Research

Publications

Below you can find a list of our published research.

9618 results

Cited 13 times since 2022 (4.6 per year) source: EuropePMC

EMBO reports, Volume 23, Issue 12, 17 3 2022, Pages e55782 Dynamic chromosomal interactions and control of heterochromatin positioning by Ki-67. van Schaik T, Manzo SG, Vouzas AE, Liu NQ, Teunissen H, de Wit E, Gilbert DM, van Steensel B

Ki-67 is a chromatin-associated protein with a dynamic distribution pattern throughout the cell cycle and is thought to be involved in chromatin organization. The lack of genomic interaction maps has hampered a detailed understanding of its roles, particularly during interphase. By pA-DamID mapping in human cell lines, we find that Ki-67 associates with large genomic domains that overlap mostly with late-replicating regions. Early in interphase, when Ki-67 is present in pre-nucleolar bodies, it... Abstract

Cited 4 times since 2022 (1.4 per year) source: EuropePMC

NPJ genomic medicine, Volume 7, Issue 1, 17 3 2022, Pages 58 Identification of phenocopies improves prediction of targeted therapy response over DNA mutations alone. Bakhtiar H, Helzer KT, Park Y, Chen Y, Rydzewski NR, Bootsma ML, Shi Y, Harari PM, Sharifi M, Sjöström M, Lang JM, Yu M, Zhao SG

DNA mutations in specific genes can confer preferential benefit from drugs targeting those genes. However, other molecular perturbations can "phenocopy" pathogenic mutations, but would not be identified using standard clinical sequencing, leading to missed opportunities for other patients to benefit from targeted treatments. We hypothesized that RNA phenocopy signatures of key cancer driver gene mutations could improve our ability to predict response to targeted therapies, despite not... Abstract

Cited 7 times since 2022 (2.5 per year) source: EuropePMC

Motor control, Volume 27, Issue 2, 17 3 2022, Pages 161-178 Optimization Reduces Knee-Joint Forces During Walking and Squatting: Validating the Inverse Dynamics Approach for Full Body Movements on Instrumented Knee Prostheses. Wagner H, Boström KJ, de Lussanet MHE, de Graaf ML, Puta C, Mochizuki L

Because of the redundancy of our motor system, movements can be performed in many ways. While multiple motor control strategies can all lead to the desired behavior, they result in different joint and muscle forces. This creates opportunities to explore this redundancy, for example, for pain avoidance or reducing the risk of further injury. To assess the effect of different motor control optimization strategies, a direct measurement of muscle and joint forces is desirable, but problematic for me... Abstract

Cited 2 times since 2022 (0.7 per year) source: EuropePMC

Current medical research and opinion, Volume 39, Issue 1, 14 2 2022, Pages 1-11 Treatment and low-density lipoprotein cholesterol levels in patients with hypercholesterolaemia or mixed dyslipidaemia at high or very high cardiovascular risk: a population-based cross-sectional study in the Netherlands. Heintjes EM, Anastassopoulou A, Kuiper J, Bilitou A, Beest FJAP, Herings RMC, Postma MJ, Jukema JW

Objective: To describe treatment patterns, low-density lipoprotein cholesterol (LDL-C) levels and healthcare resource utilization (HCRU) in the Netherlands in 2018 of patients with hypercholesterolaemia or mixed dyslipidaemia at high or very high cardiovascular (CV) risk. Methods: From the PHARMO Database Network adult patients with a diagnosis or receiving lipid lowering therapy (LLT) between 2009 and 2018 were selected. Patients at high or very high CV risk according to 2016 ESC/EAS guidelines... Abstract

Cited 3 times since 2022 (1.1 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 9, 13 2 2022, Pages 969766 Systemic thrombolysis in the management of pump thrombosis in patients with left ventricular assist devices. Kortekaas KA, den Exter PL, Beeres SLMA, Palmen M, Jukema JW, Huisman MV, Tops LF

Left ventricular assist device (LVAD) implantation as destination therapy (DT) is a valuable treatment option in patients with end-stage heart failure ineligible for heart transplant. However, this therapy can be complicated by life-threatening pump thrombosis (PT). This case series reports our single-center experience with a structured systemic thrombolysis protocol in case of PT. Consecutive patients undergoing DT LVAD (HVAD, Medtronic, Framingham, MA) implantation between 2010 and April 2021... Abstract

