8684 results
Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES,
Volume 28, Issue 7, 1 1 2022, Pages 933-939
Determinants of mortality and intensive care requirement in pediatric thoracoabdominal injuries.
Akgül F, Er A, Çağlar A, Ulusoy E, Çitlenbik H, Duman M, Yılmaz D
Background: Thoracoabdominal injuries (TAI) are an important cause of trauma-related morbidity in children. Early and correct intervention is essential to reduce mortality. We aimed to determine factors associated with mortality and the need for intensive care in TAI. Methods: The children admitted to the pediatric emergency department of a tertiary care hospital with TAI in a 6-year-period were enrolled. Demographic data; mechanism of injuries; clinical, laboratory and imaging findings; length...
Abstract
Cited 10 times since 2022 (3.4 per year)
source: EuropePMC
EClinicalMedicine,
Volume 50, 1 1 2022, Pages 101532
Reliability of bedside tests for diagnosing peripheral arterial disease in patients prone to medial arterial calcification: A systematic review.
Brouwers JJWM, Willems SA, Goncalves LN, Hamming JF, Schepers A
Background: Medial arterial calcification (MAC), frequently associated with diabetes mellitus (DM) and chronic kidney disease (CKD), is a systemic vascular disorder leading to stiffness and incompressible arteries. These changes impede the accuracy of bedside tests to diagnose peripheral arterial disease (PAD). This review aimed to evaluate the reliability of bedside tests for the detection of PAD in patients prone to MAC. Methods: A systematic search (Pubmed, Embase, Web of Science, Cochrane, a...
Abstract
Cited 2 times since 2022 (0.7 per year)
source: EuropePMC
Journal of oral & maxillofacial research,
Volume 13, Issue 3, 1 1 2022, Pages e2
The Radiological Evaluation of Mandibular Canal Related Variables in Mandibular Third Molar Region: a Retrospective Multicenter Study.
Yilmaz D, Ataman-Duruel ET, Beycioğlu Z, Goyushov S, Çimen T, Duruel O, Tözüm TF
Objectives: The aim of this retrospective study was to investigate anatomical structure of mandibular canal and the factors those increase the possibility of inferior alveolar nerve damage in mandibular third molar region of Turkish population. Material and methods: Overall 320 participants with 436 mandibular third molars were included from four different study centers. Following variables were measured: type and depth of third molar impaction, position of mandibular canal in relation to third...
Abstract
Cited 9 times since 2022 (3.1 per year)
source: EuropePMC
Cardiovascular research,
Volume 118, Issue 10, 1 1 2022, Pages 2293-2303
Optical ventricular cardioversion by local optogenetic targeting and LED implantation in a cardiomyopathic rat model.
Nyns ECA, Jin T, Fontes MS, van den Heuvel T, Portero V, Ramsey C, Bart CI, Zeppenfeld K, Zeppenfeld K, Schalij MJ, van Brakel TJ, Ramkisoensing AA, Zhang G, Poelma RH, Ördög B, de Vries AAF, Pijnappels DA
Aims: Ventricular tachyarrhythmias (VTs) are common in the pathologically remodelled heart. These arrhythmias can be lethal, necessitating acute treatment like electrical cardioversion to restore normal rhythm. Recently, it has been proposed that cardioversion may also be realized via optically controlled generation of bioelectricity by the arrhythmic heart itself through optogenetics and therefore without the need of traumatizing high-voltage shocks. However, crucial mechanistic and translation...
