9011 results
Cited 3 times since 2023 (1.3 per year)
source: EuropePMC
Cellular signalling,
Volume 104, 5 1 2023, Pages 110587
Early adipogenesis is repressed through the newly identified FHL2-NFAT5 signaling complex.
Clemente-Olivo MP, Hernández-Quiles M, Sparrius R, van der Stoel MM, Janssen V, Habibe JJ, van den Burg J, Jongejan A, Alcaraz-Sobrevals P, van Es R, Vos H, Kalkhoven E, de Vries CJM
The LIM-domain-only protein FHL2 is a modulator of signal transduction and has been shown to direct the differentiation of mesenchymal stem cells towards osteoblast and myocyte phenotypes. We hypothesized that FHL2 may simultaneously interfere with the induction of the adipocyte lineage. Therefore, we investigated the role of FHL2 in adipocyte differentiation. For these studies pre-adipocytes isolated from mouse adipose tissue and the 3T3-L1 (pre)adipocyte cell line were applied. We performed FH...
Abstract
Cited 20 times since 2023 (8.8 per year)
source: EuropePMC
Science translational medicine,
Volume 15, Issue 677, 4 1 2023, Pages eabo4778
Bifunctional cancer cell-based vaccine concomitantly drives direct tumor killing and antitumor immunity.
Chen KS, Reinshagen C, Van Schaik TA, Rossignoli F, Borges P, Mendonca NC, Abdi R, Simon B, Reardon DA, Wakimoto H, Shah K
The administration of inactivated tumor cells is known to induce a potent antitumor immune response; however, the efficacy of such an approach is limited by its inability to kill tumor cells before inducing the immune responses. Unlike inactivated tumor cells, living tumor cells have the ability to track and target tumors. Here, we developed a bifunctional whole cancer cell-based therapeutic with direct tumor killing and immunostimulatory roles. We repurposed the tumor cells from interferon-β (I...
Abstract
Cited 7 times since 2023 (3.1 per year)
source: EuropePMC
EBioMedicine,
Volume 88, 4 1 2023, Pages 104431
Modeling bile duct ischemia and reoxygenation injury in human cholangiocyte organoids for screening of novel cholangio-protective agents.
Shi S, Roest HP, van den Bosch TPP, Bijvelds MJC, Boehnert MU, de Jonge J, Dekker SO, de Vries AAF, de Jonge HR, Verstegen MMA, van der Laan LJW
Background: Ischemia of the bile duct is a common feature in liver disease and transplantation, which represents a major cause of morbidity and mortality, especially after liver transplantation. Detailed knowledge of its pathogenesis remains incomplete due to the lack of appropriate in vitro models. Methods: To recapitulate biliary damage induced by ischemia and reperfusion in vitro, human intrahepatic cholangiocyte organoids (ICOs) were grown at low oxygen levels of 1% up to 72 h, followed by r...
Abstract
Epilepsy & behavior : E&B,
Volume 139, 3 1 2023, Pages 109049
What is the safe observation period for seizure recurrence in pediatric emergency departments?
Ulusoy E, Uysal Ateş Ş, Çitlenbik H, Öztürk A, Şık N, Arslan G, Yılmaz D, Yiş U, Hız S, Duman M
Background: Afebrile seizures are the common causes of emergency department (ED) admissions in childhood, and there is limited data on the observation period in emergency service follow-up of these patients in terms of seizure recurrence in the literature. This study aims to determine the seizure recurrence time in afebrile seizures and the risk factors that determine it. Methods: Patients aged between 1 month and 18 years with afebrile seizures were included in the study. Seizure recurrence tim...
Abstract
Cited 2 times since 2023 (0.9 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 16, Issue 1, 3 1 2023, Pages e010826
Pleomorphic Ventricular Tachycardia in Dilated Cardiomyopathy Predicts Ventricular Tachycardia Recurrence After Ablation Independent From Cardiac Function: Comparison With Patients With Ischemic Heart Disease.
