7694 results
Cited 146 times since 2019 (24.9 per year)
source: EuropePMC
The lancet. Diabetes & endocrinology,
Volume 7, Issue 8, 1 1 2019, Pages 618-628
Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial.
Ray KK, Colhoun HM, Szarek M, Baccara-Dinet M, Bhatt DL, Bittner VA, Budaj AJ, Diaz R, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Loizeau V, Lopes RD, Moryusef A, Murin J, Pordy R, Ristic AD, Roe MT, Tuñón J, White HD, Zeiher AM, Schwartz GG, Steg PG, ODYSSEY OUTCOMES Committees and Investigators
Background: After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4-1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue...
Abstract
Cited 3 times since 2019 (0.5 per year)
source: EuropePMC
Nature genetics,
Volume 51, Issue 7, 1 1 2019, Pages 1191-1192
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T, Feitosa MF, Masca NGD, Manning AK, Medina-Gomez C, Mudgal P, Ng MCY, Reiner AP, Vedantam S, Willems SM, Winkler TW, Abecasis G, Aben KK, Alam DS, Alharthi SE, Allison M, Amouyel P, Asselbergs FW, Auer PL, Balkau B, Bang LE, Barroso I, Bastarache L, Benn M, Bergmann S, Bielak LF, Blüher M, Boehnke M, Boeing H, Boerwinkle E, Böger CA, Bork-Jensen J, Bots ML, Bottinger EP, Bowden DW, Brandslund I, Breen G, Brilliant MH, Broer L, Brumat M, Burt AA, Butterworth AS, Campbell PT, Cappellani S, Carey DJ, Catamo E, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Chowdhury R, Christensen C, Chu AY, Cocca M, Collins FS, Cook JP, Corley J, Galbany JC, Cox AJ, Crosslin DS, Cuellar-Partida G, D'Eustacchio A, Danesh J, Davies G, Bakker PIW, Groot MCH, Mutsert R, Deary IJ, Dedoussis G, Demerath EW, Heijer M, Hol
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Abstract
Cited 23 times since 2019 (3.9 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 70, Issue 1, 1 1 2019, Pages 286-297.e1
A systematic review of the use of near-infrared fluorescence imaging in patients with peripheral artery disease.
van den Hoven P, Ooms S, van Manen L, van der Bogt KEA, van Schaik J, Hamming JF, Vahrmeijer AL, van der Vorst JR, Mieog JSD
Objective: In the diagnosis of peripheral artery disease (PAD), the ankle-brachial index plays an important role. However, results of the ankle-brachial index are unreliable in patients with severe media sclerosis. Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) can provide information about tissue perfusion and has already been studied in oncologic, reconstructive, and cardiac surgery. For patients with PAD, this technique might give insight into skin perfusion and thereb...
Abstract
Cited 31 times since 2019 (5.3 per year)
source: EuropePMC
Biological reviews of the Cambridge Philosophical Society,
Volume 94, Issue 5, 27 4 2019, Pages 1809-1829
Multimodal communication and language origins: integrating gestures and vocalizations.
Fröhlich M, Sievers C, Townsend SW, Gruber T, van Schaik CP
The presence of divergent and independent research traditions in the gestural and vocal domains of primate communication has resulted in major discrepancies in the definition and operationalization of cognitive concepts. However, in recent years, accumulating evidence from behavioural and neurobiological research has shown that both human and non-human primate communication is inherently multimodal. It is therefore timely to integrate the study of gestural and vocal communication. Herein, we rev...
Abstract
Cited 27 times since 2019 (4.6 per year)
source: EuropePMC
Injury,
Volume 50, Issue 8, 25 4 2019, Pages 1440-1447
Older polytrauma: Mortality and complications.
de Vries R, Reininga IHF, de Graaf MW, Heineman E, El Moumni M, Wendt KW
Introduction: Older adults enduring a polytrauma have an increased mortality risk. Apart from age, the role of other predisposing factors on mortality are mainly described for the total polytrauma population. This study aimed to describe the mortality pattern of older polytrauma patients, its associated risk factors, and the role and etiology of in-hospital complications. Methods: An eight-year retrospective cohort was constructed from 380 polytrauma patients aged ≥65 in a Dutch level 1 trauma c...
