Research

Publications

Below you can find a list of our published research.

6131 results

Cited 1 times since 2018 (0.1 per year) source: EuropePMC

Journal of hypertension, Volume 36, Issue 4, 1 1 2018, Pages 773-778 Association of diastolic blood pressure with cardiovascular events in older people varies upon cardiovascular history. Wijsman LW, Muller M, de Craen AJM, Jukema JW, Westendorp RGJ, Mooijaart SP

Background: In older age, a low DBP has been associated with increased risk of cardiovascular events, especially in frail older people. We tested the hypothesis that low DBP is associated with a high risk of cardiovascular events in people with a previous history of cardiovascular disease, as a proxy of vascular impairment. Methods: We included 5804 participants (mean age 75 years) from the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) who as part of the trial were intensivel... Abstract

Cited 7 times since 2018 (1 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 26, Issue 4, 1 1 2018, Pages 610-616 Early and late results of surgical treatment for isolated active native mitral valve infective endocarditis. Tomšic A, Versteegh MIM, Ajmone Marsan N, van Brakel TJ, Klautz RJM, Palmen M

Objectives: Native mitral valve infective endocarditis (IE) is a complicated disease with high mortality and morbidity rates. Mitral valve repair (MVRep) is feasible when limited valve destruction is present. However, recurrent valve dysfunction and reintervention are common. Methods: Between January 2000 and March 2016, 83 patients underwent surgery for isolated active native mitral valve IE. We applied an early surgery, MVRep-oriented approach with progressive utilization of patch techniques t... Abstract

Cited 2 times since 2018 (0.3 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 26, Issue 4, 1 1 2018, Pages 559-565 Mitral valve repair in Barlow's disease with bileaflet prolapse: the effect of annular stabilization on functional mitral valve leaflet prolapse. Tomšic A, Hiemstra YL, Bissessar DD, van Brakel TJ, Versteegh MIM, Ajmone Marsan N, Klautz RJM, Palmen M

Objectives: Barlow's disease is the most severe form of degenerative mitral valve disease, commonly characterized by bileaflet prolapse. Abnormal mitral annular dynamics is typically present and results in functional prolapse of the mitral leaflets that may be addressed with annular stabilization alone. Methods: Between January 2001 and December 2015, 128 patients with Barlow's disease and bileaflet prolapse underwent valve repair. This included anterior mitral valve leaflet (AMVL) rep... Abstract

Cited 27 times since 2018 (3.9 per year) source: EuropePMC

European heart journal, Volume 39, Issue 15, 1 1 2018, Pages 1308-1313 Inter-ethnic differences in valve morphology, valvular dysfunction, and aortopathy between Asian and European patients with bicuspid aortic valve. Kong WKF, Regeer MV, Poh KK, Yip JW, van Rosendael PJ, Yeo TC, Tay E, Kamperidis V, van der Velde ET, Mertens B, Ajmone Marsan N, Delgado V, Bax JJ

Background: Transcatheter aortic valve replacement (TAVR) has been shown safe and feasible in patients with bicuspid aortic valve (BAV) morphology. Evaluation of inter-ethnic differences in valve morphology and function and aortic root dimensions in patients with BAV is important for the worldwide spread of this therapy in this subgroup of patients. Comparisons between large European and Asian cohorts of patients with BAV have not been performed, and potential differences between populations may... Abstract

Cited 47 times since 2018 (6.8 per year) source: EuropePMC

European heart journal, Volume 39, Issue 16, 1 1 2018, Pages 1416-1425 Left atrial function to identify patients with atrial fibrillation at high risk of stroke: new insights from a large registry. Leung M, van Rosendael PJ, Abou R, Ajmone Marsan N, Leung DY, Delgado V, Bax JJ

Aims: Atrial fibrillation (AF) is an independent risk factor for ischaemic stroke. The CHA2DS2-VASc is the most widely used risk stratification model; however, echocardiographic refinement may be useful, particularly in low risk AF patients. The present study examined the association between advanced echocardiographic parameters and ischaemic stroke, independent of CHA2DS2-VASc score. Methods and results: One thousand, three hundred and sixty-one patients (mean age 65±12 years, 74% males) with f... Abstract

