9618 results
Cited 190 times since 2008 (11.2 per year)
source: EuropePMC
American heart journal,
Volume 156, Issue 5, 2 1 2008, Pages 826-832
Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes.
Cannon CP, Giugliano RP, Blazing MA, Harrington RA, Peterson JL, Sisk CM, Strony J, Musliner TA, McCabe CH, Veltri E, Braunwald E, Califf RM, IMPROVE-IT Investigators
Background: Reduction in low-density lipoprotein cholesterol (LDL-C) improves clinical outcomes in patients with chronic coronary artery disease and acute coronary syndromes (ACSs). The combination of ezetimibe/simvastatin produces greater reductions in LDL-C compared to simvastatin monotherapy. The IMProved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) is a multicenter, randomized, double-blind, active-control trial designed to test the hypothesis that the addition of...
Abstract
Cited 11 times since 2008 (0.6 per year)
source: EuropePMC
Critical care medicine,
Volume 36, Issue 9, 1 1 2008, Pages 2576-2582
Negative effects of rofecoxib treatment on cardiac function after ischemia-reperfusion injury in APOE3Leiden mice are prevented by combined treatment with thromboxane prostanoid-receptor antagonist S18886 (terutroban).
van der Hoorn JW, Jukema JW, Bekkers ME, Princen HM, Corda S, Emeis JJ, Steendijk P
Objective: Selective cyclooxygenase-2 inhibition by rofecoxib was associated with increased risk of cardiovascular events. We hypothesized that concomitant treatment with thromboxane prostanoid receptor antagonist S18886 might ameliorate possible negative effects. We evaluated the effects of S18886, rofecoxib, and the interaction of both compounds in a combined treatment on myocardial infarct (MI) size and cardiac function after experimental ischemia/reperfusion injury in hyperlipidemic APOE*3Le...
Abstract
Cited 13 times since 2008 (0.8 per year)
source: EuropePMC
Current opinion in cardiology,
Volume 23, Issue 5, 1 1 2008, Pages 431-439
Myocardial perfusion single photon emission computed tomography for the assessment of mechanical dyssynchrony.
Boogers MM, Chen J, Bax JJ
Purpose of review: Assessment of left ventricular dyssynchrony is important in the selection of patients for cardiac resynchronization therapy (CRT). In this review, the role of nuclear imaging [particularly gated myocardial perfusion single photon emission computed tomography (GMPS)] for assessment of cardiac dyssynchrony is discussed. In addition, the role of positron emission tomography for evaluation of effects of CRT is addressed. Recent findings: Phase analysis of GMPS yields accurate info...
Abstract
Cited 109 times since 2008 (6.4 per year)
source: EuropePMC
European journal of immunology,
Volume 38, Issue 9, 1 1 2008, Pages 2389-2400
Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B.
Nagasawa M, Schmidlin H, Hazekamp MG, Schotte R, Blom B
Plasmacytoid dendritic cells (pDC) are central players in the innate and adaptive immune response against viral infections. The molecular mechanism that underlies pDC development from progenitor cells is only beginning to be elucidated. Previously, we reported that the Ets factor Spi-B and the inhibitors of DNA binding protein 2 (Id2) or Id3, which antagonize E-protein activity, are crucially involved in promoting or impairing pDC development, respectively. Here we show that the basic helix-loop...
Abstract
Cited 1 times since 2008 (0.1 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 52, Issue 11, 1 1 2008, Pages 921-923
Aggressive therapy is not always the best therapy.
Bruschke AV, Jukema JW
Abstract
Cited 27 times since 2008 (1.6 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 94, Issue 9, 1 1 2008, Pages 1214-1226
Cell therapy for ischaemic heart disease.
Beeres SL, Atsma DE, van Ramshorst J, Schalij MJ, Bax JJ
Abstract
Cited 5 times since 2008 (0.3 per year)
source: EuropePMC
Molecular ecology,
Volume 17, Issue 18, 1 1 2008, Pages 4027-4038
When dispersal fails: unexpected genetic separation in Gibraltar macaques (Macaca sylvanus).
