Research

Publications

Below you can find a list of our published research.

7957 results

Cited 21 times since 2018 (3.2 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 157, Issue 6, 26 4 2018, Pages 2202-2211.e7 AVIATOR: An open international registry to evaluate medical and surgical outcomes of aortic valve insufficiency and ascending aorta aneurysm. de Heer F, Kluin J, Elkhoury G, Jondeau G, Enriquez-Sarano M, Schäfers HJ, Takkenberg JJM, Lansac E, Aortic Valve Repair Research Network Investigators

Objectives: Current national registries are lacking detailed pathology-driven analysis and long-term patients outcomes. The Heart Valve Society (HVS) aortic valve (AV) repair research network started the Aortic Valve Insufficiency and ascending aorta Aneurysm InternATiOnal Registry (AVIATOR) to evaluate long-term patient outcomes of AV repair and replacement. The purpose of the current report is to describe the AVIATOR initiative and report in a descriptive manner the patients included. Methods:... Abstract

Cited 9 times since 2018 (1.4 per year) source: EuropePMC

Heart rhythm, Volume 16, Issue 4, 26 4 2018, Pages 624-631 Evaluation and management of ventricular tachycardia in patients with dilated cardiomyopathy. Ebert M, Richter S, Dinov B, Zeppenfeld K, Hindricks G

Recurrent ventricular tachycardia (VT) is an important cause of increased morbidity and mortality in patients with non-ischemic dilated cardiomyopathy (DCM). Current recommendations for the treatment of VT in patients with structural heart disease mainly rely on data derived from patients with ischemic cardiomyopathy. Unlike postinfarction ischemic cardiomyopathy, DCM comprises multiple different etiologies with variable disease progression and prognosis, which often requires an individualized a... Abstract

Cited 38 times since 2018 (5.8 per year) source: EuropePMC

Journal of human evolution, Volume 125, 25 4 2018, Pages 38-49 The slow ape: High infant survival and long interbirth intervals in wild orangutans. van Noordwijk MA, Utami Atmoko SS, Knott CD, Kuze N, Morrogh-Bernard HC, Oram F, Schuppli C, van Schaik CP, Willems EP

Orangutans (Pongo spp.) are reported to have extremely slow life histories, including the longest average interbirth intervals of all mammals. Such slow life history can be viable only when unavoidable mortality is kept low. Thus, orangutans' survivorship under natural conditions is expected to be extremely high. Previous estimates of orangutan life history were based on captive individuals living under very different circumstances or on small samples from wild populations. Here, we combine... Abstract

Cited 22 times since 2018 (3.4 per year) source: EuropePMC

Pharmacogenomics and personalized medicine, Volume 11, 24 4 2018, Pages 179-191 <i>CYP2D6</i> genotype can help to predict effectiveness and safety during opioid treatment for chronic low back pain: results from a retrospective study in an Italian cohort. Dagostino C, Allegri M, Napolioni V, D'Agnelli S, Bignami E, Mutti A, van Schaik RH

Background: Opioids are widely used for chronic low back pain (CLBP); however, it is still unclear how to predict their effectiveness and safety. Codeine, tramadol and oxycodone are metabolized by CYP/CYP450 2D6 (CYP2D6), a highly polymorphic enzyme linked to allele-specific related differences in metabolic activity. Purpose: CYP2D6 genetic polymorphisms could potentially help to predict the effectiveness and safety of opioid-based drugs in clinical practice, especially in the treatment of CLBP.... Abstract

Cited 9 times since 2018 (1.4 per year) source: EuropePMC

Molecular plant pathology, Volume 20, Issue 1, 24 4 2018, Pages 137-152 Mediator of tolerance to abiotic stress ERF6 regulates susceptibility of Arabidopsis to Meloidogyne incognita. Warmerdam S, Sterken MG, Van Schaik C, Oortwijn MEP, Lozano-Torres JL, Bakker J, Goverse A, Smant G