Abstract
Cited 2 times since 2019 (0.3 per year)
source: EuropePMC
Veterinary sciences,
Volume 6, Issue 2, 22 4 2019, Pages E58
<i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> ELISA Responses in Milk Samples from Vaccinated and Nonvaccinated Dairy Goat Herds in The Netherlands.
Luttikholt S, Lievaart-Peterson K, Gonggrijp M, Aalberts M, van Schaik G, Vellema P
The aims of our study were to calculate the most appropriate cut-off value for milk samples in a serum-validated Mycobacterium avium subsp. paratuberculosis (MAP) ELISA and to analyze MAP ELISA responses in milk samples from vaccinated and nonvaccinated dairy goats in the Netherlands. Analyzed herds were representative for location and herd size of dairy goat herds in the Netherlands. A significantly higher proportion of the analyzed 49 herds were organic as compared with the total Dutch dairy g...
Abstract
Cited 37 times since 2019 (6.3 per year)
source: EuropePMC
APL bioengineering,
Volume 3, Issue 2, 21 3 2019, Pages 026105
Scalable microphysiological system to model three-dimensional blood vessels.
de Graaf MNS, Cochrane A, van den Hil FE, Buijsman W, van der Meer AD, van den Berg A, Mummery CL, Orlova VV
Blood vessel models are increasingly recognized to have value in understanding disease and drug discovery. However, continued improvements are required to more accurately reflect human vessel physiology. Realistic three-dimensional (3D) in vitro cultures of human vascular cells inside microfluidic chips, or vessels-on-chips (VoC), could contribute to this since they can recapitulate aspects of the in vivo microenvironment by including mechanical stimuli such as shear stress. Here, we used human...
Abstract
Cited 4 times since 2019 (0.7 per year)
source: EuropePMC
European radiology experimental,
Volume 3, Issue 1, 20 3 2019, Pages 24
The effects of age at correction of aortic coarctation and recurrent obstruction on adolescent patients: MRI evaluation of wall shear stress and pulse wave velocity.
Juffermans JF, Nederend I, van den Boogaard PJ, Ten Harkel ADJ, Hazekamp MG, Lamb HJ, Roest AAW, Westenberg JJM
Background: Coarctation patients before curative reconstruction are exposed to abnormal flow patterns which potentially could cause wall deterioration. This study evaluated the effect of age at correction on the pulse wave velocity (PWV) and peak wall shear stress (WSS) in adolescent patients with corrected coarctation. Effects of valve morphology and presence of reobstruction were also evaluated. Methods: Twenty-one patients aged 13.7 ± 2.6 years (mean ± standard deviation) were included (bicus...
Abstract
Cited 6 times since 2019 (1 per year)
source: EuropePMC
Seminars in thoracic and cardiovascular surgery,
Volume 31, Issue 4, 20 3 2019, Pages 643-649
Aortic Valve Surgery in Nonelderly Patients: Insights Gained From AVIATOR.
Lansac E, Youssefi P, de Heer F, Bavaria J, De Kerchove L, El-Hamamsy I, Elkhoury G, Enriquez-Sarano M, Jondeau LG, Kluin J, Pibarot P, Schäfers HJ, Vanoverschelde JL, Takkenberg JJM, Aortic Valve Repair Research Network Investigators from the Heart Valve Society, Collaborators
Aortic valve surgery in non-elderly patients represents a very challenging patient population. The younger the patient is at the point of aortic valve intervention, the longer their anticipated life expectancy will be, with longer exposure to valve-related complications and risk for re-operation. Although the latest international guidelines recommend aortic valve repair in patients with aortic valve insufficiency, what we see in the real world is that the vast majority of these aortic valves are...
Abstract
Cited 3 times since 2019 (0.5 per year)
source: EuropePMC
The American journal of medicine,
Volume 132, Issue 12, 20 3 2019, Pages 1466-1474.e4
Cognitive Function in Dementia-Free Subjects and Survival in Old Age: The PROSPER Study.
Rostamian S, de Haan S, van der Grond J, van Buchem MA, Ford I, Jukema JW, Sabayan B
Background: Impairment in domain-specific cognitive function is associated with the increased risk of mortality. We prospectively evaluated the association of executive function and memory with the risk of long-term mortality in dementia-free older subjects. Moreover, we investigated the role of structural brain abnormalities in this association. Methods: We included 547 dementia-free participants (mean age 78 years, 56.5% male) from the nested magnetic resonance imaging sub-study of the PROspec...
