9618 results
Cited 19 times since 2022 (6.1 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 62, Issue 2, 1 1 2022, Pages ezac290
Staging right heart failure in patients with tricuspid regurgitation undergoing tricuspid surgery.
Galloo X, Stassen J, Butcher SC, Meucci MC, Dietz MF, Mertens BJA, Prihadi EA, van der Bijl P, Ajmone Marsan N, Braun J, Bax JJ, Delgado V
Objectives: This study evaluated the prognostic value of staging right heart failure in patients with significant tricuspid regurgitation (TR) undergoing tricuspid valve (TV) surgery. Methods: Patients with significant TR who underwent TV surgery were divided into 4 right heart failure stages according to the presence of right ventricular (RV) dysfunction and clinical signs of right heart failure: stage 1 was defined as no RV dysfunction and no signs of right heart failure; stage 2 indicated RV...
Abstract
Cited 13 times since 2022 (4.1 per year)
source: EuropePMC
Clinical chemistry,
Volume 68, Issue 7, 1 1 2022, Pages 963-972
Dutch National Round Robin Trial on Plasma-Derived Circulating Cell-Free DNA Extraction Methods Routinely Used in Clinical Pathology for Molecular Tumor Profiling.
van der Leest P, Ketelaar EM, van Noesel CJM, van den Broek D, van Boerdonk RAA, Deiman B, Rifaela N, van der Geize R, Huijsmans CJJ, Speel EJM, Geerlings MJ, van Schaik RHN, Jansen MPHM, Dane-Vogelaar R, Driehuis E, Leers MPG, Sidorenkov G, Tamminga M, van Kempen LC, Schuuring E
Background: Efficient recovery of circulating tumor DNA (ctDNA) depends on the quantity and quality of circulating cell-free DNA (ccfDNA). Here, we evaluated whether various ccfDNA extraction methods routinely applied in Dutch laboratories affect ccfDNA yield, ccfDNA integrity, and mutant ctDNA detection, using identical lung cancer patient-derived plasma samples. Methods: Aliquots of 4 high-volume diagnostic leukapheresis plasma samples and one artificial reference plasma sample with predetermi...
Abstract
Cited 16 times since 2022 (5.1 per year)
source: EuropePMC
Annals of cardiothoracic surgery,
Volume 11, Issue 4, 1 1 2022, Pages 380-388
Normal and abnormal development of the aortic valve and ascending aortic wall: a comprehensive overview of the embryology and pathology of the bicuspid aortic valve.
Grewal N, Gittenberger-de Groot AC, Lindeman JH, Klautz A, Driessen A, Klautz RJM, Poelmann RE
A bicuspid aortic valve (BAV) is the most prevalent congenital cardiac anomaly, in which the valve has only two leaflets, instead of the normal three. Patients with a BAV have an increased risk of aneurysm formation and the development of an aortic dissection. Vascular smooth muscle cells in both the non- and dilated aortic wall are characterized by a maturation defect in all BAV patients, as compared to patients with a tricuspid aortic valve, which can contribute to inherent developmental susce...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 23, Issue 8, 1 1 2022, Pages e301-e302
Discussion forum: it is time to assess left ventricular segmental remodelling in aortic stenosis.
Stassen J, Bax JJ
Abstract
Cited 2 times since 2022 (0.6 per year)
source: EuropePMC
Allergy and asthma proceedings,
Volume 43, Issue 5, 1 1 2022, Pages e40-e46
Clinical utility of serum tryptase levels in pediatric anaphylaxis.
Şengül Emeksiz Z, Yılmaz D, Alan B, Tunc SD, Dibek Mısırlıoğlu E
Introduction: This study aimed to evaluate the preliminary diagnosis, demographic characteristics, and outcomes of patients whose serum total tryptase levels were measured while in a tertiary pediatric hospital and to ascertain the role of serum tryptase levels in the etiology, diagnosis, severity, and course of systemic anaphylaxis. Methods: Patients ages between 1 month and 17 years who were followed up in the pediatric emergency department or as inpatients and with a diagnosis of immediate-ty...