Root-knot nematodes transform vascular host cells into permanent feeding structures to selectively withdraw their nutrients from host plants during the course of several weeks. The susceptibility of host plants to root-knot nematode infections is thought to be a complex trait involving many genetic loci. However, genome-wide association (GWA) analysis has so far revealed only four quantitative trait loci (QTLs) linked to the reproductive success of the root-knot nematode Meloidogyne incognita in... Abstract

Cited 16 times since 2018 (2.5 per year) source: EuropePMC

Heart rhythm, Volume 16, Issue 4, 24 4 2018, Pages 536-543 Ablation compared with drug therapy for recurrent ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy: Results from a multicenter study. Mahida S, Venlet J, Saguner AM, Kumar S, Baldinger SH, AbdelWahab A, Tedrow UB, Castelletti S, Pantazis A, John RM, McKenna WJ, Lambiase PD, Duru F, Sapp JL, Zeppenfeld K, Stevenson WG

Background: The comparative efficacy of antiarrhythmic drug (AAD) therapy vs ventricular tachycardia (VT) ablation in arrhythmogenic right ventricular cardiomyopathy (ARVC) is unknown. Objective: We compared outcomes of AAD and/or β-blocker (BB) therapy with those of VT ablation (with AAD/BB) in patients with ARVC who had recurrent VT. Methods: In a multicenter retrospective study, 110 patients with ARVC (mean age 38 ± 17 years; 91[83%] men) with a minimum of 3 VT episodes were included; 77 (70%... Abstract

Cited 30 times since 2018 (4.6 per year) source: EuropePMC

Diabetes care, Volume 42, Issue 2, 23 4 2018, Pages 208-214 A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy. Grubb AL, McDonald TJ, Rutters F, Donnelly LA, Hattersley AT, Oram RA, Palmer CNA, van der Heijden AA, Carr F, Elders PJM, Weedon MN, Slieker RC, 't Hart LM, Pearson ER, Shields BM, Jones AG

Objective: Progression to insulin therapy in clinically diagnosed type 2 diabetes is highly variable. GAD65 autoantibodies (GADA) are associated with faster progression, but their predictive value is limited. We aimed to determine if a type 1 diabetes genetic risk score (T1D GRS) could predict rapid progression to insulin treatment over and above GADA testing. Research design and methods: We examined the relationship between T1D GRS, GADA (negative or positive), and rapid insulin requirement (wi... Abstract

Cited 3 times since 2018 (0.5 per year) source: EuropePMC

Open medicine (Warsaw, Poland), Volume 13, 22 4 2018, Pages 520-527 Recurrent Chronic Subdural Hematoma: Report of 13 Cases. Hacıyakupoğlu E, Yılmaz DM, Kınalı B, Arpacı T, Akbaş T, Hacıyakupoğlu S

Chronic subdural hematoma is a frequent type of hemorrhage, which terminates with mortality if not diagnosed and treated early. The aim of this clinical study is to evaluate the patients with unilateral and bilateral recurrent chronic subdural hematoma. The study group consisted of 13 cases with unilateral and bilateral recurrent chronic subdural hematomas who underwent aggressive wide craniotomy, duraectomy, inner and outer membranectomy, dural border coagulation, incision through cortical vein... Abstract

Cited 14 times since 2018 (2.1 per year) source: EuropePMC

Advances in health sciences education : theory and practice, Volume 24, Issue 1, 20 3 2018, Pages 151-165 Peer instruction improves comprehension and transfer of physiological concepts: a randomized comparison with self-explanation. Versteeg M, van Blankenstein FM, Putter H, Steendijk P

Comprehension of physiology is essential for development of clinical reasoning. However, medical students often struggle to understand physiological concepts. Interactive learning through Peer instruction (PI) is known to stimulate students' comprehension, but its relative efficacy and working mechanisms remain to be elucidated. In this study, we investigated if and how PI could optimize comprehension of physiological concepts and transfer relative to Self-explanation (SE) which is consider... Abstract