Modolo L, Martin RD, van Schaik CP, van Noordwijk MA, Krũtzen M
Barbary macaques (Macaca sylvanus), now restricted in the wild to a few isolated forested areas of Morocco and Algeria, are present in a free-ranging colony on Gibraltar. For many decades, the Gibraltar colony was exposed to multiple bottlenecks due to highly nonrandom removal of animals, followed by repeated introductions of animals from North Africa. Moreover, because of complete isolation, Gibraltar's several social groups of macaques provide an ideal system to study the genetic conseque...
Abstract
Cited 158 times since 2008 (9.3 per year)
source: EuropePMC
European journal of neurology,
Volume 15, Issue 9, 1 1 2008, Pages 893-908
EFNS guidelines for the use of intravenous immunoglobulin in treatment of neurological diseases: EFNS task force on the use of intravenous immunoglobulin in treatment of neurological diseases.
Elovaara I, Apostolski S, van Doorn P, Gilhus NE, Hietaharju A, Honkaniemi J, van Schaik IN, Scolding N, Soelberg Sørensen P, Udd B, EFNS
Despite high-dose intravenous immunoglobulin (IVIG) is widely used in treatment of a number of immune-mediated neurological diseases, the consensus on its optimal use is insufficient. To define the evidence-based optimal use of IVIG in neurology, the recent papers of high relevance were reviewed and consensus recommendations are given according to EFNS guidance regulations. The efficacy of IVIG has been proven in Guillain-Barré syndrome (level A), chronic inflammatory demyelinating polyradiculon...
Abstract
Cited 39 times since 2008 (2.3 per year)
source: EuropePMC
The Journal of bone and joint surgery. British volume,
Volume 90, Issue 9, 1 1 2008, Pages 1205-1209
Early magnetic resonance imaging compared with bone scintigraphy in suspected scaphoid fractures.
Beeres FJ, Rhemrev SJ, den Hollander P, Kingma LM, Meylaerts SA, le Cessie S, Bartlema KA, Hamming JF, Hogervorst M
We evaluated 100 consecutive patients with a suspected scaphoid fracture but without evidence of a fracture on plain radiographs using MRI within 24 hours of injury, and bone scintigraphy three to five days after injury. The reference standard for a true radiologically-occult scaphoid fracture was either a diagnosis of fracture on both MRI and bone scintigraphy, or, in the case of discrepancy, clinical and/or radiological evidence of a fracture. MRI revealed 16 scaphoid and 24 other fractures. B...
Abstract
Cited 690 times since 2008 (40.6 per year)
source: EuropePMC
Lancet (London, England),
Volume 372, Issue 9645, 29 5 2008, Pages 1231-1239
Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial.
Tavazzi L, Maggioni AP, Marchioli R, Barlera S, Franzosi MG, Latini R, Lucci D, Nicolosi GL, Porcu M, Tognoni G, Gissi-HF Investigators
Background: Large observational studies, small prospective studies and post-hoc analyses of randomised clinical trials have suggested that statins could be beneficial in patients with chronic heart failure. However, previous studies have been methodologically weak. We investigated the efficacy and safety of the statin rosuvastatin in patients with heart failure. Methods: We undertook a randomised, double-blind, placebo-controlled trial in 326 cardiology and 31 internal medicine centres in Italy....
Abstract
Cited 16 times since 2008 (0.9 per year)
source: EuropePMC
PloS one,
Volume 3, Issue 8, 29 5 2008, Pages e3084
Targeted chromosomal insertion of large DNA into the human genome by a fiber-modified high-capacity adenovirus-based vector system.
Gonçalves MA, Holkers M, van Nierop GP, Wieringa R, Pau MG, de Vries AA
A prominent goal in gene therapy research concerns the development of gene transfer vehicles that can integrate exogenous DNA at specific chromosomal loci to prevent insertional oncogenesis and provide for long-term transgene expression. Adenovirus (Ad) vectors arguably represent the most efficient delivery systems of episomal DNA into eukaryotic cell nuclei. The most advanced recombinant Ads lack all adenoviral genes. This renders these so-called high-capacity (hc) Ad vectors less cytotoxic/imm...
