Research

Publications

Below you can find a list of our published research.

7434 results

Cited 14 times since 2000 (0.6 per year) source: EuropePMC

Magnetic resonance imaging, Volume 18, Issue 3, 1 1 2000, Pages 245-253 Spin echo MRI in the evaluation of hearts with a double outlet right ventricle: usefulness and limitations. Beekmana RP, Roest AA, Helbing WA, Hazekamp MG, Schoof PH, Bartelings MM, Sobotka MA, de Roos A, Ottenkamp J

The surgical approach to a double outlet right ventricle (DORV) is dependent on the spatial relationship of the semilunar valves, outflow tracts and ventricular septal defect (VSD). The purpose of the study was to assess the value of MRI for the evaluation of cardiovascular anatomy in patients before and after surgery for DORV. Spin echo MRI was performed in 12 patients with DORV (eight preoperative and four postoperative patients). Thin-section MRI was performed in three orthogonal planes and s... Abstract

Cited 45 times since 2000 (1.8 per year) source: EuropePMC

Cardiovascular research, Volume 46, Issue 1, 1 1 2000, Pages 82-89 Comparison of intravenous and pulmonary artery injections of hypertonic saline for the assessment of conductance catheter parallel conductance. Steendijk P, Baan J

Objective: The conductance catheter provides a continuous measure of left ventricular volume. Conversion of raw data to calibrated absolute volume requires assessment of parallel conductance. Conventionally, parallel conductance is determined by injecting a small bolus hypertonic saline into the pulmonary artery and analyzing the signal obtained during passage of the bolus through the left ventricle. However, in some cases, a pulmonary artery catheter is not practicable. Therefore, we investigat... Abstract

Cited 33 times since 2000 (1.3 per year) source: EuropePMC

Virology, Volume 270, Issue 1, 1 1 2000, Pages 84-97 Genetic manipulation of equine arteritis virus using full-length cDNA clones: separation of overlapping genes and expression of a foreign epitope. de Vries AA, Glaser AL, Raamsman MJ, de Haan CA, Sarnataro S, Godeke GJ, Rottier PJ

Equine arteritis virus (EAV) is an enveloped, positive-stranded RNA virus belonging to the family Arteriviridae of the order Nidovirales. The unsegmented, infectious genome of EAV is 12,704 nt in length [exclusive of the poly(A) tail] and contains eight overlapping genes that are expressed from a 3'-coterminal nested set of seven leader-containing mRNAs. To investigate the importance of the overlapping gene arrangement in the viral life-cycle and to facilitate the genetic manipulation of th... Abstract

Cited 13 times since 2000 (0.5 per year) source: EuropePMC

European journal of nuclear medicine, Volume 27, Issue 3, 1 1 2000, Pages 302-307 Clinical evaluation of no-carrier-added meta-[123I]iodobenzylguanidine for myocardial scintigraphy. Knickmeier M, Matheja P, Wichter T, Schäfers KP, Kies P, Breithardt G, Schober O, Schäfers M

In clinical and research studies, images obtained using carrier-added meta-[123I]iodobenzylguanidine (c.a. [123I]MIBG) have shown quite variable quality, with varying levels of uptake in lung, liver and mediastinum; this is a significant problem for quantification of the myocardial uptake by means of region ratios. First experimental and preliminary human data in respect of no-carrier-added (n.c.a.) [123I]MIBG are indicative of improved imaging quality. The aim of the present study was to evalua... Abstract

Cited 44 times since 2000 (1.8 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 20, Issue 3, 1 1 2000, Pages 744-750 Not acute but chronic hypertriglyceridemia is associated with impaired endothelium-dependent vasodilation: reversal after lipid-lowering therapy by atorvastatin. de Man FH, Weverling-Rijnsburger AW, van der Laarse A, Smelt AH, Jukema JW, Blauw GJ

There is controversy regarding the relation between hypertriglyceridemia (HTG) and endothelial function. This study was designed to investigate endothelial function in a patient group with chronic HTG, before and during lipid-lowering therapy by atorvastatin. In addition, the effects of acute HTG on endothelial function were studied in normolipidemic individuals. Eight male patients with chronic HTG were studied before and after 6 weeks of lipid-lowering treatment with 80 mg atorvastatin once da... Abstract

