Research

Publications

Below you can find a list of our published research.

8684 results

Cited 2 times since 2022 (0.7 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 6, 1 1 2022, Pages 765-766 Optimization of guideline-directed medical treatment to reduce secondary mitral regurgitation: treat the ventricle, not only the valve. Stassen J, van der Bijl P, Bax JJ

Abstract

Asian Pacific journal of cancer prevention : APJCP, Volume 23, Issue 6, 1 1 2022, Pages 1913-1920 Microscopic Evaluation of Ovarian Surface Epithelium Following Treatment with Conjugated Estrogens in a Mouse Model. Al-Amri IS, Kadim IT, Al-Kindi AA, Khalaf SK, Al-Harrasi AS, Al-Hashmi SA, Al-Shibli AA, Al-Hadi WM, Al-Mahimuli MK, Jamshidi-Adegani F, Vakilian S, Al-Amri AI, Al-Yaqoobi SS, Al-Riyami KO

Background: This study was designed to evaluate the effect of different concentrations of conjugated equine estrogens (CEE) on the ovarian epithelium of female CD1 mice. Methods: Twenty-four female mice at 7 months with irregular estrus cycles were randomly divided into four groups of 6 mice each. Group one was considered as a control group and received a daily dose of 0.5ml of propylene glycol, for three weeks, while those in the treatment groups received a daily dose of 14μg/kg, 28μg/kg and 56... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 34, Issue 6, 1 1 2022, Pages 990-998 Long-term follow-up of thoracoscopic ablation in long-standing persistent atrial fibrillation. Harlaar N, Oudeman MA, Trines SA, de Ruiter GS, Mertens BJ, Khan M, Klautz RJM, Zeppenfeld K, Zeppenfeld K, Tjon A, Braun J, van Brakel TJ

Objectives: Catheter ablation of long-standing persistent atrial fibrillation (LSPAF) remains challenging, with suboptimal success rates obtained following multiple procedures. Thoracoscopic ablation has shown effective at creating transmural lesions around the pulmonary veins and box; however, long-term rhythm follow-up data are lacking. This study aims, for the first time, to assess the long-term outcomes of thoracoscopic pulmonary vein and box ablation in LSPAF. Methods: Rhythm follow-up cons... Abstract

Cited 10 times since 2022 (3.3 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 6, 1 1 2022, Pages 730-740 Clinical implications of left atrial reverse remodelling after cardiac resynchronization therapy. Stassen J, Galloo X, Chimed S, Hirasawa K, Marsan NA, Delgado V, van der Bijl P, Bax JJ

Aims: Left atrial (LA) function is a marker of prognosis in patients with heart failure. The prognostic implications of an improvement in LA function in addition to an improvement in left ventricular (LV) function after cardiac resynchronization therapy (CRT) implantation are unknown. This study aimed to evaluate the prognostic value of a significant change in LA reservoir strain (RS) and/or LV global longitudinal strain (GLS) after initiation of CRT. Methods and results: LARS and LVGLS were mea... Abstract

Cited 8 times since 2022 (2.7 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 6, 1 1 2022, Pages 781-789 Sex differences in left ventricular remodelling in patients with severe aortic valve stenosis. Kuneman JH, Singh GK, Milhorini Pio S, Hirasawa K, Hautemann D, van der Kley F, Ajmone Marsan N, Knuuti J, Delgado V, Bax JJ

Aims: Women with severe aortic stenosis (AS) have better long-term outcome after transcatheter aortic valve implantation (TAVI) but worse survival after surgical aortic valve replacement compared with men. Whether this is related to sex differences in left ventricular (LV) remodelling is unknown. The aim of this study was to examine the sex differences in LV remodelling with multidetector row computed tomography (MDCT) and outcome in patients with severe AS undergoing TAVI between 2007 and 2018.... Abstract

Studies in health technology and informatics, Volume 290, 1 1 2022, Pages 804-808 Expanding Access to CNS-TAP: Design, Development, and Initial Use of a Complex Precision Health Specialty Web App for Neuro-Oncology. Ravi K, Meng G, Roberts HJ, Schepers A, Franson A, Koschmann C, Marini BL, Flynn A