Abstract
Cited 824 times since 2008 (48.5 per year)
source: EuropePMC
Lancet (London, England),
Volume 372, Issue 9645, 29 5 2008, Pages 1223-1230
Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial.
Tavazzi L, Maggioni AP, Marchioli R, Barlera S, Franzosi MG, Latini R, Lucci D, Nicolosi GL, Porcu M, Tognoni G, Gissi-HF Investigators
Background: Several epidemiological and experimental studies suggest that n-3 polyunsaturated fatty acids (PUFA) can exert favourable effects on atherothrombotic cardiovascular disease, including arrhythmias. We investigated whether n-3 PUFA could improve morbidity and mortality in a large population of patients with symptomatic heart failure of any cause. Methods: We undertook a randomised, double-blind, placebo-controlled trial in 326 cardiology and 31 internal medicine centres in Italy. We en...
Abstract
Cited 186 times since 2008 (11 per year)
source: EuropePMC
BMJ (Clinical research ed.),
Volume 337, 29 5 2008, Pages a1331
Drug eluting and bare metal stents in people with and without diabetes: collaborative network meta-analysis.
Stettler C, Allemann S, Wandel S, Kastrati A, Morice MC, Schömig A, Pfisterer ME, Stone GW, Leon MB, de Lezo JS, Goy JJ, Park SJ, Sabaté M, Suttorp MJ, Kelbaek H, Spaulding C, Menichelli M, Vermeersch P, Dirksen MT, Cervinka P, De Carlo M, Erglis A, Chechi T, Ortolani P, Schalij MJ, Diem P, Meier B, Windecker S, Jüni P
Objective: To compare the effectiveness and safety of three types of stents (sirolimus eluting, paclitaxel eluting, and bare metal) in people with and without diabetes mellitus. Design: Collaborative network meta-analysis. Data sources: Electronic databases (Medline, Embase, the Cochrane Central Register of Controlled Trials), relevant websites, reference lists, conference abstracts, reviews, book chapters, and proceedings of advisory panels for the US Food and Drug Administration. Manufacturers...
Abstract
Cited 22 times since 2008 (1.3 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 34, Issue 6, 28 4 2008, Pages 1149-1157
Early and late outcome of left ventricular reconstruction surgery in ischemic heart disease.
Klein P, Bax JJ, Shaw LJ, Feringa HH, Versteegh MI, Dion RA, Klautz RJ
A systematic review of the literature was performed to determine early and late mortality associated with left ventricular (LV) reconstruction surgery and to assess the influence of different surgical techniques, concomitant surgical procedures, clinical and hemodynamic parameters on mortality. The MEDLINE database (January 1980-January 2005) was searched and from the pooled data, hospital mortality and survival were calculated. Summary estimates of relative risks (RR) were calculated for the te...
Abstract
Cited 201 times since 2008 (11.8 per year)
source: EuropePMC
European journal of heart failure,
Volume 10, Issue 9, 28 4 2008, Pages 884-891
Long term vagal stimulation in patients with advanced heart failure: first experience in man.
Schwartz PJ, De Ferrari GM, Sanzo A, Landolina M, Rordorf R, Raineri C, Campana C, Revera M, Ajmone-Marsan N, Tavazzi L, Odero A
Background: Experimentally, vagal stimulation (VS) is protective in chronic heart failure (HF). In man, VS is used in refractory epilepsy but has never been used in cardiovascular diseases. Increased sympathetic and reduced vagal activity predict increased mortality in HF. Aims: This pilot study assessed feasibility and safety and tested possible efficacy of chronic VS in HF patients. Methods: We studied 8 patients (mean age 54 years). CardioFit (BioControl Medical), a VS implantable system deli...