Kimura Y, de Riva M, Ebert M, Glashan C, Wijnmaalen AP, Piers SR, Dekkers OM, Trines SA, Zeppenfeld K
Background: In dilated cardiomyopathy (DCM), outcome after catheter ablation of ventricular tachycardia (VT) is modest, compared with ischemic heart disease (IHD). Pleomorphic VT (PL-VT) has been associated with fibrotic remodeling and end-stage heart failure in IHD. The prognostic role of PL-VT in DCM is unknown. Methods: Consecutive IHD (2009-2016) or DCM (2008-2018) patients undergoing ablation for monomorphic VT were included. PL-VT was defined as ≥1 spontaneous change of the 12-lead VT-morp...
Abstract
Cited 62 times since 2023 (27.3 per year)
source: EuropePMC
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,
Volume 28, Issue 1, 1 1 2023
Increase in invasive group A streptococcal (<i>Streptococcus pyogenes</i>) infections (iGAS) in young children in the Netherlands, 2022.
de Gier B, Marchal N, de Beer-Schuurman I, Te Wierik M, Hooiveld M, ISIS-AR Study Group, GAS Study group, de Melker HE, van Sorge NM, Members of the GAS study group, Members of the ISIS-AR study group
In 2022, a sevenfold increase in the number of notifiable invasive Streptococcus pyogenes (iGAS) infections among children aged 0-5 years was observed in the Netherlands compared with pre-COVID-19 pandemic years. Of 42 cases in this age group, seven had preceding or coinciding varicella zoster infections, nine were fatal. This increase is not attributable to a specific emm type. Vigilance for clinical deterioration as iGAS sign is warranted in young children, especially those with varicella zost...
Abstract
Journal of the American College of Cardiology,
Volume 81, Issue 3, 1 1 2023, Pages e25
Reply: Outcomes in Bicuspid Aortic Valve Disease.
Hecht S, Bax JJ, Pibarot P
Abstract
Cited 22 times since 2023 (9.7 per year)
source: EuropePMC
Journal for immunotherapy of cancer,
Volume 11, Issue 1, 1 1 2023, Pages e005518
Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections.
van Puffelen JH, Novakovic B, van Emst L, Kooper D, Zuiverloon TCM, Oldenhof UTH, Witjes JA, Galesloot TE, Vrieling A, Aben KKH, Kiemeney LALM, Oosterwijk E, Netea MG, Boormans JL, van der Heijden AG, Joosten LAB, Vermeulen SH
Background: BCG is recommended as intravesical immunotherapy to reduce the risk of tumor recurrence in patients with non-muscle invasive bladder cancer (NMIBC). Currently, it is unknown whether intravesical BCG application induces trained immunity. Methods: The aim of this research was to determine whether BCG immunotherapy induces trained immunity in NMIBC patients. We conducted a prospective observational cohort study in 17 NMIBC patients scheduled for BCG therapy and measured trained immunity...
Abstract
Revista latino-americana de enfermagem,
Volume 31, 1 1 2023, Pages e3923
Effect of the coughing technique during subcutaneous heparin injection on pain severity and individual satisfaction.
Yılmaz D, Ayhan D, Yılmaz DU, Düzgün F
to examine the effect of the medium intensity coughing technique during subcutaneous low molecular weight heparin injection on pain severity and individual satisfaction in general surgery patients. the prospective, quasi-experimental study included 100 patients who had been prescribed a subcutaneous low molecular weight heparin injection once in 24 hours. Each patient received two injections by the same researcher, one using the standard injection technique with medium intensity coughing techniq...
Abstract
The Turkish journal of pediatrics,
Volume 65, Issue 6, 1 1 2023, Pages 1035-1036
Response to `Attitudes of parents with children aged 12-18 to COVID-19 vaccines for themselves and their children: vaccine hesitancy in Türkiye`.
