of the Western Ontario and McMaster Universities Osteoarthritis Index for elderly patients with a femoral neck fracture. Burgers PT, Poolman RW, Van Bakel TM, Tuinebreijer WE, Zielinski SM, Bhandari M, Patka P, Van Lieshout EM, HEALTH and FAITH Trial Investigators

Background: The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) has been extensively evaluated in groups of patients with osteoarthritis, yet not in patients with a femoral neck fracture. This study aimed to determine the reliability, construct validity, and responsiveness of the WOMAC compared with the Short Form-12 (SF-12) and the EuroQol 5D (EQ-5D) questionnaires for the assessment of elderly patients with a femoral neck fracture. Methods: Reliability was tested by asse... Abstract

Cited 19 times since 2015 (1.8 per year) source: EuropePMC

Cerebrovascular diseases extra, Volume 5, Issue 2, 1 1 2015, Pages 75-83 Short Door-to-Needle Times in Acute Ischemic Stroke and Prospective Identification of Its Delaying Factors. Van Schaik SM, Scott S, de Lau LM, Van den Berg-Vos RM, Kruyt ND

Background: The clinical benefit of intravenous thrombolysis (IVT) in acute ischemic stroke is time dependent. Several studies report a short median door-to-needle time (DNT; 20 min), mainly in large tertiary referral hospitals equipped with a level 1 emergency department, a dedicated stroke team available 24/7, and on-site neuroimaging facilities. Meanwhile, in daily practice, the majority of stroke patients are admitted to secondary care hospitals, and in practice, even the generous benchmark... Abstract

Cited 16 times since 2015 (1.6 per year) source: EuropePMC

Circulation. Heart failure, Volume 8, Issue 3, 29 5 2015, Pages 428-437 Regular wine consumption in chronic heart failure: impact on outcomes, quality of life, and circulating biomarkers. Cosmi F, Di Giulio P, Masson S, Finzi A, Marfisi RM, Cosmi D, Scarano M, Tognoni G, Maggioni AP, Porcu M, Boni S, Cutrupi G, Tavazzi L, Latini R, GISSI-HF Investigators

Background: Moderate, regular alcohol consumption is generally associated with a lower risk of cardiovascular events but data in patients with chronic heart failure are scarce. We evaluated the relations between wine consumption, health status, circulating biomarkers, and clinical outcomes in a large Italian population of patients with chronic heart failure enrolled in a multicenter clinical trial. Methods and results: A brief questionnaire on dietary habits was administered at baseline to 6973... Abstract

Cited 110 times since 2015 (10.7 per year) source: EuropePMC

Critical care (London, England), Volume 19, 27 4 2015, Pages 196 Impact of ICU-acquired weakness on post-ICU physical functioning: a follow-up study. Wieske L, Dettling-Ihnenfeldt DS, Verhamme C, Nollet F, van Schaik IN, Schultz MJ, Horn J, van der Schaaf M

Introduction: ICU-acquired weakness is thought to mediate physical impairments in survivors of critical illness, but few studies have investigated this thoroughly. The purpose was to investigate differences in post-ICU mortality and physical functioning between patients with and without ICU-acquired weakness at 6 months after ICU discharge. Method: ICU patients, mechanically ventilated ≥ 2 days, were included in a single-center prospective observational cohort study. ICU-acquired weakness was di... Abstract

Cited 15 times since 2015 (1.5 per year) source: EuropePMC

Advances in health sciences education : theory and practice, Volume 20, Issue 5, 26 4 2015, Pages 1325-1338 The don't know option in progress testing. Ravesloot CJ, Van der Schaaf MF, Muijtjens AM, Haaring C, Kruitwagen CL, Beek FJ, Bakker J, Van Schaik JP, Ten Cate TJ

Formula scoring (FS) is the use of a don't know option (DKO) with subtraction of points for wrong answers. Its effect on construct validity and reliability of progress test scores, is subject of discussion. Choosing a DKO may not only be affected by knowledge level, but also by risk taking tendency, and may thus introduce construct-irrelevant variance into the knowledge measurement. On the other hand, FS may result in more reliable test scores. To evaluate the impact of FS on construct vali... Abstract

