8684 results
Cited 6 times since 2022 (2 per year)
source: EuropePMC
Nursing ethics,
Volume 29, Issue 7-8, 27 4 2022, Pages 1562-1577
CURA: A clinical ethics support instrument for caregivers in palliative care.
Metselaar S, van Schaik M, Widdershoven G, Pasman HR
This article presents an ethics support instrument for healthcare professionals called CURA. It is designed with a focus on and together with nurses and nurse assistants in palliative care. First, we shortly go into the background and the development study of the instrument. Next, we describe the four steps CURA prescribes for ethical reflection: (1) Concentrate, (2) Unrush, (3) Reflect, and (4) Act. In order to demonstrate how CURA can structure a moral reflection among caregivers, we discuss h...
Abstract
Cited 22 times since 2022 (7.2 per year)
source: EuropePMC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
Volume 40, Issue 31, 26 4 2022, Pages 3633-3641
Longitudinal Molecular Profiling of Circulating Tumor Cells in Metastatic Renal Cell Carcinoma.
Bootsma M, McKay RR, Emamekhoo H, Bade RM, Schehr JL, Mannino MC, Singh A, Wolfe SK, Schultz ZD, Sperger J, Xie W, Signoretti S, Kyriakopoulos CE, Kosoff D, Abel EJ, Helzer KT, Rydzewski N, Bakhtiar H, Shi Y, Blitzer G, Bassetti M, Floberg J, Yu M, Sethakorn N, Sharifi M, Harari PM, Choueiri TK, Lang JM, Zhao SG
Purpose: Liquid biopsies in metastatic renal cell carcinoma (mRCC) provide a unique approach to understand the molecular basis of treatment response and resistance. This is particularly important in the context of immunotherapies, which target key immune-tumor interactions. Unlike metastatic tissue biopsies, serial real-time profiling of mRCC is feasible with our noninvasive circulating tumor cell (CTC) approach. Methods: We collected 457 longitudinal liquid biopsies from 104 patients with mRCC...
Abstract
Cited 8 times since 2022 (2.6 per year)
source: EuropePMC
Frontiers in immunology,
Volume 13, 26 4 2022, Pages 886810
Immunogenicity and Reactogenicity in Q Fever Vaccine Development.
Fratzke AP, van Schaik EJ, Samuel JE
Coxiella burnetii is an obligate intracellular bacterium which, in humans, causes the disease Q fever. Although Q fever is most often a mild, self-limiting respiratory disease, it can cause a range of severe syndromes including hepatitis, myocarditis, spontaneous abortion, chronic valvular endocarditis, and Q fever fatigue syndrome. This agent is endemic worldwide, except for New Zealand and Antarctica, transmitted via aerosols, persists in the environment for long periods, and is maintained thr...
Abstract
Cited 18 times since 2022 (5.9 per year)
source: EuropePMC
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association,
Volume 21, Issue 1, 26 4 2022, Pages 182-191.e2
Superior Effectiveness of Tofacitinib Compared to Vedolizumab in Anti-TNF-experienced Ulcerative Colitis Patients: A Nationwide Dutch Registry Study.
Straatmijer T, Biemans VBC, Visschedijk M, Hoentjen F, de Vries A, van Bodegraven AA, Bodelier A, de Boer NKH, Dijkstra G, Festen N, Horjus C, Jansen JM, Jharap B, Mares W, van Schaik FDM, Ponsioen C, Romkens T, Srivastava N, van der Voorn MMPJA, West R, van der Woude J, Wolvers MDJ, Pierik M, van der Meulen-de Jong AE, Duijvestein M, Initiative on Crohn and Colitis
Background & aims: Clinicians face difficulty in when and in what order to position biologics and Janus kinase inhibitors in patients with anti-tumor necrosis factor-alpha (TNF) refractory ulcerative colitis (UC). We aimed to compare the effectiveness and safety of vedolizumab and tofacitinib in anti-TNF-exposed patients with UC in our prospective nationwide Initiative on Crohn and Colitis Registry. Methods: Patients with UC who failed anti-TNF treatment and initiated vedolizumab or tofaciti...
Abstract
Cited 3 times since 2022 (1 per year)
source: EuropePMC
JMIR cardio,
Volume 6, Issue 1, 25 4 2022, Pages e34974
Design of a Remote Coaching Program to Bridge the Gap From Hospital Discharge to Cardiac Rehabilitation: Intervention Mapping Study.