Cited 2 times since 2022 (0.7 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 9, 13 2 2022, Pages 946404 The development of a decision aid for shared decision making in the Dutch implantable cardioverter defibrillator patient population: A novel approach to patient education. Yilmaz D, Egorova AD, Schalij MJ, Spierenburg HAM, Verbunt RAM, van Erven L

Background: Counseling of Implantable Cardioverter-defibrillator (ICD) patients with regard to individual risks and benefits is challenging. An evidence-based decision aid tailored to the needs of Dutch ICD patients is not yet available. The objective of this pilot project was to structurally evaluate the current clinical practice in The Netherlands and the ICD patient experience, in order to develop an online decision aid to facilitate shared decision making in ICD procedures. Methods: Between... Abstract

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 30, Issue 2, 13 2 2022, Pages 748-750 Imaging phenotypes and outcomes after revascularization in chronic coronary artery disease. Saraste A, Bax JJ

Abstract

Cited 4 times since 2022 (1.4 per year) source: EuropePMC

Heliyon, Volume 8, Issue 10, 13 2 2022, Pages e11028 A new hybrid risk assessment method based on Fine-Kinney and ANFIS methods for evaluation spatial risks in nursing homes. Gökler SH, Yılmaz D, Ürük ZF, Boran S

Today, as the elderly population in the world increases, the increase in those living in nursing homes causes their problems to be even more important. Spatial hazards cause injury and death most of the time, therefore should be evaluated risks then corrective and preventive actions should be implemented. Fine-Kinney is one of the most widely used risk assessment methods, but it has some shortcomings. One of them is that risk factors such as probability, frequency, and severity are accepted as e... Abstract

Cited 468 times since 2022 (164.1 per year) source: EuropePMC

Nature, Volume 610, Issue 7933, 12 2 2022, Pages 704-712 A saturated map of common genetic variants associated with human height. Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU, Jiang Y, Raghavan S, Miao J, Arias JD, Graham SE, Mukamel RE, Spracklen CN, Yin X, Chen SH, Ferreira T, Highland HH, Ji Y, Karaderi T, Lin K, Lüll K, Malden DE, Medina-Gomez C, Machado M, Moore A, Rüeger S, Sim X, Vrieze S, Ahluwalia TS, Akiyama M, Allison MA, Alvarez M, Andersen MK, Ani A, Appadurai V, Arbeeva L, Bhaskar S, Bielak LF, Bollepalli S, Bonnycastle LL, Bork-Jensen J, Bradfield JP, Bradford Y, Braund PS, Brody JA, Burgdorf KS, Cade BE, Cai H, Cai Q, Campbell A, Cañadas-Garre M, Catamo E, Chai JF, Chai X, Chang LC, Chang YC, Chen CH, Chesi A, Choi SH, Chung RH, Cocca M, Concas MP, Couture C, Cuellar-Partida G, Danning R, Daw EW, Degenhard F, Delgado GE, Delitala A, Demirkan A, Deng X, Devineni P, Dietl A, Dimitriou M, Dimitrov L, Dorajoo R, Ekici AB, Engmann JE, Fairhurst-Hunter Z, Farmaki AE, Faul JD, Fernandez-Lopez JC, Forer L, Francescatto M, Freitag-Wolf S, Fuchsberger C, Galesloot TE, Gao Y, Gao Z, Geller F

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered withi... Abstract

Cited 4 times since 2022 (1.4 per year) source: EuropePMC

Acta dermato-venereologica, Volume 102, 11 2 2022, Pages adv00788 Aesthetic Outcome of Propranolol vs Atenolol Treatment of Children with Infantile Haemangioma. Hermans MM, Breugem CC, Schappin R, Jonge Poerink E, Mendels EJ, Ragamin A, Breur JMPJ, Langeveld HR, Raphael MF, De Laat PCJ, De Wildt SN, Rietman AB, Pasmans SGMA, De Graaf M