Cited 38 times since 2018 (5.8 per year) source: EuropePMC

Disease models & mechanisms, Volume 11, Issue 10, 19 3 2018, Pages dmm034637 Bicuspid aortic valve formation: <i>Nos3</i> mutation leads to abnormal lineage patterning of neural crest cells and the second heart field. Peterson JC, Chughtai M, Wisse LJ, Gittenberger-de Groot AC, Feng Q, Goumans MTH, VanMunsteren JC, Jongbloed MRM, DeRuiter MC

The bicuspid aortic valve (BAV), a valve with two instead of three aortic leaflets, belongs to the most prevalent congenital heart diseases in the world, occurring in 0.5-2% of the general population. We aimed to understand how changes in early cellular contributions result in BAV formation and impact cardiovascular outflow tract development. Detailed 3D reconstructions, immunohistochemistry and morphometrics determined that, during valvulogenesis, the non-coronary leaflet separates from the par... Abstract

Cited 215 times since 2018 (32.9 per year) source: EuropePMC

The Lancet. Oncology, Volume 19, Issue 11, 19 3 2018, Pages 1459-1467 DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis. Henricks LM, Lunenburg CATC, de Man FM, Meulendijks D, Frederix GWJ, Kienhuis E, Creemers GJ, Baars A, Dezentjé VO, Imholz ALT, Jeurissen FJF, Portielje JEA, Jansen RLH, Hamberg P, Ten Tije AJ, Droogendijk HJ, Koopman M, Nieboer P, van de Poel MHW, Mandigers CMPW, Rosing H, Beijnen JH, Werkhoven EV, van Kuilenburg ABP, van Schaik RHN, Mathijssen RHJ, Swen JJ, Gelderblom H, Cats A, Guchelaar HJ, Schellens JHM

Background: Fluoropyrimidine treatment can result in severe toxicity in up to 30% of patients and is often the result of reduced activity of the key metabolic enzyme dihydropyrimidine dehydrogenase (DPD), mostly caused by genetic variants in the gene encoding DPD (DPYD). We assessed the effect of prospective screening for the four most relevant DPYD variants (DPYD*2A [rs3918290, c.1905+1G>A, IVS14+1G>A], c.2846A>T [rs67376798, D949V], c.1679T>G [rs55886062, DPYD*13, I560S], and c.123... Abstract

Cited 2 times since 2018 (0.3 per year) source: EuropePMC

Turkish neurosurgery, 17 3 2018 Immunohistochemical Evaluation of Hemostatic Changes in Glioblastoma Multiforme and Low-Grade Astrocytoma. Haciyakupoğlu E, Yilmaz DM, Walter J, Erdoğan Ş, Haciyakupoğlu S, Kuhn SA

Aim: In glioblastoma multiforme, the balance between the procoagulant system, anticoagulant system and fibrinolytic system is impaired in favour of hypercoagulability. The aim of this study was to compare glioblastoma multiforme with astrocytoma grade II by subjectively evaluating the levels of prothrombin and biotinylation thrombin, and G protein serum protease activatin receptors, as tissue factors causing hypercoagulation and affecting coagulation. Material and methods: Specimens from 35 case... Abstract

Cited 19 times since 2018 (2.9 per year) source: EuropePMC

European radiology, Volume 29, Issue 4, 15 3 2018, Pages 2117-2126 Noninvasive CT-based hemodynamic assessment of coronary lesions derived from fast computational analysis: a comparison against fractional flow reserve. Siogkas PK, Anagnostopoulos CD, Liga R, Exarchos TP, Sakellarios AI, Rigas G, Scholte AJHA, Papafaklis MI, Loggitsi D, Pelosi G, Parodi O, Maaniitty T, Michalis LK, Knuuti J, Neglia D, Fotiadis DI