Şahin A, Kara-Aksay A, Aşcı B, Ekemen-Keleş Y, Üstundağ G, Elvan-Tüz A, Taşar S, Arslan-Maden A, İnce G, Kanık A, Karadağ-Öncel E, Elmalı F, Yılmaz D
Abstract
Cited 1 times since 2023 (0.4 per year)
source: EuropePMC
The Turkish journal of pediatrics,
Volume 65, Issue 2, 1 1 2023, Pages 194-204
Attitudes of parents with children aged 12-18 to COVID-19 vaccines for themselves and their children.
Şahin A, Aksay AK, Aşcı B, Keleş YE, Üstündağ G, Tüz AE, Taşar S, Maden AA, İnce G, Kanık A, Öncel EK, Elmalı F, Yılmaz D
Background: The incidence of vaccine hesitancy is increasing in many countries. This study aims to determine parents` attitudes and related factors regarding COVID-19 vaccine acceptance for themselves and their children aged 12-18. Methods: A cross-sectional survey was conducted on parents between 16th November and 31st December 2021, after COVID-19 vaccines were initiated for children in Türkiye. In the survey, the sociodemographic characteristics of the parents, whether they and their children...
Abstract
The Turkish journal of pediatrics,
Volume 65, Issue 3, 1 1 2023, Pages 425-432
Evaluation of ischemia-modified albumin in the diagnosis and the clinical severity of COVID-19 in children.
Öncel EK, Tüz AE, Keleş YE, Şahin A, Üstündağ G, Taşar S, Altan TK, Karakoyun İ, İşbilen Başok B, Neşelioğlu S, Kara Aksay A, Yılmaz D, Erel Ö
Background: There is no specific biomarker used in the diagnosis of COVID-19 and predicting its clinical severity. This study aimed to investigate the utility of ischemia-modified albumin (IMA) in diagnosing and predicting clinical severity in children with COVID-19. Methods: Between October 2020 and March 2021, 41 cases constituted the COVID-19 group and 41 cases constituted the healthy control group. IMA levels were measured at admission (IMA-1) and 48-72 hours (IMA- 2) in the COVID-19 group....
Abstract
Cited 34 times since 2023 (15 per year)
source: EuropePMC
European heart journal,
Volume 44, Issue 1, 1 1 2023, Pages 28-40
Valvular heart disease: shifting the focus to the myocardium.
Ajmone Marsan N, Delgado V, Shah DJ, Pellikka P, Bax JJ, Treibel T, Cavalcante JL
Adverse cardiac remodelling is the main determinant of patient prognosis in degenerative valvular heart disease (VHD). However, to give an indication for valvular intervention, current guidelines include parameters of cardiac chamber dilatation or function which are subject to variability, do not directly reflect myocardial structural changes, and, more importantly, seem to be not sensitive enough in depicting early signs of myocardial dysfunction before irreversible myocardial damage has occurr...
Abstract
Cited 41 times since 2023 (18.1 per year)
source: EuropePMC
European heart journal,
Volume 44, Issue 3, 1 1 2023, Pages 176-177
The '10 commandments' for the 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death.
Tfelt-Hansen J, Winkel BG, de Riva M, Zeppenfeld K
Abstract
Cited 171 times since 2023 (75.4 per year)
source: EuropePMC
The New England journal of medicine,
Volume 388, Issue 4, 1 1 2023, Pages 299-309
Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest.
Suverein MM, Delnoij TSR, Lorusso R, Brandon Bravo Bruinsma GJ, Otterspoor L, Elzo Kraemer CV, Vlaar APJ, van der Heijden JJ, Scholten E, den Uil C, Jansen T, van den Bogaard B, Kuijpers M, Lam KY, Montero Cabezas JM, Driessen AHG, Rittersma SZH, Heijnen BG, Dos Reis Miranda D, Bleeker G, de Metz J, Hermanides RS, Lopez Matta J, Eberl S, Donker DW, van Thiel RJ, Akin S, van Meer O, Henriques J, Bokhoven KC, Mandigers L, Bunge JJH, Bol ME, Winkens B, Essers B, Weerwind PW, Maessen JG, van de Poll MCG
Background: Extracorporeal cardiopulmonary resuscitation (CPR) restores perfusion and oxygenation in a patient who does not have spontaneous circulation. The evidence with regard to the effect of extracorporeal CPR on survival with a favorable neurologic outcome in refractory out-of-hospital cardiac arrest is inconclusive. Methods: In this multicenter, randomized, controlled trial conducted in the Netherlands, we assigned patients with an out-of-hospital cardiac arrest to receive extracorporeal...