This paper offers a case study to demonstrate how a complex scoring model tool called CNS-TAP, originally created by a neuro-oncology team at one institution, was upgraded and made accessible to a wider audience. In the Results and Discussion, many issues of web app design, development, and sustainability are covered. Overall, we chart a path to expand access to many unique software tools created and needed by today's medical specialists. Abstract

Chest, Volume 161, Issue 6, 1 1 2022, Pages e355-e358 A 79-Year-Old Woman With Advanced Lung Carcinoma and Bilateral Infiltrates. Jager EC, de Boer WS, van Schaik ML, Tomlow B

Case presentation: A 79-year-old woman was admitted to the hospital for progressive dyspnea and severe hypoxemia, requiring oxygen supplementation. The dyspnea started approximately 3 to 4 weeks before presentation and was slowly progressive throughout the following weeks. Her medical history mentioned an adenocarcinoma with an epidermal growth factor receptor (EGFR) exon 19 deletion of the lung with metastases to the bones and brain for which treatment with osimertinib was started 14 months ear... Abstract

Cited 34 times since 2022 (11.3 per year) source: EuropePMC

Current biology : CB, Volume 32, Issue 12, 1 1 2022, Pages R697-R708 The economics of brain size evolution in vertebrates. Heldstab SA, Isler K, Graber SM, Schuppli C, van Schaik CP

Across the animal kingdom, we see remarkable variation in brain size. This variation has even increased over evolutionary time. Traditionally, studies aiming to explain brain size evolution have looked at the fitness benefits of increased brain size in relation to its increased cognitive performance in the social and/or ecological domain. However, brains are among the most energetically expensive tissues in the body and also require an uninterrupted energy supply. If not compensated, these energ... Abstract

Cited 10 times since 2022 (3.3 per year) source: EuropePMC

Microbial genomics, Volume 8, Issue 6, 1 1 2022 GR13-type plasmids in <i>Acinetobacter</i> potentiate the accumulation and horizontal transfer of diverse accessory genes. Moran RA, Liu H, Doughty EL, Hua X, Cummins EA, Liveikis T, McNally A, Zhou Z, van Schaik W, Yu Y

Abstract

Cited 14 times since 2022 (4.6 per year) source: EuropePMC

Brain : a journal of neurology, Volume 145, Issue 5, 1 1 2022, Pages 1641-1652 Withdrawal of intravenous immunoglobulin in chronic inflammatory demyelinating polyradiculoneuropathy. Adrichem ME, Lucke IM, Vrancken AFJE, Goedee HS, Wieske L, Dijkgraaf MGW, Voermans NC, Notermans NC, Faber CG, Visser LH, Kuitwaard K, van Doorn PA, Merkies ISJ, de Haan RJ, van Schaik IN, Eftimov F

Intravenous immunoglobulins are an efficacious treatment for chronic inflammatory demyelinating polyradiculoneuropathy. Biomarkers for disease activity are lacking, making the need for ongoing treatment difficult to assess, leading to potential overtreatment and high health-care costs. Our objective was to determine whether intravenous immunoglobulin withdrawal is non-inferior to continuing intravenous immunoglobulin treatment and to determine how often patients are overtreated. We performed a r... Abstract

Cited 9 times since 2022 (3 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 62, Issue 1, 1 1 2022, Pages ezab478 Extracardiac conduit adequacy along the respiratory cycle in adolescent Fontan patients. Rijnberg FM, van der Woude SFS, Hazekamp MG, van den Boogaard PJ, Lamb HJ, Terol Espinosa de Los Monteros C, Kroft LJM, Kenjeres S, Karim T, Jongbloed MRM, Westenberg JJM, Wentzel JJ, Roest AAW

Objectives: Adequacy of 16-20mm extracardiac conduits for adolescent Fontan patients remains unknown. This study aims to evaluate conduit adequacy using the inferior vena cava (IVC)-conduit velocity mismatch factor along the respiratory cycle. Methods: Real-time 2D flow MRI was prospectively acquired in 50 extracardiac (16-20mm conduits) Fontan patients (mean age 16.9 ± 4.5 years) at the subhepatic IVC, conduit and superior vena cava. Hepatic venous flow was determined by subtracting IVC flow fr... Abstract