Abstract
Cited 21 times since 2019 (3.6 per year)
source: EuropePMC
Annals of the rheumatic diseases,
Volume 78, Issue 10, 19 3 2019, Pages 1339-1345
Non-response to rituximab therapy in rheumatoid arthritis is associated with incomplete disruption of the B cell receptor repertoire.
Pollastro S, Klarenbeek PL, Doorenspleet ME, van Schaik BDC, Esveldt REE, Thurlings RM, Boumans MJH, Gerlag DM, Tak PP, Vos K, Baas F, van Kampen AHC, de Vries N
Objective: To gain more insight into the dynamics of lymphocyte depletion and develop new predictors of clinical response to rituximab in rheumatoid arthritis (RA). Methods: RNA-based next-generation sequencing was used to analyse the B cell receptor (BCR) repertoire in peripheral blood and synovial tissue samples collected from 24 seropositive patients with RA treated with rituximab. Clonal expansion, mutation load and clonal overlap were assessed in samples collected before, at week 4 and at w...
Abstract
Cited 10 times since 2019 (1.7 per year)
source: EuropePMC
International journal of clinical pharmacy,
Volume 41, Issue 4, 17 3 2019, Pages 963-971
Cost-effectiveness of a clinical medication review in vulnerable older patients at hospital discharge, a randomized controlled trial.
van der Heijden AAWA, de Bruijne MC, Nijpels G, Hugtenburg JG
Background Drug-related problems (DRP) following hospital discharge may cause morbidity, mortality and hospital re-admissions. It is unclear whether a clinical medication review (CMR) and counseling at discharge is a cost-effective method to reduce DRP. Objective To assess the effect of a CMR on health care utilization and to investigate whether CMR is a cost-effective method to reduce DRP in older polypharmacy patients discharged from hospital. Setting 24 community pharmacies in the Netherlands...
Abstract
Cited 12 times since 2019 (2 per year)
source: EuropePMC
PloS one,
Volume 14, Issue 6, 14 2 2019, Pages e0217582
Hypercholesterolemia affects cardiac function, infarct size and inflammation in APOE*3-Leiden mice following myocardial ischemia-reperfusion injury.
Pluijmert NJ, den Haan MC, van Zuylen VL, Steendijk P, de Boer HC, van Zonneveld AJ, Fibbe WE, Schalij MJ, Quax PHA, Atsma DE
Background: Hypercholesterolemia is a major risk factor for ischemic heart disease including acute myocardial infarction. However, long-term effects of hypercholesterolemia in a rodent myocardial ischemia-reperfusion injury model are unknown. Therefore, the effects of diet-induced hypercholesterolemia on cardiac function and remodeling were investigated up to eight weeks after myocardial ischemia-reperfusion (MI-R) injury which was induced in either normocholesterolemic (NC-MI) or hypercholester...
Abstract
Cited 5 times since 2019 (0.8 per year)
source: EuropePMC
Journal of cardiothoracic and vascular anesthesia,
Volume 33, Issue 12, 14 2 2019, Pages 3273-3280
Vasoplegia After Restrictive Mitral Annuloplasty for Functional Mitral Regurgitation in Patients With Heart Failure.
van Vessem ME, Petrus AHJ, Palmen M, Braun J, Schalij MJ, Klautz RJM, Beeres SLMA
Objectives: Patients undergoing heart failure surgery are at risk for developing postoperative vasoplegia. The aim of this study was to determine the incidence, survival, and predictors of vasoplegia in heart failure patients undergoing mitral valve repair for functional mitral regurgitation and to evaluate the effect of ischemic versus non-ischemic etiology. Design: Retrospective. Setting: University medical center, single institutional. Participants: Heart failure patients with functional mitr...
Abstract
Cited 9 times since 2019 (1.5 per year)
source: EuropePMC
American journal of primatology,
Volume 81, Issue 6, 13 2 2019, Pages e22996
Determining overweight and underweight with a new weight-for-height index in captive group-housed macaques.
Sterck EHM, Zijlmans DGM, de Vries H, van den Berg LM, van Schaik CP, Langermans JAM
Housing primates in naturalistic groups provides social benefits relative to solitary housing. However, food intake may vary across individuals, possibly resulting in overweight and underweight individuals. Information on relative adiposity (the amount of fat tissue relative to body weight) is needed to monitor overweight and underweight of group-housed individuals. However, the upper and lower relative adiposity boundaries are currently only known for macaques living solitarily in small cages....
