Research

Publications

Below you can find a list of our published research.

8684 results

Cited 3 times since 2022 (0.9 per year) source: EuropePMC

European heart journal. Case reports, Volume 6, Issue 2, 16 3 2022, Pages ytac067 Case report of the broad spectrum of late complications in an adult patient with univentricular physiology palliated by the Fontan circulation. Nederend M, Egorova AD, Vliegen HW, Roest AAW, Ruijter BN, Korteweg T, Ninaber MK, Zeppenfeld K, Hazekamp MG, Kiès P, Jongbloed MRM

Background: At the most severe end of the spectrum of congenital heart disease are patients with an univentricular physiology. They comprise a heterogeneous group of congenital heart malformations that have the common characteristic that the cardiac morphology is not equipped for sustaining a biventricular circulation. Case summary: Here, we present a case of an adult patient after Fontan palliation, illustrative of the complex clinical course and the broad spectrum of complications that can be... Abstract

Cited 14 times since 2022 (4.2 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 63, Issue 3, 16 3 2022, Pages 390-399 Editor's Choice - Post-operative Surveillance and Long Term Outcome after Endovascular Aortic Aneurysm Repair in Patients with an Initial Post-operative Computed Tomography Angiogram Without Abnormalities: the Multicentre Retrospective ODYSSEUS Study. Geraedts ACM, Mulay S, Vahl AC, Verhagen HJM, Wisselink W, de Mik SML, van Dieren S, Koelemay MJW, Balm R, ODYSSEUS study group

Objective: Lifelong imaging surveillance is recommended following endovascular aneurysm repair (EVAR). This study aimed to examine the association between adherence to post-operative surveillance and survival and secondary interventions in patients with an initial post-operative computed tomography angiogram (CTA) without abnormalities. Methods: All consecutive patients undergoing EVAR for intact abdominal aortic aneurysm (AAA) in 16 hospitals between 2007 and 2012 were identified retrospectivel... Abstract

Cited 142 times since 2022 (43.1 per year) source: EuropePMC

Nature communications, Volume 13, Issue 1, 16 3 2022, Pages 893 Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial. Reyman M, van Houten MA, Watson RL, Chu MLJN, Arp K, de Waal WJ, Schiering I, Plötz FB, Willems RJL, van Schaik W, Sanders EAM, Bogaert D

Broad-spectrum antibiotics for suspected early-onset neonatal sepsis (sEONS) may have pronounced effects on gut microbiome development and selection of antimicrobial resistance when administered in the first week of life, during the assembly phase of the neonatal microbiome. Here, 147 infants born at ≥36 weeks of gestational age, requiring broad-spectrum antibiotics for treatment of sEONS in their first week of life were randomized 1:1:1 to receive three commonly prescribed intravenous antibioti... Abstract

Cited 12 times since 2022 (3.6 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 9, 15 3 2022, Pages 708298 Abutting Left Atrial Appendage and Left Superior Pulmonary Vein Predicts Recurrence of Atrial Fibrillation After Point-by-Point Pulmonary Vein Isolation. Szegedi N, Simon J, Szilveszter B, Salló Z, Herczeg S, Száraz L, Kolossváry M, Orbán G, Széplaki G, Nagy KV, Mahdiui ME, Smit JM, Delgado V, Bax JJ, Maurovich-Horvat P, Merkely B, Gellér L

Introduction: The role of the spatial relationship between the left superior pulmonary vein (LSPV) and left atrial appendage (LAA) is unknown. We sought to evaluate whether an abutting LAA and LSPV play a role in AF recurrence after catheter ablation for paroxysmal AF. Methods: Consecutive patients, who underwent initial point-by-point radiofrequency catheter ablation for paroxysmal AF at the Heart and Vascular Center of Semmelweis University, Budapest, Hungary, between January of 2014 and Decem... Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

Frontiers in physiology, Volume 12, 14 2 2022, Pages 741317 Long-Term Endurance Exercise Training Alters Repolarization in a New Rabbit Athlete's Heart Model. Kui P, Polyák A, Morvay N, Tiszlavicz L, Nagy N, Ördög B, Takács H, Leprán I, Farkas A, Papp JG, Jost N, Varró A, Baczkó I, Farkas AS