Objectives: Application of computational fluid dynamics (CFD) to three-dimensional CTCA datasets has been shown to provide accurate assessment of the hemodynamic significance of a coronary lesion. We aim to test the feasibility of calculating a novel CTCA-based virtual functional assessment index (vFAI) of coronary stenoses > 30% and ≤ 90% by using an automated in-house-developed software and to evaluate its efficacy as compared to the invasively measured fractional flow reserve (FFR). Method... Abstract

Cited 2 times since 2018 (0.3 per year) source: EuropePMC

International journal of chronic obstructive pulmonary disease, Volume 13, 12 2 2018, Pages 3297-3306 A systematic diagnostic evaluation combined with an internet-based self-management support system for patients with asthma or COPD. van Buul AR, Wildschut TS, Bonten TN, Kasteleyn MJ, Slats AM, Chavannes NH, Taube C

Introduction: An (inter)national systematic approach for patients with asthma COPD referred to secondary care is lacking. Therefore, a novel systematic approach was designed and tested in clinical practice. Methods: This was a retrospective observational study of data from the electronic record system of the Leiden University Medical Center. Asthma and COPD patients were included if they were evaluated with a novel systematic approach or if they had a new record for asthma or COPD and received u... Abstract

Cited 6 times since 2018 (0.9 per year) source: EuropePMC

BMC musculoskeletal disorders, Volume 19, Issue 1, 12 2 2018, Pages 366 The acceptance of the clinical photographic posture assessment tool (CPPAT). Fortin C, van Schaik P, Aubin-Fournier JF, Bettany-Saltikov J, Bernard JC, Ehrmann Feldman D

Background: There is a lack of evidence-based quantitative clinical methods to adequately assess posture. Our team developed a clinical photographic posture assessment tool (CPPAT) and implemented this tool in clinical practice to standardize posture assessment. The objectives were to determine the level of acceptance of the CPPAT and to document predictors as well as facilitators of and barriers to the acceptance of this tool by clinicians doing posture re-education. Methods: This is a prospect... Abstract

Cited 5 times since 2018 (0.8 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 57, Issue 2, 11 2 2018, Pages 229-237 The Value of Sigmoidoscopy to Detect Colonic Ischaemia After Ruptured Abdominal Aortic Aneurysm Repair. Jalalzadeh H, van Schaik TG, Duin JJ, Indrakusuma R, van Beek SC, Vahl AC, Wisselink W, Balm R, Koelemay MJW

Objectives: Diagnosing colonic ischaemia (CI) after ruptured abdominal aortic aneurysm (RAAA) repair is challenging. This study determined the diagnostic value of sigmoidoscopy in patients suspected of CI after RAAA repair. Methods: This was a retrospective multicentre cohort study. Patients who underwent RAAA repair in three hospitals in Amsterdam, the Netherlands, between 2004 and 2011 (AJAX cohort) were included. Sigmoidoscopies were carried out based on clinical judgment. Endoscopy results w... Abstract

Cited 38 times since 2018 (5.8 per year) source: EuropePMC

Clinical research in cardiology : official journal of the German Cardiac Society, Volume 108, Issue 5, 8 2 2018, Pages 520-538 Apolipoproteins A1, B, and apoB/apoA1 ratio are associated with first ST-segment elevation myocardial infarction but not with recurrent events during long-term follow-up. Bodde MC, Hermans MPJ, Jukema JW, Schalij MJ, Lijfering WM, Rosendaal FR, Romijn FPHTM, Ruhaak LR, van der Laarse A, Cobbaert CM

Introduction: The current way to assess the risk of cardiovascular disease (CVD) is to measure conventional lipid and lipoprotein cholesterol fractions. Despite the success of statin treatment, residual cardiovascular risk remains high. Therefore, the value of extensive serum apolipoprotein (apo) profiling to assess the risk of ST-segment elevation myocardial infarction (STEMI) and of major adverse cardiac events (MACE) in patients with STEMI was investigated in a case-control design. Methods an... Abstract

