Research

Publications

Below you can find a list of our published research.

9166 results

Cited 10 times since 2018 (1.4 per year) source: EuropePMC

Revista espanola de cardiologia (English ed.), Volume 71, Issue 11, 30 5 2018, Pages 961-970 Sudden Cardiac Death Risk Prediction: The Role of Cardiac Magnetic Resonance Imaging. van der Bijl P, Podlesnikar T, Bax JJ, Delgado V

Sudden cardiac death (SCD) accounts for more than 4 million global deaths per year. While it is most commonly caused by coronary artery disease, a final common pathway of ventricular arrhythmias is shared by different etiologies. The most effective primary and secondary prevention strategy is an implantable cardioverter-defibrillator (ICD). The decision to implant an ICD for primary prevention is largely based on a left ventricular ejection fraction ≤ 35%, but this criterion in isolation is neit... Abstract

Cited 12 times since 2018 (1.7 per year) source: EuropePMC

Journal of clinical and translational hepatology, Volume 6, Issue 3, 28 4 2018, Pages 339-344 Incidental Collision Tumor of Hepatocellular Carcinoma and Neuroendocrine Carcinoma. Yılmaz DB, Bayramoğlu Z, Ünay G, Ayık E, Başsorgun Cİ, Elpek GÖ

The composite tumors of the liver are very rare, including the coexistence of HCC (hepatocellular carcinoma) with NEC (neuroendocrine carcinoma). The rare occurrence of these tumors necessitates more reported cases in order to fully understand their clinical characteristics, behaviors and treatments. Herein is described an incidental collision tumor of HCC-NEC, along with a review of the literature focusing on their clinicopathological findings and prognosis. The tumor presented here was found i... Abstract

Cited 3 times since 2018 (0.4 per year) source: EuropePMC

BMJ open, Volume 8, Issue 6, 27 4 2018, Pages e020844 A Reduction in Time with Electronic Monitoring In Stroke (ARTEMIS): study protocol for a randomised multicentre trial. Koster GT, Nguyen TTM, Groot AED, Coutinho JM, Bosch J, den Hertog HM, van Walderveen MAA, Algra A, Wermer MJH, Roos YB, Kruyt ND, ARTEMIS investigators

Introduction: Time is the most crucial factor limiting efficacy of intravenous thrombolysis (IVT) and intra-arterial thrombectomy (IAT). The delay between alarming the Emergency Medical Services (EMS) dispatch office and IVT/IAT initiation, that is, the 'total system delay' (TSD), depends on logistics and team effort. A promising method to reduce TSD is real-time audio-visual feedback to caregivers involved. With 'A Reduction in Time with Electronic Monitoring in Stroke' (ART... Abstract

Cited 45 times since 2018 (6.4 per year) source: EuropePMC

Journal of the American Heart Association, Volume 7, Issue 13, 22 4 2018, Pages e008163 Infective Endocarditis After Melody Valve Implantation in the Pulmonary Position: A Systematic Review. Abdelghani M, Nassif M, Blom NA, Van Mourik MS, Straver B, Koolbergen DR, Kluin J, Tijssen JG, Mulder BJM, Bouma BJ, de Winter RJ

Background: Infective endocarditis (IE) after transcatheter pulmonary valve implantation (TPVI) in dysfunctioning right ventricular outflow tract conduits has evoked growing concerns. We aimed to investigate the incidence and the natural history of IE after TPVI with the Melody valve through a systematic review of published data. Methods and results: PubMed, EMBASE, and Web of Science databases were systematically searched for articles published until March 2017, reporting on IE after TPVI with... Abstract

Cited 16 times since 2018 (2.3 per year) source: EuropePMC

Current cardiology reports, Volume 20, Issue 8, 21 3 2018, Pages 66 HDL Mimetics Infusion and Regression of Atherosclerosis: Is It Still Considered a Valid Therapeutic Option? Karalis I, Jukema JW

