Research

Publications

Below you can find a list of our published research.

9618 results

Cited 4 times since 2009 (0.2 per year) source: EuropePMC

The Journal of the Acoustical Society of America, Volume 125, Issue 4, 1 1 2009, Pages 2233-2242 A psychophysical evaluation of near-field head-related transfer functions synthesized using a distance variation function. Kan A, Jin C, van Schaik A

A method for synthesizing near-field head-related transfer functions (HRTFs) from far-field HRTFs measured using an acoustic point-source of sound is presented. Near-field HRTFs are synthesized by applying an analytic function describing the change in the transfer function when the location of a sound source changes from the far-field to the near-field: the distance variation function (DVF). The DVF is calculated from a rigid sphere model and approximates the change in the frequency-dependent in... Abstract

Cited 5 times since 2009 (0.3 per year) source: EuropePMC

American heart journal, Volume 157, Issue 5, 25 4 2009, Pages 882.e1-8 Real-time 3-dimensional echocardiography early after acute myocardial infarction: incremental value of echo-contrast for assessment of left ventricular function. Nucifora G, Marsan NA, Holman ER, Siebelink HM, van Werkhoven JM, Scholte AJ, van der Wall EE, Schalij MJ, Bax JJ

Background: Accurate and reproducible assessment of left ventricular (LV) systolic function is important in patients with acute myocardial infarction (AMI). Real-time 3-dimensional echocardiography (RT3DE) is an accurate technique, but it relies heavily on good image quality. The aim of the present study was to evaluate the incremental value of contrast-enhanced RT3DE. Methods: A total of 140 consecutive patients (58 +/- 11 years, 78% men) with ST-elevation AMI clinically underwent nonenhanced a... Abstract

Cited 280 times since 2009 (17.1 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 2, Issue 3, 23 4 2009, Pages 183-190 Infarct tissue heterogeneity assessed with contrast-enhanced MRI predicts spontaneous ventricular arrhythmia in patients with ischemic cardiomyopathy and implantable cardioverter-defibrillator. Roes SD, Borleffs CJ, van der Geest RJ, Westenberg JJ, Marsan NA, Kaandorp TA, Reiber JH, Zeppenfeld K, Lamb HJ, de Roos A, Schalij MJ, Bax JJ

Background: The relation between infarct tissue heterogeneity on contrast-enhanced MRI and the occurrence of spontaneous ventricular arrhythmia (or sudden cardiac death) is unknown. Therefore, the study purpose was to evaluate the predictive value of infarct tissue heterogeneity assessed with contrast-enhanced MRI on the occurrence of spontaneous ventricular arrhythmia with subsequent implantable cardioverter-defibrillator (ICD) therapy (as surrogate of sudden cardiac death) in patients with pre... Abstract

Cited 27 times since 2009 (1.6 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 35, Issue 6, 20 3 2009, Pages 953-7; discussion 957 Therapeutic decisions for patients with symptomatic severe aortic stenosis: room for improvement? van Geldorp MW, van Gameren M, Kappetein AP, Arabkhani B, de Groot-de Laat LE, Takkenberg JJ, Bogers AJ

Objective: Symptomatic severe aortic stenosis is an indication for aortic valve replacement. Some patients are denied intervention. This study provides insight into the proportion of conservatively treated patients and into the reasons why conservative treatment is chosen. Methods: Of a patient cohort presenting with severe aortic stenosis between 2004 and 2007, medical records were retrospectively analyzed. Only symptomatic patients (n=179) were included. We studied their characteristics, treat... Abstract

Cited 36 times since 2009 (2.2 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 36, Issue 1, 20 3 2009, Pages 96-104; discussion 104 Seventeen years of adult congenital heart surgery: a single centre experience. Putman LM, van Gameren M, Meijboom FJ, de Jong PL, Roos-Hesselink JW, Witsenburg M, Takkenberg JJ, Bogers AJ

Objective: With a growing number of children with congenital heart disease (CHD) reaching adulthood, an extensive experience with cardiac surgery in adults with CHD is accumulating. To increase insight in this patient category we report our 17-year single centre experience including predictors for adverse outcome and EuroSCORE performance. Methods: Patients and operative characteristics of all consecutive adult CHD patients operated upon between January 1990 and January 2007 were collected. Cate... Abstract

Cited 2 times since 2009 (0.1 per year) source: EuropePMC

Acta physiologica (Oxford, England), Volume 196, Issue 4, 19 3 2009, Pages 375-383 Left ventricular mechanical dyssynchrony is load independent at rest and during endotoxaemia in a porcine model. A'roch R, Steendijk P, Oldner A, Weitzberg E, Konrad D, Johansson G, Haney M

Aim: In diseased or injured states, the left ventricle displays higher degrees of mechanical dyssynchrony. We aimed at assessing mechanical dyssynchrony ranges in health related to variation in load as well as during acute endotoxin-induced ventricular injury. Methods: In 16 juvenile anaesthetized pigs, a five-segment conductance catheter was placed in the left ventricle as well as a balloon-tipped catheter in the inferior vena cava. Mechanical dyssynchrony during systole, including dyssynchrony... Abstract