In the present study, the effect of long-term exercise training was investigated on myocardial morphological and functional remodeling and on proarrhythmic sensitivity in a rabbit athlete's heart model. New-Zealand white rabbits were trained during a 12-week long treadmill running protocol and compared with their sedentary controls. At the end of the training protocol, echocardiography, in vivo and in vitro ECG recordings, proarrhythmic sensitivity with dofetilide (nM) were performed in iso... Abstract

Cited 21 times since 2022 (6.4 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 9, 14 2 2022, Pages 820962 The Intriguing Role of TLR Accessory Molecules in Cardiovascular Health and Disease. Bezhaeva T, Karper J, Quax PHA, de Vries MR

Activation of Toll like receptors (TLR) plays an important role in cardiovascular disease development, progression and outcomes. Complex TLR mediated signaling affects vascular and cardiac function including tissue remodeling and repair. Being central components of both innate and adaptive arms of the immune system, TLRs interact as pattern recognition receptors with a series of exogenous ligands and endogenous molecules or so-called danger associated molecular patterns (DAMPs) that are released... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

Frontiers in neuroscience, Volume 16, 14 2 2022, Pages 813555 Neuromorphic Engineering Needs Closed-Loop Benchmarks. Milde MB, Afshar S, Xu Y, Marcireau A, Joubert D, Ramesh B, Bethi Y, Ralph NO, El Arja S, Dennler N, van Schaik A, Cohen G

Neuromorphic engineering aims to build (autonomous) systems by mimicking biological systems. It is motivated by the observation that biological organisms-from algae to primates-excel in sensing their environment, reacting promptly to their perils and opportunities. Furthermore, they do so more resiliently than our most advanced machines, at a fraction of the power consumption. It follows that the performance of neuromorphic systems should be evaluated in terms of real-time operation, power consu... Abstract

Cited 3 times since 2022 (0.9 per year) source: EuropePMC

BMC pediatrics, Volume 22, Issue 1, 12 2 2022, Pages 85 Myocardial infarction due to thrombotic occlusion despite anticoagulation in Kawasaki disease - a case report. van Stijn D, Schoenmaker NJ, Planken RN, Koolbergen DR, Gouw SC, Kuijpers TW, Blom NA, Kuipers IM

Background: Kawasaki disease (KD) is a pediatric vasculitis. Mainly the coronary arteries become affected due to acute inflammation and formation of coronary artery aneurysms (CAAs) can occur. The larger the CAA, the higher the risk for clinical complications and major adverse cardiac events, as the blood flow changes to vortex or turbulent flow facilitating thrombosis. Such patients may develop life threatening thrombotic coronary artery occlusion and myocardial ischemiaunless anti-platelet and... Abstract

Cited 16 times since 2022 (4.8 per year) source: EuropePMC

Prostate cancer and prostatic diseases, Volume 25, Issue 4, 12 2 2022, Pages 755-761 Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score. Huynh-Le MP, Karunamuni R, Fan CC, Asona L, Thompson WK, Martinez ME, Eeles RA, Kote-Jarai Z, Muir KR, Lophatananon A, Schleutker J, Pashayan N, Batra J, Grönberg H, Neal DE, Nordestgaard BG, Tangen CM, MacInnis RJ, Wolk A, Albanes D, Haiman CA, Travis RC, Blot WJ, Stanford JL, Mucci LA, West CML, Nielsen SF, Kibel AS, Cussenot O, Berndt SI, Koutros S, Sørensen KD, Cybulski C, Grindedal EM, Menegaux F, Park JY, Ingles SA, Maier C, Hamilton RJ, Rosenstein BS, Lu YJ, Watya S, Vega A, Kogevinas M, Wiklund F, Penney KL, Huff CD, Teixeira MR, Multigner L, Leach RJ, Brenner H, John EM, Kaneva R, Logothetis CJ, Neuhausen SL, De Ruyck K, Ost P, Razack A, Newcomb LF, Fowke JH, Gamulin M, Abraham A, Claessens F, Castelao JE, Townsend PA, Crawford DC, Petrovics G, van Schaik RHN, Parent MÉ, Hu JJ, Zheng W, UKGPCS collaborators, APCB (Australian Prostate Cancer BioResource), NC-LA PCaP Investigators, IMPACT Study Steering Committee and Collaborators, Canary PASS Investigators, Profile Study Steering Committee, PRACTICAL