Cited 13 times since 2022 (4.3 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 6, 1 1 2022, Pages 790-799 Moderate aortic stenosis: importance of symptoms and left ventricular ejection fraction. Stassen J, Ewe SH, Butcher SC, Amanullah MR, Hirasawa K, Singh GK, Sin KYK, Ding ZP, Pio SM, Sia CH, Chew NWS, Kong WKF, Poh KK, Cohen DJ, Généreux P, Leon MB, Marsan NA, Delgado V, Delgado V, Bax JJ

Aims: The aim of this study is to investigate the independent determinants of survival in patients with moderate aortic stenosis (AS), stratified by severity of symptoms and left ventricular ejection fraction (LVEF). Methods and results: Patients with a first diagnosis of moderate AS (aortic valve area >1.0 and ≤1.5 cm2) were identified. Patients were stratified by New York Heart Association (NYHA) functional class (NYHA I, NYHA II, or NYHA III-IV) and LVEF (LVEF ≥60%, LVEF 50-59%, or LVEF... Abstract

Cited 4 times since 2022 (1.3 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 30, Issue 11, 1 1 2022, Pages 503-509 Transcatheter aortic valve implantation amid the COVID-19 pandemic: a nationwide analysis of the first COVID-19 wave in the Netherlands. Rooijakkers MJP, Li WWL, Stens NA, Vis MM, Tonino PAL, Timmers L, Van Mieghem NM, den Heijer P, Kats S, Stella PR, Roolvink V, van der Werf HW, Stoel MG, Schotborgh CE, Amoroso G, Porta F, van der Kley F, van Wely MH, Gehlmann H, van Garsse LAFM, Geuzebroek GSC, Verkroost MWA, Mourisse JM, Medendorp NM, van Royen N

Introduction: The coronavirus disease 2019 (COVID-19) pandemic has put tremendous pressure on healthcare systems. Most transcatheter aortic valve implantation (TAVI) centres have adopted different triage systems and procedural strategies to serve highest-risk patients first and to minimise the burden on hospital logistics and personnel. We therefore assessed the impact of the COVID-19 pandemic on patient selection, type of anaesthesia and outcomes after TAVI. Methods: We used data from the Nethe... Abstract

Cited 6 times since 2022 (2 per year) source: EuropePMC

Journal of cardiovascular computed tomography, Volume 16, Issue 6, 31 5 2022, Pages 491-497 Age related compositional plaque burden by CT in patients with future ACS. van Rosendael AR, van den Hoogen IJ, Lin FY, Gianni U, Lu Y, Andreini D, Al-Mallah MH, Cademartiri F, Chinnaiyan K, Chow BJW, Conte E, Cury RC, Feuchtner G, de Araújo Gonçalves P, Hadamitzky M, Kim YJ, Leipsic JA, Maffei E, Marques H, Plank F, Pontone G, Raff GL, Villines TC, Lee SE, Al'Aref SJ, Baskaran L, Cho I, Danad I, Gransar H, Budoff MJ, Samady H, Virmani R, Min JK, Narula J, Berman DS, Chang HJ, Shaw LJ, Bax JJ

Background: We examined age differences in whole-heart volumes of non-calcified and calcified atherosclerosis by coronary computed tomography angiography (CCTA) of patients with future ACS. Methods: A total of 234 patients with core-lab adjudicated ACS after baseline CCTA were enrolled. Atherosclerotic plaque was quantified and characterized from the main epicardial vessels and side branches on a 0.5 mm cross-sectional basis. Calcified plaque and non-calcified plaque were defined by above or be... Abstract

Cited 9 times since 2022 (3 per year) source: EuropePMC

Journal of clinical medicine, Volume 11, Issue 11, 31 5 2022, Pages 3128 Lymphatic Phenotype of Noonan Syndrome: Innovative Diagnosis and Possible Implications for Therapy. Kleimeier LER, van Schaik C, Leenders E, Itkin M, Klein WM, Draaisma JMT

