9618 results
Cited 38 times since 2008 (2.2 per year)
source: EuropePMC
Experimental and molecular pathology,
Volume 85, Issue 2, 5 1 2008, Pages 90-95
Release kinetics of intact and degraded troponin I and T after irreversible cell damage.
Hessel MH, Michielsen EC, Atsma DE, Schalij MJ, van der Valk EJ, Bax WH, Hermens WT, van Dieijen-Visser MP, van der Laarse A
Purpose: We characterized the release kinetics of cardiac troponin I and T in relation to lactate dehydrogenase (LDH) from cardiomyocytes before and after the transition from reversible to irreversible cell damage. Methods: Cardiomyocytes were exposed to mild metabolic inhibition (1 mmol/L sodium azide) to induce a necrotic cell death process that is characterized by a reversible (0-12 h) and irreversible phase (12-30 h). At various time intervals cells and media were collected and analyzed for...
Abstract
Cited 32 times since 2008 (1.9 per year)
source: EuropePMC
Journal of leukocyte biology,
Volume 84, Issue 6, 4 1 2008, Pages 1379-1391
Insights into mechanisms behind arteriogenesis: what does the future hold?
van Oostrom MC, van Oostrom O, Quax PH, Verhaar MC, Hoefer IE
Arteriogenesis, the enlargement of collateral vessels, seems a promising new target to improve blood flow to ischemic regions in patients suffering from cardiovascular conditions. With the growing knowledge of the mechanisms involved in arteriogenesis and the factors that influence the process, an increasing number of clinical trials are being performed to stimulate arteriogenesis, providing more insight in therapeutic opportunities for arteriogenesis. The expression of growth factors and the co...
Abstract
Cited 3 times since 2008 (0.2 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 94, Issue 8, 1 1 2008, Pages 973-975
Multislice CT: is it essential before atrial fibrillation ablation?
Tops LF, Schalij MJ
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 16, Issue 7-8, 1 1 2008, Pages 270-271
Atrial fibrillation: an unusual cause.
Siebelink HJ, Willems TP, Götte MJ
Abstract
Cited 93 times since 2008 (5.5 per year)
source: EuropePMC
Structure (London, England : 1993),
Volume 16, Issue 8, 1 1 2008, Pages 1245-1256
Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3.
van Ingen H, van Schaik FM, Wienk H, Ballering J, Rehmann H, Dechesne AC, Kruijzer JA, Liskamp RM, Timmers HT, Boelens R
Trimethylation of lysine residue K4 of histone H3 (H3K4me3) strongly correlates with active promoters for RNA polymerase II-transcribed genes. Several reader proteins, including the basal transcription factor TFIID, for this nucleosomal mark have been identified. Its TAF3 subunit specifically binds the H3K4me3 mark via its conserved plant homeodomain (PHD) finger. Here, we report the solution structure of the TAF3-PHD finger and its complex with an H3K4me3 peptide. Using a combination of NMR, mu...
Abstract
Cited 19 times since 2008 (1.1 per year)
source: EuropePMC
Cyberpsychology & behavior : the impact of the Internet, multimedia and virtual reality on behavior and society,
Volume 11, Issue 4, 1 1 2008, Pages 415-424
Involving persons with dementia in the evaluation of outdoor environments.
Van Schaik P, Martyr A, Blackman T, Robinson J
Using virtual reality (VR), we examined the barriers to and facilitators of functioning outdoors in persons with dementia (PwD) and investigated the generalizability of findings in VR to the real world. An existing town center was modeled in VR. PwD took part in both real-world and VR walks. Based on the results, the model was redesigned and then tested again. Performance on the walks improved, and potentially beneficial adaptations to outdoor environments were identified, but limitations of VR...
Abstract
Cited 11 times since 2008 (0.6 per year)
source: EuropePMC
Current problems in cardiology,
Volume 33, Issue 8, 1 1 2008, Pages 417-457
Percutaneous valve procedures: an update.
Tops LF, Kapadia SR, Tuzcu EM, Vahanian A, Alfieri O, Webb JG, Bax JJ
Valvular heart disease is an important cause of morbidity and mortality. Aortic stenosis and mitral regurgitation account for the majority of patients with native valve disease. Although surgical treatment provides satisfactory outcome, a large proportion of patients do not undergo a surgical intervention, because of the high estimated operative risk and multiple comorbidities. Recently, new techniques that enable percutaneous treatment of valvular heart disease have been developed and their fea...
Abstract
Cited 26 times since 2008 (1.5 per year)
source: EuropePMC
Circulation research,
Volume 103, Issue 4, 1 1 2008, Pages 334-336
Unraveling pleiotropic effects of statins: bit by bit, a slow case with perspective.