Cited 11 times since 2018 (1.6 per year) source: EuropePMC

Heart rhythm, Volume 15, Issue 10, 29 5 2018, Pages 1533-1539 Prognostic value of global longitudinal strain in heart failure patients treated with cardiac resynchronization therapy. Khidir MJH, Abou R, Yilmaz D, Ajmone Marsan N, Delgado V, Bax JJ

Background: Myocardial fibrosis (macroscopic scar or diffuse reactive fibrosis) is one of the determinants of impaired left ventricular (LV) global longitudinal strain (GLS) in heart failure (HF) patients. Objective: The purpose of this study was to evaluate the prognostic value of LV GLS in HF patients treated with cardiac resynchronization therapy (CRT). Methods: The study included 829 HF patients (mean age 64.6 ± 10.4 years; 72% men) treated with CRT. Before CRT implantation, LV GLS was asses... Abstract

Turkish journal of haematology : official journal of Turkish Society of Haematology, Volume 35, Issue 2, 28 4 2018, Pages 122-128 Acute Traumatic Coagulopathy: The Value of Histone in Pediatric Trauma Patients. Ulusoy E, Duman M, Çağlar A, Küme T, Er A, Akgül F, Çitlenbik H, Yılmaz D, Ören H

Objective: Acute traumatic coagulopathy occurs after trauma with impairment of hemostasis and activation of fibrinolysis. Some endogenous substances may play roles in this failure of the coagulation system. Extracellular histone is one such molecule that has recently attracted attention. This study investigated the association between plasma histone-complexed DNA (hcDNA) fragments and coagulation abnormalities in pediatric trauma patients. Materials and methods: This prospective case-control stu... Abstract

Cited 4 times since 2018 (0.6 per year) source: EuropePMC

JACC. Clinical electrophysiology, Volume 4, Issue 6, 28 4 2018, Pages 781-793 Slow Conducting Electroanatomic Isthmuses: An Important Link Between QRS Duration and Ventricular Tachycardia in Tetralogy of Fallot. Kapel GFL, Brouwer C, Jalal Z, Sacher F, Venlet J, Schalij MJ, Thambo JB, Jongbloed MRM, Blom NA, de Riva M, Zeppenfeld K

Objectives: This study sought to evaluate the influence of slow conducting anatomic isthmuses (SCAI) as dominant ventricular tachycardia (VT) substrate on QRS duration. Background: QRS prolongation has been associated with VT in repaired tetralogy of Fallot. Methods: Seventy-eight repaired tetralogy of Fallot patients (age 37 ± 15 years, 52 male, QRS duration 153 ± 29 ms, 67 right bundle branch blocks [RBBB]) underwent programmed stimulation and electroanatomic activation mapping during sinus rh... Abstract

Cited 7 times since 2018 (1 per year) source: EuropePMC

Cytokine, Volume 108, 26 4 2018, Pages 96-104 CXCL8 hyper-signaling in the aortic abdominal aneurysm. Kokje VBC, Gäbel G, Dalman RL, Koole D, Northoff BH, Holdt LM, Hamming JF, Lindeman JHN

There are indications for elevated CXCL8 levels in abdominal aortic aneurysm disease (AAA). CXCL8 is concurrently involved in neutrophil-mediated inflammation and angiogenesis, two prominent and distinctive characteristics of AAA. As such we considered an evaluation of a role for CXCL8 in AAA progression relevant. ELISA's, real time PCR and array analysis were used to explore CXCL8 signaling in AAA wall samples. A role for CXCL8 in AAA disease was tested through the oral CXCR1/2 antagonist... Abstract

Cited 14 times since 2018 (2 per year) source: EuropePMC

BMJ open, Volume 8, Issue 3, 22 4 2018, Pages e019003 Prevalence of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants: a cross-sectional study. O Riordan D, Aubert CE, Walsh KA, Van Dorland A, Rodondi N, Du Puy RS, Poortvliet RKE, Gussekloo J, Sinnott C, Byrne S, Galvin R, Jukema JW, Mooijaart SP, Baumgartner C, McCarthy V, Walsh EK, Collet TH, Dekkers OM, Blum MR, Kearney PM