Abstract
Cited 5 times since 2022 (1.6 per year)
source: EuropePMC
Journal of clinical research in pediatric endocrinology,
Volume 14, Issue 4, 30 5 2022, Pages 402-408
Are Thyroid Functions Affected in Multisystem Inflammatory Syndrome in Children?
Elvan-Tüz A, Ayrancı İ, Ekemen-Keleş Y, Karakoyun İ, Çatlı G, Kara-Aksay A, Karadağ-Öncel E, Dündar BN, Yılmaz D
Objective: Multisystem inflammatory syndrome in children (MIS-C), associated with Coronavirus disease-2019, is defined as the presence of documented fever, inflammation, and at least two signs of multisystem involvement and lack of an alternative microbial diagnosis in children who have recent or current Severe acute respiratory syndrome-Coronavirus-2 infection or exposure. In this study, we evaluated thyroid function tests in pediatric cases with MIS-C in order to understand how the hypothalamu...
Abstract
Cited 63 times since 2022 (20.1 per year)
source: EuropePMC
Circulation,
Volume 146, Issue 9, 30 5 2022, Pages 657-672
Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab.
Hagström E, Steg PG, Szarek M, Bhatt DL, Bittner VA, Danchin N, Diaz R, Goodman SG, Harrington RA, Jukema JW, Liberopoulos E, Marx N, McGinniss J, Manvelian G, Pordy R, Scemama M, White HD, Zeiher AM, Schwartz GG, ODYSSEY OUTCOMES Investigators
Background: Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein cholesterol is uncertain. Methods: The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor al...
Abstract
Cited 10 times since 2022 (3.2 per year)
source: EuropePMC
Pharmacogenomics and personalized medicine,
Volume 15, 30 5 2022, Pages 675-696
The Impact of Pharmacogenetics on Pharmacokinetics and Pharmacodynamics in Neonates and Infants: A Systematic Review.
Yalçin N, Flint RB, van Schaik RHN, Simons SHP, Allegaert K
In neonates, pharmacogenetics has an additional layer of complexity. This is because in addition to genetic variability in genes that code for proteins relevant to clinical pharmacology, there are rapidly maturational changes in these proteins. Consequently, pharmacotherapy in neonates has unique challenges. To provide a contemporary overview on pharmacogenetics in neonates, we conducted a systematic review to identify, describe and quantify the impact of pharmacogenetics on pharmacokinetics and...
Abstract
Cited 4 times since 2022 (1.3 per year)
source: EuropePMC
Cancer immunology, immunotherapy : CII,
Volume 72, Issue 1, 30 5 2022, Pages 137-149
Intratumoral T cell depletion following neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer is associated with poor clinical outcome.
van Wilpe S, Sultan S, Gorris MAJ, Somford DM, Kusters-Vandevelde HVN, Koornstra RHT, Gerritsen WR, Simons M, van der Heijden AG, de Vries IJM, Mehra N
Background: Whereas neoadjuvant cisplatin-based chemotherapy (NAC) followed by a radical cystectomy remains the standard treatment for patients with muscle-invasive bladder cancer (MIBC), increasing evidence suggests that checkpoint inhibitors, either alone or in combination with chemotherapy, are effective in the (neo)adjuvant setting. The major aim of this study was to improve our understanding of the immune-modulating effects of NAC in MIBC. Methods: Tumor tissue of 81 patients was used, incl...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
Revista espanola de cardiologia (English ed.),
Volume 76, Issue 1, 24 4 2022, Pages 2-3
Fusion imaging in congenital heart disease: just a pretty picture or a new tool to improve patient management?
Regeer MV, Ajmone Marsan N
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
Frontiers in physiology,
Volume 13, 23 4 2022, Pages 909870
Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis.