Purpose of review: This review aims to summarize and discuss the recent findings in the field of using HDL mimetics for the treatment of patients with coronary artery disease. Recent findings: Following the largely disappointing results with the cholesteryl ester transfer protein inhibitors, focus moved to HDL functionality rather than absolute HDL cholesterol values. A number of HDL/apoA-I mimicking molecules were developed, aiming to enhance reverse cholesterol transport that has been associat... Abstract

Cited 7 times since 2018 (1 per year) source: EuropePMC

Journal of dairy science, Volume 101, Issue 9, 21 3 2018, Pages 8383-8395 Development of an objective and uniform scoring method to evaluate the quality of rearing in Dutch dairy herds. Santman-Berends IMGA, Brouwer H, Ten Wolthuis-Bronsvoort A, De Bont-Smolenaars AJG, Haarman-Zantinge S, Van Schaik G

Young stock rearing is an essential part of dairy management, and it is important that the quality of rearing can be monitored and altered if necessary. In this study, a young stock rearing quality system (KalfOK) was developed with the aim to provide an objective and standardized means to evaluate and monitor the quality of young stock rearing in Dutch dairy herds. In the project, 201 dairy farmers participated. Twelve key indicators were defined that were related to calving and successful rear... Abstract

Cited 9 times since 2018 (1.3 per year) source: EuropePMC

The American journal of cardiology, Volume 122, Issue 4, 20 3 2018, Pages 656-662 Development of and Progression of Overt Heart Failure in Nonobstructive Hypertrophic Cardiomyopathy. Hiemstra YL, Debonnaire P, van Zwet EW, Bootsma M, Schalij MJ, Bax JJ, Delgado V, Marsan NA

Only few studies aimed at identifying predictors of heart failure (HF) in hypertrophic cardiomyopathy (HC) patients. Furthermore, serial echocardiographic analyses are lacking in these patients and little is known about the natural progression of left ventricular (LV) abnormalities and their association with HF development. Aim of this study was to assess the prognostic value of LV global longitudinal strain (GLS) and other clinical and echocardiographic characteristics for the development of HF... Abstract

Cited 10 times since 2018 (1.4 per year) source: EuropePMC

Elementa (Washington, D.C.), Volume 6, 20 3 2018, Pages 46 Sewage loading and microbial risk in urban waters of the Great Lakes. McLellan SL, Sauer EP, Corsi SR, Bootsma MJ, Boehm AB, Spencer SK, Borchardt MA

Despite modern sewer system infrastructure, the release of sewage from deteriorating pipes and sewer overflows is a major water pollution problem in US cities, particularly in coastal watersheds that are highly developed with large human populations. We quantified fecal pollution sources and loads entering Lake Michigan from a large watershed of mixed land use using host-associated indicators. Wastewater treatment plant influent had stable concentrations of human Bacteroides and human Lachnospir... Abstract

Cited 9 times since 2018 (1.3 per year) source: EuropePMC

Travel medicine and infectious disease, Volume 27, 19 3 2018, Pages 87-91 Carriage of Blastocystis spp. in travellers - A prospective longitudinal study. van Hattem JM, Arcilla MS, Schultsz C, Bootsma MC, Verhaar N, Rebers SP, Goorhuis A, Grobusch MP, Penders J, de Jong MD, van Gool T, Bart A, COMBAT consortium

Introduction: A lack of prospective and longitudinal data on pre- and post-travel carriage of Blastocystis spp. complicates interpretation of a positive test post-travel. Therefore we studied dynamics of Blastocystis carriage in a cohort of Dutch travellers. Methods: From the prospective, multicentre COMBAT study among 2001 Dutch travellers, a subset of 491 travellers was selected based on travel destination to 7 subregions (70 or 71 travellers each). Faecal samples taken directly before and aft... Abstract

Cited 5 times since 2018 (0.7 per year) source: EuropePMC

BMC medical education, Volume 18, Issue 1, 19 3 2018, Pages 145 Motivation for feedback-seeking among pediatric residents: a mixed methods study. Henry D, Vesel T, Boscardin C, van Schaik S