Objectives: To estimate and compare the prevalence and type of potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) among community-dwelling older adults (≥65 years) enrolled to a clinical trial in three European countries. Design: A secondary analysis of the Thyroid Hormone Replacement for Subclinical Hypothyroidism Trial dataset. Participants: A subset of 48/80 PIP and 22/34 PPOs indicators from the Screening Tool of Older Persons Prescriptions/Screening Tool... Abstract

Cited 28 times since 2018 (4 per year) source: EuropePMC

JACC. Clinical electrophysiology, Volume 4, Issue 3, 19 3 2018, Pages 316-327 Targeting the Hidden Substrate Unmasked by Right Ventricular Extrastimulation Improves Ventricular Tachycardia Ablation Outcome After Myocardial Infarction. de Riva M, Naruse Y, Ebert M, Androulakis AFA, Tao Q, Watanabe M, Wijnmaalen AP, Venlet J, Brouwer C, Trines SA, Schalij MJ, Zeppenfeld K

Objectives: This study sought to determine whether ablation of hidden substrate unmasked by right ventricular extrastimulation (RVE) improves ablation outcome of post-myocardial infarction (MI) ventricular tachycardia (VT). Background: In patients with small or nontransmural scars after MI, part of the VT substrate may be functional and, in addition, masked by high-voltage far-field signals arising from adjacent normal myocardium. Methods: In 60 consecutive patients, systematic analysis of elect... Abstract

Cited 4 times since 2018 (0.6 per year) source: EuropePMC

Atherosclerosis, Volume 272, 16 3 2018, Pages 94-100 Associations between normal range albuminuria, renal function and cardiovascular function in a population-based imaging study. Dekkers IA, de Mutsert R, Rabelink TJ, Jukema JW, de Roos A, Rosendaal FR, Lamb HJ, de Vries APJ

Background and aims: In patients with impaired renal function and macroalbuminuria, cardiovascular risk factors are highly prevalent, however, whether this is also present in the general population is unclear. We investigated whether normal-range albuminuria and renal function are associated with cardiovascular function in the general population. Methods: In this cross-sectional analysis of the NEO study, urinary albumin-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), and i... Abstract

Cited 1 times since 2018 (0.1 per year) source: EuropePMC

American journal of translational research, Volume 10, Issue 3, 15 3 2018, Pages 816-826 No indications for platelet activation in acute clinical myocardial or renal ischemia/reperfusion injury. Kortekaas KA, de Vries DK, Roest M, Reinders ME, van der Veer EP, Klautz RJ, de Groot PG, Schaapherder AF, Lindeman JH

The pathophysiology of ischemia/reperfusion (I/R) injury is complex and poorly understood. Animal studies imply platelet activation as an initiator of the inflammatory response upon reperfusion. However, it remains unclear whether and how these results translate to clinical I/R. This study evaluates putative platelet activation in the context of two forms of clinical I/R (heart valve surgery with aortic-cross clamping, n = 39 and kidney transplantation, n = 34). The technique of sequential selec... Abstract

Cited 60 times since 2018 (8.6 per year) source: EuropePMC

Circulation research, Volume 122, Issue 12, 15 3 2018, Pages 1648-1660 The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking. Fedoseienko A, Wijers M, Wolters JC, Dekker D, Smit M, Huijkman N, Kloosterhuis N, Klug H, Schepers A, Willems van Dijk K, Levels JHM, Billadeau DD, Hofker MH, van Deursen J, Westerterp M, Burstein E, Kuivenhoven JA, van de Sluis B

Rationale: COMMD (copper metabolism MURR1 domain)-containing proteins are a part of the CCC (COMMD-CCDC22 [coiled-coil domain containing 22]-CCDC93 [coiled-coil domain containing 93]) complex facilitating endosomal trafficking of cell surface receptors. Hepatic COMMD1 inactivation decreases CCDC22 and CCDC93 protein levels, impairs the recycling of the LDLR (low-density lipoprotein receptor), and increases plasma low-density lipoprotein cholesterol levels in mice. However, whether any of the oth... Abstract

