Research

Publications

Below you can find a list of our published research.

9618 results

Cited 1 times since 2022 (0.4 per year) source: EuropePMC

BMC primary care, Volume 23, Issue 1, 22 4 2022, Pages 336 Non-acute chest pain in primary care; referral rates, communication and guideline adherence: a cohort study using routinely collected health data. van den Bulk S, Spoelman WA, van Dijkman PRM, Numans ME, Bonten TN, Leiden University Medical Center(LUMC)

Background: The prevalence of coronary artery disease is increasing due to the aging population and increasing prevalence of cardiovascular risk factors. Non-acute chest pain often is the first symptom of stable coronary artery disease. To optimise care for patients with non-acute chest pain and make efficient use of available resources, we need to know more about the current incidence, referral rate and management of these patients. Methods: We used routinely collected health data from the STIZ... Abstract

Cited 3 times since 2022 (1.1 per year) source: EuropePMC

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Volume 53, Issue 2, 22 4 2022, Pages 239-243 Biomarkers in tear fluid of dupilumab-treated moderate-to-severe atopic dermatitis patients. Achten R, Thijs J, van Luijk C, Knol E, Delemarre E, de Graaf M, Bakker D, de Boer J, van Wijk F, de Bruin-Weller M

Abstract

Frontiers in cardiovascular medicine, Volume 9, 22 4 2022, Pages 1012147 A percutaneous treatment strategy of an adult patient with a bicuspid aortic valve, coarctation of the aorta, and an exceptionally large aneurysm of a collateral artery: Case report and literature overview. Verheijen DBH, Stöger JL, van der Kley F, Schalij MJ, Jongbloed MRM, Vliegen HW, Kiès P, Egorova AD

Coarctation of the aorta (CoA) is a congenital heart defect that is associated with a bicuspid aortic valve (BAV), ascending aorta dilatation, intracerebral aneurysms, and premature atherosclerotic disease. The first presentation during late adulthood is rare and is frequently driven by late sequelae. Hypertrophic collateral arteries can develop aneurysms which are at risk for spontaneous rupture, however, treatment recommendations for these aneurysms are scarce. Here, we describe the clinical c... Abstract

Cited 2 times since 2022 (0.8 per year) source: EuropePMC

American journal of psychotherapy, Volume 76, Issue 2, 21 3 2022, Pages 69-74 Pilot Study of Blended-Format Interpersonal Psychotherapy for Major Depressive Disorder. van Schaik DJF, Schotanus AY, Dozeman E, Huibers MJH, Cuijpers P, Donker T

Objective: Blended-format interpersonal psychotherapy (IPT) is an integrated approach consisting of alternating face-to-face (in person or videoconferencing) and online sessions, and this format may increase access to care, empower patients, and improve quality and cost-effectiveness of care. This study, conducted in the Netherlands, was one of the first to investigate the feasibility of blended-format IPT in specialized mental health care. Methods: Participants (ages 18-64, N=21) with a unipola... Abstract

Cited 1 times since 2022 (0.4 per year) source: EuropePMC

The American journal of cardiology, Volume 190, 20 3 2022, Pages 41-47 Association Between Chronic Obstructive Pulmonary Disease and All-Cause Mortality After Aortic Valve Replacement for Aortic Stenosis. Myagmardorj R, Nabeta T, Hirasawa K, Singh GK, van der Kley F, de Weger A, Ajmone Marsan N, Bax JJ, Delgado V

Chronic obstructive pulmonary disease (COPD) and aortic stenosis (AS) are the most common diseases in which age plays a major role in the increase of their prevalence and when they co-exist, the outcomes prognosis worsens significantly. The aim of the present study was to evaluate the association between pulmonary functional parameters and all-cause mortality after aortic valve replacement (transcatheter or surgical). A total of 400 patients with severe AS and preoperative pulmonary functional t... Abstract

Cited 10 times since 2022 (3.8 per year) source: EuropePMC

Lab on a chip, Volume 23, Issue 1, 20 3 2022, Pages 168-181 Multiplexed fluidic circuit board for controlled perfusion of 3D blood vessels-on-a-chip. de Graaf MNS, Vivas A, Kasi DG, van den Hil FE, van den Berg A, van der Meer AD, Mummery CL, Orlova VV

