8799 results
Cited 9 times since 2013 (0.7 per year)
source: EuropePMC
Circulation,
Volume 127, Issue 12, 1 1 2013, Pages 1340-1341
Compression of the left main coronary artery by a giant pulmonary artery aneurysm.
Jurado-Román A, Hernández-Hernández F, Ruíz-Cano MJ, Velázquez-Martín MT, Medina JM, Pérez-López I, Barrios-Garrido-Lestache E, Montero-Cabezas JM, Escribano-Subías P
Abstract
Cited 7 times since 2013 (0.6 per year)
source: EuropePMC
Annals of plastic surgery,
Volume 70, Issue 3, 1 1 2013, Pages 360-365
Intraoperative prediction of postoperative flap outcome using the near-infrared fluorophore methylene blue.
Ashitate Y, Lee BT, Laurence RG, Lunsford E, Hutteman M, Oketokoun R, Choi HS, Frangioni JV
Methylene blue (MB) is a near-infrared fluorophore that provides a stable visual map of skin perfusion after intravenous injection. We explored the capability of MB to predict submental flap postoperative outcome using a single intraoperative measurement. Submental flaps were created in N = 15 pigs and imaged using the FLARE imaging system immediately after surgery and at 72 hours. Using the first 3 pigs, optimal MB dosing was found to be 2.0 mg/kg. Training and validation sets of 6 pigs each we...
Abstract
Cited 28 times since 2013 (2.3 per year)
source: EuropePMC
Pharmacogenetics and genomics,
Volume 23, Issue 3, 1 1 2013, Pages 148-155
Impact of POR*28 on the clinical pharmacokinetics of CYP3A phenotyping probes midazolam and erythromycin.
Elens L, Nieuweboer AJ, Clarke SJ, Charles KA, de Graan AJ, Haufroid V, van Gelder T, Mathijssen RH, van Schaik RH
Objective: P450 oxidoreductase (POR) is essential for cytochrome P450 (CYP) activity in humans. The POR*28 allele (A503V) has been shown to impact on in-vitro CYP-mediated metabolism, including CYP3A isoenzymes. The aim of the present study was to determine the in vivo impact of the POR*28 allele on the pharmacokinetics of the classic CYP3A phenotyping probes midazolam and erythromycin. Whereas midazolam is metabolized by both CYP3A4 and CYP3A5, erythromycin is exclusively oxidized by CYP3A4. Ma...
Abstract
Cited 82 times since 2013 (6.7 per year)
source: EuropePMC
The Journal of urology,
Volume 190, Issue 2, 1 1 2013, Pages 574-579
Intraoperative near infrared fluorescence guided identification of the ureters using low dose methylene blue: a first in human experience.
Verbeek FP, van der Vorst JR, Schaafsma BE, Swijnenburg RJ, Gaarenstroom KN, Elzevier HW, van de Velde CJ, Frangioni JV, Vahrmeijer AL
Purpose: Near infrared fluorescence imaging is a promising technique that offers real-time visual information during surgery. In this study we report the first clinical results to our knowledge of ureteral imaging using near infrared fluorescence after a simple peripheral infusion of methylene blue. Furthermore, we assessed the optimal timing and dose of methylene blue. Materials and methods: A total of 12 patients who underwent lower abdominal surgery were included in this prospective feasibili...
Abstract
Cited 57 times since 2013 (4.6 per year)
source: EuropePMC
PLoS genetics,
Volume 9, Issue 2, 28 4 2013, Pages e1003301
Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency.
Kiezun A, Pulit SL, Francioli LC, van Dijk F, Swertz M, Boomsma DI, van Duijn CM, Slagboom PE, van Ommen GJ, Wijmenga C, Genome of the Netherlands Consortium, de Bakker PI, Sunyaev SR
Large-scale population sequencing studies provide a complete picture of human genetic variation within the studied populations. A key challenge is to identify, among the myriad alleles, those variants that have an effect on molecular function, phenotypes, and reproductive fitness. Most non-neutral variation consists of deleterious alleles segregating at low population frequency due to incessant mutation. To date, studies characterizing selection against deleterious alleles have been based on all...
Abstract
Cited 65 times since 2013 (5.3 per year)
source: EuropePMC
The Journal of infectious diseases,
Volume 207, Issue 11, 27 4 2013, Pages 1780-1786
Identification of a genetic determinant in clinical Enterococcus faecium strains that contributes to intestinal colonization during antibiotic treatment.
Zhang X, Top J, de Been M, Bierschenk D, Rogers M, Leendertse M, Bonten MJ, van der Poll T, Willems RJ, van Schaik W
Intestinal colonization by antibiotic-resistant Enterococcus faecium is the first step in a process that can lead to infections in hospitalized patients. By comparative genome analysis and subsequent polymerase chain reaction screening, we identified a locus that encodes a putative phosphotransferase system (PTS). The PTS locus was widespread in isolates from hospital outbreaks of infection (84.2%) and nonoutbreak clinical infections (66.0%) but absent from human commensal isolates. Deletion of...