Cited 15 times since 2018 (2.1 per year) source: EuropePMC

Pediatric pulmonology, Volume 53, Issue 6, 12 2 2018, Pages 809-815 Early predictors of unresponsiveness to high-flow nasal cannula therapy in a pediatric emergency department. Er A, Çağlar A, Akgül F, Ulusoy E, Çitlenbik H, Yılmaz D, Duman M

Aim: High-flow nasal cannula (HFNC) is a new treatment option for pediatric respiratory distress and we aimed to assess early predictive factors of unresponsiveness to HFNC therapy in a pediatric emergency department (ED). Method: Patients who presented with respiratory distress and were treated by HFNC, were included. The age, gender, weight, medical history, diagnosis, vital signs, oxygen saturation/fraction of inspired oxygen (SpO2 /FiO2 ) ratio, modified Respiratory Distress Assessment Instr... Abstract

Cited 808 times since 2018 (115.7 per year) source: EuropePMC

Nature genetics, Volume 50, Issue 4, 12 2 2018, Pages 524-537 Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K,

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage-dise... Abstract

Cited 12 times since 2018 (1.7 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 31, Issue 7, 10 2 2018, Pages 777-783 Left Ventricular Mechanical Dispersion and Global Longitudinal Strain and Ventricular Arrhythmias in Predialysis and Dialysis Patients. Hensen LCR, Goossens K, Podlesnikar T, Rotmans JI, Jukema JW, Delgado V, Bax JJ

Background: Patients with advanced chronic kidney disease (CKD) have high risk for sudden cardiac death (SCD) and may benefit from implantable cardioverter-defibrillators (ICDs). However, the risk for ICD-related complications is also high in this population. Therefore, there is an unmet need for accurate risk stratification tools to identify patients with CKD at risk for ventricular arrhythmias (VAs), who may benefit from ICD implantation. The aim of this hypothesis-generating study was to inve... Abstract

Cited 6 times since 2018 (0.9 per year) source: EuropePMC

International journal of cardiology, Volume 268, 8 2 2018, Pages 156-161 Right heart function interacts with left ventricular remodeling after CRT: A pressure volume loop study. Schmeisser A, Rauwolf T, Ghanem A, Groscheck T, Adolf D, Grothues F, Fischbach K, Kosiek O, Huth C, Kropf S, Lange S, Luani B, Smid J, Schäfer MH, Schreiber J, Tanev I, Wengler F, Yeritsyan NB, Steendijk P, Braun-Dullaeus RC

Background: Right ventricular (RV) dysfunction is recognized as a cardinal prognostic marker in systolic heart failure patients. Conflicting data exist on the interaction of RV function and left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT). This prospective monocentric trial was set up to assess the predictive value of baseline RV function and corresponding RV-pulmonary artery (PA) coupling on LV reverse remodeling after CRT. Methods: 110 patients with a CRT... Abstract

Cited 2 times since 2018 (0.3 per year) source: EuropePMC

Transplant international : official journal of the European Society for Organ Transplantation, Volume 31, Issue 6, 5 1 2018, Pages 610-619 The center effect in liver transplantation in the Eurotransplant region: a retrospective database analysis. Blok JJ, de Boer JD, Putter H, Rogiers X, Guba MO, Strassburg CP, Samuel U, van Hoek B, Hamming JF, Braat AE, Eurotransplant Liver Intestine Advisory Committee

Apart from donor and recipient risk factors, the effect of center-related factors has significant impact on graft survival after liver transplantation (LT). To investigate this effect in Eurotransplant, a retrospective database analysis was performed, including all LT's in adult recipients (≥18 years) in the Eurotransplant region from 1.1.2007 until 31.12.2013. Additionally, a survey was sent out to all transplant centers requesting information on surgeons' experience and exposure. In... Abstract

Circulation. Cardiovascular imaging, Volume 11, Issue 3, 1 1 2018, Pages e007643 Aortic Valve Calcium Load: Diagnostic and Prognostic Implications in Aortic Stenosis. Vollema EM, Delgado V, Bax JJ

Abstract