Cited 114 times since 2000 (4.6 per year) source: EuropePMC

Journal of virology, Volume 74, Issue 5, 1 1 2000, Pages 2333-2342 Characterization of the coronavirus mouse hepatitis virus strain A59 small membrane protein E. Raamsman MJ, Locker JK, de Hooge A, de Vries AA, Griffiths G, Vennema H, Rottier PJ

The small envelope (E) protein has recently been shown to play an essential role in the assembly of coronaviruses. Expression studies revealed that for formation of the viral envelope, actually only the E protein and the membrane (M) protein are required. Since little is known about this generally low-abundance virion component, we have characterized the E protein of mouse hepatitis virus strain A59 (MHV-A59), an 83-residue polypeptide. Using an antiserum to the hydrophilic carboxy terminus of t... Abstract

Cited 3 times since 2000 (0.1 per year) source: EuropePMC

Medicine and science in sports and exercise, Volume 32, Issue 3, 1 1 2000, Pages 571-575 Correlated neurocardiologic and fitness changes in athletes interrupting training. Frederiks J, Swenne CA, Bruschke AV, van der Velde ET, Maan AC, TenVoorde BJ, Vanrooijen MG, Mosterd WL, Schiereck P

Purpose: We studied nine male Dutch top marathon skaters during a 1-month interruption of their training schedules after their last contest in the winter to investigate a possible decline in baroreflex sensitivity. Methods: Before and after this period, a maximal exercise test was done, and at days 0, 4, 7, 14, and 28 neurocardiologic measurement sessions--heart rate and noninvasive baroreflex sensitivity, recumbent and tilt--were performed. Results: Interruption of training resulted in a signif... Abstract

Cited 26 times since 2000 (1 per year) source: EuropePMC

Congestive heart failure (Greenwich, Conn.), Volume 6, Issue 2, 1 1 2000, Pages 86-89 Bioimpedance monitoring: better than chest x-ray for predicting abnormal pulmonary fluid? Peacock WF, Albert NM, Kies P, White RD, Emerman CL

Bioimpedance monitoring may aid in treating heart failure. Mean thoracic electrical impedance (Zo) is inversely proportional to thoracic fluid volume and may offer greater sensitivity for detecting thoracic fluid. OBJECTIVE. Compare bioimpedance monitoring thoracic fluid detection to that of chest x-ray. METHOD. Prospective convenience sample. SETTING. 1000 bed teaching hospital. PARTICIPANTS. Patients with suspected heart failure and shortness of breath. A single blinded radiologist interpreted... Abstract

Cited 31 times since 2000 (1.2 per year) source: EuropePMC

Biochemistry, Volume 39, Issue 11, 1 1 2000, Pages 3023-3033 Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution. Broekhuis CH, Neubauer G, van der Heijden A, Mann M, Proud CG, van Venrooij WJ, Pruijn GJ

The La (SS-B) autoantigen is an evolutionarily conserved phosphoprotein which plays an important role, most likely as an RNA chaperone, in various processes, such as the biosynthesis and maturation of RNA polymerase III transcripts in the cell nucleus and (internal) initiation of translation in the cytoplasm. In this study, the phosphorylation state of this protein from human HeLa and HEp-2 cells was characterized by high-resolution two-dimensional IEF/SDS-PAGE analysis, and phosphorylation site... Abstract

Cited 5 times since 2000 (0.2 per year) source: EuropePMC

Thrombosis research, Volume 97, Issue 5, 1 1 2000, Pages 275-280 The -323Ins10 polymorphism for factor VII is not associated with coronary atherosclerosis in symptomatic men. The REGRESS study group. Lievers KJ, Mennen LI, Rattink AP, Zwinderman AH, Jukema JW, Schouten EG, de Maat MP

Elevated factor VII coagulant activity (FVII:C) has been associated with an increased risk of ischaemic heart disease, particularly for fatal events. Results of studies on the association between FVII:C and atherosclerosis are not consistent. FVII:C levels are influenced by several environmental factors and by genetic factors. One of the genetic factors is the -323Ins10 polymorphism in the promoter region of the factor VII gene, which is strongly related to FVII:C, and thus may be associated wit... Abstract