Abstract
Cited 5 times since 2013 (0.4 per year)
source: EuropePMC
EJIFCC,
Volume 24, Issue 3, 21 3 2013, Pages 105-112
Clinical Application of Pharmacogenetics: Where are We Now?
van Schaik RH, IFCC Task Force on Pharmacogenetics: Prof Dr Maurizio Ferrari (IT), Prof Dr Michael Neumaier (GER), Prof Dr Munir Pirmohamed (UK), Prof Dr Henk-Jan Guchelaar (NL), Prof Dr Ron van Schaik (NL)
Pharmacogenetic (PGx) testing has the potential to improve drug therapy in an individual by informing appropriate drug dosing or drug selection in order to maximize efficacy and safety. Although multiple studies have illustrated the potential benefits of such testing when applied to specific drugs across a broad range of therapy areas, the uptake of PGx testing in routine clinical practice has been relatively limited. Implementation appears to be hampered by the absence of sufficiently strong ev...
Abstract
Cited 14 times since 2013 (1.1 per year)
source: EuropePMC
PLoS computational biology,
Volume 9, Issue 2, 21 3 2013, Pages e1002874
Cost and effects of different admission screening strategies to control the spread of methicillin-resistant Staphylococcus aureus.
Gurieva T, Bootsma MC, Bonten MJ
Nosocomial infection rates due to antibiotic-resistant bacteriae, e.g., methicillin-resistant Staphylococcus aureus (MRSA) remain high in most countries. Screening for MRSA carriage followed by barrier precautions for documented carriers (so-called screen and isolate (S&I)) has been successful in some, but not all settings. Moreover, different strategies have been proposed, but comparative studies determining their relative effects and costs are not available. We, therefore, used a mathemati...
Abstract
Cited 40 times since 2013 (3.2 per year)
source: EuropePMC
BJOG : an international journal of obstetrics and gynaecology,
Volume 120, Issue 6, 19 3 2013, Pages 758-764
Near-infrared fluorescence sentinel lymph node biopsy in vulvar cancer: a randomised comparison of lymphatic tracers.
Schaafsma BE, Verbeek FP, Peters AA, van der Vorst JR, de Kroon CD, van Poelgeest MI, Trimbos JB, van de Velde CJ, Frangioni JV, Vahrmeijer AL, Gaarenstroom KN
This study aims to confirm the feasibility of near-infrared (NIR) fluorescence imaging for sentinel lymph node (SLN) biopsy in vulvar cancer and to compare the tracer indocyanine green (ICG) bound to human serum albumin (HSA) versus ICG alone. Women received 99mTc-nanocolloid and patent blue for SLN detection. Subsequently, women randomly received ICG:HSA or ICG alone. In 24 women, 35 SLNs were intraoperatively detected. All SLNs detected were radioactive and NIR fluorescent and 27 (77%) were bl...
Abstract
Cited 27 times since 2013 (2.2 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 6, Issue 2, 18 3 2013, Pages 380-391
Engraftment patterns of human adult mesenchymal stem cells expose electrotonic and paracrine proarrhythmic mechanisms in myocardial cell cultures.
Askar SF, Ramkisoensing AA, Atsma DE, Schalij MJ, de Vries AA, Pijnappels DA
Background: After intramyocardial injection, mesenchymal stem cells (MSCs) may engraft and influence host myocardium. However, engraftment rate and pattern of distribution are difficult to control in vivo, hampering assessment of potential adverse effects. In this study, the role of the engraftment patterns of MSCs on arrhythmicity in controllable in vitro models is investigated. Methods and results: Cocultures of 4×10(5) neonatal rat cardiomyocytes and 7% or 28% adult human MSCs (hMSCs) in diff...
Abstract
Cited 129 times since 2013 (10.5 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 29, Issue 5, 16 3 2013, Pages 1177-1190
Automatic quantification and characterization of coronary atherosclerosis with computed tomography coronary angiography: cross-correlation with intravascular ultrasound virtual histology.
de Graaf MA, Broersen A, Kitslaar PH, Roos CJ, Dijkstra J, Lelieveldt BP, Jukema JW, Schalij MJ, Delgado V, Bax JJ, Reiber JH, Scholte AJ
Plaque constitution on computed tomography coronary angiography (CTA) is associated with prognosis. At present only visual assessment of plaque constitution is possible. An accurate automatic, quantitative approach for CTA plaque constitution assessment would improve reproducibility and allows higher accuracy. The present study assessed the feasibility of a fully automatic and quantitative analysis of atherosclerosis on CTA. Clinically derived CTA and intravascular ultrasound virtual histology (...