Abstract
Cited 3 times since 2022 (1 per year)
source: EuropePMC
JCO precision oncology,
Volume 6, 1 1 2022, Pages e2200180
<i>DPYD*7</i> as a Predictor of Severe Fluoropyrimidine-Related Adverse Events.
de With M, Brufau G, van den Berg LA, de Man FM, Trajkovic M, Thijs MF, Castel R, Vermeer HJ, El Bouazzaoui S, van Hemel A, Matic M, Mathijssen RHJ, Bins S, van Schaik RHN
Purpose: Around 20%-30% of patients treated with fluoropyrimidines develop severe treatment-related adverse events (AEs). These are mainly caused by deficiency of dihydropyrimidine dehydrogenase, its main metabolizing enzyme. The DPYD*7 variant allele contains a frameshift mutation that leads to absence of dihydropyrimidine dehydrogenase. Clinical studies on this variant in patients treated with fluoropyrimidines are lacking because of its low minor allelic frequency. However, the DPYD*7 minor a...
Abstract
Cited 4 times since 2022 (1.4 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 23, Issue 8, 1 1 2022, Pages 1090-1097
Association between computed tomography-derived tricuspid annular dimensions and prognosis: insights from whole-beat computed tomography assessment.
Hirasawa K, Fortuni F, van Rosendael PJ, Ajmone Marsan N, Bax JJ, Delgado V
Aims: Tricuspid regurgitation (TR) has been associated with outcome in patients treated with transcatheter aortic valve implantation (TAVI). Tricuspid annulus (TA) dimensions are associated with TR. However, the TA is highly dynamic during the cardiac cycle, and the interaction between the TA dimensions, TR, and patient prognosis has never been evaluated. This study aimed to characterize the dynamics of the TA along with the cardiac cycle and its association with prognosis in patients undergoing...
Abstract
Cited 13 times since 2022 (4.4 per year)
source: EuropePMC
Clinical chemistry,
Volume 68, Issue 7, 1 1 2022, Pages 963-972
Dutch National Round Robin Trial on Plasma-Derived Circulating Cell-Free DNA Extraction Methods Routinely Used in Clinical Pathology for Molecular Tumor Profiling.
van der Leest P, Ketelaar EM, van Noesel CJM, van den Broek D, van Boerdonk RAA, Deiman B, Rifaela N, van der Geize R, Huijsmans CJJ, Speel EJM, Geerlings MJ, van Schaik RHN, Jansen MPHM, Dane-Vogelaar R, Driehuis E, Leers MPG, Sidorenkov G, Tamminga M, van Kempen LC, Schuuring E
Background: Efficient recovery of circulating tumor DNA (ctDNA) depends on the quantity and quality of circulating cell-free DNA (ccfDNA). Here, we evaluated whether various ccfDNA extraction methods routinely applied in Dutch laboratories affect ccfDNA yield, ccfDNA integrity, and mutant ctDNA detection, using identical lung cancer patient-derived plasma samples. Methods: Aliquots of 4 high-volume diagnostic leukapheresis plasma samples and one artificial reference plasma sample with predetermi...
Abstract
JACC. Cardiovascular interventions,
Volume 15, Issue 14, 1 1 2022, Pages 1491
Reply: Could Left Atrial Function Modify Outcomes After Transcatheter Edge-to-Edge Repair of the Mitral Valve?
Yoon SH, Siegel RJ, Bax JJ, Makkar RR
Abstract
Cited 17 times since 2022 (5.8 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 62, Issue 2, 1 1 2022, Pages ezac290
Staging right heart failure in patients with tricuspid regurgitation undergoing tricuspid surgery.
Galloo X, Stassen J, Butcher SC, Meucci MC, Dietz MF, Mertens BJA, Prihadi EA, van der Bijl P, Ajmone Marsan N, Braun J, Bax JJ, Delgado V
Objectives: This study evaluated the prognostic value of staging right heart failure in patients with significant tricuspid regurgitation (TR) undergoing tricuspid valve (TV) surgery. Methods: Patients with significant TR who underwent TV surgery were divided into 4 right heart failure stages according to the presence of right ventricular (RV) dysfunction and clinical signs of right heart failure: stage 1 was defined as no RV dysfunction and no signs of right heart failure; stage 2 indicated RV...