Dysregulation of the Ras/Mitogen-activated protein kinase (MAPK) signaling pathway is suggested to play a pivotal role in the development of the lymphatic system in patients with Noonan Syndrome (NS). Pathogenic gene variants in the Ras/MAPK pathway can therefore lead to various lymphatic diseases such as lymphedema, chylo-thorax and protein losing enteropathy. Diagnosis and treatment of the lymphatic phenotype in patients with NS remain difficult due to the variability of clinical presentation,... Abstract

Cited 2 times since 2022 (0.7 per year) source: EuropePMC

BMC health services research, Volume 22, Issue 1, 31 5 2022, Pages 720 Organisational implementation climate in implementing internet-based cognitive behaviour therapy for depression. Vis C, Kleiboer A, Mol M, Pedersen CD, Finch T, Smit J, Riper H, MasterMind Consortium

Background: Internet-based Cognitive Behaviour Therapy (iCBT) for depression have been implemented in routine care across Europe in varying ways, at various scales and with varying success. This study aimed to advance our understanding of organisational implementation climate from the perspectives of implementers and mental health service deliverers. Methods: Qualitative and quantitative methods were combined to study the concept of organisational implementation climate in mental health care set... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

Artificial organs, Volume 46, Issue 8, 31 5 2022, Pages 1709-1710 Unexpected negative results for CytoSorb during left ventricular assist device implantation: interpret with caution. Papazisi O, Arabkhani B, Palmen M

Abstract

Cited 3 times since 2022 (1 per year) source: EuropePMC

The Thoracic and cardiovascular surgeon, Volume 71, Issue 5, 29 5 2022, Pages 387-397 Minimally Invasive Aortic Valve Replacement in Contemporary Practice: Clinical and Hemodynamic Performance from a Prospective Multicenter Trial. Velders BJJ, Vriesendorp MD, Reardon MJ, Rao V, Lange R, Patel HJ, Gearhart E, Sabik JF, Klautz RJM

Background: The advent of transcatheter aortic valve replacement (AVR) has led to an increased emphasis on reducing the invasiveness of surgical procedures. The aim of this study was to evaluate clinical outcomes and hemodynamic performance achieved with minimally invasive aortic valve replacement (MI-AVR) as compared with conventional AVR. Methods: Patients who underwent surgical AVR with the Avalus bioprosthesis, as part of a prospective multicenter non-randomized trial, were included in this... Abstract

Cited 12 times since 2022 (4 per year) source: EuropePMC

The Canadian journal of cardiology, Volume 38, Issue 10, 27 4 2022, Pages 1542-1549 Alirocumab and Cardiovascular Outcomes in Patients With Previous Myocardial Infarction: Prespecified Subanalysis From ODYSSEY OUTCOMES. Chiang CE, Schwartz GG, Elbez Y, Szarek M, Bhatt DL, Bittner VA, Diaz R, Erglis A, Goodman SG, Hagström E, Jukema JW, Liberopoulos E, Loy M, Pordy R, White HD, Simon T, Steg PG, ODYSSEY OUTCOMES Investigators

Background: After acute coronary syndrome (ACS), patients with a previous myocardial infarction (MI) may be at particularly high risk for major adverse cardiovascular events (MACE) and death. We studied the effects of the PCSK9 inhibitor alirocumab in patients with recent ACS according to previous history of MI. Methods: The ODYSSEY OUTCOMES trial compared alirocumab with placebo, beginning 1 to 12 months after ACS with median 2.8-year follow-up. The primary MACE outcome comprised death from cor... Abstract

Cited 5 times since 2022 (1.6 per year) source: EuropePMC

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, Volume 31, Issue 12, 27 4 2022, Pages 3317-3330 The patient-reported outcomes measurement information systems (PROMIS®) physical function and its derivative measures in adults: a systematic review of content validity. Zonjee VJ, Abma IL, de Mooij MJ, van Schaik SM, Van den Berg-Vos RM, Roorda LD, Terwee CB

Purpose: This study aims to systematically review and critically appraise the content validity of the adult versions of the Patient-Reported Outcomes Measurement Information System Physical Function (PROMIS-PF) item bank and its derivative measures in any adult population. Methods: MEDLINE and EMBASE were searched in October 2021 for studies on measurement properties of PROMIS-PF measures in an adult population. Studies were included if the study described the development of a PROMIS-PF measure... Abstract