Abstract
Cited 4 times since 2023 (1.8 per year)
source: EuropePMC
Age and ageing,
Volume 52, Issue 1, 1 1 2023, Pages afac312
Weight loss, visit-to-visit body weight variability and cognitive function in older individuals.
Zonneveld MH, Noordam R, Sabayan B, Stott DJ, Mooijaart SP, Blauw GJ, Jukema JW, Sattar N, Trompet S
Objective: to investigate the association between variability and loss of body weight with subsequent cognitive performance and activities of daily living in older individuals. Design: cross-sectional cohort study. Setting: PROspective Study of Pravastatin in the Elderly at Risk, multicentre trial with participants from Scotland, Ireland and the Netherlands. Subjects: 4,309 participants without severe cognitive dysfunction (mean age 75.1 years, standard deviation (SD) = 3.3), at higher risk for...
Abstract
Cited 2 times since 2023 (0.9 per year)
source: EuropePMC
Journal of cardiovascular pharmacology and therapeutics,
Volume 28, 1 1 2023, Pages 10742484231210704
The Clinical Implementation of <i>CYP2C19</i> Genotyping in Patients with an Acute Coronary Syndrome: Insights From the FORCE-ACS Registry.
Azzahhafi J, Broek WWAVD, Chan Pin Yin DRPP, Harmsze AM, van Schaik RHN, Ten Berg JM
Background: Guidelines recommend prasugrel or ticagrelor for acute coronary syndrome (ACS) patients. However, these P2Y12 inhibitors increase bleeding risk compared to clopidogrel. Although genotype-guided P2Y12-inhibitor selection has been shown to reduce bleeding risk, data on its clinical implementation is lacking. Methods: The study included ACS patients receiving genotype-guided antiplatelet therapy, utilising either a point-of-care (POC) device or laboratory-based testing. We aimed to coll...
Abstract
Cited 2 times since 2023 (0.9 per year)
source: EuropePMC
European heart journal,
Volume 44, Issue 2, 1 1 2023, Pages 159-161
Guideline-based use of cardiac imaging for chronic coronary syndromes.
van der Bijl P, Stassen J, Bax JJ
Abstract
Cited 5 times since 2023 (2.2 per year)
source: EuropePMC
Clinical and translational allergy,
Volume 13, Issue 1, 1 1 2023, Pages e12221
High dupilumab levels in tear fluid of atopic dermatitis patients with moderate-to-severe ocular surface disease.
Achten R, Thijs J, van der Wal M, van Luijk C, van Luin M, El Amrani M, Knol E, Delemarre E, Jager CDH, de Graaf M, Bakker D, de Boer J, van Wijk F, de Bruin-Weller M
Background: The patho-mechanism of ocular surface disease (OSD) in dupilumab-treated atopic dermatitis (AD) patients remains unclear. The aim of this study is to measure dupilumab levels in tear fluid and serum, and relate these findings to the severity of OSD during dupilumab treatment in AD patients. Methods: This prospective study included dupilumab-treated moderate-to-severe AD patients who were seen by a dermatologist and an ophthalmologist before the start of dupilumab (baseline), and afte...
Abstract
Cited 2 times since 2023 (0.9 per year)
source: EuropePMC
Clinical and translational allergy,
Volume 13, Issue 1, 1 1 2023, Pages e12219
The positive effect of dupilumab on comorbid asthma in patients with atopic dermatitis.
Spekhorst LS, de Graaf M, van der Rijst LP, Zuithoff NPA, Schweizer RC, Kamsteeg M, Haeck I, van Lynden-van Nes AMT, van Lumig P, Romeijn GLE, Schuttelaar ML, de Bruin-Weller MS
Abstract