Abstract
Cited 2 times since 2022 (0.7 per year)
source: EuropePMC
Allergy and asthma proceedings,
Volume 43, Issue 5, 1 1 2022, Pages e40-e46
Clinical utility of serum tryptase levels in pediatric anaphylaxis.
Şengül Emeksiz Z, Yılmaz D, Alan B, Tunc SD, Dibek Mısırlıoğlu E
Introduction: This study aimed to evaluate the preliminary diagnosis, demographic characteristics, and outcomes of patients whose serum total tryptase levels were measured while in a tertiary pediatric hospital and to ascertain the role of serum tryptase levels in the etiology, diagnosis, severity, and course of systemic anaphylaxis. Methods: Patients ages between 1 month and 17 years who were followed up in the pediatric emergency department or as inpatients and with a diagnosis of immediate-ty...
Abstract
Cited 2 times since 2022 (0.7 per year)
source: EuropePMC
Holistic nursing practice,
Volume 36, Issue 4, 1 1 2022, Pages 209-222
The Effect of Aromatherapy on Blood Pressure and Stress Responses by Inhalation and Foot Massage in Patients With Essential Hypertension: Randomized Clinical Trial.
Can Çiçek S, Demir Ş, Yılmaz D, Açıkgöz A, Yıldız S, Yis ÖM
A 3-arm, parallel group, randomized clinical trial examines the effect of aromatherapy through inhalation and foot massage on blood pressure and stress response in patients with essential hypertension. Lavender oil reduced blood pressure, heart rate, serum cortisol, and subjective anxiety in hypertensive patients.
Abstract
Cited 14 times since 2022 (4.8 per year)
source: EuropePMC
Annals of cardiothoracic surgery,
Volume 11, Issue 4, 1 1 2022, Pages 380-388
Normal and abnormal development of the aortic valve and ascending aortic wall: a comprehensive overview of the embryology and pathology of the bicuspid aortic valve.
Grewal N, Gittenberger-de Groot AC, Lindeman JH, Klautz A, Driessen A, Klautz RJM, Poelmann RE
A bicuspid aortic valve (BAV) is the most prevalent congenital cardiac anomaly, in which the valve has only two leaflets, instead of the normal three. Patients with a BAV have an increased risk of aneurysm formation and the development of an aortic dissection. Vascular smooth muscle cells in both the non- and dilated aortic wall are characterized by a maturation defect in all BAV patients, as compared to patients with a tricuspid aortic valve, which can contribute to inherent developmental susce...
Abstract
Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES,
Volume 28, Issue 7, 1 1 2022, Pages 1031-1034
Uncommon presentation of Meckel's diverticulum in a child with decompensated hypovolemic shock.
Şık N, Uzun A, Öztürk A, Aydın E, Karakuş OZ, Duman M, Yılmaz D
Meckel's diverticulum (MD) is the most common congenital anomaly of the gastrointestinal tract and may cause serious complications such as intestinal obstruction, gastrointestinal hemorrhage, or inflammation with/without perforation, which can present with non-spe-cific symptoms and signs. We report on the case of a 2.5-year-old boy admitted to our emergency department in poor condition, with compatible signs of decompensated hypovolemic shock. This case finally resulted in intestinal volvu...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir,
Volume 50, Issue 5, 1 1 2022, Pages 314-319
Study of Transesophageal Echocardiography in Young Patients with Cryptogenic Stroke: Prevalence of Patent Foramen Ovale and Interpretation of the RoPE Score.
Arslan A, Yılmaz DÇ, Adıyaman M, Kara C, Örsçelik Ö, Yılmaz IA
Objective: Cryptogenic stroke (CS) is considered to be the most common stroke subtype in young patients. The Risk of Paradoxical Embolism (RoPE) score is a tool that stratifies patients with CS according to the probability of patent foramen ovale (PFO). The aim of this retrospective study is to determine the prevalence of PFO in young patients with transesophageal echocardi- ography (TEE) and to evaluate the role of RoPE score in PFO-related strokes. Methods: The medical records of patients with...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 23, Issue 8, 1 1 2022, Pages e301-e302
Discussion forum: it is time to assess left ventricular segmental remodelling in aortic stenosis.