Cited 11 times since 2015 (1.1 per year) source: EuropePMC

Transboundary and emerging diseases, Volume 64, Issue 1, 23 4 2015, Pages 116-120 Two Years After the Schmallenberg Virus Epidemic in the Netherlands: Does the Virus still Circulate? Veldhuis AM, Mars MH, Roos CA, van Wuyckhuise L, van Schaik G

Two years after the introduction of the Schmallenberg virus in north-western Europe, it is unknown whether the virus is still circulating in countries that were the first to be confronted with it. When the population-level immunity declines in Europe, reintroduction or the re-emergence of SBV in Europe might eventually result in an outbreak of similar magnitude of that seen in 2011-2012. The Netherlands was part of the primary outbreak region of SBV in 2011. The aim of this study was to determin... Abstract

Cited 20 times since 2015 (1.9 per year) source: EuropePMC

The Journal of general virology, Volume 96, Issue 8, 22 4 2015, Pages 2050-2060 Influenza A virus evolution and spatio-temporal dynamics in Eurasian wild birds: a phylogenetic and phylogeographical study of whole-genome sequence data. Lewis NS, Verhagen JH, Javakhishvili Z, Russell CA, Lexmond P, Westgeest KB, Bestebroer TM, Halpin RA, Lin X, Ransier A, Fedorova NB, Stockwell TB, Latorre-Margalef N, Olsen B, Smith G, Bahl J, Wentworth DE, Waldenström J, Fouchier RAM, de Graaf M

Low pathogenic avian influenza A viruses (IAVs) have a natural host reservoir in wild waterbirds and the potential to spread to other host species. Here, we investigated the evolutionary, spatial and temporal dynamics of avian IAVs in Eurasian wild birds. We used whole-genome sequences collected as part of an intensive long-term Eurasian wild bird surveillance study, and combined this genetic data with temporal and spatial information to explore the virus evolutionary dynamics. Frequent reassort... Abstract

Cited 43 times since 2015 (4.2 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 65, Issue 18, 22 4 2015, Pages 1954-1959 Predictive value of programmed ventricular stimulation after catheter ablation of post-infarction ventricular tachycardia. Yokokawa M, Kim HM, Baser K, Stevenson W, Nagashima K, Della Bella P, Vergara P, Hindricks G, Arya A, Zeppenfeld K, de Riva Silva M, Daoud EG, Kumar S, Kuck KH, Tilz R, Mathew S, Ghanbari H, Latchamsetty R, Morady F, Bogun FM

Background: A recent meta-analysis demonstrated a survival benefit in post-infarction patients whose ventricular tachycardia (VT) was rendered noninducible by catheter ablation. Furthermore, patients with noninducible VT had a lower VT recurrence rate than did patients whose VT remained inducible after ablation. Objectives: The purpose of this multicenter cohort study was to assess whether noninducibility after VT ablation is independently associated with improved survival. Methods: Data from 1,... Abstract

Cited 5 times since 2015 (0.5 per year) source: EuropePMC

IEEE transactions on biomedical circuits and systems, Volume 9, Issue 2, 22 4 2015, Pages 188-196 Turn Down That Noise: Synaptic Encoding of Afferent SNR in a Single Spiking Neuron. Afshar S, George L, Thakur CS, Tapson J, van Schaik A, de Chazal P, Hamilton TJ

We have added a simplified neuromorphic model of Spike Time Dependent Plasticity (STDP) to the previously described Synapto-dendritic Kernel Adapting Neuron (SKAN), a hardware efficient neuron model capable of learning spatio-temporal spike patterns. The resulting neuron model is the first to perform synaptic encoding of afferent signal-to-noise ratio in addition to the unsupervised learning of spatio-temporal spike patterns. The neuron model is particularly suitable for implementation in digita... Abstract

Cited 3 times since 2015 (0.3 per year) source: EuropePMC

Nature reviews. Cardiology, Volume 12, Issue 6, 21 3 2015, Pages 321-322 Genetics: Genetic risk scores--new promises for drug evaluation. Jukema JW, Trompet S

Abstract