Research

Publications

Below you can find a list of our published research.

8684 results

Cited 29 times since 2022 (8.6 per year) source: EuropePMC

Neurology, Volume 98, Issue 4, 24 4 2022, Pages e343-e351 Cardiovascular Risk Factors and MRI Markers of Cerebral Small Vessel Disease: A Mendelian Randomization Study. Taylor-Bateman V, Gill D, Georgakis MK, Malik R, Munroe P, Traylor M, International Consortium of Blood Pressure (ICBP)

Background and objectives: Cardiovascular risk factors have been implicated in the etiology of cerebral small vessel disease (CSVD); however, whether the associations are causal remains unclear in part due to the susceptibility of observational studies to reverse causation and confounding. Here, we use mendelian randomization (MR) to determine which cardiovascular risk factors are likely to be involved in the etiology of CSVD. Methods: We used data from large-scale genome-wide association studie... Abstract

The American journal of cardiology, Volume 169, 23 4 2022, Pages 93-99 Long-Term Impact of Preventive Tricuspid Valve Annuloplasty on Right Ventricular Remodeling. Dietz MF, van Wijngaarden AL, Mack MJ, Braun J, Ajmone Marsan N, Delgado V, Klautz R, Bax JJ

In patients with primary mitral regurgitation (MR), concomitant tricuspid valve (TV) annuloplasty at the time of left-sided valve surgery is indicated in case of a dilated TV annulus ≥40 mm independent of the presence or severity of tricuspid regurgitation (TR). However, the long-term impact on right ventricular (RV) adverse remodeling is less well established and the benefit of preventive TV annuloplasty remains controversial. The aim of the study was to assess differences in long-term RV adver... Abstract

Cited 12 times since 2022 (3.6 per year) source: EuropePMC

ESC heart failure, Volume 9, Issue 2, 22 4 2022, Pages 912-924 Functional classification of left ventricular remodelling: prognostic relevance in myocardial infarction. Chimed S, van der Bijl P, Lustosa R, Fortuni F, Montero-Cabezas JM, Ajmone Marsan N, Gersh BJ, Delgado V, Bax JJ

Aims: The current definition of post ST-segment elevation myocardial infarction (STEMI) left ventricular (LV) remodelling is purely structural (LV dilatation) and does not consider LV function (ejection fraction, EF), even though it is known to be a predictor of long-term post-STEMI outcome. This study aimed to reclassify LV remodelling after STEMI by integrating LV dilatation and function (LVEF) and to investigate the prognostic implications. Methods and results: Data from an ongoing registry o... Abstract

Cited 21 times since 2022 (6.2 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 35, Issue 5, 21 3 2022, Pages 477-485.e3 Left Atrial Reservoir Function and Outcomes in Secondary Mitral Regurgitation. Stassen J, Namazi F, van der Bijl P, van Wijngaarden SE, Kamperidis V, Marsan NA, Delgado V, Bax JJ

Background: Left atrial (LA) size is a marker of disease severity and is related to worse outcomes in secondary mitral regurgitation (MR). The prognostic value of LA function assessed by LA reservoir strain (LARS), however, remains unknown. The aim of this study was to investigate the prognostic implications of LARS in patients with significant secondary MR. Methods: LARS was evaluated using speckle-tracking echocardiography in patients with more than mild (grade ≥ 2) secondary MR. The populatio... Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

Life (Basel, Switzerland), Volume 12, Issue 2, 21 3 2022, Pages 154 Near-Infrared Fluorescence with Indocyanine Green to Assess Bone Perfusion: A Systematic Review. Michi M, Madu M, Winters HAH, de Bruin DM, van der Vorst JR, Driessen C

Background: Adequate perfusion of a bone flap is essential for successful reconstruction of osseous defects. Unfortunately, complications related to inadequate bone perfusion are common. Near-infrared fluorescence (NIRF) imaging enables intraoperative visualization of perfusion. NIRF has been investigated in reconstructive surgery to aid the surgeon in clinical perioperative assessment of soft tissue perfusion. However, little is known on the beneficial use of NIRF to assess bone perfusion. Ther... Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 116, Issue 3, 20 3 2022, Pages 483-490 Outcomes of Surgical Bioprosthetic Aortic Valve Replacement in Patients Aged ≤65 and >65 Years. Kiaii BB, Moront MG, Patel HJ, Ruel M, Bensari FN, Kress DC, Liu F, Klautz RJM, Sabik JF

Background: Implantation of a bioprosthetic valve is a reasonable choice for patients aged > 65 years. For middle-aged patients there is less certainty about whether a mechanical or bioprosthetic valve is best. Methods: The Pericardial Surgical Aortic Valve Replacement (PERIGON) Pivotal Trial is evaluating the safety and efficacy of the Avalus bioprosthesis (Medtronic). We evaluated clinical and echocardiographic outcomes through 5 years of follow-up, stratified by age ≤ 65 and >65 years.... Abstract

