9618 results
Cited 7 times since 2008 (0.4 per year)
source: EuropePMC
Nucleic acids research,
Volume 36, Issue 13, 19 3 2008, Pages e83
Conditional gene vectors regulated in cis.
Pich D, Humme S, Spindler MP, Schepers A, Hammerschmidt W
Non-integrating gene vectors, which are stably and extrachromosomally maintained in transduced cells would be perfect tools to support long-term expression of therapeutic genes but preserve the genomic integrity of the cellular host. Small extrachromosomal plasmids share some of these ideal characteristics but are primarily based on virus blueprints. These plasmids are dependent on viral trans-acting factors but they can replicate their DNA molecules in synchrony with the chromosome of the cellu...
Abstract
Cited 78 times since 2008 (4.5 per year)
source: EuropePMC
American journal of respiratory and critical care medicine,
Volume 178, Issue 7, 19 3 2008, Pages 695-700
Impact of cardioselective beta-blockers on mortality in patients with chronic obstructive pulmonary disease and atherosclerosis.
van Gestel YR, Hoeks SE, Sin DD, Welten GM, Schouten O, Witteveen HJ, Simsek C, Stam H, Mertens FW, Bax JJ, van Domburg RT, Poldermans D
Rationale: beta-Blocker use is associated with improved health outcomes in patients with cardiovascular disease. There is a general reluctance to prescribe beta-blockers in patients with chronic obstructive pulmonary disease (COPD) because they may worsen symptoms. Objectives: We investigated the relationship between cardioselective beta-blockers and mortality in patients with COPD undergoing major vascular surgery. Methods: We evaluated 3,371 consecutive patients who underwent major vascular su...
Abstract
Cited 7 times since 2008 (0.4 per year)
source: EuropePMC
The American journal of cardiology,
Volume 102, Issue 6, 18 3 2008, Pages 718-721
Effects of interruption of long-term cardiac resynchronization therapy on left ventricular function and dyssynchrony.
Ypenburg C, Van Bommel RJ, Marsan NA, Delgado V, Bleeker GB, van der Wall EE, Schalij MJ, Bax JJ
Interruption of short-term cardiac resynchronization therapy (CRT) has been shown to acutely worsen left ventricular (LV) function, mitral regurgitation, and LV dyssynchrony. The present study aims to assess whether LV reverse remodeling influences interruption of CRT, and, more practically, whether long-term continuous pacing is necessary in patients with reverse LV remodeling. A total of 135 recipients of CRT were selected after showing LV reverse remodeling defined as a decrease in LV end-sys...
Abstract
Cited 1 times since 2008 (0.1 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 24, Issue 7, 18 3 2008, Pages 761-762
Characterization of carotid plaques with a new CT technique.
van der Laarse A, Bax JJ, van der Wall EE
Abstract
Cited 74 times since 2008 (4.3 per year)
source: EuropePMC
The Journal of clinical endocrinology and metabolism,
Volume 93, Issue 9, 17 3 2008, Pages 3348-3356
Aortic valve calcification and mild tricuspid regurgitation but no clinical heart disease after 8 years of dopamine agonist therapy for prolactinoma.
Kars M, Delgado V, Holman ER, Feelders RA, Smit JW, Romijn JA, Bax JJ, Pereira AM
Objective: Treatment with ergot-derived dopamine agonists, pergolide, and cabergoline has been associated with an increased frequency of valvular heart disease in Parkinson's disease. The aim of the present study was to assess the prevalence of valvular heart disease in patients treated with dopamine agonists for prolactinomas. Design: This was a cross-sectional study. Patients: We performed two-dimensional and Doppler echocardiography in 78 consecutive patients with prolactinoma (mean age...
