Research

Publications

Below you can find a list of our published research.

6136 results

Cited 12 times since 2014 (1.2 per year) source: Scopus

The American journal of cardiology, Volume 115, Issue 5, 18 3 2014, Pages 664-669 Effect of aortic regurgitation following transcatheter aortic valve implantation on outcomes. Ewe SH, Muratori M, van der Kley F, Pepi M, Delgado V, Tamborini G, Fusini L, de Weger A, Gripari P, Bartorelli A, Bax JJ, Marsan NA

The prognosis of aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) and the changes in AR grade over time remain unclear. This study evaluated the midterm survival associated with AR after TAVI and examined the evolution of AR over time and its effect on cardiac performance. Successful TAVI was performed in 314 patients (age 81 ± 7 years, 36% men). Serial transthoracic echocardiography and clinical assessment were available in 175 patients who survived >12 months.... Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 149, Issue 4, 18 3 2014, Pages 968 Long-term follow-up after the arterial switch operation: Not as perfect as we would have hoped? Hazekamp MG

Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

Behavior modification, Volume 39, Issue 3, 16 3 2014, Pages 390-412 Cognitive behavior therapy for anxiety in people with dementia: a clinician guideline for a person-centered approach. Charlesworth G, Sadek S, Schepers A, Spector A

This article describes a 10-session cognitive-behavioral therapy (CBT) used in a randomized controlled trial with people with anxiety and mild-to-moderate dementia. The aim of the therapy is to reduce symptoms of anxiety by increasing a sense of safety and self-efficacy. The therapy is characterized by a person-centered approach to CBT, using individual tailoring to accommodate for cognitive deficits and other challenges. Three phases of therapy are described: (a) socialization to model (includi... Abstract

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

Injury, Volume 46, Issue 5, 16 3 2014, Pages 863-869 Impact of combat events on first responders: experiences of the armed conflict in Uruzgan, Afghanistan. Hoencamp R, Idenburg FJ, Vermetten E, Tan E, Plat MC, Hoencamp E, Leenen LP, Hamming JF

Introduction: Care for battle casualties demands special skills from medics, nurses, and tactical commanders. To date, no inventory has been performed evaluating the first responders (medics, nurses and tactical commanders) around battle casualties. Method: This observational cohort study was conducted amongst the first responders (n=195) who were deployed to Southern Afghanistan (2009-2010) in three Marine companies. The survey focused on four main topics: (1) participants general background, (... Abstract

Cited 27 times since 2014 (2.6 per year) source: EuropePMC

BMC nephrology, Volume 15, 11 2 2014, Pages 197 Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients. Buiten MS, de Bie MK, Bouma-de Krijger A, van Dam B, Dekker FW, Jukema JW, Rabelink TJ, Rotmans JI

Background: Dialysis patients suffer from a high burden of cardiovascular disease (CVD). Partly this is due to progressive deterioration of calcium-phosphate homeostasis. Previous studies suggested that besides FGF-23, low levels of Klotho, a protein linked to aging, might constitute a key factor in this detrimental relationship. The purpose of the present study was to determine the relationship between serum Klotho (sKlotho) and the presence of CVD in dialysis patients. Methods: Plasma levels o... Abstract

Cited 6 times since 2014 (0.6 per year) source: EuropePMC

Forensic science international, Volume 248, 8 2 2014, Pages 101-112 Isotopic and elemental profiling of ammonium nitrate in forensic explosives investigations. Brust H, Koeberg M, van der Heijden A, Wiarda W, Mügler I, Schrader M, Vivo-Truyols G, Schoenmakers P, van Asten A

Ammonium nitrate (AN) is frequently encountered in explosives in forensic casework. It is widely available as fertilizer and easy to implement in explosive devices, for example by mixing it with a fuel. Forensic profiling methods to determine whether material found on a crime scene and material retrieved from a suspect arise from the same source are becoming increasingly important. In this work, we have explored the possibility of using isotopic and elemental profiling to discriminate between di... Abstract

Cited 24 times since 2014 (2.3 per year) source: EuropePMC

Journal of molecular and cellular cardiology, Volume 79, 5 1 2014, Pages 244-253 Clinical symptoms of right ventricular failure in experimental chronic pressure load are associated with progressive diastolic dysfunction. Borgdorff MA, Koop AM, Bloks VW, Dickinson MG, Steendijk P, Sillje HH, van Wiechen MP, Berger RM, Bartelds B

Background: Right ventricular failure (RVF) due to pressure load is a major cause of death in congenital heart diseases and pulmonary hypertension. The mechanisms of RVF are unknown. We used an experimental approach based upon clinical signs of RVF to delineate functional and biological processes associated with RVF. Methods and results: Wistar rats were subjected to a pulmonary artery banding (PAB n=12) or sham surgery (CON, n=7). After 52±5days, 5/12 PAB rats developed clinical symptoms of RVF... Abstract

Cited 48 times since 2014 (4.7 per year) source: Scopus

PloS one, Volume 9, Issue 12, 4 1 2014, Pages e111952 ACE inhibitors potently reduce vascular inflammation, results of an open proof-of-concept study in the abdominal aortic aneurysm. Kortekaas KE, Meijer CA, Hinnen JW, Dalman RL, Xu B, Hamming JF, Lindeman JH

