Research

Publications

Below you can find a list of our published research.

9618 results

Cited 12 times since 2023 (4.6 per year) source: EuropePMC

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Volume 159, 9 2 2023, Pages 114232 Capecitabine-induced hand-foot syndrome: A pharmacogenetic study beyond DPYD. de With M, van Doorn L, Maasland DC, Mulder TAM, Oomen-de Hoop E, Mostert B, Homs MYV, El Bouazzaoui S, Mathijssen RHJ, van Schaik RHN, Bins S

Aim of the study: Occurrence of hand-foot syndrome (HFS) during capecitabine treatment often results in treatment interruptions (26 %) or treatment discontinuation (17 %), and can severely decrease quality of life. In this study, we investigated whether single nucleotide polymorphisms (SNPs) in genes involved in capecitabine metabolism - other than DPYD - are associated with an increased risk for capecitabine-induced HFS. Methods: Patients treated with capecitabine according to standard of care... Abstract

Cited 10 times since 2023 (3.8 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 9, 9 2 2023, Pages 1032755 Are acute type A aortic dissections atherosclerotic? Grewal N, Dolmaci O, Jansen E, Klautz R, Driessen A, Lindeman J, Poelmann RE

Background: Type A aortic dissections (TAAD) are devastating aortic complications. Patients with Marfan syndrome, a bicuspid aortic valve or a thoracic aortic aneurysm have an increased risk to develop a TAAD. These predisposing conditions are characterized by a histologically thin intimal layer and hardly any atherosclerosis. Little is known about the susceptibility for atherosclerosis in patients with a type A aortic dissection. Objective: We aim to systematically describe atherosclerotic lesi... Abstract

Cited 3 times since 2023 (1.2 per year) source: EuropePMC

Journal of cardiovascular translational research, Volume 16, Issue 6, 9 2 2023, Pages 1251-1266 Phenotypic and Genetic Factors Associated with Absence of Cardiomyopathy Symptoms in PLN:c.40_42delAGA Carriers. Lopera-Maya EA, Li S, de Brouwer R, Nolte IM, van Breen J, Netherlands A C M/P L N Registry, Lifelines Cohort Study, Jongbloed JDH, Swertz MA, Snieder H, Franke L, Wijmenga C, de Boer RA, Deelen P, van der Zwaag PA, Sanna S

The c.40_42delAGA variant in the phospholamban gene (PLN) has been associated with dilated and arrhythmogenic cardiomyopathy, with up to 70% of carriers experiencing a major cardiac event by age 70. However, there are carriers who remain asymptomatic at older ages. To understand the mechanisms behind this incomplete penetrance, we evaluated potential phenotypic and genetic modifiers in 74 PLN:c.40_42delAGA carriers identified in 36,339 participants of the Lifelines population cohort. Asymptomati... Abstract

Pediatric emergency care, Volume 39, Issue 2, 9 2 2023, Pages 91-97 The Role of Ultrasound in Pediatric Skull Fractures: Determination of Fracture and Optic Nerve Sheath Diameter Measurements. Şık N, Öztürk A, Yılmaz D, Duman M

Background: The aim of the present study was to determine the accuracy of point-of-care ultrasound (POCUS) for detecting skull fractures and to evaluate sonographic measurements of optic nerve sheath diameter (ONSD) and ONSD/eyeball vertical diameter (EVD) ratios in children with head trauma. Methods: Children who presented with local signs of head trauma and underwent cranial computed tomography (CT) were enrolled. The suspected area was examined by POCUS to identify a skull fracture, and then... Abstract

Cited 2 times since 2023 (0.8 per year) source: EuropePMC

Archives of cardiovascular diseases, Volume 116, Issue 2, 7 1 2023, Pages 69-78 Prolongation of the heart rate-corrected QT interval is associated with cardiovascular diseases: Systematic review and meta-analysis. Welten SJGC, Elders PJM, Remmelzwaal S, Doekhie R, Kee KW, Nijpels G, van der Heijden AA, ESCAPE-NET investigators

Background: Conflicting findings have described the association between prolonged heart rate-corrected QT interval (QTc) and cardiovascular disease. Aims: To identify articles investigating the association between QTc and cardiovascular disease morbidity and mortality, and to summarize the available evidence for the general and type 2 diabetes populations. Methods: A systematic search was performed in PubMed and Embase in May 2022 to identify studies that investigated the association between QTc... Abstract