Abstract
Cited 13 times since 2013 (1.1 per year)
source: EuropePMC
PloS one,
Volume 8, Issue 2, 15 3 2013, Pages e56262
Non-homologous end-joining pathway associated with occurrence of myocardial infarction: gene set analysis of genome-wide association study data.
Verschuren JJ, Trompet S, Deelen J, Stott DJ, Sattar N, Buckley BM, Ford I, Heijmans BT, Guchelaar HJ, Houwing-Duistermaat JJ, Slagboom PE, Jukema JW
Purpose: DNA repair deficiencies have been postulated to play a role in the development and progression of cardiovascular disease (CVD). The hypothesis is that DNA damage accumulating with age may induce cell death, which promotes formation of unstable plaques. Defects in DNA repair mechanisms may therefore increase the risk of CVD events. We examined whether the joints effect of common genetic variants in 5 DNA repair pathways may influence the risk of CVD events. Methods: The PLINK set-based t...
Abstract
Cited 15 times since 2013 (1.2 per year)
source: EuropePMC
Systematic reviews,
Volume 2, 15 3 2013, Pages 13
Individual patient data meta-analysis for the clinical assessment of coronary computed tomography angiography: protocol of the Collaborative Meta-Analysis of Cardiac CT (CoMe-CCT).
Schuetz GM, Schlattmann P, Achenbach S, Budoff M, Garcia MJ, Roehle R, Pontone G, Meijboom WB, Andreini D, Alkadhi H, Honoris L, Bettencourt N, Hausleiter J, Leschka S, Gerber BL, Meijs MF, Shabestari AA, Sato A, Zimmermann E, Schoepf UJ, Diederichsen A, Halon DA, Mendoza-Rodriguez V, Hamdan A, Nørgaard BL, Brodoefel H, Ovrehus KA, Jenkins SM, Halvorsen BA, Rixe J, Sheikh M, Langer C, Martuscelli E, Romagnoli A, Scholte AJ, Marcus RP, Ulimoen GR, Nieman K, Mickley H, Nikolaou K, Tardif JC, Johnson TR, Muraglia S, Chow BJ, Maintz D, Laule M, Dewey M
Unlabelled: Background: Coronary computed tomography angiography has become the foremost noninvasive imaging modality of the coronary arteries and is used as an alternative to the reference standard, conventional coronary angiography, for direct visualization and detection of coronary artery stenoses in patients with suspected coronary artery disease. Nevertheless, there is considerable debate regarding the optimal target population to maximize clinical performance and patient benefit. The most...
Abstract
Cited 24 times since 2013 (1.9 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 44, Issue 2, 13 2 2013, Pages 269-274
Disparity in right vs left ventricular recovery during follow-up after ventricular septal defect correction in children.
Klitsie LM, Kuipers IM, Roest AA, Van der Hulst AE, Stijnen T, Hazekamp MG, Blom NA, Ten Harkel AD
Objectives: Long-term prognosis after ventricular septal defect (VSD) correction in childhood is excellent. Nevertheless, decreased biventricular systolic performance has been described immediately following VSD surgery in children. In an effort to better understand this decrease and its time-course, we characterized biventricular systolic performance following VSD closure in paediatric patients up to 20 months postoperatively. Methods: Thirty-nine children undergoing VSD surgery and 22 age-matc...
Abstract
Cited 23 times since 2013 (1.9 per year)
source: EuropePMC
Frontiers in neuroscience,
Volume 7, 13 2 2013, Pages 14
An FPGA Implementation of a Polychronous Spiking Neural Network with Delay Adaptation.
Wang R, Cohen G, Stiefel KM, Hamilton TJ, Tapson J, van Schaik A
We present an FPGA implementation of a re-configurable, polychronous spiking neural network with a large capacity for spatial-temporal patterns. The proposed neural network generates delay paths de novo, so that only connections that actually appear in the training patterns will be created. This allows the proposed network to use all the axons (variables) to store information. Spike Timing Dependent Delay Plasticity is used to fine-tune and add dynamics to the network. We use a time multiplexing...
Abstract
Cited 7 times since 2013 (0.6 per year)
source: EuropePMC
ISRN obesity,
Volume 2013, 12 2 2013, Pages 342802
Plasma Levels of Acylation-Stimulating Protein Are Strongly Predicted by Waist/Hip Ratio and Correlate with Decreased LDL Size in Men.
Saleh J, Wahab RA, Farhan H, Al-Amri I, Cianflone K
The association of abdominal obesity with cardiovascular risk is often linked to altered secretion of adipose-derived factors and an abnormal lipid profile including formation of atherogenic small dense low density lipoprotein particles (sdLDL). Acylation-stimulating protein (ASP) is an adipose-derived hormone that exhibits potent lipogenic effects. Plasma ASP levels increase in obesity; however, the association of ASP levels with body fat distribution is not yet established, and no study to dat...