Three-dimensional (3D) blood vessels-on-a-chip (VoC) models integrate the biological complexity of vessel walls with dynamic microenvironmental cues, such as wall shear stress (WSS) and circumferential strain (CS). However, these parameters are difficult to control and are often poorly reproducible due to the high intrinsic diameter variation of individual 3D-VoCs. As a result, the throughput of current 3D systems is one-channel-at-a-time. Here, we developed a fluidic circuit board (FCB) for sim... Abstract

Cited 7 times since 2022 (2.6 per year) source: EuropePMC

Journal of the American Heart Association, Volume 11, Issue 24, 19 3 2022, Pages e027260 Performance of the American Heart Association/American College of Cardiology Guideline-Recommended Pretest Probability Model for the Diagnosis of Obstructive Coronary Artery Disease. Winther S, Murphy T, Schmidt SE, Bax JJ, Wijns W, Knuuti J, Bøttcher M

Background Substantial differences exist between different guideline-recommended pretest probability (PTP) models for the detection of obstructive coronary artery disease (CAD). This study was performed to study the performance of the 2021 American Heart Association/American College of Cardiology (AHA/ACC) guideline-recommended PTP (AHA/ACC-PTP) model in assessing the likelihood of obstructive CAD compared with previously proposed models. Methods and Results Symptomatic patients (N=50 561) refer... Abstract

Cited 4 times since 2022 (1.5 per year) source: EuropePMC

Pharmaceutics, Volume 14, Issue 12, 18 3 2022, Pages 2840 Predicting the Temperature Evolution during Nanomilling of Drug Suspensions via a Semi-Theoretical Lumped-Parameter Model. Guner G, Yilmaz D, Yao HF, Clancy DJ, Bilgili E

Although temperature can significantly affect the stability and degradation of drug nanosuspensions, temperature evolution during the production of drug nanoparticles via wet stirred media milling, also known as nanomilling, has not been studied extensively. This study aims to establish both descriptive and predictive capabilities of a semi-theoretical lumped parameter model (LPM) for temperature evolution. In the experiments, the mill was operated at various stirrer speeds, bead loadings, and b... Abstract

Cited 6 times since 2022 (2.2 per year) source: EuropePMC

Journal of asthma and allergy, Volume 15, 16 3 2022, Pages 1783-1794 Airway Inflammation Before and After Bronchial Thermoplasty in Severe Asthma. Wijsman PC, Goorsenberg AWM, Ravi A, d'Hooghe JNS, Dierdorp BS, Dekker T, van Schaik CCLM, Ten Hacken NHT, Shah PL, Weersink EJM, Bel EH, Annema JT, Lutter R, Bonta PI

Background: Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma, of which the working mechanism and responder profile are partly unknown. The aim of this study is to analyse whether BT alters airway inflammation by epithelial gene expression, inflammatory cell counts and cytokines, and whether this relates to treatment response. Methods: In this clinical trial, 28 severe asthma patients underwent bronchoscopy before and after treatment to obtain bronchial brushes and bronc... Abstract

Cited 1 times since 2022 (0.4 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 9, 16 3 2022, Pages 1094094 Editorial: Inflammation and immunomodulation in cardiovascular remodeling. Ewing M, Karper JC, de Vries MR, Quax PHA

Abstract

Cited 8 times since 2022 (3 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 16, Issue 4, 14 2 2022, Pages 495-504 Clinical and Coronary Plaque Predictors of Atherosclerotic Nonresponse to Statin Therapy. van Rosendael SE, van den Hoogen IJ, Lin FY, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Conte E, Marques H, de Araújo Gonçalves P, Gottlieb I, Hadamitzky M, Leipsic JA, Maffei E, Pontone G, Raff GL, Shin S, Kim YJ, Lee BK, Chun EJ, Sung JM, Lee SE, Virmani R, Samady H, Stone PH, Min JK, Narula J, Shaw LJ, Chang HJ, van Rosendael AR, Bax JJ