Cited 38 times since 2022 (11.3 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 8, 20 3 2022, Pages 827515 Robotic Cardiac Surgery in Europe: Status 2020. Cerny S, Oosterlinck W, Onan B, Singh S, Segers P, Bolcal C, Alhan C, Navarra E, Pettinari M, Van Praet F, De Praetere H, Vojacek J, Cebotaru T, Modi P, Doguet F, Franke U, Ouda A, Melly L, Malapert G, Labrousse L, Gianoli M, Agnino A, Philipsen T, Jansens JL, Folliguet T, Palmen M, Pereda D, Musumeci F, Suwalski P, Cathenis K, Van den Eynde J, Bonatti J

Background: European surgeons were the first worldwide to use robotic techniques in cardiac surgery and major steps in procedure development were taken in Europe. After a hype in the early 2000s case numbers decreased but due to technological improvements renewed interest can be noted. We assessed the current activities and outcomes in robotically assisted cardiac surgery on the European continent. Methods: Data were collected in an international anonymized registry of 26 European centers with a... Abstract

Cited 6 times since 2022 (1.8 per year) source: EuropePMC

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, Volume 26, Issue 5, 20 3 2022, Pages 1063-1069 In-hospital Delay of Appendectomy in Acute, Complicated Appendicitis. Bolmers MDM, de Jonge J, Bom WJ, van Rossem CC, van Geloven AAW, Bemelman WA, Snapshot Appendicitis Collaborative Study group

Background: Present theory is that uncomplicated and complicated appendicitis are different entities. Recent studies suggest it is safe to delay surgery in patients with uncomplicated appendicitis. We hypothesize that patients with complicated appendicitis are at higher risk for postoperative complications when surgery is delayed. Methods: Data was used from the multicenter, prospective SNAPSHOT appendicitis study of 1975 patients undergoing surgery for suspected appendicitis. Adult patients (≥ ... Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

The American journal of cardiology, Volume 171, 19 3 2022, Pages 151-158 Prognostic Implications of Right Ventricular Free Wall Strain in Recipients of Cardiac Resynchronization Therapy. Stassen J, van der Bijl P, Galloo X, Hirasawa K, Prihadi EA, Marsan NA, Bax JJ

Right ventricular (RV) function is an important prognostic marker in cardiac resynchronization therapy (CRT) recipients. Measuring RV systolic function with echocardiography, however, remains challenging due to the complexity of right heart morphology. Evaluation of RV function with RV free wall strain (FWS) may improve risk stratification in recipients of CRT compared with conventional RV function parameters. In 871 recipients of CRT (mean age 65 ± 11 years, 75% were men), RV function was asses... Abstract

Cited 24 times since 2022 (7.1 per year) source: EuropePMC

International journal of molecular sciences, Volume 23, Issue 3, 19 3 2022, Pages 1057 N-6-Methyladenosine in Vasoactive microRNAs during Hypoxia; A Novel Role for METTL4. van den Homberg DAL, van der Kwast RVCT, Quax PHA, Nossent AY

N-6-methyladenosine (m6A) is the most prevalent post-transcriptional RNA modification in eukaryotic cells. The modification is reversible and can be dynamically regulated by writer and eraser enzymes. Alteration in the levels of these enzymes can lead to changes in mRNA stability, alternative splicing or microRNA processing, depending on the m6A-binding proteins. Dynamic regulation of mRNA m6A methylation after ischemia and hypoxia influences mRNA stability, alternative splicing and translation,... Abstract

Cited 20 times since 2022 (5.9 per year) source: EuropePMC

The Journal of biological chemistry, Volume 298, Issue 3, 14 2 2022, Pages 101589 Immunosuppressive calcineurin inhibitor cyclosporine A induces proapoptotic endoplasmic reticulum stress in renal tubular cells. Yilmaz DE, Kirschner K, Demirci H, Himmerkus N, Bachmann S, Mutig K

Current immunosuppressive strategies in organ transplantation rely on calcineurin inhibitors cyclosporine A (CsA) or tacrolimus (Tac). Both drugs are nephrotoxic, but CsA has been associated with greater renal damage than Tac. CsA inhibits calcineurin by forming complexes with cyclophilins, whose chaperone function is essential for proteostasis. We hypothesized that stronger toxicity of CsA may be related to suppression of cyclophilins with ensuing endoplasmic reticulum (ER) stress and unfolded... Abstract

Cited 6 times since 2022 (1.8 per year) source: EuropePMC

Journal of plastic, reconstructive & aesthetic surgery : JPRAS, Volume 75, Issue 6, 14 2 2022, Pages 1820-1825 Quantification of near-infrared fluorescence imaging with indocyanine green in free flap breast reconstruction. Van Den Hoven P, Verduijn PS, Van Capelle L, Tange FP, Michi M, Corion LUM, Sibinga Mulder BG, Mureau MAM, Vahrmeijer AL, Van Der Vorst JR

Background: One of the complications of free flap breast reconstruction is the occurrence of skin and fat necrosis. Intra-operative use of near-infrared (NIR) fluorescence imaging with Indocyanine Green (ICG) has the potential to predict these complications. In this study, the quantification of the fluorescence intensity measured in free flap breast reconstruction was performed to gain insight into the perfusion patterns observed with ICG NIR fluorescence imaging. Methods: ICG NIR fluorescence i... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