Abstract
Cited 36 times since 2008 (2.1 per year)
source: EuropePMC
Current medical research and opinion,
Volume 24, Issue 8, 17 3 2008, Pages 2151-2157
Prevention of sudden cardiac death: rationale and design of the Implantable Cardioverter Defibrillators in Dialysis patients (ICD2) Trial--a prospective pilot study.
de Bie MK, Lekkerkerker JC, van Dam B, Gaasbeek A, van Buren M, Putter H, van Erven L, Bax JJ, Schalij MJ, Rabelink TJ, Jukema JW
Objective: Sudden cardiac (arrhythmic) death (SCD) is the single largest cause of death in dialysis patients. Prophylactic Implantable Cardioverter Defibrillator (ICD) therapy reduces SCD and reduces all-cause mortality in several groups of patients at high risk for arrhythmic death. Whether this also applies to dialysis patients is unknown. Research design and methods: The Implantable Cardioverter Defibrillator in Dialysis patients (ICD2) trial is a prospective randomised controlled study. It h...
Abstract
Cited 82 times since 2008 (4.8 per year)
source: EuropePMC
Circulation,
Volume 118, Issue 1, 16 3 2008, Pages 26-32
Gender and outcome in adult congenital heart disease.
Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, Vliegen HW, van Dijk AP, Bouma BJ, Grobbee DE, Mulder BJ
Background: Gender differences in prognosis have frequently been reported in cardiovascular disease but less so in congenital heart disease. We investigated whether gender is associated with outcome in adult patients with congenital heart disease. Methods and results: From the CONgenital CORvitia (CONCOR) national registry for adults with congenital heart disease, 7414 patients were identified. All outcomes before entry into the registry and during subsequent follow-up were recorded, and differe...
Abstract
Cited 16 times since 2008 (0.9 per year)
source: EuropePMC
American journal of physiology. Heart and circulatory physiology,
Volume 295, Issue 2, 13 2 2008, Pages H755-60
Biventricular pacing in chronic heart failure acutely facilitates the arterial baroreflex.
Gademan MG, van Bommel RJ, Ypenburg C, Haest JC, Schalij MJ, van der Wall EE, Bax JJ, Swenne CA
Metabolic and mechanical stress in the failing heart activates the cardiac sympathetic afferent reflex (CSAR). It has been demonstrated that cardiac resynchronization therapy (CRT) acutely reduces MSNA in clinical responders. Mechanistically, this beneficial effect might be explained by acute deactivation of the CSAR. In addition to sympathoexcitation, CSAR inhibits the arterial baroreflex at the level of the nucleus tractus solitarii. Hence, in responders, CRT is likely to remove/reduce this in...
Abstract
Cited 96 times since 2008 (5.6 per year)
source: EuropePMC
Circulation research,
Volume 103, Issue 2, 12 2 2008, Pages 167-176
Forced alignment of mesenchymal stem cells undergoing cardiomyogenic differentiation affects functional integration with cardiomyocyte cultures.
Pijnappels DA, Schalij MJ, Ramkisoensing AA, van Tuyn J, de Vries AA, van der Laarse A, Ypey DL, Atsma DE
Alignment of cardiomyocytes (CMCs) contributes to the anisotropic (direction-related) tissue structure of the heart, thereby facilitating efficient electrical and mechanical activation of the ventricles. This study aimed to investigate the effects of forced alignment of stem cells during cardiomyogenic differentiation on their functional integration with CMC cultures. Labeled neonatal rat (nr) mesenchymal stem cells (nrMSCs) were allowed to differentiate into functional heart muscle cells in dif...
Abstract
Cited 5 times since 2008 (0.3 per year)
source: EuropePMC
Clinical pediatrics,
Volume 47, Issue 9, 10 2 2008, Pages 856-860
Attitudes of parents and physicians toward febrile seizures.
Yilmaz D, Arhan E, Yuksel D, Ozçelik A, Senbil N, Serdaroglu A, Gurer YK
Objectives: Although febrile seizures are common in children, attitudes may change among parents. The management of a child may differ depending on the specialty of the attending physician. This study was carried out to analyze attitudes of Turkish parents and physicians toward febrile seizures. Material and methods: 308 children with febrile seizure who were admitted to the Department of Pediatric Neurology at Dr Sami Ulus Children's Hospital and Gazi University in Turkey between January 2...
Abstract
Cited 37 times since 2008 (2.2 per year)
source: EuropePMC
Vaccine,
Volume 26, Issue 33, 6 1 2008, Pages 4224-4230
Immunogenicity and efficacy of two candidate human metapneumovirus vaccines in cynomolgus macaques.