Keessen P, van Duijvenbode IC, Latour CH, Kraaijenhagen RA, Janssen VR, Jørstad HT, Scholte Op Reimer WJ, Visser B
Background: Remote coaching might be suited for providing information and support to patients with coronary artery disease (CAD) in the vulnerable phase between hospital discharge and the start of cardiac rehabilitation (CR). Objective: The goal of the research was to explore and summarize information and support needs of patients with CAD and develop an early remote coaching program providing tailored information and support. Methods: We used the intervention mapping approach to develop a remot...
Abstract
Cited 8 times since 2022 (2.6 per year)
source: EuropePMC
Journal of the peripheral nervous system : JPNS,
Volume 27, Issue 2, 25 4 2022, Pages 144-158
Assessing deterioration using impairment and functional outcome measures in chronic inflammatory demyelinating polyneuropathy: A post-hoc analysis of the immunoglobulin overtreatment in CIDP trial.
van Veen R, Wieske L, Lucke I, Adrichem ME, Merkies ISJ, van Schaik IN, Eftimov F
It is unclear whether frequently used cutoff values for outcome measures defining minimal clinically important differences (MCIDs) can accurately identify meaningful deterioration in chronic inflammatory demyelinating polyneuropathy (CIDP). We used data from the immunoglobulin overtreatment in CIDP (IOC) trial, in which 60 clinically stable patients with CIDP were randomized to intravenous immunoglobulin (IVIg) withdrawal or continuation. We calculated change scores of the Inflammatory Rasch-Bui...
Abstract
Cited 17 times since 2022 (5.6 per year)
source: EuropePMC
The Lancet. Global health,
Volume 10, Issue 7, 24 4 2022, Pages e1003-e1011
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study.
GlobalSurg Collaborative and NIHR Global Health Research Unit on Global Surgery
Background: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre,...
Abstract
Cited 5 times since 2022 (1.6 per year)
source: EuropePMC
PloS one,
Volume 17, Issue 5, 23 4 2022, Pages e0267985
Impact of delayed sternal closure on wound infections following neonatal and infant cardiac surgery.
von Stumm M, Leps Y, Jochheim L, van Rüth V, Gottschalk U, Mueller G, Kozlik-Feldmann R, Hazekamp MG, Sachweh JS, Biermann D
Objectives: Delayed sternal closure is a routine procedure to reduce hemodynamic and respiratory instability in pediatric patients following cardiac surgery, particularly in neonates and infants. In this setting, the possible links between sternal wound infection and delayed sternal closure are still a matter of debate. As a part of our routine, there was a low threshold for delayed sternal closure, so we reviewed our experience with sternal wound infections with a focus on potentially related p...
Abstract
Cited 12 times since 2022 (3.9 per year)
source: EuropePMC
Surgical endoscopy,
Volume 36, Issue 10, 23 4 2022, Pages 7764-7774
Laparoscopic peritoneal lavage versus sigmoidectomy for perforated diverticulitis with purulent peritonitis: three-year follow-up of the randomised LOLA trial.
Hoek VT, Edomskis PP, Stark PW, Lambrichts DPV, Draaisma WA, Consten ECJ, Lange JF, Bemelman WA, LADIES trial collaborators
Background: This study aimed to compare laparoscopic lavage and sigmoidectomy as treatment for perforated diverticulitis with purulent peritonitis during a 36 month follow-up of the LOLA trial. Methods: Within the LOLA arm of the international, multicentre LADIES trial, patients with perforated diverticulitis with purulent peritonitis were randomised between laparoscopic lavage and sigmoidectomy. Outcomes were collected up to 36 months. The primary outcome of the present study was cumulative mor...
Abstract
Cited 13 times since 2022 (4.3 per year)
source: EuropePMC
PloS one,
Volume 17, Issue 5, 20 3 2022, Pages e0268768
Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium.
Siland JE, Geelhoed B, Roselli C, Wang B, Lin HJ, Weiss S, Trompet S, van den Berg ME, Soliman EZ, Chen LY, Ford I, Jukema JW, Macfarlane PW, Kornej J, Lin H, Lunetta KL, Kavousi M, Kors JA, Ikram MA, Guo X, Yao J, Dörr M, Felix SB, Völker U, Sotoodehnia N, Arking DE, Stricker BH, Heckbert SR, Lubitz SA, Benjamin EJ, Alonso A, Ellinor PT, van der Harst P, Rienstra M
Background: Both elevated and low resting heart rates are associated with atrial fibrillation (AF), suggesting a U-shaped relationship. However, evidence for a U-shaped causal association between genetically-determined resting heart rate and incident AF is limited. We investigated potential directional changes of the causal association between genetically-determined resting heart rate and incident AF. Method and results: Seven cohorts of the AFGen consortium contributed data to this meta-analysi...