Background: For effective self-directed life-long learning physicians need to engage in feedback-seeking, which means fostering such behavior during training. Self-determination theory (SDT) posits that intrinsic motivation is fostered when the environment optimizes the individual's experience of autonomy, relatedness, and competence. Educational settings meeting these psychological needs may foster intrinsic motivation in trainees, enhance their desire for feedback, and promote feedback-se... Abstract

Cited 14 times since 2018 (2 per year) source: EuropePMC

PloS one, Volume 13, Issue 6, 18 3 2018, Pages e0198666 Chemical, molecular and structural studies of Boswellia species: β-Boswellic Aldehyde and 3-epi-11β-Dihydroxy BA as precursors in biosynthesis of boswellic acids. Al-Harrasi A, Rehman NU, Khan AL, Al-Broumi M, Al-Amri I, Hussain J, Hussain H, Csuk R

The distribution and biosynthesis of boswellic acids (BAs) is scarce in current literature. Present study aims to elucidate the BAs biosynthetic and its diversity in the resins of Boswellia sacra and Boswellia papyrifera. Results revealed the isolation of new (3β, 11β-dihydroxy BA) and recently known (as new source, β-boswellic aldehyde) precursors from B. sacra resin along with α-amyrin. Following this, a detailed nomenclature of BAs was elucidated. The quantification and distribution of amyrin... Abstract

Cited 8 times since 2018 (1.1 per year) source: EuropePMC

Acta obstetricia et gynecologica Scandinavica, Volume 97, Issue 10, 17 3 2018, Pages 1192-1199 Increased cardiovascular disease risk in women with a history of recurrent miscarriage. Wagner MM, Beshay MM, Rooijakkers S, Hermes W, Jukema JW, Le Cessie S, De Groot CJM, Ballieux BEPB, Van Lith JMM, Bloemenkamp KWM

Introduction: Cardiovascular disease is the leading cause of death in women. Observational studies suggest that women with a history of recurrent miscarriage have an increased risk of cardiovascular disease. Material and methods: Women who visited the recurrent miscarriage clinic at Leiden University Medical Center between 2000 and 2010 and who had their third consecutive miscarriage before the age of 31 years, were invited to participate in this follow-up study (between 2012 and 2014). The refe... Abstract

Cited 237 times since 2018 (33.6 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 11, Issue 10, 13 2 2018, Pages 1475-1484 Effects of Statins on Coronary Atherosclerotic Plaques: The PARADIGM Study. Lee SE, Chang HJ, Sung JM, Park HB, Heo R, Rizvi A, Lin FY, Kumar A, Hadamitzky M, Kim YJ, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, Leipsic JA, Shin S, Choi JH, Chinnaiyan K, Raff G, Virmani R, Samady H, Stone PH, Berman DS, Narula J, Shaw LJ, Bax JJ, Min JK

Objectives: This study sought to describe the impact of statins on individual coronary atherosclerotic plaques. Background: Although statins reduce the risk of major adverse cardiovascular events, their long-term effects on coronary atherosclerosis remain unclear. Methods: We performed a prospective, multinational study consisting of a registry of consecutive patients without history of coronary artery disease who underwent serial coronary computed tomography angiography at an interscan interval... Abstract

Cited 18 times since 2018 (2.6 per year) source: EuropePMC

Atherosclerosis, Volume 275, 13 2 2018, Pages 214-224 Lipocalin-2 contributes to experimental atherosclerosis in a stage-dependent manner. Amersfoort J, Schaftenaar FH, Douna H, van Santbrink PJ, Kröner MJ, van Puijvelde GHM, Quax PHA, Kuiper J, Bot I

Background and aims: Lipocalin-2 (Lcn2) is a glycoprotein which can be secreted by immune cells. Several studies in humans have suggested Lcn2 can be used as a biomarker for the detection of unstable atherosclerotic lesions, partly as it is known to interact with MMP-9. Methods: In this study, we generated Ldlr-/-Lcn2-/- mice to assess the functional role of Lcn2 in different stages of atherosclerosis. Atherosclerotic lesions were characterized through histological analysis and myeloid cell popu... Abstract