Frontiers in robotics and AI, Volume 8, 13 2 2022, Pages 781985 Who Wants to Grant Robots Rights? De Graaf MMA, Hindriks FA, Hindriks KV

The robot rights debate has thus far proceeded without any reliable data concerning the public opinion about robots and the rights they should have. We have administered an online survey (n = 439) that investigates layman's attitudes toward granting particular rights to robots. Furthermore, we have asked them the reasons for their willingness to grant them those rights. Finally, we have administered general perceptions of robots regarding appearance, capacities, and traits. Results show tha... Abstract

Cited 23 times since 2022 (6.8 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 15, Issue 6, 12 2 2022, Pages 961-970 Prognostic Impact of Extra-Mitral Valve Cardiac Involvement in Patients With Primary Mitral Regurgitation. van Wijngaarden AL, Mantegazza V, Hiemstra YL, Volpato V, van der Bijl P, Pepi M, Palmen M, Delgado V, Ajmone Marsan N, Tamborini G, Bax JJ

Background: In patients with severe primary mitral regurgitation (MR), the indication for surgery is currently based on the presence of symptoms, left ventricular dilatation and dysfunction, atrial fibrillation, and pulmonary hypertension. Objectives: The aim of this study was to evaluate the prognostic impact of the presence of extra-mitral valve cardiac involvement (including known risk factors but also severe left atrial [LA] dilatation and right ventricular [RV] dysfunction) in a large multi... Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 15, Issue 2, 12 2 2022, Pages 221-223 Apical Rocking and Septal Flash: Predictors of Secondary Mitral Regurgitation Improvement After Cardiac Resynchronization Therapy. Bax JJ, van der Bijl P

Abstract

Cited 4 times since 2022 (1.2 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 15, Issue 5, 12 2 2022, Pages 745-746 Etiology and Outcomes of Isolated Tricuspid Regurgitation. Bax JJ, van der Bijl P

Abstract

Cited 12 times since 2022 (3.5 per year) source: EuropePMC

The Cochrane database of systematic reviews, Volume 1, 11 2 2022, Pages CD004429 Immunoglobulin for multifocal motor neuropathy. Keddie S, Eftimov F, van den Berg LH, Brassington R, de Haan RJ, van Schaik IN

Background: Multifocal motor neuropathy (MMN) is a rare, probably immune-mediated disorder characterised by slowly progressive, asymmetric, distal weakness of one or more limbs with no objective loss of sensation. It may cause prolonged periods of disability. Treatment options for MMN are few. People with MMN do not usually respond to steroids or plasma exchange. Uncontrolled studies have suggested a beneficial effect of intravenous immunoglobulin (IVIg). This is an update of a Cochrane Review f... Abstract

Cited 6 times since 2022 (1.8 per year) source: EuropePMC

Ultrastructural pathology, Volume 46, Issue 1, 11 2 2022, Pages 63-79 Distribution of Aquaporin-4 channels in hippocampus and prefrontal cortex in mk-801-treated balb/c mice. Ericek OB, Akillioglu K, Saker D, Cevik I, Donmez Kutlu M, Kara S, Yilmaz DM

Functional disorders of the glymphatic system and Aquaporin-4 (AQP-4) channels take part in the pathophysiology of neurodegenerative disease. The aim of this study was to describe the distribution of AQP-4 channels in the prefrontal cortex and hippocampus in a mouse model of NMDA receptor blocking agent-induced schizophrenia-like behavior model. NMDA receptor antagonist MK-801 was used to produce the experimental schizophrenia model. MK-801 injections were administered for eleven days to Balb/c... Abstract

Cited 3 times since 2022 (0.9 per year) source: EuropePMC

Cardiovascular revascularization medicine : including molecular interventions, Volume 40, 11 2 2022, Pages 189-194 Bailout Intravascular Lithotripsy for the Treatment of Acutely Underexpanded Stents in Heavily Calcified Coronary Lesions: A Case Series. Mousa MAA, Bingen BO, Amri IA, Digiacomo S, Karalis I, Jukema JW, Montero-Cabezas JM

Stent underexpansion is a common problem in heavily calcified coronary lesions treated with percutaneous coronary intervention, and has been associated with in-stent restenosis, stent thrombosis and, subsequently, poor clinical outcomes. Adequate preparation of heavily calcified coronary lesions (e.g. using non-compliant balloons, cutting/scoring balloons, rotational/orbital atherectomy or intravascular lithotripsy) prior to stent implantation is essential in preventing stent underexpansion. How... Abstract

Cited 27 times since 2022 (7.9 per year) source: EuropePMC

Communications medicine, Volume 2, 11 2 2022, Pages 6 Resisting disinfectants. van Dijk HFG, Verbrugh HA, Ad hoc advisory committee on disinfectants of the Health Council of the Netherlands

Although often overlooked, the use of disinfectants can lead to antimicrobial resistance and this may exacerbate resistance to antibiotics. Here, we explain why all antimicrobial agents, including disinfectants, should be used prudently in a way that is guided by evidence. Abstract