Infantile haemangiomas are common benign tumours of infancy, which can be treated effectively with beta-blockers such as propranolol and atenolol. Different types of beta-blockers may result in different long-term aesthetic outcomes. This study evaluated the difference in long-term aesthetic outcomes between infantile haemangiomas treated with either propranolol or atenolol, including the perspective of physicians, parents, and children. Children, aged ≥6 years, treated with propranolol or ateno... Abstract

Cited 5 times since 2022 (1.8 per year) source: EuropePMC

The American journal of cardiology, Volume 185, 11 2 2022, Pages 53-62 Factors Affecting Rate of Progression of Aortic Stenosis and Its Impact on Outcomes. Amanullah MR, Pio SM, Sin KYK, Marsan NA, Ding ZP, Stassen J, Leon MB, Genereux P, Delgado V, Ewe SH, Bax JJ

The rate of aortic stenosis (AS) progression in patients with moderate AS is unclear. This study examined the risk factors of progression from moderate to severe AS and its impact on clinical outcomes. A total of 954 patients with moderate AS (valve area >1.0 and ≤1.5 cm²) and follow-up echocardiograms were included. AS progressed to severe (valve area Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

Nutrition, metabolism, and cardiovascular diseases : NMCD, Volume 33, Issue 1, 8 2 2022, Pages 56-64 Development, internal reliability and preliminary construct validity of the Dutch Dietary Intention Evaluation Tool for In-patients (DIETI). de Frel DL, Wicks H, Bakk Z, van Keulen N, van Adrichem V, van Tussenbroek N, Atsma PDE, Janssen VR

Background and aims: Diet is important in prevention and management of non-communicable disease and in particular, cardiovascular disease. Recently, more hospitals gear towards healthier dietary policies, however, a tool to assess the effect of these interventions in patient populations is currently lacking. The Theory of Planned Behavior (TPB) is generally used to assess health-related behavior and offers a framework for development of questionnaires. In this study, we aim to evaluate the relia... Abstract

Cited 25 times since 2022 (8.7 per year) source: EuropePMC

Circulation, Volume 146, Issue 19, 7 1 2022, Pages 1434-1443 Programmed Ventricular Stimulation as an Additional Primary Prevention Risk Stratification Tool in Arrhythmogenic Right Ventricular Cardiomyopathy: A Multinational Study. Gasperetti A, Carrick RT, Costa S, Compagnucci P, Bosman LP, Chivulescu M, Tichnell C, Murray B, Tandri H, Tadros R, Rivard L, van den Berg MP, Zeppenfeld K, Wilde AAM, Pompilio G, Carbucicchio C, Dello Russo A, Casella M, Svensson A, Brunckhorst CB, van Tintelen JP, Platonov PG, Haugaa KH, Duru F, Te Riele ASJM, Khairy P, Tondo C, Calkins H, James CA, Saguner AM, Cadrin-Tourigny J

Background: A novel risk calculator based on clinical characteristics and noninvasive tests that predicts the onset of clinical sustained ventricular arrhythmias (VA) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) has been proposed and validated by recent studies. It remains unknown whether programmed ventricular stimulation (PVS) provides additional prognostic value. Methods: All patients with a definite ARVC diagnosis, no history of sustained VAs at diagnosis, and PVS... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

Disability and rehabilitation, Volume 45, Issue 21, 7 1 2022, Pages 3539-3548 Conservative management for lumbar radiculopathy based on the stage of the disorder: a Delphi study. Thoomes E, Falla D, Cleland JA, Fernández-de-Las-Peñas C, Gallina A, de Graaf M

Purpose: Conservative management of lumbar radiculopathy (LR) is the first treatment option. To date, systematic reviews and clinical practice guidelines have not considered the most appropriate timing of management. This study aimed to establish consensus on effective conservative treatment modalities across different stages (i.e., acute, sub-acute, or chronic) of LR. Materials and methods: Through an iterative multistage Delphi process, experts rated agreement with proposed treatment modalitie... Abstract