Background: Independent of their blood pressure lowering effect, ACE inhibitors are thought to reduce vascular inflammation. The clinical relevance of this effect is unclear with the current knowledge. Abdominal aortic aneurysms (AAA) are characterized by a broad, non-specific inflammatory response, and thus provide a clinical platform to evaluate the anti-inflammatory potential of ACE inhibitors. Methods and results: Eleven patients scheduled for open AAA repair received ramipril (5 mg/day) dur... Abstract

Cited 35 times since 2014 (3.4 per year) source: EuropePMC

PLoS genetics, Volume 10, Issue 12, 4 1 2014, Pages e1004799 Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers. Taylor AE, Morris RW, Fluharty ME, Bjorngaard JH, Åsvold BO, Gabrielsen ME, Campbell A, Marioni R, Kumari M, Hällfors J, Männistö S, Marques-Vidal P, Kaakinen M, Cavadino A, Postmus I, Husemoen LL, Skaaby T, Ahluwalia TS, Treur JL, Willemsen G, Dale C, Wannamethee SG, Lahti J, Palotie A, Räikkönen K, Kisialiou A, McConnachie A, Padmanabhan S, Wong A, Dalgård C, Paternoster L, Ben-Shlomo Y, Tyrrell J, Horwood J, Fergusson DM, Kennedy MA, Frayling T, Nohr EA, Christiansen L, Ohm Kyvik K, Kuh D, Watt G, Eriksson J, Whincup PH, Vink JM, Boomsma DI, Davey Smith G, Lawlor D, Linneberg A, Ford I, Jukema JW, Power C, Hyppönen E, Jarvelin MR, Preisig M, Borodulin K, Kaprio J, Kivimaki M, Smith BH, Hayward C, Romundstad PR, Sørensen TI, Munafò MR, Sattar N

We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis. While seeking to extend these findings in a larger sample we found that this SNP is associated with 0.74% lower body mass index (BMI) per minor allele in current smokers (95% CI -0.97 to -0.51, P = 2.00 × 10(-10)), but also unexpectedly found t... Abstract

Cited 4 times since 2014 (0.4 per year) source: EuropePMC

International journal of cardiology, Volume 183, 3 1 2014, Pages 249-257 Abnormal sinoatrial node development resulting from disturbed vascular endothelial growth factor signaling. Calkoen EE, Vicente-Steijn R, Hahurij ND, van Munsteren CJ, Roest AA, DeRuiter MC, Steendijk P, Schalij MJ, Gittenberger-de Groot AC, Blom NA, Jongbloed MR

Background: Sinus node dysfunction is frequently observed in patients with congenital heart disease (CHD). Variants in the Vascular Endothelial Growth Factor-A (VEGF) pathway are associated with CHD. In Vegf(120/120) mice, over-expressing VEGF120, a reduced sinoatrial node (SAN) volume was suggested. Aim of the study is to assess the effect of VEGF over-expression on SAN development and function. Methods: Heart rate was measured in Vegf(120/120) and wildtype (WT) embryos during high frequency ul... Abstract

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 21, Issue 6, 1 1 2014, Pages 1245-1251 Multimodality imaging: bird's eye view from The European Society of Cardiology Congress 2014 Barcelona, August 30-September 3, 2014. Bax JJ, Delgado V, Achenbach S, Sechtem U, Knuuti J

Abstract

Cited 114 times since 2014 (11.1 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 111, Issue 50, 1 1 2014, Pages E5383-92 Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue. Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M

Jervell and Lange-Nielsen syndrome (JLNS) is one of the most severe life-threatening cardiac arrhythmias. Patients display delayed cardiac repolarization, associated high risk of sudden death due to ventricular tachycardia, and congenital bilateral deafness. In contrast to the autosomal dominant forms of long QT syndrome, JLNS is a recessive trait, resulting from homozygous (or compound heterozygous) mutations in KCNQ1 or KCNE1. These genes encode the α and β subunits, respectively, of the ion c... Abstract

Cited 18 times since 2014 (1.8 per year) source: EuropePMC

European heart journal, Volume 35, Issue 48, 1 1 2014, Pages 3417-3425 Non-invasive cardiac imaging evaluation of patients with chronic systolic heart failure: a report from the European Association of Cardiovascular Imaging (EACVI). Gimelli A, Lancellotti P, Badano LP, Lombardi M, Gerber B, Plein S, Neglia D, Edvardsen T, Kitsiou A, Scholte AJ, Schröder S, Cosyns B, Gargiulo P, Zamorano JL, Perrone-Filardi P

Abstract

Cited 18 times since 2014 (1.7 per year) source: EuropePMC

Lung cancer (Amsterdam, Netherlands), Volume 87, Issue 2, 29 5 2014, Pages 201-203 Tumor flare after start of RAF inhibition in KRAS mutated NSCLC: a case report. Mellema WW, Burgers SA, Smit EF

