8900 results
Cited 5 times since 2022 (1.4 per year)
source: EuropePMC
Nature microbiology,
Volume 7, Issue 4, 1 1 2022, Pages 482-483
Baas Becking meets One Health.
van Schaik W
Abstract
Nature cardiovascular research,
Volume 1, Issue 4, 1 1 2022, Pages 289-290
R-SMAD in control of the R-smooth muscle cell.
Goumans MJ, Quax PHA
Abstract
Cited 24 times since 2022 (6.7 per year)
source: EuropePMC
European heart journal,
Volume 43, Issue 16, 1 1 2022, Pages 1554-1565
Alirocumab after acute coronary syndrome in patients with a history of heart failure.
White HD, Schwartz GG, Szarek M, Bhatt DL, Bittner VA, Chiang CE, Diaz R, Goodman SG, Jukema JW, Loy M, Pagidipati N, Pordy R, Ristić AD, Zeiher AM, Wojdyla DM, Steg PG, ODYSSEY OUTCOMES Investigators
Aims: Patients with heart failure (HF) have not been shown to benefit from statins. In a post hoc analysis, we evaluated outcomes in ODYSSEY OUTCOMES in patients with vs. without a history of HF randomized to the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor alirocumab or placebo. Methods and results: Among 18 924 patients with recent acute coronary syndrome (ACS) receiving intensive or maximum-tolerated statin treatment, the primary outcome of major adverse cardiovascular even...
Abstract
Cited 2 times since 2022 (0.6 per year)
source: EuropePMC
European journal of radiology open,
Volume 9, 31 5 2022, Pages 100417
Correlation between quantification of myocardial area at risk and ischemic burden at cardiac computed tomography.
van Driest FY, Bijns CM, van der Geest RJ, Broersen A, Dijkstra J, Jukema JW, Scholte AJHA
Purpose: This study aims to investigate the correlation between myocardial area at risk at coronary computed tomography angiography (CCTA) and the ischemic burden derived from myocardial computed tomography perfusion (CTP) by using the 17-segment model. Methods: Forty-two patients with chest pain complaints who underwent a combined CCTA and CTP protocol were identified. Patients with reversible ischemia at CTP and at least one stenosis of ≥ 50% at CCTA were selected. Myocardial area at risk was...
Abstract
JACC. Cardiovascular interventions,
Volume 15, Issue 8, 30 5 2022, Pages e95-e97
"Level Crossroads": A Venous Graft Compressing a Left Internal Mammary Graft Presenting as Myocardial Infarction.
Bingen BO, Amri IA, Scherptong RWC, Montero Cabezas JM
Abstract
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 30, Issue 1, 30 5 2022, Pages 321-323
Application of a deep learning algorithm to calcium scoring in myocardial perfusion imaging.
van der Bijl P, Stassen J, Bax JJ
Abstract
Cited 24 times since 2022 (6.7 per year)
source: EuropePMC
ESC heart failure,
Volume 9, Issue 3, 30 5 2022, Pages 2007-2012
The first experience with sodium-glucose cotransporter 2 inhibitor for the treatment of systemic right ventricular failure.
Egorova AD, Nederend M, Tops LF, Vliegen HW, Jongbloed MRM, Kiès P
In congenitally corrected transposition of the great arteries, the morphological right ventricle supports the systemic circulation. This chronic exposure to pressure overload ultimately leads to systemic right ventricular (sRV) dysfunction and heart failure. Pharmacological options for the treatment of sRV failure are poorly defined and no solid recommendations are made in the most recent guidelines. Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are a new class of antihyperglycaemic drugs t...
Abstract
Cited 5 times since 2022 (1.4 per year)
source: EuropePMC
European heart journal open,
Volume 2, Issue 3, 29 5 2022, Pages oeac022
Determinants of label non-adherence to non-vitamin K oral anticoagulants in patients with newly diagnosed atrial fibrillation.
Seelig J, Trinks-Roerdink EM, Chu G, Pisters R, Theunissen LJHJ, Trines SA, Pos L, Kirchhof CJHJ, de Jong SFAMS, den Hartog FR, van Alem AP, Polak PE, Tieleman RG, van der Voort PH, Lenderink T, Otten AM, de Jong JSSG, Gu YL, Luermans JGLM, Kruip MJHA, Timmer SAJ, de Vries TAC, Cate HT, Geersing GJ, Rutten FH, Huisman MV, Hemels MEW
Aims: To evaluate the extent and determinants of off-label non-vitamin K oral anticoagulant (NOAC) dosing in newly diagnosed Dutch AF patients. Methods and results: In the DUTCH-AF registry, patients with newly diagnosed AF (
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 30, Issue 10, 29 5 2022, Pages 481-485
Percutaneous left atrial appendage closure reduces cost of care independent of the institutional cumulative caseload in patients with non-valvular atrial fibrillation.
