Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
6630 results
Cited 76 times since 1991 (2.2 per year) source: EuropePMC
Circulation, Volume 83, Issue 1, 1 1 1991, Pages 315-327 Nonlinearity and load sensitivity of end-systolic pressure-volume relation of canine left ventricle in vivo. van der Velde ET, Burkhoff D, Steendijk P, Karsdon J, Sagawa K, Baan J
The effects of mechanical changes in loading conditions on the left ventricular end-systolic pressure-volume relation (ESPVR) were studied in nine open-chest dogs, including three dogs studied before and after beta-adrenergic blockade. Left ventricular pressure was measured with a micromanometer, and left ventricular volume was measured with a conductance catheter. ESPVRs were obtained by increasing left atrial inflow over wide volume ranges (as much as threefold) under three different condition... Abstract
Cited 10 times since 1991 (0.3 per year) source: EuropePMC
European journal of cancer (Oxford, England : 1990), Volume 27, Issue 10, 1 1 1991, Pages 1315-1316 An unusual cause of diplopia in a cancer patient. van der Heijden A, Twijnstra A, Lamers WP, Hupperets PS, Freling G
A 47-year-old woman with metastatic infiltrating lobular carcinoma of the breast developed diplopia. Computed tomography of the orbits showed enlargement and irregularity of the right inferior rectus and inferior obliques muscles. Biopsies of these muscles contained breast carcinoma cells. This case report discusses the causes of diplopia in cancer patients, with special attention to the diagnostic problems of metastasis in extraocular muscles. The possible combined occurrence of metastasis in t... Abstract
Cited 10 times since 1991 (0.3 per year) source: EuropePMC
Journal of lipid research, Volume 32, Issue 1, 1 1 1991, Pages 173-181 Partial characterization of low density lipoprotein preparations isolated from fresh and frozen plasma after radiolabeling by seven different methods. Atsma DE, Kempen HJ, Nieuwenhuizen W, van 't Hooft FM, Pauwels EK
Four 99mTc and three 123I labeling methods were evaluated for their suitability to label low density lipoproteins (LDL) for the purpose of scintigraphic biodistribution studies. For 99mTc these methods were: direct incorporation in LDL of 99mTcO4- using sodium dithionite (dithionite method); a method using first N,N-dimethylformamide to prepare a 99mTc-complex reacting with LDL in a subsequent step (DMF method); a technique in which 99mTcO4- is first coupled to a diamide dithiolate derivative of... Abstract
Cited 4 times since 1991 (0.1 per year) source: EuropePMC
Journal of cardiovascular pharmacology, Volume 18 Suppl 9, 1 1 1991, Pages S55-60 Long-term efficacy of diltiazem controlled release versus metoprolol in patients with stable angina pectoris. Vliegen HW, van der Wall EE, Niemeyer MG, Holwerda NJ, Bernink PJ, de Weerd P, Bosma AH, van der Wieken LR, Timmermans AJ, Molhoek GP
In a randomized, double-blind, multicenter study, the efficacy of diltiazem controlled-release (CR) 120 mg b.i.d. was compared with metoprolol 100 mg b.i.d. in 56 patients with stable exertional angina pectoris. Fifty-one patients (28 receiving diltiazem CR, 23 receiving metoprolol), completed a follow-up period of 8 weeks. Thirty-nine patients (20 receiving diltiazem CR, 19 receiving metoprolol), completed a follow-up period of 32 weeks. Maximal exercise testing was performed at baseline and af... Abstract
Cited 54 times since 1990 (1.6 per year) source: EuropePMC
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, Volume 9, Issue 12, 1 1 1990, Pages 864-868 Detection of Chlamydia trachomatis in clinical specimens by the polymerase chain reaction. Claas HC, Melchers WJ, de Bruijn IH, de Graaf M, van Dijk WC, Lindeman J, Quint WG