Cited 6 times since 2000 (0.2 per year) source: EuropePMC

International journal of cardiac imaging, Volume 16, Issue 1, 1 1 2000, Pages 35-41 Imaging of an aneurysm of the sinus of Valsalva with transesophageal echocardiography, contrast angiography and MRI. Baur LH, Vliegen HW, van der Wall EE, Hazekamp M, Bootsma M, de Roos A, Bruschke AV

A sinus of Valsalva aneurysm is an uncommon congenital defect, which requires appropriate diagnosis with either echocardiography, magnetic resonance imaging or contrast angiography. Treatment consists of aortic valve repair. We describe a young woman with an aneurysm of the non-coronary sinus of Valsalva, an atrial septal defect and pulmonary insufficiency. The different imaging techniques and possibilities of surgical correction are described. Abstract

Cited 1 times since 2000 (0 per year) source: EuropePMC

Biology of the neonate, Volume 78, Issue 2, 1 1 2000, Pages 98-105 Influence of inhibition of nitric oxide synthesis on cardiac function in the newborn lamb after hypoxic-ischemic injury. Dorrepaal CA, van Bel F, Steendijk P, Shadid M, van de Velde ET, Moison RM, Berger HM, Baan J

The aim of the present study was to investigate the effect of immediate post-hypoxic-ischemic (HI) inhibition of nitric oxide synthesis by N(omega)-nitro-L-arginine (NLA) on cardiac function and reactive oxygen species production. Fifteen newborn lambs were subjected to severe HI. Upon resuscitation 5 received 10 mg NLA/kg, 4 40 mg NLA/kg and 6 a placebo. Left ventricular (LV) contractility, cardiac output (CO), non-protein-bound iron (NPBI), ratio of reduced/oxidized ascorbic acid, alpha-tocoph... Abstract

Cited 24 times since 2000 (1 per year) source: EuropePMC

Clinical & experimental metastasis, Volume 18, Issue 6, 1 1 2000, Pages 445-453 Antibodies to PAI-1 alter the invasive and migratory properties of human tumour cells in vitro. Brooks TD, Slomp J, Quax PH, De Bart AC, Spencer MT, Verheijen JH, Charlton PA

Recent reports suggest that elevated levels of plasminogen activator inhibitor-1 (PAI-1) may contribute to tumour progression. The studies reported here were designed to help elucidate PAI-1's contribution to the invasive and migratory phenotype. Antibodies to PA-1 dose-dependently, and significantly, inhibited the invasive and migratory potential of human HT1080 fibrosarcoma cells, as did an antibody to uPA and the plasmin inhibitor aprotinin. Invasion of the human melanoma cell line, BLM,... Abstract

Cited 49 times since 2000 (1.9 per year) source: EuropePMC

American journal of physiology. Heart and circulatory physiology, Volume 278, Issue 1, 1 1 2000, Pages H100-5 Improved contractile performance of right ventricle in response to increased RV afterload in newborn lamb. de Vroomen M, Cardozo RH, Steendijk P, van Bel F, Baan J

Pulmonary hypertension results in an increased afterload for the right ventricle (RV). To determine the effects of this increased afterload on RV contractile performance, we examined RV performance before and during 4 h of partial balloon occlusion of the pulmonary artery and again after releasing the occlusion in nine newborn lambs. RV contractile performance was quantified by indexes derived from systolic RV pressure-volume relations obtained by a combined pressure-conductance catheter during... Abstract

Cited 7 times since 1999 (0.3 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 82, Issue 6, 1 1 1999, Pages 697-703 Left ventricular function in adults with mild pulmonary insufficiency late after Fallot repair. Niezen RA, Helbing WA, van Der Wall EE, van Der Geest RJ, Vliegen HW, de Roos A

Objective: To assess left ventricular function in adult Fallot patients with residual pulmonary regurgitation. Setting: The radiology department of a tertiary referral centre. Patients: 14 patients with chronic pulmonary regurgitation and right ventricular volume overload after repair of tetralogy of Fallot and 10 healthy subjects were studied using magnetic resonance imaging. Main outcome measures: Biventricular volumes, global biventricular function, and regional left ventricular function were... Abstract