Cited 15 times since 2023 (5.7 per year) source: EuropePMC

Vascular pharmacology, Volume 148, 7 1 2023, Pages 107141 The effect of the 2019 ESC/EAS dyslipidaemia guidelines on low-density lipoprotein cholesterol goal achievement in patients with acute coronary syndromes: The ACS EuroPath IV project. Laufs U, Catapano AL, De Caterina R, Schiele F, Sionis A, Zaman A, Jukema JW

Aims: To evaluate the effect of the ESC/EAS 2019 dyslipidaemia guidelines on patient management of lipid-lowering therapy in patients with acute coronary syndrome (ACS), through a survey designed to compare post-ACS patient management in 2022 with that in 2018. Methods: Online questionnaires focused on lipid profile and medications were used to gather data from 2650 ACS patients in 6 European countries, treated between March-June 2022 (ACS EuroPath IV survey). These data were compared with data... Abstract

Cited 9 times since 2023 (3.4 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 120, Issue 2, 6 1 2023, Pages e2121467120 Parental provisioning drives brain size in birds. Griesser M, Drobniak SM, Graber SM, van Schaik CP

Large brains support numerous cognitive adaptations and therefore may appear to be highly beneficial. Nonetheless, the high energetic costs of brain tissue may have prevented the evolution of large brains in many species. This problem may also have a developmental dimension: juveniles, with their immature and therefore poorly performing brains, would face a major energetic hurdle if they were to pay for the construction of their own brain, especially in larger-brained species. Here, we explore t... Abstract

Cited 3 times since 2023 (1.1 per year) source: EuropePMC

Cellular signalling, Volume 104, 5 1 2023, Pages 110587 Early adipogenesis is repressed through the newly identified FHL2-NFAT5 signaling complex. Clemente-Olivo MP, Hernández-Quiles M, Sparrius R, van der Stoel MM, Janssen V, Habibe JJ, van den Burg J, Jongejan A, Alcaraz-Sobrevals P, van Es R, Vos H, Kalkhoven E, de Vries CJM

The LIM-domain-only protein FHL2 is a modulator of signal transduction and has been shown to direct the differentiation of mesenchymal stem cells towards osteoblast and myocyte phenotypes. We hypothesized that FHL2 may simultaneously interfere with the induction of the adipocyte lineage. Therefore, we investigated the role of FHL2 in adipocyte differentiation. For these studies pre-adipocytes isolated from mouse adipose tissue and the 3T3-L1 (pre)adipocyte cell line were applied. We performed FH... Abstract

Cited 30 times since 2023 (11.5 per year) source: EuropePMC

Science translational medicine, Volume 15, Issue 677, 4 1 2023, Pages eabo4778 Bifunctional cancer cell-based vaccine concomitantly drives direct tumor killing and antitumor immunity. Chen KS, Reinshagen C, Van Schaik TA, Rossignoli F, Borges P, Mendonca NC, Abdi R, Simon B, Reardon DA, Wakimoto H, Shah K

The administration of inactivated tumor cells is known to induce a potent antitumor immune response; however, the efficacy of such an approach is limited by its inability to kill tumor cells before inducing the immune responses. Unlike inactivated tumor cells, living tumor cells have the ability to track and target tumors. Here, we developed a bifunctional whole cancer cell-based therapeutic with direct tumor killing and immunostimulatory roles. We repurposed the tumor cells from interferon-β (I... Abstract

Cited 11 times since 2023 (4.2 per year) source: EuropePMC

EBioMedicine, Volume 88, 4 1 2023, Pages 104431 Modeling bile duct ischemia and reoxygenation injury in human cholangiocyte organoids for screening of novel cholangio-protective agents. Shi S, Roest HP, van den Bosch TPP, Bijvelds MJC, Boehnert MU, de Jonge J, Dekker SO, de Vries AAF, de Jonge HR, Verstegen MMA, van der Laan LJW