Abstract
Cited 45 times since 2013 (3.6 per year)
source: EuropePMC
Journal of lipid research,
Volume 54, Issue 5, 10 2 2013, Pages 1265-1274
Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation.
Bot M, de Jager SC, MacAleese L, Lagraauw HM, van Berkel TJ, Quax PH, Kuiper J, Heeren RM, Biessen EA, Bot I
Lysophosphatidic acid (LPA), a bioactive lysophospholipid, accumulates in the atherosclerotic plaque. It has the capacity to activate mast cells, which potentially exacerbates plaque progression. In this study, we thus aimed to investigate whether LPA contributes to plaque destabilization by modulating mast cell function. We here show by an imaging mass spectrometry approach that several LPA species are present in atherosclerotic plaques. Subsequently, we demonstrate that LPA is a potent mast ce...
Abstract
Cited 51 times since 2013 (4.1 per year)
source: EuropePMC
Clinical research in cardiology : official journal of the German Cardiac Society,
Volume 102, Issue 5, 8 2 2013, Pages 329-336
Discussing sexual function in the cardiology practice.
Nicolai MP, Both S, Liem SS, Pelger RC, Putter H, Schalij MJ, Elzevier HW
Background: In patients with cardiovascular disease, sexual dysfunction is frequently encountered. Erectile dysfunction shares the same modifiable risk factors as coronary artery disease and the fear of triggering cardiovascular events can create stress and anxiety impacting the sexual lives of patients and their partners. To optimise healthcare, knowledge of cardiologists' attitude and practice patterns regarding the discussion about sexual function is essential. Methods: A 31-itemed anony...
Abstract
Cited 4 times since 2013 (0.3 per year)
source: EuropePMC
Cytometry. Part B, Clinical cytometry,
Volume 84, Issue 4, 7 1 2013, Pages 218-221
Effector memory and late memory T cells accumulate in the blood of CMV-carrying individuals but not in their cerebrospinal fluid.
de Jongste AH, de Graaf MT, van den Broek PD, Kraan J, Sillevis Smitt PA, Gratama JW
Cytomegalovirus (CMV)-carrying individuals have significantly higher levels of effector memory and late memory T lymphocytes in their blood than non-carriers. To date, it is well recognized that the central nervous system is subjected to active immunosurveillance, as evidenced by the presence of central memory T cells in cerebrospinal fluid (CSF) of healthy individuals. In order to investigate whether levels of effector memory and late memory T cells were also increased in the CSF of CMV-carryin...
Abstract
Cited 166 times since 2013 (13.4 per year)
source: EuropePMC
PLoS genetics,
Volume 9, Issue 2, 7 1 2013, Pages e1003266
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
Porcu E, Medici M, Pistis G, Volpato CB, Wilson SG, Cappola AR, Bos SD, Deelen J, den Heijer M, Freathy RM, Lahti J, Liu C, Lopez LM, Nolte IM, O'Connell JR, Tanaka T, Trompet S, Arnold A, Bandinelli S, Beekman M, Böhringer S, Brown SJ, Buckley BM, Camaschella C, de Craen AJ, Davies G, de Visser MC, Ford I, Forsen T, Frayling TM, Fugazzola L, Gögele M, Hattersley AT, Hermus AR, Hofman A, Houwing-Duistermaat JJ, Jensen RA, Kajantie E, Kloppenburg M, Lim EM, Masciullo C, Mariotti S, Minelli C, Mitchell BD, Nagaraja R, Netea-Maier RT, Palotie A, Persani L, Piras MG, Psaty BM, Räikkönen K, Richards JB, Rivadeneira F, Sala C, Sabra MM, Sattar N, Shields BM, Soranzo N, Starr JM, Stott DJ, Sweep FC, Usala G, van der Klauw MM, van Heemst D, van Mullem A, Vermeulen SH, Visser WE, Walsh JP, Westendorp RG, Widen E, Zhai G, Cucca F, Deary IJ, Eriksson JG, Ferrucci L, Fox CS, Jukema JW, Kiemeney LA, Pramstaller PP, Schlessinger D, Shuldiner AR, Slagboom EP, Uitterlinden AG, Vaidya B, Visser TJ, Wolffenbuttel BH, Meulenbel
Thyroid hormone is essential for normal metabolism and development, and overt abnormalities in thyroid function lead to common endocrine disorders affecting approximately 10% of individuals over their life span. In addition, even mild alterations in thyroid function are associated with weight changes, atrial fibrillation, osteoporosis, and psychiatric disorders. To identify novel variants underlying thyroid function, we performed a large meta-analysis of genome-wide association studies for serum...
Abstract