Cited 13 times since 1999 (0.5 per year) source: EuropePMC

Annals of human genetics, Volume 63, Issue Pt 6, 1 1 1999, Pages 499-510 Analysis of lipoprotein lipase haplotypes reveals associations not apparent from analysis of the constituent loci. Hallman DM, Groenemeijer BE, Jukema JW, Boerwinkle E, Kastelein JJ

Simultaneously analysing genotype effects at several closely-linked loci may be preferable to analysing them separately, but can be difficult, due to multiple genotype classes, small class sizes, and non-independence induced by associations among loci. Analysis of haplotype effects offers an alternative approach. We studied effects of haplotypes comprising 3 loci (5' to 3': PvuII, HindIII, and Ser 447 -Stop) in the lipoprotein lipase (LPL) gene on plasma lipid levels and LPL activity,... Abstract

Cited 195 times since 1999 (7.7 per year) source: EuropePMC

The American journal of cardiology, Volume 84, Issue 10, 1 1 1999, Pages 1192-1197 The design of a prospective study of Pravastatin in the Elderly at Risk (PROSPER). PROSPER Study Group. PROspective Study of Pravastatin in the Elderly at Risk. Shepherd J, Blauw GJ, Murphy MB, Cobbe SM, Bollen EL, Buckley BM, Ford I, Jukema JW, Hyland M, Gaw A, Lagaay AM, Perry IJ, Macfarlane PW, Meinders AE, Sweeney BJ, Packard CJ, Westendorp RG, Twomey C, Stott DJ

The PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) is a randomized, double-blind, placebo-controlled trial designed to test the hypothesis that treatment with pravastatin will diminish risk of subsequent major vascular events in a cohort of men and women (70 to 82 years old) with preexisting vascular disease or significant risk of developing this condition. Five thousand eight hundred four men and women in addition to receiving advice on diet and smoking, have been randomized... Abstract

Cited 13 times since 1999 (0.5 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 6, Issue 6, 1 1 1999, Pages 577-582 Automated ejection fraction determination from gated myocardial FDG-PET data. Willemsen AT, Siebelink HJ, Blanksma PK, Paans AM

Background: The aim of this study was to determine the potential of the automated calculation of the left ventricular ejection fraction from gated myocardial positron emission tomography (PET) scans. Methods: We retrospectively analyzed the data of 20 patients who underwent both gated fluorine 18 deoxyglucose (FDG)-PET and equilibrium radionuclide angiography (ERNA). Gated PET data were analyzed by 2 independent programs (ie, quantitative gated single photon emission computed tomography [QGS]) o... Abstract

Cited 4 times since 1999 (0.2 per year) source: EuropePMC

Seminars in thoracic and cardiovascular surgery, Volume 11, Issue 4 Suppl 1, 1 1 1999, Pages 133-138 Dehiscence of the Freestyle stentless bioprosthesis. Schoof PH, Baur LH, Kappetein AP, Hazekamp MG, van Rijk-Zwikker GL, Huysmans HA

This study aimed to identify and characterize patients who developed prosthetic dehiscence after aortic valve replacement with the Freestyle Stentless bioprosthesis. Review of patients' records and preoperative echocardiogram was performed. Prosthetic dehiscence developed in 10 patients after 2.5 to 49 months (mean 19). Most patients were symptomatic at presentation. Nine patients were reoperated. Dehiscence was typically located at the inflow suture line beneath the noncoronary cusp. Four... Abstract

Cited 75 times since 1999 (2.9 per year) source: EuropePMC

Cell death and differentiation, Volume 6, Issue 10, 1 1 1999, Pages 976-986 The La (SS-B) autoantigen, a key protein in RNA biogenesis, is dephosphorylated and cleaved early during apoptosis. Rutjes SA, Utz PJ, van der Heijden A, Broekhuis C, van Venrooij WJ, Pruijn GJ

In the past few years, a role for apoptotic processes in the development of autoimmune diseases has been suggested. An increasing number of cellular proteins, which are modified during apoptosis, has been described, and many of these proteins have been identified as autoantigens. We have studied the effects of apoptosis on the La protein in more detail and for the first time demonstrate that this autoantigen is rapidly dephosphorylated after the induction of apoptosis. Dephosphorylation of the L... Abstract