Background: Ischemia of the bile duct is a common feature in liver disease and transplantation, which represents a major cause of morbidity and mortality, especially after liver transplantation. Detailed knowledge of its pathogenesis remains incomplete due to the lack of appropriate in vitro models. Methods: To recapitulate biliary damage induced by ischemia and reperfusion in vitro, human intrahepatic cholangiocyte organoids (ICOs) were grown at low oxygen levels of 1% up to 72 h, followed by r... Abstract

Cited 3 times since 2023 (1.1 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 16, Issue 1, 3 1 2023, Pages e010826 Pleomorphic Ventricular Tachycardia in Dilated Cardiomyopathy Predicts Ventricular Tachycardia Recurrence After Ablation Independent From Cardiac Function: Comparison With Patients With Ischemic Heart Disease. Kimura Y, de Riva M, Ebert M, Glashan C, Wijnmaalen AP, Piers SR, Dekkers OM, Trines SA, Zeppenfeld K

Background: In dilated cardiomyopathy (DCM), outcome after catheter ablation of ventricular tachycardia (VT) is modest, compared with ischemic heart disease (IHD). Pleomorphic VT (PL-VT) has been associated with fibrotic remodeling and end-stage heart failure in IHD. The prognostic role of PL-VT in DCM is unknown. Methods: Consecutive IHD (2009-2016) or DCM (2008-2018) patients undergoing ablation for monomorphic VT were included. PL-VT was defined as ≥1 spontaneous change of the 12-lead VT-morp... Abstract

Epilepsy & behavior : E&B, Volume 139, 3 1 2023, Pages 109049 What is the safe observation period for seizure recurrence in pediatric emergency departments? Ulusoy E, Uysal Ateş Ş, Çitlenbik H, Öztürk A, Şık N, Arslan G, Yılmaz D, Yiş U, Hız S, Duman M

Background: Afebrile seizures are the common causes of emergency department (ED) admissions in childhood, and there is limited data on the observation period in emergency service follow-up of these patients in terms of seizure recurrence in the literature. This study aims to determine the seizure recurrence time in afebrile seizures and the risk factors that determine it. Methods: Patients aged between 1 month and 18 years with afebrile seizures were included in the study. Seizure recurrence tim... Abstract

Cited 246 times since 2023 (93.6 per year) source: EuropePMC

The New England journal of medicine, Volume 388, Issue 4, 1 1 2023, Pages 299-309 Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest. Suverein MM, Delnoij TSR, Lorusso R, Brandon Bravo Bruinsma GJ, Otterspoor L, Elzo Kraemer CV, Vlaar APJ, van der Heijden JJ, Scholten E, den Uil C, Jansen T, van den Bogaard B, Kuijpers M, Lam KY, Montero Cabezas JM, Driessen AHG, Rittersma SZH, Heijnen BG, Dos Reis Miranda D, Bleeker G, de Metz J, Hermanides RS, Lopez Matta J, Eberl S, Donker DW, van Thiel RJ, Akin S, van Meer O, Henriques J, Bokhoven KC, Mandigers L, Bunge JJH, Bol ME, Winkens B, Essers B, Weerwind PW, Maessen JG, van de Poll MCG

Background: Extracorporeal cardiopulmonary resuscitation (CPR) restores perfusion and oxygenation in a patient who does not have spontaneous circulation. The evidence with regard to the effect of extracorporeal CPR on survival with a favorable neurologic outcome in refractory out-of-hospital cardiac arrest is inconclusive. Methods: In this multicenter, randomized, controlled trial conducted in the Netherlands, we assigned patients with an out-of-hospital cardiac arrest to receive extracorporeal... Abstract

Journal of the American College of Cardiology, Volume 81, Issue 3, 1 1 2023, Pages e25 Reply: Outcomes in Bicuspid Aortic Valve Disease. Hecht S, Bax JJ, Pibarot P

Abstract

Cited 5 times since 2023 (1.9 per year) source: EuropePMC

Journal of cardiovascular pharmacology and therapeutics, Volume 28, 1 1 2023, Pages 10742484231210704 The Clinical Implementation of <i>CYP2C19</i> Genotyping in Patients with an Acute Coronary Syndrome: Insights From the FORCE-ACS Registry. Azzahhafi J, Broek WWAVD, Chan Pin Yin DRPP, Harmsze AM, van Schaik RHN, Ten Berg JM