D'Ancona G, Arslan F, Safak E, Weber D, Ince H
Background: Data on the impact of the cumulative percutaneous left atrial appendage closure (LAAC) caseload on cardiovascular outpatient and hospitalisation costs are limited. Methods: The present single-institution analysis includes patients treated consecutively from the beginning of our LAAC experience in January 2012 until December 2016. Pre- and post-LAAC costs for hospitalisation and ambulatory visits were included. Results: A total of 676 patients underwent percutaneous LAAC (using the Wa...
Abstract
Cited 30 times since 2022 (8.4 per year)
source: EuropePMC
Clinical pharmacology and therapeutics,
Volume 112, Issue 6, 29 5 2022, Pages 1159-1171
PharmVar GeneFocus: CYP3A5.
Rodriguez-Antona C, Savieo JL, Lauschke VM, Sangkuhl K, Drögemöller BI, Wang D, van Schaik RHN, Gilep AA, Peter AP, Boone EC, Ramey BE, Klein TE, Whirl-Carrillo M, Pratt VM, Gaedigk A
The Pharmacogene Variation Consortium (PharmVar) catalogs star (*) allele nomenclature for the polymorphic human CYP3A5 gene. Genetic variation within the CYP3A5 gene locus impacts the metabolism of several clinically important drugs, including the immunosuppressants tacrolimus, sirolimus, cyclosporine, and the benzodiazepine midazolam. Variable CYP3A5 activity is of clinical importance regarding tacrolimus metabolism. This GeneFocus provides a CYP3A5 gene summary with a focus on aspects regardi...
Abstract
Cited 30 times since 2022 (8.4 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 16, Issue 5, 28 4 2022, Pages 415-422
Coronary CTA plaque volume severity stages according to invasive coronary angiography and FFR.
Min JK, Chang HJ, Andreini D, Pontone G, Guglielmo M, Bax JJ, Knaapen P, Raman SV, Chazal RA, Freeman AM, Crabtree T, Earls JP
Background: Atherosclerotic plaque characterization by coronary computed tomography angiography (CCTA) enables quantification of coronary artery disease (CAD) burden and type, which has been demonstrated as the strongest discriminant of future risk of major adverse cardiac events (MACE). To date, there are no clinically useful thresholds to assist with understanding a patient's disease burden and guide diagnosis and management, as there exists with coronary artery calcium (CAC) scoring. The...
Abstract
Cited 29 times since 2022 (8.1 per year)
source: EuropePMC
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance,
Volume 24, Issue 1, 28 4 2022, Pages 21
4D flow cardiovascular magnetic resonance derived energetics in the Fontan circulation correlate with exercise capacity and CMR-derived liver fibrosis/congestion.
Rijnberg FM, Westenberg JJM, van Assen HC, Juffermans JF, Kroft LJM, van den Boogaard PJ, Terol Espinosa de Los Monteros C, Warmerdam EG, Leiner T, Grotenhuis HB, Jongbloed MRM, Hazekamp MG, Roest AAW, Lamb HJ
Aim: This study explores the relationship between in vivo 4D flow cardiovascular magnetic resonance (CMR) derived blood flow energetics in the total cavopulmonary connection (TCPC), exercise capacity and CMR-derived liver fibrosis/congestion. Background: The Fontan circulation, in which both caval veins are directly connected with the pulmonary arteries (i.e. the TCPC) is the palliative approach for single ventricle patients. Blood flow efficiency in the TCPC has been associated with exercise ca...
Abstract
Radiology case reports,
Volume 17, Issue 5, 24 4 2022, Pages 1734-1736
Transmural ischemia visualized using routine Chest CTA.
van Driest FY, Hertgers O, Scholte AJHA, Jukema JW, de Graaf MA
Chest computed tomography (CT) is not routinely used for the diagnosis of myocardial infarction. However, there have been some reports of patients undergoing chest CT for other indications in which ultimately MI was diagnosed due to the presence of areas of myocardial hypoperfusion. The authors present the case of a 60-years old male who is referred due to acute chest pain radiating between the scapulae. Thoracic computed tomography angiography to rule out an aortic dissection revealed an occlus...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
Spinal cord,
Volume 60, Issue 9, 24 4 2022, Pages 789-798
Standard set of network outcomes for traumatic spinal cord injury: a consensus-based approach using the Delphi method.
van Schaik TJA, Pouw MH, Curt A, van Nes IJW, Vos-van der Hulst M, van Hooff ML
Study design: Consensus study. Objectives: The purpose of this study is to define a standardized (network) outcomes set for traumatic spinal cord injury (t-SCI), covering the patient journey from acute to chronic rehabilitation phase, including patient-relevant outcomes, adequate measurement instruments, as well as case-mix and risk factors. Setting: Acute Spinal Cord Injury (ASCI) Unit Nijmegen, the Netherlands. Methods: A modified Delphi method was performed, including a multidisciplinary pane...