Background: Prostate cancer risk stratification using single-nucleotide polymorphisms (SNPs) demonstrates considerable promise in men of European, Asian, and African genetic ancestries, but there is still need for increased accuracy. We evaluated whether including additional SNPs in a prostate cancer polygenic hazard score (PHS) would improve associations with clinically significant prostate cancer in multi-ancestry datasets. Methods: In total, 299 SNPs previously associated with prostate cancer... Abstract

Cited 12 times since 2022 (3.6 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 63, Issue 5, 11 2 2022, Pages 743-750 Aortic and Iliac Involvement in Brucellosis - A Rare but Life Threatening Manifestation: A Review of the Literature. Willems SA, Brouwers JJWM, Eefting D

Objective: Brucellosis is the most common zoonosis worldwide. Although cardiovascular complications in human brucellosis comprise only 3% of morbidity, they are the principal cause of death. Endocarditis covers the majority of these cases. Infected aneurysms and ulcerative processes of the aorta are rare but can be life threatening as well. Currently, limited information is available about aortic and iliac involvement in brucellosis. Methods: A PubMed, Web of Science, and AccessMedicine search (... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 63, Issue 5, 10 2 2022, Pages 773-774 Hypothesis of the High Mortality of Female Patients Following Elective Open Abdominal Aortic Aneurysm Repair. Bulder RMA, Tedjawirja VN, Hamming JF, Koelemay MJ, Balm R, Lindeman JHN, study group collaborators

Abstract

Cited 9 times since 2022 (2.7 per year) source: EuropePMC

Scientific reports, Volume 12, Issue 1, 10 2 2022, Pages 2283 Metabolic profile in endothelial cells of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension. Smolders VFED, Rodríguez C, Blanco I, Szulcek R, Timens W, Piccari L, Roger Y, Hu X, Morén C, Bonjoch C, Sebastián L, Castellà M, Osorio J, Peinado VI, Bogaard HJ, Quax PHA, Cascante M, Barberà JA, Tura-Ceide O

Chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH) are two forms of pulmonary hypertension (PH) characterized by obstructive vasculopathy. Endothelial dysfunction along with metabolic changes towards increased glycolysis are important in PAH pathophysiology. Less is known about such abnormalities in endothelial cells (ECs) from CTEPH patients. This study provides a systematic metabolic comparison of ECs derived from CTEPH and PAH patients. Metabolic g... Abstract

Cited 10 times since 2022 (3 per year) source: EuropePMC

Annals of the rheumatic diseases, Volume 81, Issue 5, 10 2 2022, Pages 644-652 Proteogenomic analysis of the autoreactive B cell repertoire in blood and tissues of patients with Sjögren's syndrome. Broeren MGA, Wang JJ, Balzaretti G, Groenen PJTA, van Schaik BDC, Chataway T, Kaffa C, Bervoets S, Hebeda KM, Bounova G, Pruijn GJM, Gordon TP, De Vries N, Thurlings RM

Objective: To comparatively analyse the aberrant affinity maturation of the antinuclear and rheumatoid factor (RF) B cell repertoires in blood and tissues of patients with Sjögren's syndrome (SjS) using an integrated omics workflow. Methods: Peptide sequencing of anti-Ro60, anti-Ro52, anti-La and RF was combined with B cell repertoire analysis at the DNA, RNA and single cell level in blood B cell subsets, affected salivary gland and extranodal marginal zone lymphomas of mucosa-associated ly... Abstract

BMC research notes, Volume 15, Issue 1, 8 2 2022, Pages 28 The effect of estrogen on brown adipose tissue activity in male rats. Sievers W, Kettle C, Green RA, Van Schaik L, Hale MW, Irving HR, Whelan DR, Rathner JA