Cited 6 times since 2022 (2.1 per year) source: EuropePMC

Journal of medical Internet research, Volume 24, Issue 10, 6 1 2022, Pages e38339 Investigating Rewards and Deposit Contract Financial Incentives for Physical Activity Behavior Change Using a Smartphone App: Randomized Controlled Trial. de Buisonjé DR, Reijnders T, Cohen Rodrigues TR, Prabhakaran S, Kowatsch T, Lipman SA, Bijmolt THA, Breeman LD, Janssen VR, Kraaijenhagen RA, Kemps HMC, Evers AWM

Background: Financial incentive interventions for improving physical activity have proven to be effective but costly. Deposit contracts (in which participants pledge their own money) could be an affordable alternative. In addition, deposit contracts may have superior effects by exploiting the power of loss aversion. Previous research has often operationalized deposit contracts through loss framing a financial reward (without requiring a deposit) to mimic the feelings of loss involved in a deposi... Abstract

Cited 6 times since 2022 (2.1 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 9, 6 1 2022, Pages 758265 Acute myocardial infarction induces remodeling of the murine superior cervical ganglia and the carotid body. Ge Y, van Roon L, van Gils JM, Geestman T, van Munsteren CJ, Smits AM, Goumans MJTH, DeRuiter MC, Jongbloed MRM

A role for cardiac sympathetic hyperinnervation in arrhythmogenesis after myocardial infarction (MI) has increasingly been recognized. In humans and mice, the heart receives cervical as well as thoracic sympathetic contributions. In mice, superior cervical ganglia (SCG) have been shown to contribute significantly to myocardial sympathetic innervation of the left ventricular anterior wall. Of interest, the SCG is situated adjacent to the carotid body (CB), a small organ involved in oxygen and met... Abstract

Cited 3 times since 2022 (1 per year) source: EuropePMC

British journal of cancer, Volume 127, Issue 11, 3 1 2022, Pages 2043-2051 Multicentric validation of diagnostic tests based on BC-116 and BC-106 urine peptide biomarkers for bladder cancer in two prospective cohorts of patients. Mengual L, Frantzi M, Mokou M, Ingelmo-Torres M, Vlaming M, Merseburger AS, Roesch MC, Culig Z, Alcaraz A, Vlahou A, Mischak H, Van der Heijden AG

Background: Non-invasive urine-based biomarkers can potentially improve current diagnostic and monitoring protocols for bladder cancer (BC). Here we assess the performance of earlier published biomarker panels for BC detection (BC-116) and monitoring of recurrence (BC-106) in combination with cytology, in two prospectively collected patient cohorts. Methods: Of the 602 patients screened for BC, 551 were found eligible. For the primary setting, 73 patients diagnosed with primary BC (n = 27) and b... Abstract

Cited 6 times since 2022 (2.1 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 11, 1 1 2022, Pages 1540-1551 Prognostic implications of mitral valve geometry in patients with secondary mitral regurgitation: the COAPT trial. Namazi F, Delgado V, Delgado V, Pio SM, Ajmone Marsan N, Asch FM, Medvedofsky D, Weissman NJ, Zhou Z, Redfors B, Lindenfeld J, Abraham WT, Mack MJ, Stone GW, Bax JJ

Aims: The impact of mitral valve geometry on outcomes after MitraClip treatment in secondary mitral regurgitation (MR) has not been examined. We therefore sought to evaluate the association between mitral valve geometry and outcomes of patients with heart failure (HF) and secondary MR treated with guideline-directed medical therapy (GDMT) and MitraClip. Methods and results: Mitral valve geometry was assessed from the baseline echocardiograms in 614 patients from the COAPT trial. The primary endp... Abstract

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 63, Issue 10, 1 1 2022, Pages 1455-1458 Integrating Nuclear Imaging and Cardiology in Clinical Practice: A Conversation Between Jeroen J. Bax and Frank M. Bengel. Bax JJ, Bengel FM

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Cited 1 times since 2022 (0.3 per year) source: EuropePMC

European journal of human genetics : EJHG, Volume 30, Issue 10, 1 1 2022, Pages 1196 Correction: Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6 and opioids (codeine, tramadol and oxycodone). Matic M, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Houwink EJF, Mulder H, Rongen GAPJM, Weide JV, Wilffert B, Swen JJ, Guchelaar HJ, Deneer VHM, van Schaik RHN

Abstract