Background: Statins reduce the incidence of major cardiovascular events, but residual risk remains. The study examined the determinants of atherosclerotic statin nonresponse. Objectives: This study aimed to investigate factors associated with statin nonresponse-defined atherosclerosis progression in patients treated with statins. Methods: The multicenter PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) registry included patients who underwen... Abstract

Cited 3 times since 2022 (1.1 per year) source: EuropePMC

Nutrients, Volume 14, Issue 24, 14 2 2022, Pages 5309 Periconceptional Maternal Protein Intake from Animal and Plant Sources and the Impact on Early and Late Prenatal Growth and Birthweight: The Rotterdam Periconceptional Cohort. van Zundert S, van der Padt S, Willemsen S, Rousian M, Mirzaian M, van Schaik R, Steegers-Theunissen R, van Rossem L

Plant-based diets continue to rise in popularity, including among women of reproductive age, while consequences for pregnancy outcomes have hardly been studied. During pregnancy, maternal diet is the only source of proteins for the developing fetus. Hence, we investigated the effects of periconceptional maternal animal and plant protein intake on prenatal growth and birthweight. 501 pregnancies were included from the prospective Rotterdam Periconceptional Cohort. Embryonic growth was depicted by... Abstract

Cited 7 times since 2022 (2.6 per year) source: EuropePMC

Ecology and evolution, Volume 12, Issue 12, 14 2 2022, Pages e9591 A new GTSeq resource to facilitate multijurisdictional research and management of walleye <i>Sander vitreus</i>. Euclide PT, Larson WA, Bootsma M, Miller LM, Scribner KT, Stott W, Wilson CC, Latch EK

Conservation and management professionals often work across jurisdictional boundaries to identify broad ecological patterns. These collaborations help to protect populations whose distributions span political borders. One common limitation to multijurisdictional collaboration is consistency in data recording and reporting. This limitation can impact genetic research, which relies on data about specific markers in an organism's genome. Incomplete overlap of markers between separate studies c... Abstract

Cited 5 times since 2022 (1.9 per year) source: EuropePMC

Journal of bone and joint infection, Volume 7, Issue 6, 13 2 2022, Pages 259-267 The concordance between preoperative synovial fluid culture and intraoperative tissue cultures in periprosthetic joint infection: a systematic review. van Schaik TJA, de Jong LD, van Meer MPA, Goosen JHM, Somford MP

Background: this systematic review aims to evaluate the concordance between preoperative synovial fluid culture and intraoperative tissue cultures in patients with periprosthetic joint infection (PJI) undergoing total hip (THA) or knee arthroplasty (TKA) revision surgery. Methods: this review was conducted in accordance with the preferred reporting items for a systematic review and meta-analysis of diagnostic test accuracy studies (PRISMA-DTA) statement. Cochrane, Embase, PubMed, and Web of Scie... Abstract

Cited 1 times since 2022 (0.4 per year) source: EuropePMC

Pharmaceuticals (Basel, Switzerland), Volume 15, Issue 12, 13 2 2022, Pages 1550 A Possible Explanation for the Low Penetrance of Pathogenic KCNE1 Variants in Long QT Syndrome Type 5. Déri S, Hartai T, Virág L, Jost N, Labro AJ, Varró A, Baczkó I, Nattel S, Ördög B

Long QT syndrome (LQTS) is an inherited cardiac rhythm disorder associated with increased incidence of cardiac arrhythmias and sudden death. LQTS type 5 (LQT5) is caused by dominant mutant variants of KCNE1, a regulatory subunit of the voltage-gated ion channels generating the cardiac potassium current IKs. While mutant LQT5 KCNE1 variants are known to inhibit IKs amplitudes in heterologous expression systems, cardiomyocytes from a transgenic rabbit LQT5 model displayed unchanged IKs amplitudes,... Abstract