Schillemans T, Tragante V, Maitusong B, Gigante B, Cresci S, Laguzzi F, Vikström M, Richards M, Pilbrow A, Cameron V, Foco L, Doughty RN, Kuukasjärvi P, Allayee H, Hartiala JA, Tang WHW, Lyytikäinen LP, Nikus K, Laurikka JO, Srinivasan S, Mordi IR, Trompet S, Kraaijeveld A, van Setten J, Gijsberts CM, Maitland-van der Zee AH, Saely CH, Gong Y, Johnson JA, Cooper-DeHoff RM, Pepine CJ, Casu G, Leiherer A, Drexel H, Horne BD, van der Laan SW, Marziliano N, Hazen SL, Sinisalo J, Kähönen M, Lehtimäki T, Lang CC, Burkhardt R, Scholz M, Jukema JW, Eriksson N, Åkerblom A, James S, Held C, Hagström E, Spertus JA, Algra A, de Faire U, Åkesson A, Asselbergs FW, Patel RS, Leander K
Background: The knowledge of factors influencing disease progression in patients with established coronary heart disease (CHD) is still relatively limited. One potential pathway is related to peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A), a transcription factor linked to energy metabolism which may play a role in the heart function. Thus, its associations with subsequent CHD events remain unclear. We aimed to investigate the effect of three different SNPs in the...
Abstract
Cited 6 times since 2022 (1.9 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 11, Issue 13, 22 4 2022, Pages e024924
Arrhythmia Monitoring and Outcomes in Patients With Cardiac Sarcoidosis: Insights From the Cardiac Sarcoidosis Consortium.
Bressi E, Crawford TC, Bogun FM, Gu X, Ellenbogen KA, Chicos AB, Roukoz H, Zimetbaum PJ, Kalbfleisch SJ, Murgatroyd FD, Steckman DA, Rosenfeld LE, Garlitski AC, Soejima K, Bhan AK, Vedantham V, Dickfeld TM, De Lurgio DB, Platonov PG, Zipse MM, Nishiuchi S, Ortman ML, Narasimhan C, Patton KK, Rosenthal DG, Mukerji SS, Hoogendoorn JC, Zeppenfeld K, Sauer WH, Kron J, Cardiac Sarcoidosis Consortium *
Abstract
Cited 3 times since 2022 (0.9 per year)
source: EuropePMC
Molecular syndromology,
Volume 14, Issue 1, 21 3 2022, Pages 30-34
<i>CLN3</i>-Associated NCL Case with a Preliminary Diagnosis of Niemann Pick Type C.
Kasapkara ÇS, Ceylan AC, Yılmaz D, Kıreker Köylü O, Yürek B, Civelek Ürey B, Gündüz M
Introduction: Neuronal ceroid lipofuscinoses (NCLs) are a broad class of inherited lysosomal storage disorders. Known mutations in at least 13 different genes can result in NCL with variable ages of onset, symptoms, and pathologic findings. Generally, these patients experience cognitive and motor decline, seizures, visual impairment, and premature death. Pathologically, NCL patients display heterogeneous histologic abnormalities, but consistently exhibit neuronal loss, reactive gliosis, and lyso...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 30, Issue 1, 20 3 2022, Pages 251-253
Using a deep learning algorithm to score coronary artery calcium in myocardial perfusion imaging: A real opportunity or just a new hype?
Stassen J, van der Bijl P, Bax JJ
Abstract
Cited 38 times since 2022 (12 per year)
source: EuropePMC
Science (New York, N.Y.),
Volume 376, Issue 6599, 17 3 2022, Pages eabf9088
Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity.
O'Neill AC, Uzbas F, Antognolli G, Merino F, Draganova K, Jäck A, Zhang S, Pedini G, Schessner JP, Cramer K, Schepers A, Metzger F, Esgleas M, Smialowski P, Guerrini R, Falk S, Feederle R, Freytag S, Wang Z, Bahlo M, Jungmann R, Bagni C, Borner GHH, Robertson SP, Hauck SM, Götz M
The centrosome provides an intracellular anchor for the cytoskeleton, regulating cell division, cell migration, and cilia formation. We used spatial proteomics to elucidate protein interaction networks at the centrosome of human induced pluripotent stem cell-derived neural stem cells (NSCs) and neurons. Centrosome-associated proteins were largely cell type-specific, with protein hubs involved in RNA dynamics. Analysis of neurodevelopmental disease cohorts identified a significant overrepresentat...