Stassen J, Bax JJ
Abstract
Cited 50 times since 2022 (17 per year)
source: EuropePMC
Circulation,
Volume 146, Issue 9, 30 5 2022, Pages 657-672
Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab.
Hagström E, Steg PG, Szarek M, Bhatt DL, Bittner VA, Danchin N, Diaz R, Goodman SG, Harrington RA, Jukema JW, Liberopoulos E, Marx N, McGinniss J, Manvelian G, Pordy R, Scemama M, White HD, Zeiher AM, Schwartz GG, ODYSSEY OUTCOMES Investigators
Background: Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein cholesterol is uncertain. Methods: The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor al...
Abstract
Cited 7 times since 2022 (2.4 per year)
source: EuropePMC
Pharmacogenomics and personalized medicine,
Volume 15, 30 5 2022, Pages 675-696
The Impact of Pharmacogenetics on Pharmacokinetics and Pharmacodynamics in Neonates and Infants: A Systematic Review.
Yalçin N, Flint RB, van Schaik RHN, Simons SHP, Allegaert K
In neonates, pharmacogenetics has an additional layer of complexity. This is because in addition to genetic variability in genes that code for proteins relevant to clinical pharmacology, there are rapidly maturational changes in these proteins. Consequently, pharmacotherapy in neonates has unique challenges. To provide a contemporary overview on pharmacogenetics in neonates, we conducted a systematic review to identify, describe and quantify the impact of pharmacogenetics on pharmacokinetics and...
Abstract
Cited 4 times since 2022 (1.4 per year)
source: EuropePMC
Cancer immunology, immunotherapy : CII,
Volume 72, Issue 1, 30 5 2022, Pages 137-149
Intratumoral T cell depletion following neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer is associated with poor clinical outcome.
van Wilpe S, Sultan S, Gorris MAJ, Somford DM, Kusters-Vandevelde HVN, Koornstra RHT, Gerritsen WR, Simons M, van der Heijden AG, de Vries IJM, Mehra N
Background: Whereas neoadjuvant cisplatin-based chemotherapy (NAC) followed by a radical cystectomy remains the standard treatment for patients with muscle-invasive bladder cancer (MIBC), increasing evidence suggests that checkpoint inhibitors, either alone or in combination with chemotherapy, are effective in the (neo)adjuvant setting. The major aim of this study was to improve our understanding of the immune-modulating effects of NAC in MIBC. Methods: Tumor tissue of 81 patients was used, incl...
Abstract
Cited 5 times since 2022 (1.7 per year)
source: EuropePMC
Journal of clinical research in pediatric endocrinology,
Volume 14, Issue 4, 30 5 2022, Pages 402-408
Are Thyroid Functions Affected in Multisystem Inflammatory Syndrome in Children?
Elvan-Tüz A, Ayrancı İ, Ekemen-Keleş Y, Karakoyun İ, Çatlı G, Kara-Aksay A, Karadağ-Öncel E, Dündar BN, Yılmaz D
Objective: Multisystem inflammatory syndrome in children (MIS-C), associated with Coronavirus disease-2019, is defined as the presence of documented fever, inflammation, and at least two signs of multisystem involvement and lack of an alternative microbial diagnosis in children who have recent or current Severe acute respiratory syndrome-Coronavirus-2 infection or exposure. In this study, we evaluated thyroid function tests in pediatric cases with MIS-C in order to understand how the hypothalamu...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
Revista espanola de cardiologia (English ed.),
Volume 76, Issue 1, 24 4 2022, Pages 2-3
Fusion imaging in congenital heart disease: just a pretty picture or a new tool to improve patient management?
Regeer MV, Ajmone Marsan N
Abstract