Abstract
Cited 3 times since 2008 (0.2 per year)
source: EuropePMC
The American journal of cardiology,
Volume 102, Issue 9, 27 4 2008, Pages 1156-1158
Prognostic significance of myocardial ischemia by dobutamine stress echocardiography in patients without angina pectoris after coronary revascularization.
Pedone C, Elhendy A, Biagini E, van Domburg RT, Schinkel AF, Di Pasquale G, Bax JJ, Poldermans D
The clinical utility of stress testing in patients without angina pectoris after revascularization has been questioned. Dobutamine stress echocardiography (DSE) is an established technique for detection of myocardial ischemia and cardiac risk stratification. We studied the prognostic value of DSE in 393 patients without typical angina pectoris after coronary revascularization. Ischemia was incremental to clinical data in predicting all-cause death (hazard ratio 3.5, 95% confidence interval 1.8 t...
Abstract
Cited 1 times since 2008 (0.1 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 24, Issue 8, 12 2 2008, Pages 907-909
Coronary artery calcium screening: sufficient evidence for accurate risk assessment?
van der Wall EE, Schuijf JD, Jukema JW, Bax JJ
Abstract
Cited 10 times since 2008 (0.6 per year)
source: EuropePMC
Molecular and cellular biochemistry,
Volume 320, Issue 1-2, 9 2 2008, Pages 75-84
Integrin stimulation-induced hypertrophy in neonatal rat cardiomyocytes is NO-dependent.
Umar S, van der Valk EJ, Schalij MJ, van der Wall EE, Atsma DE, van der Laarse A
Prolonged myocardial stretch typically leads to hypertrophy of cardiomyocytes. As integrins are cellular receptors of stretch, we hypothesize that integrin stimulation induces cardiomyocyte hypertrophy. Integrins of neonatal rat cardiomyocytes (NRCMs) were stimulated with a peptide containing the Arg-Gly-Asp (RGD) sequence for 24 h. For comparison, alpha(1)-adrenergic stimulation by phenylephrine (PE) for 24 h was applied. Saline-treated NRCMs were used as control. The hypertrophic response was...
Abstract
Cited 47 times since 2008 (2.8 per year)
source: EuropePMC
Heart rhythm,
Volume 5, Issue 9, 6 1 2008, Pages 1257-1264
Real-time three-dimensional echocardiography as a novel approach to assess left ventricular and left atrium reverse remodeling and to predict response to cardiac resynchronization therapy.
Marsan NA, Bleeker GB, Ypenburg C, Van Bommel RJ, Ghio S, Van de Veire NR, Delgado V, Holman ER, van der Wall EE, Schalij MJ, Bax JJ
Background: Real-time 3-dimensional echocardiography (RT3DE) is a novel promising technique for the assessment of left ventricular (LV) dyssynchrony. Objective: This study sought to explore the value of RT3DE to assess LV and left atrium (LA) reverse remodeling and to predict response to cardiac resynchronization therapy (CRT). Methods: A total of 57 consecutive heart failure patients scheduled for CRT were included, and RT3DE was performed before and 6 months after implantation. LV dyssynchrony...
Abstract
Cited 160 times since 2008 (9.4 per year)
source: EuropePMC
European heart journal,
Volume 29, Issue 19, 5 1 2008, Pages 2373-2381
Evaluation of plaque characteristics in acute coronary syndromes: non-invasive assessment with multi-slice computed tomography and invasive evaluation with intravascular ultrasound radiofrequency data analysis.
Pundziute G, Schuijf JD, Jukema JW, Decramer I, Sarno G, Vanhoenacker PK, Boersma E, Reiber JH, Schalij MJ, Wijns W, Bax JJ
Aims: Atherosclerotic plaque characteristics play an important role in the development of coronary events. We investigated coronary plaque characteristics on multi-slice computed tomography (MSCT) and virtual histology intravascular ultrasound (VH IVUS) in patients with acute coronary syndromes (ACS) and stable coronary artery disease (CAD). Methods and results: Fifty patients (25 with ACS, 25 with stable CAD) underwent 64-slice MSCT followed by VH IVUS in 48 (96%) patients. In ACS patients, 32%...
Abstract