Abstract
Cited 2 times since 2022 (0.6 per year)
source: EuropePMC
Frontiers in plant science,
Volume 13, 17 3 2022, Pages 909593
Comparative Transcriptome Analysis Reveals the Specific Activation of Defense Pathways Against <i>Globodera pallida</i> in Gpa2 Resistant Potato Roots.
Zheng Q, Bertran A, Brand A, van Schaik CC, van de Ruitenbeek SJS, Smant G, Goverse A, Sterken MG
Cyst nematodes are considered a dominant threat to yield for a wide range of major food crops. Current control strategies are mainly dependent on crop rotation and the use of resistant cultivars. Various crops exhibit single dominant resistance (R) genes that are able to activate effective host-specific resistance to certain cyst nematode species and/or populations. An example is the potato R gene Gpa2, which confers resistance against the potato cyst nematode (PCN), Globodera pallida population...
Abstract
Cited 3 times since 2022 (0.9 per year)
source: EuropePMC
BMC psychiatry,
Volume 22, Issue 1, 16 3 2022, Pages 403
Violent victimization and revictimization in patients with depressive disorders: context characteristics, disclosure rates, and gender differences.
Christ C, de Waal MM, Kikkert MJ, Fluri DG, Beekman ATF, Dekker JJM, van Schaik DJF
Background: Depressed patients are prone to violent victimization, and patients who were victimized once are at increased risk to fall victim to violence again. However, knowledge on the context of victimization in depressed patients is lacking, and research identifying targets for prevention is urgently needed. Methods: This cross-sectional study explored context characteristics, disclosure rates and gender differences regarding violent victimization in 153 recently victimized depressed patient...
Abstract
Cited 32 times since 2022 (10.1 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 15, Issue 10, 15 3 2022, Pages 1760-1767
Association Between Changes in Perivascular Adipose Tissue Density and Plaque Progression.
Lee SE, Sung JM, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, Conte E, Gottlieb I, Hadamitzky M, Kim YJ, Lee BK, Leipsic JA, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Shin S, Kitslaar PH, Reiber JHC, Stone PH, Samady H, Virmani R, Narula J, Berman DS, Shaw LJ, Bax JJ, Lin FY, Min JK, Chang HJ
Background: The association between the change in vessel inflammation, as quantified by perivascular adipose tissue (PVAT) density, and the progression of coronary atherosclerosis remains to be determined. Objectives: The purpose of this study was to explore the association between the change in PVAT density and the progression of total and compositional plaque volume (PV). Methods: Patients were selected from a prospective multinational registry. Patients who underwent serial coronary computed...
Abstract
Cited 8 times since 2022 (2.5 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 76, Issue 6, 15 3 2022, Pages 1527-1536.e3
Major adverse cardiac events after elective infrarenal endovascular aortic aneurysm repair.
Diender E, Vermeulen JJM, Pisters R, van Schaik PM, Reijnen MMPJ, Holewijn S
Objective: There is a significant cardiac morbidity and mortality after endovascular aneurysm repair (EVAR). However, information about long-term risk of cardiac events after EVAR and potential predictors is lacking. Therefore, the aim of this study was to determine incidence and predictors of major adverse cardiac events (MACE) at 1 and 5 years after elective EVAR for infrarenal abdominal aortic aneurysms. Methods: Baseline, perioperative, and postoperative information of 320 patients was evalu...
Abstract
Cited 27 times since 2022 (8.5 per year)
source: EuropePMC
International journal of cardiology,
Volume 363, 15 3 2022, Pages 87-93
Left atrioventricular coupling index in hypertrophic cardiomyopathy and risk of new-onset atrial fibrillation.
Meucci MC, Fortuni F, Galloo X, Bootsma M, Crea F, Bax JJ, Marsan NA, Delgado V
Backgrounds: This study aimed to investigate the association between left atrioventricular coupling index (LACI) and the occurrence of atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM). Methods: A total of 373 patients with HCM and no history of AF were evaluated by transthoracic echocardiography. LACI was defined by the ratio of left atrial (LA) end-diastolic volume divided by left ventricular (LV) end-diastolic volume. The cut-off value for LACI (≥40%) to identify LA-...
Abstract