Arslan F, Pasterkamp G, de Kleijn DP
Abstract
Cited 30 times since 2008 (1.8 per year)
source: EuropePMC
Therapeutic drug monitoring,
Volume 30, Issue 4, 1 1 2008, Pages 439-444
AcylMPAG plasma concentrations and mycophenolic acid-related side effects in patients undergoing renal transplantation are not related to the UGT2B7-840G>A gene polymorphism.
van Agteren M, Armstrong VW, van Schaik RH, de Fijter H, Hartmann A, Zeier M, Budde K, Kuypers D, Pisarski P, Le Meur Y, van der Werf M, Mamelok RD, Oellerich M, van Gelder T
Mycophenolic acid (MPA) is metabolized primarily by glucuronidation to form the biologically inactive 7-O-glucuronide conjugate (MPAG), which is the major urinary excretion product. MPA is also converted to acyl-glucuronide metabolite (AcylMPAG), which has been suggested to be involved in the generation of MPA-related adverse events such as diarrhea or leucopenia. This conversion of MPA to AcylMPAG is catalyzed by UDP-glucuronosyltransferase 2B7 (UGT2B7). We studied the impact of the -840G>A...
Abstract
Cited 9 times since 2008 (0.5 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 16, Issue 7-8, 1 1 2008, Pages 250-254
Pulmonary hypertension: the role of the electrocardiogram.
Henkens IR, Scherptong RW, van Kralingen KW, Said SA, Vliegen HW
A 54-year-old female was referred to our centre for further evaluation of recently established severe pulmonary hypertension. Six months prior to presentation to the cardiologist of the referring centre, the patient had first experienced exertional dyspnoea. At the time of presentation to the referring cardiologist, the patient's ECG showed signs of an increased right heart load. Interestingly, this patient had undergone a thorough cardiac evaluation in the referring centre seven years befo...
Abstract
Cited 121 times since 2008 (7.1 per year)
source: EuropePMC
Arteriosclerosis, thrombosis, and vascular biology,
Volume 28, Issue 11, 31 5 2008, Pages 2016-2022
Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl ester transfer protein in APOE*3Leiden.CETP mice.
van der Hoorn JW, de Haan W, Berbée JF, Havekes LM, Jukema JW, Rensen PC, Princen HM
Objective: Niacin potently decreases plasma triglycerides and LDL-cholesterol. In addition, niacin is the most potent HDL-cholesterol-increasing drug used in the clinic. In the present study, we aimed at elucidation of the mechanism underlying its HDL-raising effect. Methods and results: In APOE*3Leiden transgenic mice expressing the human CETP transgene, niacin dose-dependently decreased plasma triglycerides (up to -77%, P
Abstract
Cited 99 times since 2008 (5.8 per year)
source: EuropePMC
Circulation. Cardiovascular imaging,
Volume 1, Issue 2, 30 5 2008, Pages 131-140
123 I-mIBG scintigraphy to predict inducibility of ventricular arrhythmias on cardiac electrophysiology testing: a prospective multicenter pilot study.
Bax JJ, Kraft O, Buxton AE, Fjeld JG, Parízek P, Agostini D, Knuuti J, Flotats A, Arrighi J, Muxi A, Alibelli MJ, Banerjee G, Jacobson AF
Background: Disturbances of autonomic function after infarction are associated with both total mortality and sudden death. Although many imaging techniques for assessing the cardiac autonomic nervous system have been studied, the clinical usefulness of these techniques remains uncertain. This exploratory pilot study examined the relationship between abnormalities of ventricular sympathetic innervation delineated by scintigraphic imaging with (123)I-mIBG and inducible ventricular tachyarrhythmias...
Abstract
Cited 15 times since 2008 (0.9 per year)
source: EuropePMC
Microbes and infection,
Volume 10, Issue 12-13, 29 5 2008, Pages 1291-1299
Development of novel animal infection models for the study of acute and chronic Burkholderia pseudomallei pulmonary infections.
van Schaik E, Tom M, DeVinney R, Woods DE
Burkholderia pseudomallei causes the disease melioidosis. The most common clinical presentation of melioidosis is pneumonia which can occur in acute and chronic forms. The tsunami of 2004 demonstrated a new risk factor for the acquisition of melioidosis and resulted in the proposal that direct delivery of B. pseudomallei into the lungs may result in the enhanced ability of this pathogen to cause disease. In the present studies, we present the development and characterization of rat models of acu...