Abstract
Cited 9 times since 2022 (2.9 per year)
source: EuropePMC
BMC infectious diseases,
Volume 22, Issue 1, 20 3 2022, Pages 482
Transmission routes of antibiotic resistant bacteria: a systematic review.
Godijk NG, Bootsma MCJ, Bonten MJM
Background: Quantification of acquisition routes of antibiotic resistant bacteria (ARB) is pivotal for understanding transmission dynamics and designing cost-effective interventions. Different methods have been used to quantify the importance of transmission routes, such as relative risks, odds ratios (OR), genomic comparisons and basic reproduction numbers. We systematically reviewed reported estimates on acquisition routes' contributions of ARB in humans, animals, water and the environmen...
Abstract
Cited 7 times since 2022 (2.3 per year)
source: EuropePMC
Circulation research,
Volume 131, Issue 1, 19 3 2022, Pages 24-41
Sbk2, a Newly Discovered Atrium-Enriched Regulator of Sarcomere Integrity.
van Gorp PRR, Zhang J, Liu J, Tsonaka R, Mei H, Dekker SO, Bart CI, De Coster T, Post H, Heck AJR, Schalij MJ, Atsma DE, Pijnappels DA, de Vries AAF
Background: Heart development relies on tight spatiotemporal control of cardiac gene expression. Genes involved in this intricate process have been identified using animals and pluripotent stem cell-based models of cardio(myo)genesis. Recently, the repertoire of cardiomyocyte differentiation models has been expanded with iAM-1, a monoclonal line of conditionally immortalized neonatal rat atrial myocytes (NRAMs), which allows toggling between proliferative and differentiated (ie, excitable and co...
Abstract
Cited 2 times since 2022 (0.7 per year)
source: EuropePMC
BMC microbiology,
Volume 22, Issue 1, 18 3 2022, Pages 135
Using unique ORFan genes as strain-specific identifiers for Escherichia coli.
Ferrandis-Vila M, Tiwari SK, Mamerow S, Semmler T, HECTOR consortium, Menge C, Berens C
Background: Bacterial identification at the strain level is a much-needed, but arduous and challenging task. This study aimed to develop a method for identifying and differentiating individual strains among multiple strains of the same bacterial species. The set used for testing the method consisted of 17 Escherichia coli strains picked from a collection of strains isolated in Germany, Spain, the United Kingdom and Vietnam from humans, cattle, swine, wild boars, and chickens. We targeted unique...
Abstract
Cited 7 times since 2022 (2.3 per year)
source: EuropePMC
Proceedings. Biological sciences,
Volume 289, Issue 1975, 18 3 2022, Pages 20220200
Individual variation and plasticity in the infant-directed communication of orang-utan mothers.
Fröhlich M, van Schaik CP, van Noordwijk MA, Knief U
Between-individual variation in behavioural expression, such as social responsiveness, has been shown to have important eco-evolutionary consequences. However, most comparative research on non-human primate communication has focused on species- or population-level variation, while among- and within-individual variation has been largely ignored or considered as noise. Here, we apply a behavioural reaction norm framework to repeated observations of mother-offspring interactions in wild and zoo-hou...
Abstract
Cited 2 times since 2022 (0.7 per year)
source: EuropePMC
Clinical pharmacology and therapeutics,
Volume 112, Issue 2, 18 3 2022, Pages 316-326
Model-Based Prediction of Irinotecan-Induced Grade 4 Neutropenia in Advanced Cancer Patients: Influence of Demographic and Clinical Factors.
Karas S, Mathijssen RHJ, van Schaik RHN, Forrest A, Wiltshire T, Innocenti F, Bies RR
Severe neutropenia is the major dose-liming toxicity of irinotecan-based chemotherapy. The objective was to assess to what extent a population pharmacokinetic/pharmacodynamic model including patient-specific demographic/clinical characteristics, individual pharmacokinetics, and absolute neutrophil counts (ANCs) can predict irinotecan-induced grade 4 neutropenia. A semimechanistic population pharmacokinetic/pharmacodynamic model was developed to describe neutrophil response over time in 197 patie...