Herfst S, Schrauwen EJ, de Graaf M, van Amerongen G, van den Hoogen BG, de Swart RL, Osterhaus AD, Fouchier RA
Human metapneumovirus (HMPV) is an important cause of acute respiratory tract disease for which the development of vaccine candidates is warranted. We have previously described the generation of an iscom matrix-adjuvanted HMPV fusion protein subunit vaccine (Fsol) and a live-attenuated vaccine (HMPVM11). Here, we evaluate the immunogenicity and efficacy of these vaccines in cynomolgus macaques. Immunization with Fsol induced HMPV F-specific antibody responses, virus neutralizing antibody titers,...
Abstract
Cited 47 times since 2008 (2.7 per year)
source: EuropePMC
Current gene therapy,
Volume 8, Issue 3, 1 1 2008, Pages 147-161
Episomal vectors for gene therapy.
Ehrhardt A, Haase R, Schepers A, Deutsch MJ, Lipps HJ, Baiker A
The increasing knowledge of the molecular and genetic background of many different human diseases has led to the vision that genetic engineering might be used one day for their phenotypic correction. The main goal of gene therapy is to treat loss-of-function genetic disorders by delivering correcting therapeutic DNA sequences into the nucleus of a cell, allowing its long-term expression at physiologically relevant levels. Manifold different vector systems for the therapeutic gene delivery have b...
Abstract
Cited 4 times since 2008 (0.2 per year)
source: EuropePMC
Tijdschrift voor gerontologie en geriatrie,
Volume 39, Issue 3, 1 1 2008, Pages 100-106
[Screening for depression and anxiety in residential homes for the elderly].
Dozeman E, van Schaik DJ, van Marwijk HW, de Wit AE, Beekman AT
Elderly persons in residential homes in the Netherlands are at high risk for developing major depressive and anxiety disorders. A stepped-care protocol being used in a study for vulnerable elderly in the community may also be feasible and effective for this group. A pilot study in a residential home in Amsterdam showed more problems than expected in screening and motivating the inhabitants for this intervention protocol. This article describes the problems in our screening procedure. A personal...
Abstract
Cited 34 times since 2008 (2 per year)
source: EuropePMC
Pediatric research,
Volume 63, Issue 6, 1 1 2008, Pages 674-679
Postmenstrual age and CYP2D6 polymorphisms determine tramadol o-demethylation in critically ill neonates and infants.
Allegaert K, van Schaik RH, Vermeersch S, Verbesselt R, Cossey V, Vanhole C, van Fessem M, de Hoon J, van den Anker JN
To document determinants of O-demethylation in critically ill (pre)term neonates and infants, tramadol (M) and O-demethyl tramadol (M1) concentrations were quantified in eighty-six 24 h urine collections and 168 plasma samples. A significant correlation of urine log M/M1 (0.98, SD 0.66) and plasma log M/M1 (0.78, SD 0.45) with postmenstrual age (PMA) (r = -0.69 and -0.65) was observed. One-way analysis of variance documented a significant decrease in urine log and plasma log M/M1 with increasing...
Abstract
Cited 8 times since 2008 (0.5 per year)
source: EuropePMC
Pharmacogenomics,
Volume 9, Issue 6, 1 1 2008, Pages 783-789
A drug transporter for all ages? ABCB1 and the developmental pharmacogenetics of cyclosporine.
Hesselink DA, van Schaik RH, Nauta J, van Gelder T
Evaluation of: Fanta S, Niemi M, Jönsson S et al.: Pharmacogenetics of cyclosporine in children suggests an age-dependent influence of ABCB1polymorphisms. Pharmacogenet. Genomics 18(2), 77-90 (2008). The clinical use of the immunosuppressive agent cyclosporine is complicated by its toxicity, narrow therapeutic window and highly variable pharmacokinetics between individuals. In adults, genetic polymorphisms in the genes encoding the cyclosporine-metabolizing enzymes CYP3A4 and CYP3A5, as well as...
Abstract
Cited 55 times since 2008 (3.2 per year)
source: EuropePMC
American journal of primatology,
Volume 70, Issue 6, 1 1 2008, Pages 533-541
Begging for information: mother-offspring food sharing among wild Bornean orangutans.