Objective: Centrally administered estrogen can increase sympathetic nerve activity to brown adipose tissue, resulting in thermogenesis. The central thermogenic effects of estrogen have not been investigated in males. Therefore, this study sought to investigate the effects of peripherally and centrally administered estrogen on thermogenesis, heart rate and mean arterial pressure in male rats. Thermogenesis was assessed by monitoring brown adipose tissue temperature. Results: Peripherally administ... Abstract

Cited 45 times since 2022 (13.5 per year) source: EuropePMC

Water research, Volume 214, 5 1 2022, Pages 118162 Prevalence and circulation patterns of SARS-CoV-2 variants in European sewage mirror clinical data of 54 European cities. Agrawal S, Orschler L, Schubert S, Zachmann K, Heijnen L, Tavazzi S, Gawlik BM, de Graaf M, Medema G, Lackner S

For community-level monitoring, the European Commission under the EU Sewage Sentinel System recommends wastewater-based SARS-CoV-2 surveillance. Tracking SARS-CoV-2 variants in a community is pivotal for appropriate public health response. Genome sequencing of SARS-CoV-2 in wastewater samples for tracking variants is challenging, often resulting in low coverage genome sequences, thereby impeding the detection of the SARS-CoV-2 mutations. Therefore, we aimed at high-coverage SARS-CoV-2 genome seq... Abstract

Cited 9 times since 2022 (2.7 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 8, 3 1 2022, Pages 784980 Interfering in the ALK1 Pathway Results in Macrophage-Driven Outward Remodeling of Murine Vein Grafts. de Jong A, Sier VQ, Peters HAB, Schilder NKM, Jukema JW, Goumans MJTH, Quax PHA, de Vries MR

Aims: Vein grafts are frequently used to bypass coronary artery occlusions. Unfortunately, vein graft disease (VGD) causes impaired patency rates. ALK1 mediates signaling by TGF-β via TGFβR2 or BMP9/10 via BMPR2, which is an important pathway in fibrotic, inflammatory, and angiogenic processes in vascular diseases. The role of the TGF-β pathway in VGD is previously reported, however, the contribution of ALK1 signaling is not known. Therefore, we investigated ALK1 signaling in VGD in a mouse mode... Abstract

Cited 5 times since 2022 (1.5 per year) source: EuropePMC

Journal of interprofessional care, 2 1 2022, Pages 1-9 Exploring the role of power during debriefing of interprofessional simulations. Robertson K, Ju M, O'Brien BC, van Schaik SM, Bochatay N

Interprofessional simulation aims to improve teamwork and patient care by bringing participants from multiple professions together to practice simulated patient care scenarios. Yet, power dynamics may influence interprofessional learning during simulation, which typically occurs during the debriefing. This issue has received limited attention to date but may explain why communication breakdowns and conflicts among healthcare teams persist despite widespread adoption of interprofessional simulati... Abstract

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 29, Issue 1, 1 1 2022, Pages 4 Correction to: The Role of Editors. Iskandrian AE, Bax JJ

Abstract

Cited 16 times since 2022 (4.8 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 3, 1 1 2022, Pages 412-422 The Leiden Convention coronary coding system: translation from the surgical to the universal view. Koppel CJ, Vliegen HW, Bökenkamp R, Ten Harkel ADJ, Kiès P, Egorova AD, Jukema JW, Hazekamp MG, Schalij MJ, Gittenberger-de Groot AC, Jongbloed MRM

Aims: The Leiden Convention coronary coding system structures the large variety of coronary anatomical patterns; isolated and in congenital heart disease. It is widely used by surgeons but not by cardiologists as the system uses a surgeons' cranial view. Since thoracic surgeons and cardiologists work closely together, a coronary coding system practical for both disciplines is mandatory. To this purpose, the 'surgical' coronary coding system was adapted to an 'imaging' sy... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

JAMA surgery, Volume 157, Issue 2, 1 1 2022, Pages 176 Generalizability of the Results and Concerns About Leakage Rates of the ICAN Trial. de Steur WO, Hutteman M, Hartgrink HH

Abstract