Cited 10 times since 2009 (0.6 per year) source: EuropePMC

Atherosclerosis, Volume 206, Issue 2, 19 3 2009, Pages 444-450 Mannose binding lectin deficiency and triglyceride-rich lipoprotein metabolism in normolipidemic subjects. Alipour A, van Oostrom AJ, Van Wijk JP, Verseyden C, Plokker HW, Jukema JW, Rabelink AJ, Castro Cabezas M

Mannose binding lectin (MBL) is one of the three initiators of complement activation and is therefore closely linked to inflammation. MBL deficiency has been associated with the generation of atherosclerosis. Since atherosclerosis, the complement system and postprandial lipemia are linked to inflammation, we studied postprandial lipoprotein metabolism in MBL deficiency. An observational study was carried out in 107 volunteers (21% MBL deficient). Classical cardiovascular risk factors were not di... Abstract

Cited 2343 times since 2009 (142.6 per year) source: EuropePMC

The New England journal of medicine, Volume 360, Issue 13, 18 3 2009, Pages 1320-1328 Screening and prostate-cancer mortality in a randomized European study. Schröder FH, Hugosson J, Roobol MJ, Tammela TL, Ciatto S, Nelen V, Kwiatkowski M, Lujan M, Lilja H, Zappa M, Denis LJ, Recker F, Berenguer A, Määttänen L, Bangma CH, Aus G, Villers A, Rebillard X, van der Kwast T, Blijenberg BG, Moss SM, de Koning HJ, Auvinen A, ERSPC Investigators

Background: The European Randomized Study of Screening for Prostate Cancer was initiated in the early 1990s to evaluate the effect of screening with prostate-specific-antigen (PSA) testing on death rates from prostate cancer. Methods: We identified 182,000 men between the ages of 50 and 74 years through registries in seven European countries for inclusion in our study. The men were randomly assigned to a group that was offered PSA screening at an average of once every 4 years or to a control gro... Abstract

Cited 28 times since 2009 (1.7 per year) source: EuropePMC

Pediatric nephrology (Berlin, Germany), Volume 24, Issue 7, 12 2 2009, Pages 1345-1353 Reliability of renal ultrasound measurements in children. Geelhoed JJ, Kleyburg-Linkers VE, Snijders SP, Lequin M, Nauta J, Steegers EA, van der Heijden AJ, Jaddoe VW

The aim of the investigation reported here was to assess the intraobserver and interobserver variability of renal measurements in children. The study comprised 56 paired measurements in 28 children (median age 7.5 years, range 3.0-15.0 years) without renal or ureterovesical anomalies. Intraobserver and interobserver reproducibility was assessed by repeated measurements of the left and right renal length, width, and thickness. Intraclass correlation coefficients (ICCs) with the corresponding 95%... Abstract

Cited 101 times since 2009 (6.1 per year) source: EuropePMC

American journal of human genetics, Volume 84, Issue 4, 12 2 2009, Pages 468-476 Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillation. Alders M, Koopmann TT, Christiaans I, Postema PG, Beekman L, Tanck MW, Zeppenfeld K, Loh P, Koch KT, Demolombe S, Mannens MM, Bezzina CR, Wilde AA

Idiopathic Ventricular Fibrillation (IVF) is defined as spontaneous VF without any known structural or electrical heart disease. A family history is present in up to 20% of probands with the disorder, suggesting that at least a subset of IVF is hereditary. A genome-wide haplotype-sharing analysis was performed for identification of the responsible gene in three distantly related families in which multiple individuals died suddenly or were successfully resuscitated at young age. We identified a h... Abstract

Cited 29 times since 2009 (1.8 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 35, Issue 5, 9 2 2009, Pages 847-52; discussion 852-3 Wall motion score index predicts mortality and functional result after surgical ventricular restoration for advanced ischemic heart failure. Klein P, Holman ER, Versteegh MI, Boersma E, Verwey HF, Bax JJ, Dion RA, Klautz RJ

Objective: Advanced ischemic heart failure can be treated with surgical ventricular restoration (SVR). While numerous risk factors for mortality and recurrent heart failure have been identified, no plain predictor for identifying SVR patients with left ventricular damage beyond recovery is yet available. We tested echocardiographic wall motion score index (WMSI) as a predictor for mortality or poor functional result. Methods: One hundred and one patients electively operated between April 2002 an... Abstract

Cited 52 times since 2009 (3.2 per year) source: EuropePMC

Circulation, Volume 119, Issue 11, 9 2 2009, Pages 1467-1472 Tricuspid valve surgery in adults with a dysfunctional systemic right ventricle: repair or replace? Scherptong RW, Vliegen HW, Winter MM, Holman ER, Mulder BJ, van der Wall EE, Hazekamp MG

Background: In patients with a right ventricle (RV) in the systemic position, tricuspid valve surgery for regurgitation beyond adolescence is a subject of debate. The aim of the present study was to evaluate the complications, survival, and benefit of tricuspid surgery in adult patients with an atrium-level correction for transposition of the great arteries or congenitally corrected transposition of the great arteries. Methods and results: All adult patients (n=16; 7 men, 9 women; age 35+/-11 ye... Abstract