Sequences derived from the endogenous plasmid of Chlamydia trachomatis and from the genes coding for ribosomal 16S RNA of Chlamydia psittaci were used as primers and oligonucleotide probes for detection of chlamydiae by the polymerase chain reaction. The endogenous plasmid primers generated specific amplified products of 517 bp with all known Chlamydia trachomatis serovars. No specific products of Chlamydia psittaci and Chlamydia pneumoniae could be detected using these primers. With the rRNA pr... Abstract
Cited 12 times since 1990 (0.3 per year) source: EuropePMC
Protein engineering, Volume 4, Issue 2, 1 1 1990, Pages 191-198 Involvement of aspartic and glutamic residues in kringle-2 of tissue-type plasminogen activator in lysine binding, fibrin binding and stimulation of activity as revealed by chemical modification and oligonucleotide-directed mutagenesis. Weening-Verhoeff EJ, Quax PH, van Leeuwen RT, Rehberg EF, Marotti KR, Verheijen JH
Modification of glutamic and aspartic acid residues of tissue-type plasminogen activator (t-PA) with 1-ethyl-3(3-dimethyl-aminopropyl)-carbodiimide leads to a decrease in affinity for lysine and fibrin, to a decrease of plasminogen activation activity in the presence of a fibrin mimic, but leaves amidolytic activity and plasminogen activation without fibrin mimic unaffected. Experiments with kringle-2 ligands and a deletion mutant of t-PA (K2P) suggests that glutamic or aspartic acid residues in... Abstract
Cited 2 times since 1990 (0.1 per year) source: EuropePMC
The American journal of physiology, Volume 259, Issue 5 Pt 2, 1 1 1990, Pages H1419-26 Comparison between force-velocity and end-systolic pressure-volume characterization of intrinsic LV function. van der Linden LP, van der Velde ET, Bruschke AV, Baan J
We reanalyzed experiments in in situ hearts of 16 open-chest anesthetized dogs, in which two different loading interventions were performed, i.e., an occlusion of the descending aorta (InP) and a rapid volume infusion (InV). Previous studies had demonstrated that the end-systolic elastance (Ees) of the InP was substantially larger than the Ees of the InV suggesting either a load dependency of Ees as such, or an increase in contractility during InP. The data were reanalyzed in the light of the mu... Abstract
Helvetica chirurgica acta, Volume 57, Issue 3, 1 1 1990, Pages 415-421 [Long-term results in the treatment of metastasizing kidney carcinoma using recombinant alpha-2 or gamma interferon]. Schneider AW, Otto U, Conrad S, Klosterhalfen H
To evaluate whether response to alpha-2- or gamma-interferon in metastatic renal cell carcinoma is associated with a prolonged survival, we studied a total of 65 patients being treated in two phase-II- or phase-III-trials between 1984 and 1986 with one of these interferons. After a median follow-up of 3 years for the alpha-interferon-treated patients and of more than 4 years for gamma-interferon-therapy, respectively, there is a significantly increased duration of survival for patients showing a... Abstract
Cited 85 times since 1990 (2.5 per year) source: EuropePMC
The American journal of physiology, Volume 259, Issue 4 Pt 2, 1 1 1990, Pages H1254-63 Quantification of spatial inhomogeneity in conduction and initiation of reentrant atrial arrhythmias. Lammers WJ, Schalij MJ, Kirchhof CJ, Allessie MA
In isolated superfused left atria of the rabbit, inhomogeneity in conduction was quantified using the activation times measured with a high-density mapping system. At each recording site, the maximal difference with neighboring activation times (i.e., phase difference) was calculated. Local phase differences were plotted in a phase map, revealing the spatial distribution of inhomogeneities in conduction, and from each map a total index of inhomogeneity was calculated. During slow pacing (2 Hz) l... Abstract
Cited 21 times since 1990 (0.6 per year) source: EuropePMC