Background: Guidelines recommend prasugrel or ticagrelor for acute coronary syndrome (ACS) patients. However, these P2Y12 inhibitors increase bleeding risk compared to clopidogrel. Although genotype-guided P2Y12-inhibitor selection has been shown to reduce bleeding risk, data on its clinical implementation is lacking. Methods: The study included ACS patients receiving genotype-guided antiplatelet therapy, utilising either a point-of-care (POC) device or laboratory-based testing. We aimed to coll... Abstract

Cited 24 times since 2023 (9.1 per year) source: EuropePMC

Journal for immunotherapy of cancer, Volume 11, Issue 1, 1 1 2023, Pages e005518 Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections. van Puffelen JH, Novakovic B, van Emst L, Kooper D, Zuiverloon TCM, Oldenhof UTH, Witjes JA, Galesloot TE, Vrieling A, Aben KKH, Kiemeney LALM, Oosterwijk E, Netea MG, Boormans JL, van der Heijden AG, Joosten LAB, Vermeulen SH

Background: BCG is recommended as intravesical immunotherapy to reduce the risk of tumor recurrence in patients with non-muscle invasive bladder cancer (NMIBC). Currently, it is unknown whether intravesical BCG application induces trained immunity. Methods: The aim of this research was to determine whether BCG immunotherapy induces trained immunity in NMIBC patients. We conducted a prospective observational cohort study in 17 NMIBC patients scheduled for BCG therapy and measured trained immunity... Abstract

Cited 85 times since 2023 (32.4 per year) source: EuropePMC

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, Volume 28, Issue 1, 1 1 2023 Increase in invasive group A streptococcal (<i>Streptococcus pyogenes</i>) infections (iGAS) in young children in the Netherlands, 2022. de Gier B, Marchal N, de Beer-Schuurman I, Te Wierik M, Hooiveld M, ISIS-AR Study Group, GAS Study group, de Melker HE, van Sorge NM, Members of the GAS study group, Members of the ISIS-AR study group

In 2022, a sevenfold increase in the number of notifiable invasive Streptococcus pyogenes (iGAS) infections among children aged 0-5 years was observed in the Netherlands compared with pre-COVID-19 pandemic years. Of 42 cases in this age group, seven had preceding or coinciding varicella zoster infections, nine were fatal. This increase is not attributable to a specific emm type. Vigilance for clinical deterioration as iGAS sign is warranted in young children, especially those with varicella zost... Abstract

Cited 46 times since 2023 (17.5 per year) source: EuropePMC

European heart journal, Volume 44, Issue 1, 1 1 2023, Pages 28-40 Valvular heart disease: shifting the focus to the myocardium. Ajmone Marsan N, Delgado V, Shah DJ, Pellikka P, Bax JJ, Treibel T, Cavalcante JL

Adverse cardiac remodelling is the main determinant of patient prognosis in degenerative valvular heart disease (VHD). However, to give an indication for valvular intervention, current guidelines include parameters of cardiac chamber dilatation or function which are subject to variability, do not directly reflect myocardial structural changes, and, more importantly, seem to be not sensitive enough in depicting early signs of myocardial dysfunction before irreversible myocardial damage has occurr... Abstract

Revista latino-americana de enfermagem, Volume 31, 1 1 2023, Pages e3923 Effect of the coughing technique during subcutaneous heparin injection on pain severity and individual satisfaction. Yılmaz D, Ayhan D, Yılmaz DU, Düzgün F

to examine the effect of the medium intensity coughing technique during subcutaneous low molecular weight heparin injection on pain severity and individual satisfaction in general surgery patients. the prospective, quasi-experimental study included 100 patients who had been prescribed a subcutaneous low molecular weight heparin injection once in 24 hours. Each patient received two injections by the same researcher, one using the standard injection technique with medium intensity coughing techniq... Abstract

The Turkish journal of pediatrics, Volume 65, Issue 6, 1 1 2023, Pages 1035-1036 Response to `Attitudes of parents with children aged 12-18 to COVID-19 vaccines for themselves and their children: vaccine hesitancy in Türkiye`. Şahin A, Kara-Aksay A, Aşcı B, Ekemen-Keleş Y, Üstundağ G, Elvan-Tüz A, Taşar S, Arslan-Maden A, İnce G, Kanık A, Karadağ-Öncel E, Elmalı F, Yılmaz D

Abstract