Abstract
Cited 6 times since 2019 (1 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 6, 13 2 2019, Pages 77
CD8+ T Cells Protect During Vein Graft Disease Development.
Simons KH, de Vries MR, Peters HAB, Jukema JW, Quax PHA, Arens R
Aims: Vein grafts are frequently used conduits for arterial reconstruction in patients with cardiovascular disease. Unfortunately, vein graft disease (VGD) causes diminished patency rates. Innate immune system components are known to contribute to VGD. However, the role of T cells has yet to be established. The purpose of this study was to investigate the role of T cells and T cell activation pathways via the T cell receptor (TCR), co-stimulation and bystander effect in VGD. Methods and results:...
Abstract
Cited 20 times since 2019 (3.4 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 13, Issue 2 Pt 1, 12 2 2019, Pages 425-434
Application of Low Tube Potentials in CCTA: Results From the PROTECTION VI Study.
Stocker TJ, Leipsic J, Hadamitzky M, Chen MY, Rubinshtein R, Deseive S, Heckner M, Bax JJ, Kitagawa K, Marques H, Schmermund A, Silva C, Mahmarian J, Kang JW, Grove EL, Lesser J, Massberg S, Hausleiter J
Objectives: The aim of this study was to assess the use of low tube potentials for coronary computed tomography angiography (CCTA) in worldwide clinical practice and its influence on radiation exposure, contrast agent volume, and image quality. Background: CCTA is frequently used in clinical practice. Lowering of tube potential is a potent method to reduce radiation exposure and to economize contrast agent volume. Methods: CCTAs of 4,006 patients from 61 international study sites were analyzed r...
Abstract
Cited 35 times since 2019 (5.9 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 13, Issue 2 Pt 2, 12 2 2019, Pages 577-585
Prognostic Value of Global Longitudinal Strain and Etiology After Surgery for Primary Mitral Regurgitation.
Hiemstra YL, Tomsic A, van Wijngaarden SE, Palmen M, Klautz RJM, Bax JJ, Delgado V, Ajmone Marsan N
Objectives: This study sought to investigate whether left ventricular (LV) global longitudinal strain (GLS) is associated with long-term outcome after mitral valve (MV) surgery for primary mitral regurgitation (MR) and assess the differences in outcome according to MR etiology: Barlow's disease (BD), fibroelastic deficiency (FED), and forme fruste (FF). Background: Appropriate timing of MV surgery for primary MR is still challenging and may differ according to the etiology. In these patient...
Abstract
Cited 66 times since 2019 (11.1 per year)
source: EuropePMC
Circulation,
Volume 140, Issue 10, 12 2 2019, Pages 836-845
Prognostic Implications of Right Ventricular Remodeling and Function in Patients With Significant Secondary Tricuspid Regurgitation.
Dietz MF, Prihadi EA, van der Bijl P, Goedemans L, Mertens BJA, Gursoy E, van Genderen OS, Ajmone Marsan N, Delgado V, Bax JJ
Background: In patients with significant (moderate and severe) tricuspid regurgitation (TR), the decision to intervene is influenced by right ventricular (RV) size and function. RV remodeling in significant secondary TR has been underexplored. The aim of this study was to characterize RV remodeling in patients with significant secondary TR and to investigate its prognostic implications. Methods: RV remodeling was characterized by transthoracic echocardiography in 1292 patients with significant s...
Abstract
Cited 10 times since 2019 (1.7 per year)
source: EuropePMC
Biology open,
Volume 8, Issue 6, 10 2 2019, Pages bio039263
Influence of arm swing on cost of transport during walking.
de Graaf ML, Hubert J, Houdijk H, Bruijn SM
Normal arm swing plays a role in decreasing the cost of transport during walking. However, whether excessive arm swing can reduce the cost of transport even further is unknown. Therefore, we tested the effects of normal and exaggerated arm swing on the cost of transport in the current study. Healthy participants (n=12) walked on a treadmill (1.25 m/s) in seven trials with different arm swing amplitudes (in-phase, passive restricted, active restricted, normal, three gradations of extra arm swing)...
Abstract