Journal of molecular and cellular cardiology, Volume 22, Issue 9, 1 1 1990, Pages 987-998 Altered calcium handling at normal contractility in hypertrophied rat heart. Schouten VJ, Vliegen HW, van der Laarse A, Huysmans HA
Left or right ventricular hypertrophy was induced by banding of the aorta or pulmonary artery in different groups of rats. After 5 to 10 weeks the degree of hypertrophy was about 15% in left and 80-160% in right ventricles, as determined by weight of the ventricle or by myocyte size. Action potentials and force-interval relationships were measured in papillary muscles isolated from either ventricle. As compared to muscles from control and SHAM-operated rats, hypertrophied papillary muscles showe... Abstract
Cited 66 times since 1990 (1.9 per year) source: EuropePMC
The Journal of biological chemistry, Volume 265, Issue 26, 1 1 1990, Pages 15560-15563 Endotoxin induction of plasminogen activator and plasminogen activator inhibitor type 1 mRNA in rat tissues in vivo. Quax PH, van den Hoogen CM, Verheijen JH, Padro T, Zeheb R, Gelehrter TD, van Berkel TJ, Kuiper J, Emeis JJ
The tissue-specific distribution of tissue-type and urokinase-type plasminogen activator (t-PA and u-PA) and their inhibitor type 1 (PAI-1) was analyzed at mRNA level in five major rat organ tissues. t-PA mRNA was detected in lung, kidney, heart, and liver. u-PA mRNA was detected in kidney and lung. Presence of PA mRNA correlated with the detection of PA activity in extracts of these tissues. PAI-1 mRNA was detected predominantly in heart and lung. Although PAI activity could not be measured dir... Abstract
Cited 9 times since 1990 (0.3 per year) source: EuropePMC
The Journal of urology, Volume 144, Issue 3, 1 1 1990, Pages 637-9; discussion 639-40 Quantitative immunocytology in the management of patients with superficial bladder carcinoma. I. A marker to identify patients who do not require prophylaxis. Huland E, Huland H, Schneider AW
We used monoclonal antibody 486P 3/12 to monitor 55 patients after transurethral resection of stages Ta and T1 transitional cell bladder carcinoma. The method has a high sensitivity (89%) in detecting grades 1 to 3 lesions. We examined voided urinary specimens taken every 4 weeks after transurethral resection for a mean of approximately 2 years. Of the 55 patients 22 remained negative for marker without prophylaxis and only 2 of them had another tumor. Only 6 of 33 patients who were positive for... Abstract
Cited 73 times since 1990 (2.1 per year) source: EuropePMC
Nucleic acids research, Volume 18, Issue 11, 1 1 1990, Pages 3241-3247 All subgenomic mRNAs of equine arteritis virus contain a common leader sequence. de Vries AA, Chirnside ED, Bredenbeek PJ, Gravestein LA, Horzinek MC, Spaan WJ
During the replication of equine arteritis virus (EAV) six subgenomic mRNAs are synthesized. We present evidence that the viral mRNAs form a 3'-coterminal nested set and contain a common leader sequence of 208 nucleotides which is encoded by the 5'-end of the genome. The leader is joined to the bodies of mRNA 5 and 6 at positions defined by the sequence 5' UCAAC 3'. The part of the leader sequence flanking the UCAAC motif is very similar to the 5'-splice site of the Tetr... Abstract
Cited 4 times since 1990 (0.1 per year) source: EuropePMC
European heart journal, Volume 11 Suppl B, 1 1 1990, Pages 162-171 Neurohumoral activation during acute myocardial ischaemia. Effects of ACE inhibition. Remme WJ, Look MP, Bootsma M, Kruyssen HA, Verrostte JM, Krauss XH, van Hoogenhuyze DC, Storm CJ
ACE inhibition may be useful in several manifestations of ischaemic heart disease, such as heart failure due to ischaemic cardiomyopathy. Recent evidence suggests that these effects may also be present in normotensive patients with ischaemic heart disease without heart failure. Theoretically, converting-enzyme inhibition, through coronary and systemic vasodilating effects and negative inotropic properties, should have a favourable effect on the myocardial oxygen supply/demand ratio and, hence, a... Abstract