Jaeggi AV, van Noordwijk MA, van Schaik CP
Transfer of solid food from mothers or other adults to dependent offspring is commonly observed in various primate species and both nutritional and informational benefits have been proposed to explain the function of such food sharing. Predictions from these hypotheses are tested using observational data on wild orangutans (Pongo pygmaeus wurmbii) at Tuanan, Central Borneo, Indonesia. In 1,145 hr of focal observation and 458 recorded food interactions between four pairs of females with offspring...
Abstract
Cited 11 times since 2008 (0.6 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 135, Issue 6, 1 1 2008, Pages 1247-52; discussion 1252-3
Magnetic resonance imaging assessment of reverse left ventricular remodeling late after restrictive mitral annuloplasty in early stages of dilated cardiomyopathy.
Westenberg JJ, Braun J, Van de Veire NR, Klautz RJ, Versteegh MI, Roes SD, van der Geest RJ, de Roos A, van der Wall EE, Reiber JH, Bax JJ, Dion RA
Objective: Magnetic resonance imaging was used to evaluate left ventricular reverse remodeling at long-term follow-up (3-4 years) after restrictive mitral annuloplasty in patients with early stages of nonischemic, dilated cardiomyopathy, and severe mitral regurgitation. Methods: Twenty-two selected patients (eligible to undergo magnetic resonance imaging) with mild to moderate heart failure (mean New York Heart Association class 2.2 +/- 0.4), dilated cardiomyopathy (left ventricular ejection fra...
Abstract
Cited 12 times since 2008 (0.7 per year)
source: EuropePMC
Pediatric hematology and oncology,
Volume 25, Issue 4, 1 1 2008, Pages 301-311
Single-center experience: use of recombinant factor VIIa for acute life-threatening bleeding in children without congenital hemorrhagic disorder.
Yilmaz D, Karapinar B, Balkan C, Akisü M, Kavakli K
Coagulopathy is an important cause of mortality in critically ill children. Traditional therapies to correct coagulopathy lead to great time delays and cause fluid overload in patients. The authors report the effectiveness and safety of the activated recombinant factor VII (rFVIIa) administration in a series of 13 nonhemophiliac children with acute, life-threatening bleeding. In this retrospective study, the records of the patients who were not diagnosed with congenital hemorrhagic disorder and...
Abstract
Cited 15 times since 2008 (0.9 per year)
source: EuropePMC
The American journal of cardiology,
Volume 102, Issue 2, 28 4 2008, Pages 135-139
Prognostic value of free plasma homocysteine levels in patients hospitalized with acute coronary syndrome.
van Oijen MG, Claessen BE, Clappers N, van Schaik A, Laheij RJ, Jansen JB, Peters WH, Verheugt FW
Elevated total plasma homocysteine is an established risk factor for cardiovascular disease. Experimental evidence suggests that non-protein-bound free homocysteine is particularly hazardous to the vascular endothelium. This study evaluates the predictive role of free plasma homocysteine levels on cardiovascular endpoints in patients with acute coronary syndrome (ACS). In a cohort of 379 hospitalized patients with a diagnosis of myocardial infarction or unstable angina pectoris, total and free p...
Abstract
Cited 120 times since 2008 (7 per year)
source: EuropePMC
Clinical pharmacology and therapeutics,
Volume 85, Issue 2, 28 4 2008, Pages 155-163
Pharmacogenetic pathway analysis of docetaxel elimination.
Baker SD, Verweij J, Cusatis GA, van Schaik RH, Marsh S, Orwick SJ, Franke RM, Hu S, Schuetz EG, Lamba V, Messersmith WA, Wolff AC, Carducci MA, Sparreboom A
The purpose of this study was to evaluate the affinity of docetaxel for 14 transporter proteins and assess the functional significance of 17 variants in five genes involved in drug elimination. Among the transfected models investigated, OATP1B3 (SLCO1B3) was identified as the most efficient influx transporter for docetaxel. None of the observed genotypes (SLCO1B3, ABCB1, and ABCC2) was related with docetaxel clearance in 92 white patients (P > 0.17). However, the simultaneous presence of the...
Abstract