Abstract
Cited 7 times since 2022 (2.3 per year)
source: EuropePMC
International journal of colorectal disease,
Volume 37, Issue 6, 18 3 2022, Pages 1385-1391
Accuracy of imaging in discriminating complicated from uncomplicated appendicitis in daily clinical practice.
Bolmers MDM, Bom WJ, Scheijmans JCG, van Geloven AAW, Boermeester MA, Bemelman WA, van Rossem CC, SNAPSHOT collaborators
Background: Radiologic imaging can accurately diagnose acute appendicitis, but little is known about its discriminatory capacity between complicated and uncomplicated appendicitis. Objective: This study aims to investigate the accuracy of imaging in discriminating complicated from uncomplicated appendicitis. Methods: Data was used from the prospective, nationwide, observational SNAPSHOT appendicitis database, including patients with suspected acute appendicitis who were planned for an appendecto...
Abstract
Cited 58 times since 2022 (19 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 80, Issue 8, 17 3 2022, Pages 783-800
Evolution and Prognostic Impact of Cardiac Damage After Aortic Valve Replacement.
Généreux P, Pibarot P, Redfors B, Bax JJ, Zhao Y, Makkar RR, Kapadia S, Thourani VH, Mack MJ, Nazif TM, Lindman BR, Babaliaros V, Vincent F, Russo M, McCabe JM, Gillam LD, Alu MC, Hahn RT, Webb JG, Leon MB, Cohen DJ
Background: The impact of aortic valve replacement (AVR) on progression/regression of extravalvular cardiac damage and its association with subsequent prognosis is unknown. Objectives: The purpose of this study was to describe the evolution of cardiac damage post-AVR and its association with outcomes. Methods: Patients undergoing transcatheter or surgical AVR from the PARTNER (Placement of Aortic Transcatheter Valves) 2 and 3 trials were pooled and classified by cardiac damage stage at baseline...
Abstract
Cited 3 times since 2022 (1 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 11, Issue 10, 16 3 2022, Pages e023313
Differences in Characteristics and Outcomes Between Patients With Hypertrophic Cardiomyopathy From Asian and European Centers.
Tjahjadi C, Butcher SC, Zegkos T, Sia CH, Hirasawa K, Kamperidis V, Ngiam JN, Wong RCC, Efthimiadis G, Bax JJ, Delgado V, Ajmone Marsan N
Abstract
Vascular,
Volume 31, Issue 6, 16 3 2022, Pages 1051-1060
What we have learned from in-vitro studies of the chimney endovascular technique for treatment of complex abdominal aortic aneurysms: A systematic review.
Meekel JP, Tran BL, van Schaik TG, Donas KP, Taneva GT, Jongkind V, Yeung KK
Background: A considerable number of patients with abdominal aortic aneurysms (AAA) is not eligible for standard endovascular repair. These complex cases require alternative surgical approaches including the readily available chimney graft endovascular aneurysm repair (Ch-EVAR) or sealing (Ch-EVAS). The optimal configuration for Ch-EVAR or Ch-EVAS is important for success but not yet known. Objective: The aim of the present study was to analyze current data of the outcomes of in-vitro chimney gr...
Abstract
Cited 6 times since 2022 (2 per year)
source: EuropePMC
Cardiovascular drugs and therapy,
Volume 37, Issue 5, 14 2 2022, Pages 941-953
Implications of ACC/AHA Versus ESC/EAS LDL-C Recommendations for Residual Risk Reduction in ASCVD: A Simulation Study From DA VINCI.
Vallejo-Vaz AJ, Bray S, Villa G, Brandts J, Kiru G, Murphy J, Banach M, De Servi S, Gaita D, Gouni-Berthold I, Kees Hovingh G, Jozwiak JJ, Jukema JW, Gabor Kiss R, Kownator S, Iversen HK, Maher V, Masana L, Parkhomenko A, Peeters A, Clifford P, Raslova K, Siostrzonek P, Romeo S, Tousoulis D, Vlachopoulos C, Vrablik M, Catapano AL, Poulter NR, Ray KK, DA VINCI Study Investigators
Purpose: Low-density lipoprotein cholesterol (LDL-C) recommendations differ between the 2018 American College of Cardiology/American Heart Association (ACC/AHA) and 2019 European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines for patients with atherosclerotic cardiovascular disease (ASCVD) (
Abstract