Cited 12 times since 2022 (4.5 per year) source: EuropePMC

European journal of human genetics : EJHG, Volume 31, Issue 12, 12 2 2022, Pages 1364-1370 Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction of CYP2D6 and COMT with atomoxetine and methylphenidate. Nijenhuis M, Soree B, Jama WOM, de Boer-Veger NJ, Buunk AM, Guchelaar HJ, Houwink EJF, Rongen GA, van Schaik RHN, Swen JJ, Touw D, van der Weide J, van Westrhenen R, Deneer VHM, Risselada A

Pharmacogenetics (PGx) studies the effect of heritable genetic variation on drug response. Clinical adoption of PGx has remained limited, despite progress in the field. To promote implementation, the Dutch Pharmacogenetics Working Group (DPWG) develops evidence-based guidelines on how to optimize pharmacotherapy based on PGx test results. This guideline describes optimization of atomoxetine therapy based on genetic variation in the CYP2D6 gene. The CYP2D6 enzyme is involved in conversion of atom... Abstract

Cited 19 times since 2022 (7.1 per year) source: EuropePMC

The American journal of medicine, Volume 136, Issue 3, 10 2 2022, Pages 260-269.e7 Integrating Coronary Atherosclerosis Burden and Progression with Coronary Artery Disease Risk Factors to Guide Therapeutic Decision Making. Freeman AM, Raman SV, Aggarwal M, Maron DJ, Bhatt DL, Parwani P, Osborne J, Earls JP, Min JK, Bax JJ, Shapiro MD

Importance: Although atherosclerosis represents the primary driver of coronary artery disease, evaluation and treatment approaches have historically relied upon indirect markers of atherosclerosis that include surrogates (cholesterol), signs (angina), and sequelae (ischemia) of atherosclerosis. Direct quantification and characterization of atherosclerosis may encourage a precision heart care paradigm that improves diagnosis, risk stratification, therapeutic decision-making, and longitudinal dise... Abstract

Cited 6 times since 2022 (2.2 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 57, Issue 5, 9 2 2022, Pages 1320-1339 Particle Tracing Based on 4D Flow Magnetic Resonance Imaging: A Systematic Review into Methods, Applications, and Current Developments. Roos PR, Rijnberg FM, Westenberg JJM, Lamb HJ

Background: Particle tracing based on 4D Flow MRI has been applied as a quantitative and qualitative postprocessing technique to study temporally evolving blood flow patterns. Purpose: To systematically review the various methods to perform 4D Flow MRI-based particle tracing, as well as the clinical value, clinical applications, and current developments of the technique. Study type: The study type is systematic review. Subjects: Patients with cardiovascular disease (such as Marfan, Fontan, Tetra... Abstract

Cited 23 times since 2022 (8.5 per year) source: EuropePMC

Environmental research, Volume 218, 8 2 2022, Pages 114961 The spatial distribution of microplastics in topsoils of an urban environment - Coimbra city case-study. Leitão IA, van Schaik L, Ferreira AJD, Alexandre N, Geissen V

Due to their seemingly ubiquitous nature and links to environmental and human health problems, microplastics are quickly becoming a major concern worldwide. Artificial environments, such as those found in urban environments, represent some of the main sources of microplastic. However, very few studies have focused on the occurrence of microplastics in urban soils. The aim of the current research was to evaluate the microplastic contamination in urban soils from artificial and natural land uses t... Abstract

Cited 8 times since 2022 (3 per year) source: EuropePMC

European journal of pediatrics, Volume 182, Issue 2, 7 1 2022, Pages 757-767 Long-term neurocognitive functioning of children treated with propranolol or atenolol for infantile hemangioma. Hermans MM, Rietman AB, Schappin R, de Laat PCJ, Mendels EJ, Breur JMPJ, Langeveld HR, de Wildt SN, Breugem CC, de Graaf M, Raphael MF, Pasmans SGMA

The purpose of this study was to compare long-term neurocognitive functioning (working memory, processing speed, and attention) between children who had been treated with either propranolol or atenolol for infantile hemangioma during infancy. All eligible children (n = 158) aged 6 years or older and treated with propranolol or atenolol as infants were invited to participate in this two-center cross-sectional study. The primary outcome was the Wechsler Intelligence Scale for Children-V Cognitive... Abstract