Here we describe a case of striking tumor flare after start of treatment with sorafenib and metformin as part of a phase II clinical trial. Previous reports have described a paradoxal activation of the MAPK pathway after treatment with a weak RAF inhibitor. This mechanism is based on inhibition of a negative feedback loop to upstream effectors of RAF and subsequently increased stimulation of the RAS-RAF-MEK-ERK (MAPK) pathway. We suggest that sorafenib may contribute to tumor progression through... Abstract

Cited 55 times since 2014 (5.3 per year) source: EuropePMC

European journal of heart failure, Volume 17, Issue 1, 27 4 2014, Pages 51-62 Subclinical left ventricular dysfunction by echocardiographic speckle-tracking strain analysis relates to outcome in sarcoidosis. Joyce E, Ninaber MK, Katsanos S, Debonnaire P, Kamperidis V, Bax JJ, Taube C, Delgado V, Ajmone Marsan N

Aims: Limited data exist on the risk of developing cardiac sarcoidosis (CS) and/or adverse events in sarcoidosis patients. Using LV global longitudinal strain (GLS), an emerging sensitive parameter of LV function, we evaluated the prevalence of subclinical cardiac dysfunction in sarcoidosis and investigated whether LVGLS predicts adverse outcomes in this population. Methods and results: A total of 130 patients with proven sarcoidosis undergoing echocardiography at our referral centre were identi... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Journal of chromatography. A, Volume 1374, 27 4 2014, Pages 224-230 Impurity profiling of trinitrotoluene using vacuum-outlet gas chromatography-mass spectrometry. Brust H, Willemse S, Zeng T, van Asten A, Koeberg M, van der Heijden A, Bolck A, Schoenmakers P

In this work, a reliable and robust vacuum-outlet gas chromatography-mass spectrometry (GC-MS) method is introduced for the identification and quantification of impurities in trinitrotoluene (TNT). Vacuum-outlet GC-MS allows for short analysis times; the analysis of impurities in TNT was performed in 4min. This study shows that impurity profiling of TNT can be used to investigate relations between TNT samples encountered in forensic casework. A wide variety of TNT samples were analyzed with the... Abstract

Cited 42 times since 2014 (4.1 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 8, Issue 1, 24 4 2014, Pages 102-109 Re-entry using anatomically determined isthmuses: a curable ventricular tachycardia in repaired congenital heart disease. Kapel GF, Reichlin T, Wijnmaalen AP, Piers SR, Holman ER, Tedrow UB, Schalij MJ, Stevenson WG, Zeppenfeld K

Background: Ventricular tachycardia (VT) is an important cause of late morbidity and mortality in repaired congenital heart disease. The substrate often includes anatomic isthmuses that can be transected by radiofrequency catheter ablation similar to isthmus block for atrial flutter. This study evaluates the long-term efficacy of isthmus block for treatment of re-entry VT in adults with repaired congenital heart disease. Methods and results: Thirty-four patients (49±13 years; 74% male) with repa... Abstract

Cited 41 times since 2014 (4 per year) source: EuropePMC

Preventive veterinary medicine, Volume 118, Issue 1, 23 4 2014, Pages 80-92 Housing and management factors associated with indicators of dairy cattle welfare. de Vries M, Bokkers EA, van Reenen CG, Engel B, van Schaik G, Dijkstra T, de Boer IJ

Knowledge of potential synergies and trade-offs between housing and management factors for different aspects of animal welfare is essential for farmers who aim to improve the level of welfare in their herds. The aim of this research was to identify and compare housing and management factors associated with prevalence of lameness, prevalence of lesions or swellings, prevalence of dirty hindquarters, and frequency of displacements (social behavior) in dairy herds in free-stall housing. Seven obser... Abstract

Cited 16 times since 2014 (1.6 per year) source: EuropePMC

Atherosclerosis, Volume 238, Issue 1, 22 4 2014, Pages 132-139 RP105 deficiency attenuates early atherosclerosis via decreased monocyte influx in a CCR2 dependent manner. Wezel A, van der Velden D, Maassen JM, Lagraauw HM, de Vries MR, Karper JC, Kuiper J, Bot I, Quax PH

Objective: Toll like receptor 4 (TLR4) plays a key role in inflammation and previously it was established that TLR4 deficiency attenuates atherosclerosis. RadioProtective 105 (RP105) is a structural homolog of TLR4 and an important regulator of TLR4 signaling, suggesting that RP105 may also be an important effector in atherosclerosis. We thus aimed to determine the role of RP105 in atherosclerotic lesion development using RP105 deficient mice on an atherosclerotic background. Methods and results... Abstract

Cited 21 times since 2014 (2 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 101, Issue 2, 20 3 2014, Pages 94-100 Non-invasive imaging in atrial fibrillation: focus on prognosis and catheter ablation. Bax JJ, Marsan NA, Delgado V

Imaging identifies patients with high-risk phenotype among the general population with atrial fibrillation, such as the presence of structural and valvular heart disease, which are both related to adverse outcome. Imaging is also potentially important for prediction of success of catheter ablation. Specifically, patients with larger left atrial size, reduced left atrial function and increased left atrial fibrosis content are more likely to experience atrial fibrillation recurrences after ablatio... Abstract