Abstract
Cited 8 times since 2022 (2.2 per year)
source: EuropePMC
BMC medical ethics,
Volume 23, Issue 1, 23 4 2022, Pages 32
Participatory development of CURA, a clinical ethics support instrument for palliative care.
van Schaik MV, Pasman HR, Widdershoven G, Metselaar S
Background: Existing clinical ethics support (CES) instruments are considered useful. However, users report obstacles in using them in daily practice. Including end users and other stakeholders in developing CES instruments might help to overcome these limitations. This study describes the development process of a new ethics support instrument called CURA, a low-threshold four-step instrument focused on nurses and nurse assistants working in palliative care. Method: We used a participatory devel...
Abstract
Journal of cardiovascular development and disease,
Volume 9, Issue 4, 23 4 2022, Pages 92
Introduction to Special Issue "Leaders in Cardiovascular Research, Dedicated to the Memory of Professor Adriana Gittenberger-de Groot".
Gittenberger E, Poelmann RE, Jongbloed MRM
This Introduction provides both a short reflection on the scientific career of Adriana Gittenberger-de Groot and an overview of the papers that form the basis of this Special Issue giving them a proper perspective. The papers have as a central focus the outflow tract, and include contributions on development and pathology of the ventricles including AV valves, as well as developmental and pathomorphological aspects of the great arteries including semilunar valves and coronary arteries.
Abstract
Cited 2 times since 2022 (0.6 per year)
source: EuropePMC
Journal of visualized experiments : JoVE,
Issue 181, 23 4 2022
Low-input Nucleus Isolation and Multiplexing with Barcoded Antibodies of Mouse Sympathetic Ganglia for Single-nucleus RNA Sequencing.
Ge Y, van Roon L, Chen HS, Methorst R, Paton M, DeRuiter MC, Kielbasa SM, Jongbloed MRM
The cardiac autonomic nervous system is crucial in controlling cardiac function, such as heart rate and cardiac contractility, and is divided into sympathetic and parasympathetic branches. Normally, there is a balance between these two branches to maintain homeostasis. However, cardiac disease states such as myocardial infarction, heart failure, and hypertension can induce the remodeling of cells involved in cardiac innervation, which is associated with an adverse clinical outcome. Although ther...
Abstract
Cited 7 times since 2022 (2 per year)
source: EuropePMC
Infection and immunity,
Volume 90, Issue 5, 22 4 2022, Pages e0057921
A Resourceful Race: Bacterial Scavenging of Host Sulfur Metabolism during Colonization.
Kies PJ, Hammer ND
Sulfur is a requirement for life. Therefore, both the host and colonizing bacteria must regulate sulfur metabolism in a coordinated fashion to meet cellular demands. The host environment is a rich source of organic and inorganic sulfur metabolites that are utilized in critical physiological processes such as redox homeostasis and cellular signaling. As such, modulating enzymes dedicated to sulfur metabolite biosynthesis plays a vital role in host fitness. This is exemplified from a molecular sta...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 166, 21 3 2022, Pages D6190
[Disorders of the central lymphatic system].
van Schaik CJ, Janssen JJ, van der Vleuten CJM, Te Loo MWM, Schultze Kool LJ, Klein WM
The central lymphatic system consists of the thoracic duct, cisterna chyli and the retroperitoneal lymphatics through which lymph and chyle flows. Disorders of the central lymphatic system can for instance lead to leakage (chylothorax), accumulation of fluid (lymphedema) and retrograde flow (protein losing enteropathy). Abnormalities in the central lymphatic system were overlooked for years, followed by lack of diagnostic and therapeutic options. This has changed, as the technique of intranodal...
Abstract
Cited 7 times since 2022 (2 per year)
source: EuropePMC
Transplant international : official journal of the European Society for Organ Transplantation,
Volume 35, 21 3 2022, Pages 10122
Donor-Derived Cell-Free DNA for the Detection of Heart Allograft Injury: The Impact of the Timing of the Liquid Biopsy.
Verhoeven JGHP, Hesselink DA, Peeters AMA, de Jonge E, von der Thüsen JH, van Schaik RHN, Matic M, Baan CC, Manintveld OC, Boer K
Background: In heart transplant recipients, donor-derived cell-free DNA (ddcfDNA) is a potential biomarker for acute rejection (AR), in that increased values may indicate rejection. For the assessment of ddcfDNA as new biomarker for rejection, blood plasma sampling around the endomyocardial biopsy (EMB) seems a practical approach. To evaluate the effect of the EMB procedure on ddcfDNA values, ddcfDNA values before the EMB were pairwise compared to ddcfDNA values after the EMB. We aimed at evalua...
Abstract