Cited 1126 times since 2018 (171.3 per year) source: EuropePMC

Nature genetics, Volume 50, Issue 11, 8 2 2018, Pages 1505-1513 Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Mahajan A, Taliun D, Thurner M, Robertson NR, Torres JM, Rayner NW, Payne AJ, Steinthorsdottir V, Scott RA, Grarup N, Cook JP, Schmidt EM, Wuttke M, Sarnowski C, Mägi R, Nano J, Gieger C, Trompet S, Lecoeur C, Preuss MH, Prins BP, Guo X, Bielak LF, Below JE, Bowden DW, Chambers JC, Kim YJ, Ng MCY, Petty LE, Sim X, Zhang W, Bennett AJ, Bork-Jensen J, Brummett CM, Canouil M, Ec Kardt KU, Fischer K, Kardia SLR, Kronenberg F, Läll K, Liu CT, Locke AE, Luan J, Ntalla I, Nylander V, Schönherr S, Schurmann C, Yengo L, Bottinger EP, Brandslund I, Christensen C, Dedoussis G, Florez JC, Ford I, Franco OH, Frayling TM, Giedraitis V, Hackinger S, Hattersley AT, Herder C, Ikram MA, Ingelsson M, Jørgensen ME, Jørgensen T, Kriebel J, Kuusisto J, Ligthart S, Lindgren CM, Linneberg A, Lyssenko V, Mamakou V, Meitinger T, Mohlke KL, Morris AD, Nadkarni G, Pankow JS, Peters A, Sattar N, Stančáková A, Strauch K, Taylor KD, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tuomilehto J, Witte DR, Dupuis J, Peyser PA, Zeggini E, Loos

We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density reference panels. With these data, we (i) extend the inventory of T2D-risk variants (243 loci, 135 newly implicated in T2D predisposition, comprising 403 distinct association signals); (ii) enrich discovery of lower-frequency risk alleles (80 index variants with minor allele frequency 2); (iii) substantially improve fine-mapping of causal v... Abstract

Cited 6 times since 2018 (0.9 per year) source: EuropePMC

Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Volume 373, Issue 1760, 8 2 2018, Pages 20170408 Widespread reduction in sun-induced fluorescence from the Amazon during the 2015/2016 El Niño. Koren G, van Schaik E, Araújo AC, Boersma KF, Gärtner A, Killaars L, Kooreman ML, Kruijt B, van der Laan-Luijkx IT, von Randow C, Smith NE, Peters W

The tropical carbon balance dominates year-to-year variations in the CO2 exchange with the atmosphere through photosynthesis, respiration and fires. Because of its high correlation with gross primary productivity (GPP), observations of sun-induced fluorescence (SIF) are of great interest. We developed a new remotely sensed SIF product with improved signal-to-noise in the tropics, and use it here to quantify the impact of the 2015/2016 El Niño Amazon drought. We find that SIF was strongly suppres... Abstract

Cited 6 times since 2018 (0.9 per year) source: EuropePMC

Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Volume 373, Issue 1760, 8 2 2018, Pages 20180084 Changes in surface hydrology, soil moisture and gross primary production in the Amazon during the 2015/2016 El Niño. van Schaik E, Killaars L, Smith NE, Koren G, van Beek LPH, Peters W, van der Laan-Luijkx IT

The 2015/2016 El Niño event caused severe changes in precipitation across the tropics. This impacted surface hydrology, such as river run-off and soil moisture availability, thereby triggering reductions in gross primary production (GPP). Many biosphere models lack the detailed hydrological component required to accurately quantify anomalies in surface hydrology and GPP during droughts in tropical regions. Here, we take the novel approach of coupling the biosphere model SiBCASA with the advanced... Abstract