Cited 43 times since 2018 (6.1 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 5, 12 2 2018, Pages 55 The BCR-ABL1 Inhibitors Imatinib and Ponatinib Decrease Plasma Cholesterol and Atherosclerosis, and Nilotinib and Ponatinib Activate Coagulation in a Translational Mouse Model. Pouwer MG, Pieterman EJ, Verschuren L, Caspers MPM, Kluft C, Garcia RA, Aman J, Jukema JW, Princen HMG

Treatment with the second and third generation BCR-ABL1 tyrosine kinase inhibitors (TKIs) increases cardiovascular risk in chronic myeloid leukemia (CML) patients. We investigated the vascular adverse effects of three generations of TKIs in a translational model for atherosclerosis, the APOE*3Leiden.CETP mouse. Mice were treated for sixteen weeks with imatinib (150 mg/kg BID), nilotinib (10 and 30 mg/kg QD) or ponatinib (3 and 10 mg/kg QD), giving similar drug exposures as in CML-patients. Cardi... Abstract

Cited 39 times since 2018 (5.5 per year) source: EuropePMC

Nature communications, Volume 9, Issue 1, 11 2 2018, Pages 2266 In situ atomistic insight into the growth mechanisms of single layer 2D transition metal carbides. Sang X, Xie Y, Yilmaz DE, Lotfi R, Alhabeb M, Ostadhossein A, Anasori B, Sun W, Li X, Xiao K, Kent PRC, van Duin ACT, Gogotsi Y, Unocic RR

Developing strategies for atomic-scale controlled synthesis of new two-dimensional (2D) functional materials will directly impact their applications. Here, using in situ aberration-corrected scanning transmission electron microscopy, we obtain direct insight into the homoepitaxial Frank-van der Merwe atomic layer growth mechanism of TiC single adlayers synthesized on surfaces of Ti3C2 MXene substrates with the substrate being the source material. Activated by thermal exposure and electron-beam i... Abstract

Cited 80 times since 2018 (11.3 per year) source: EuropePMC

Nature communications, Volume 9, Issue 1, 11 2 2018, Pages 2256 Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants. Dadaev T, Saunders EJ, Newcombe PJ, Anokian E, Leongamornlert DA, Brook MN, Cieza-Borrella C, Mijuskovic M, Wakerell S, Olama AAA, Schumacher FR, Berndt SI, Benlloch S, Ahmed M, Goh C, Sheng X, Zhang Z, Muir K, Govindasami K, Lophatananon A, Stevens VL, Gapstur SM, Carter BD, Tangen CM, Goodman P, Thompson IM, Batra J, Chambers S, Moya L, Clements J, Horvath L, Tilley W, Risbridger G, Gronberg H, Aly M, Nordström T, Pharoah P, Pashayan N, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Albanes D, Weinstein S, Wolk A, Hakansson N, West C, Dunning AM, Burnet N, Mucci L, Giovannucci E, Andriole G, Cussenot O, Cancel-Tassin G, Koutros S, Freeman LEB, Sorensen KD, Orntoft TF, Borre M, Maehle L, Grindedal EM, Neal DE, Donovan JL, Hamdy FC, Martin RM, Travis RC, Key TJ, Hamilton RJ, Fleshner NE, Finelli A, Ingles SA, Stern MC, Rosenstein B, Kerns S, Ostrer H, Lu YJ, Zhang HW, Feng N, Mao X, Guo X, Wang G, Sun Z, Giles GG, Southey MC, MacInnis RJ, FitzGerald LM, Kibel AS, Drake BF, Vega A, Gómez-Caamaño A, Fachal L,

Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among t... Abstract

Cited 609 times since 2018 (86.4 per year) source: EuropePMC

Nature genetics, Volume 50, Issue 7, 11 2 2018, Pages 928-936 Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Schumacher FR, Al Olama AA, Berndt SI, Benlloch S, Ahmed M, Saunders EJ, Dadaev T, Leongamornlert D, Anokian E, Cieza-Borrella C, Goh C, Brook MN, Sheng X, Fachal L, Dennis J, Tyrer J, Muir K, Lophatananon A, Stevens VL, Gapstur SM, Carter BD, Tangen CM, Goodman PJ, Thompson IM, Batra J, Chambers S, Moya L, Clements J, Horvath L, Tilley W, Risbridger GP, Gronberg H, Aly M, Nordström T, Pharoah P, Pashayan N, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Albanes D, Weinstein S, Wolk A, Håkansson N, West CML, Dunning AM, Burnet N, Mucci LA, Giovannucci E, Andriole GL, Cussenot O, Cancel-Tassin G, Koutros S, Beane Freeman LE, Sorensen KD, Orntoft TF, Borre M, Maehle L, Grindedal EM, Neal DE, Donovan JL, Hamdy FC, Martin RM, Travis RC, Key TJ, Hamilton RJ, Fleshner NE, Finelli A, Ingles SA, Stern MC, Rosenstein BS, Kerns SL, Ostrer H, Lu YJ, Zhang HW, Feng N, Mao X, Guo X, Wang G, Sun Z, Giles GG, Southey MC, MacInnis RJ, FitzGerald LM, Kibel AS, Drake BF, Vega A, Gómez-Caamaño A, Szulkin R, Eklund M, Kogevinas

Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06; P = 2.3 × 10-9; T>G, p.Val109... Abstract

Cited 495 times since 2018 (70.2 per year) source: EuropePMC

Nature genetics, Volume 50, Issue 9, 11 2 2018, Pages 1225-1233 Multi-ethnic genome-wide association study for atrial fibrillation. Roselli C, Chaffin MD, Weng LC, Aeschbacher S, Ahlberg G, Albert CM, Almgren P, Alonso A, Anderson CD, Aragam KG, Arking DE, Barnard J, Bartz TM, Benjamin EJ, Bihlmeyer NA, Bis JC, Bloom HL, Boerwinkle E, Bottinger EB, Brody JA, Calkins H, Campbell A, Cappola TP, Carlquist J, Chasman DI, Chen LY, Chen YI, Choi EK, Choi SH, Christophersen IE, Chung MK, Cole JW, Conen D, Cook J, Crijns HJ, Cutler MJ, Damrauer SM, Daniels BR, Darbar D, Delgado G, Denny JC, Dichgans M, Dörr M, Dudink EA, Dudley SC, Esa N, Esko T, Eskola M, Fatkin D, Felix SB, Ford I, Franco OH, Geelhoed B, Grewal RP, Gudnason V, Guo X, Gupta N, Gustafsson S, Gutmann R, Hamsten A, Harris TB, Hayward C, Heckbert SR, Hernesniemi J, Hocking LJ, Hofman A, Horimoto ARVR, Huang J, Huang PL, Huffman J, Ingelsson E, Ipek EG, Ito K, Jimenez-Conde J, Johnson R, Jukema JW, Kääb S, Kähönen M, Kamatani Y, Kane JP, Kastrati A, Kathiresan S, Katschnig-Winter P, Kavousi M, Kessler T, Kietselaer BL, Kirchhof P, Kleber ME, Knight S, Krieger JE, Kubo M, Launer LJ, L

Atrial fibrillation (AF) affects more than 33 million individuals worldwide1 and has a complex heritability2. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associa... Abstract

Cited 33 times since 2018 (4.7 per year) source: EuropePMC

Journal of immunology (Baltimore, Md. : 1950), Volume 201, Issue 2, 11 2 2018, Pages 417-422 In Rheumatoid Arthritis, Synovitis at Different Inflammatory Sites Is Dominated by Shared but Patient-Specific T Cell Clones. Musters A, Klarenbeek PL, Doorenspleet ME, Balzaretti G, Esveldt REE, van Schaik BDC, Jongejan A, Tas SW, van Kampen AHC, Baas F, de Vries N

Genetic and immunological evidence clearly points to a role for T cells in the pathogenesis of rheumatoid arthritis (RA). Selective targeting of such disease-associated T cell clones might be highly effective while having few side effects. However, such selective targeting may only be feasible if the same T cell clones dominate the immune response at different sites of inflammation. We leveraged high-throughput technology to quantitatively assess whether different T cell clones dominate the infl... Abstract