Cited 45 times since 1990 (1.3 per year) source: EuropePMC
Cancer research, Volume 50, Issue 5, 1 1 1990, Pages 1488-1494 Protein and messenger RNA levels of plasminogen activators and inhibitors analyzed in 22 human tumor cell lines. Quax PH, van Leeuwen RT, Verspaget HW, Verheijen JH
In 22 human tumor cell lines the regulation of production of plasminogen activators urokinase (u-PA) and tissue-type (t-PA) and their inhibitors PAI-1 and PAI-2 was studied. These four components may determine the net plasminogen activator activity, which is often associated with tumor development and metastatic processes. The amount of specific mRNA and protein produced by the cells was measured for all four components. The frequent finding of t-PA (alone or in combination with u-PA) suggests t... Abstract
Der Urologe. Ausg. A, Volume 29, Issue 2, 1 1 1990, Pages 71-76 [Tumor markers and prognostic parameters in urinary bladder cancer]. Schneider AW, Huland H
Ideal tumor markers for use in the primary diagnosis or follow up of superficial or invasive cancers have not yet been found. Nonetheless, the literature contains references to parameters that are relevant to prognosis and to markers for bladder tumors, and many of these are certainly of value when specific questions are addressed. Urinalysis has been considerably refined and yields information on superficial tumors. Quantitative immunocytology is used to check whether prophylactic treatments ar... Abstract
Cited 5 times since 1990 (0.1 per year) source: EuropePMC
Annals of the New York Academy of Sciences, Volume 591, 1 1 1990, Pages 247-256 Electrophysiology of spiral waves in two dimensions: the role of anisotropy. Allessie MA, Schalij MJ, Kirchhof CJ, Boersma L, Huyberts M, Hollen J
Cited 10 times since 1990 (0.3 per year) source: EuropePMC
Comparative biochemistry and physiology. A, Comparative physiology, Volume 95, Issue 1, 1 1 1990, Pages 109-114 Different response of cellular DNA content to cardiac hypertrophy in human and rat heart myocytes. Vliegen HW, Bruschke AV, Van der Laarse A
1. Rat and human heart myocytes adapt to overload-induced hypertrophy differently. 2. Human myocyte nuclei respond with polyploidization and multinucleation, thus increasing the DNA content per myocyte from 20 to 40 pg. As a result, nuclear DNA content per 10,000 microns3 of cell volume decreases from 12 to 10 pg. 3. In rat hearts with aortic constriction nuclear DNA content remains constant (13 pg), and the DNA content per 10,000 microns3 of myocyte volume falls from 9 to 6 pg. 4. We hypothesiz... Abstract
Cited 2 times since 1990 (0.1 per year) source: EuropePMC
Progress in clinical and biological research, Volume 350, 1 1 1990, Pages 275-282 Recombinant alpha-2 or gamma interferon in the treatment of metastatic renal cell carcinoma: results of two phase II/III trials. Otto U, Schneider AW, Conrad S, Klosterhalfen H
Cited 26 times since 1990 (0.7 per year) source: EuropePMC
International journal of cancer, Volume 45, Issue 1, 1 1 1990, Pages 16-20 Frequency and degree of aneuploidy in benign and malignant thyroid neoplasms. Schelfhout LJ, Cornelisse CJ, Goslings BM, Hamming JF, Kuipers-Dijkshoorn NJ, van de Velde CJ, Fleuren GJ
The frequency and degree of aneuploidy in 44 benign and 124 malignant thyroid neoplasms were analyzed by DNA flow cytometry. Single aneuploid cell populations were found in 72% of the undifferentiated carcinomas, 64% of the follicular carcinomas, 24% of the papillary carcinomas and in 24% of the follicular adenomas. Multiple aneuploid cell populations were detected in 4% of the papillary and in 36% of the follicular carcinomas but not in undifferentiated carcinomas. A low degree of aneuploidy wa... Abstract