Abstract
The international journal of cardiovascular imaging,
Volume 24, Issue 8, 24 4 2008, Pages 837-839
Single injection, double acquisition: a double-edged sword?
van der Wall EE, America YG, Scholte AJ, Bax JJ
Abstract
Cited 29 times since 2008 (1.7 per year)
source: EuropePMC
Heart rhythm,
Volume 5, Issue 10, 24 4 2008, Pages 1403-1410
Real-time integration of intracardiac echocardiography and multislice computed tomography to guide radiofrequency catheter ablation for atrial fibrillation.
den Uijl DW, Tops LF, Tolosana JM, Schuijf JD, Trines SA, Zeppenfeld K, Bax JJ, Schalij MJ
Background: Multislice computed tomography (MSCT) integration is commonly used to guide radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF). MSCT provides detailed anatomical information but lacks the ability to provide real-time anatomy during RFCA. Intracardiac echocardiography (ICE) allows real-time visualization of cardiac structures. Objective: The purpose of this study was to investigate the feasibility of three-dimensional (3D) anatomical mapping of the left atrium (LA) w...
Abstract
Cited 6 times since 2008 (0.4 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 24, Issue 8, 24 4 2008, Pages 867-870
Diastolic dysfunction: a new additional criterion for optimal timing of pulmonary valve replacement in adult patient with tetralogy of Fallot?
Mulder BJ, Vliegen HW, van der Wall EE
Abstract
Cited 43 times since 2008 (2.5 per year)
source: EuropePMC
Current medical research and opinion,
Volume 24, Issue 9, 24 4 2008, Pages 2477-2487
Lipidomic approach to evaluate rosuvastatin and atorvastatin at various dosages: investigating differential effects among statins.
Bergheanu SC, Reijmers T, Zwinderman AH, Bobeldijk I, Ramaker R, Liem AH, van der Greef J, Hankemeier T, Jukema JW
Objective: Lipid profiling (lipidomics) may be useful in revealing detailed information with regard to the effects on lipid metabolism, the cardiovascular risk and to differentiate between therapies. The aims of the present study were to: (1) analyze in depth the lipid changes induced by rosuvastatin and atorvastatin at different dosages; (2) compare differences between the two drugs with respect to the lipid profile change; (3) relate the findings with meaningful pathological mechanisms of coro...
Abstract
Cited 22 times since 2008 (1.3 per year)
source: EuropePMC
Journal of human hypertension,
Volume 23, Issue 1, 24 4 2008, Pages 27-32
Low blood pressure in the very old, a consequence of imminent heart failure: the Leiden 85-plus Study.
van Bemmel T, Holman ER, Gussekloo J, Blauw GJ, Bax JJ, Westendorp RG
Low blood pressure in the very old has been associated with organ dysfunction and excess mortality but the underlying mechanism has yet to be elucidated. We hypothesized that cardiac dysfunction contributes to low blood pressure in the very old. We invited a convenience sample consisting of 82 participants all aged 90 years from a population-based cohort study in the very old. Blood pressure was measured twice, and all but one underwent echocardiography to assess cardiac dimensions and functiona...
Abstract
Cited 79 times since 2008 (4.6 per year)
source: EuropePMC
The American journal of cardiology,
Volume 102, Issue 7, 18 3 2008, Pages 847-853
Comparison of left atrial volumes and function by real-time three-dimensional echocardiography in patients having catheter ablation for atrial fibrillation with persistence of sinus rhythm versus recurrent atrial fibrillation three months later.
Marsan NA, Tops LF, Holman ER, Van de Veire NR, Zeppenfeld K, Boersma E, van der Wall EE, Schalij MJ, Bax JJ
Real-time 3-dimensional echocardiography (RT3DE) can provide a unique combination of accurate left atrial (LA) volume quantification and rapid, automatic assessment of LA function. The aim of the study was to evaluate the changes in LA volumes and function in patients with atrial fibrillation (AF) undergoing radiofrequency catheter ablation (RFCA) using RT3DE; 57 consecutive patients referred for RFCA were studied. Paroxysmal AF was present in 43 patients (75%) and persistent AF in 14 (25%). Aft...
Abstract
Cited 107 times since 2008 (6.3 per year)
source: EuropePMC
Chest,
Volume 134, Issue 5, 18 3 2008, Pages 925-930
The obesity paradox in patients with peripheral arterial disease.
Galal W, van Gestel YRBM, Hoeks SE, Sin DD, Winkel TA, Bax JJ, Verhagen H, Awara AMM, Klein J, van Domburg RT, Poldermans D
Background: Cardiac events are the predominant cause of late mortality in patients with peripheral arterial disease (PAD). In these patients, mortality decreases with increasing body mass index (BMI). COPD is identified as a cardiac risk factor, which preferentially affects underweight individuals. Whether or not COPD explains the obesity paradox in PAD patients is unknown. Methods: We studied 2,392 patients who underwent major vascular surgery at one teaching institution. Patients were classifi...
Abstract