Cited 3 times since 2009 (0.2 per year) source: EuropePMC

Journal of neurology, Volume 256, Issue 7, 7 1 2009, Pages 1187-1188 Acquired rippling muscle disease associated with mild myasthenia gravis: a case report. van Schaik SM, Kwa VI, van der Kooi AJ

Abstract

Cited 8 times since 2009 (0.5 per year) source: EuropePMC

European journal of pediatrics, Volume 168, Issue 12, 5 1 2009, Pages 1479-1481 Double aortic arch with double aneuploidy--rare anomaly in combined Down and Klinefelter syndrome. Gerretsen MF, Peelen W, Rammeloo LA, Koolbergen DR, Hruda J

A 14-month-old boy with double aneuploidy and a double aortic arch suffered from frequently recurrent severe feeding and respiratory problems. Chromosomal analysis showed a 48,XXY + 21 karyotype: a double aneuploidy of Down syndrome (DS) and Klinefelter syndrome (KS). Only four cases of double aneuploidy (DS + KS) associated with congenital heart defects have been published of which none had a double aortic arch. Our case report should draw attention to the possibility of a double aortic arch in... Abstract

Cited 19 times since 2009 (1.2 per year) source: EuropePMC

The Journal of general virology, Volume 90, Issue Pt 6, 4 1 2009, Pages 1408-1416 Fusion protein is the main determinant of metapneumovirus host tropism. de Graaf M, Schrauwen EJA, Herfst S, van Amerongen G, Osterhaus ADME, Fouchier RAM

Human metapneumovirus (HMPV) and avian metapneumovirus subgroup C (AMPV-C) infect humans and birds, respectively. This study confirmed the difference in host range in turkey poults, and analysed the contribution of the individual metapneumovirus genes to host range in an in vitro cell-culture model. Mammalian Vero-118 cells supported replication of both HMPV and AMPV-C in contrast to avian quail fibroblast (QT6) cells in which only AMPV-C replicated to high titres. Inoculation of Vero-118 and QT... Abstract

Cited 13 times since 2009 (0.8 per year) source: EuropePMC

Echocardiography (Mount Kisco, N.Y.), Volume 26, Issue 3, 1 1 2009, Pages 315-323 The role of speckle tracking strain imaging in cardiac pacing. Tops LF, Delgado V, Bax JJ

In recent years, concerns have been raised about possible harmful effects of long-term right ventricular (RV) apical pacing. These detrimental effects may be related to changes in left ventricular (LV) mechanics during RV apical pacing. As a consequence, alternative RV pacing sites have been proposed, and in selected patients an upgrade from RV to biventricular pacing may be considered. Novel two-dimensional (2D) speckle tracking strain imaging allows detailed evaluation of LV mechanics, includi... Abstract

Critical care medicine, Volume 37, Issue 3, 1 1 2009, Pages 1130-1131 The fate and role of mesenchymal stem cells engrafted in the heart after a myocardial infarction during a second ischemic event. Steendijk P

Abstract

Cited 8 times since 2009 (0.5 per year) source: EuropePMC

European journal of anaesthesiology, Volume 26, Issue 3, 1 1 2009, Pages 253-259 Impact of calcium-channel blockers on right heart function in a controlled model of chronic pulmonary hypertension. Zierer A, Voeller RK, Melby SJ, Steendijk P, Moon MR

Background and objective: Patients with chronic pulmonary hypertension (CPH) who demonstrate pulmonary vasodilation following calcium-channel blocker (CCB) administration are defined as 'responders'. In contrast, 'nonresponders' are patients who do not show such pulmonary vasodilation with CCB therapy. The purpose of this investigation was to study the effects of CCB therapy on right heart mechanics in experimental CCB responders versus CCB nonresponders. Methods: In 12 dogs,... Abstract

Cited 36 times since 2009 (2.2 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 2, Issue 2, 1 1 2009, Pages e12-3 Successful deployment of a transcatheter aortic valve in bicuspid aortic stenosis: role of imaging with multislice computed tomography. Delgado V, Tops LF, Schuijf JD, van der Kley F, van de Veire NR, Schalij MJ, Bax JJ

Abstract

Cited 12 times since 2009 (0.7 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 4, Issue 5, 1 1 2009, Pages 662-668 Incidence, patient characteristics and predictors of aborted myocardial infarction in patients undergoing primary PCI: prospective study comparing pre- and in-hospital abciximab pretreatment. Hassan AK, Jukema JW, van der Laarse A, Hasan-Ali H, Wolterbeek R, van der Kley F, Spano F, Atsma DE, Schalij MJ

Aims: This study was performed to assess the incidence, patient characteristics and predictors of aborted myocardial infarction (MI) in patients with ST-segment elevation MI (STEMI) undergoing primary percutaneous coronary intervention (PPCI). Methods and results: We enrolled 179 consecutive patients with STEMI within a fixed protocol for PPCI (Leiden MISSION! project); 90 patients received abciximab bolus in the hospital (in-hospital group) and 89 patients received abciximab bolus in the ambula... Abstract