6143 results
Cited 15 times since 2020 (3.4 per year)
source: EuropePMC
The Journal of experimental medicine,
Volume 217, Issue 10, 1 1 2020, Pages e20200318
Liver X receptors are required for thymic resilience and T cell output.
Chan CT, Fenn AM, Harder NK, Mindur JE, McAlpine CS, Patel J, Valet C, Rattik S, Iwamoto Y, He S, Anzai A, Kahles F, Poller WC, Janssen H, Wong LP, Fernandez-Hernando C, Koolbergen DR, van der Laan AM, Yvan-Charvet L, Sadreyev RI, Nahrendorf M, Westerterp M, Tall AR, Gustafsson JA, Swirski FK
The thymus is a primary lymphoid organ necessary for optimal T cell development. Here, we show that liver X receptors (LXRs)-a class of nuclear receptors and transcription factors with diverse functions in metabolism and immunity-critically contribute to thymic integrity and function. LXRαβ-deficient mice develop a fatty, rapidly involuting thymus and acquire a shrunken and prematurely immunoinhibitory peripheral T cell repertoire. LXRαβ's functions are cell specific, and the resulting phen...
Abstract
Alcohol and alcoholism (Oxford, Oxfordshire),
Volume 55, Issue 6, 1 1 2020, Pages 705
Corrigendum to: L-Cysteine Containing Vitamin Supplement Which Prevents or Alleviates Alcohol-related Hangover Symptoms: Nausea, Headache, Stress and Anxiety.
Eriksson CJP, Metsälä M, Möykkynen T, Mäkisalo H, Kärkkäinen O, Palmén M, Salminen JE, Kauhanen J
Abstract
Cited 15 times since 2020 (3.4 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 107, Issue 5, 1 1 2020, Pages 411-418
Parameters associated with ventricular arrhythmias in mitral valve prolapse with significant regurgitation.
van Wijngaarden AL, de Riva M, Hiemstra YL, van der Bijl P, Fortuni F, Bax JJ, Delgado V, Ajmone Marsan N
Objective: Mitral valve prolapse (MVP) has been associated with ventricular arrhythmias (VA), but little is known about VA in patients with significant primary mitral regurgitation (MR). Our aim was to describe the prevalence of symptomatic VA in patients with MVP (fibro-elastic deficiency or Barlow's disease) referred for mitral valve (MV) surgery because of moderate-to-severe MR, and to identify clinical, electrocardiographic, standard and advanced echocardiographic parameters associated...
Abstract
Cited 7 times since 2020 (1.6 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 21, Issue 11, 1 1 2020, Pages 1227-1234
Left ventricular mechanical dispersion in ischaemic cardiomyopathy: association with myocardial scar burden and prognostic implications.
Abou R, Prihadi EA, Goedemans L, van der Geest R, El Mahdiui M, Schalij MJ, Ajmone Marsan N, Bax JJ, Delgado V
Aims: Left ventricular (LV) mechanical dispersion (MD) may result from heterogeneous electrical conduction and is associated with adverse events. The present study investigated (i) the association between LV MD and the extent of LV scar as assessed with contrast-enhanced cardiac magnetic resonance (CMR) and (ii) the prognostic implications of LV MD in patients after ST-segment elevation myocardial infarction. Methods and results: LV MD was calculated by echocardiography and myocardial scar was a...
Abstract
Cited 6 times since 2020 (1.3 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 15, Issue 3, 1 1 2020, Pages 232-239
Impact of age on coronary artery plaque progression and clinical outcome: A PARADIGM substudy.
Kim M, Lee SP, Kwak S, Yang S, Kim YJ, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Conte E, Marques H, de Araújo Gonçalves P, Gottlieb I, Hadamitzky M, Leipsic JA, Maffei E, Pontone G, Raff GL, Shin S, Lee BK, Chun EJ, Sung JM, Lee SE, Berman DS, Lin FY, Virmani R, Samady H, Stone PH, Narula J, Bax JJ, Shaw LJ, Min JK, Chang HJ
Background: The association of age with coronary plaque dynamics is not well characterized by coronary computed tomography angiography (CCTA). Methods: From a multinational registry of patients who underwent serial CCTA, 1153 subjects (61 ± 5 years old, 61.1% male) were analyzed. Annualized volume changes of total, fibrous, fibrofatty, necrotic core, and dense calcification plaque components of the whole heart were compared by age quartile groups. Clinical events, a composite of all-cause death,...
Abstract
Cited 5 times since 2020 (1.1 per year)
source: EuropePMC
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association,
Volume 29, Issue 12, 30 5 2020, Pages 105326
CT Angiography of the Heart and Aorta in TIA and Ischaemic Stroke: Cardioembolic Risk Sources and Clinical Implications.
Holswilder G, Wermer MJ, Holman ER, Kruyt ND, Kroft LJ, van Walderveen MA
Background: Cardiac emboli are important causes of (recurrent) ischaemic stroke. Aorta atherosclerosis might also be associated with an increased risk of stroke recurrence. This study aimed to evaluate the yield and clinical implications of CT-angiography (CTA) of the heart and aorta in the diagnostic workup of transient ischaemic attack (TIA) or ischaemic stroke. Methods: CTA of the heart and aortic arch was performed in TIA/ischaemic stroke patients, in addition to routine diagnostic workup. O...
Abstract
Cited 43 times since 2020 (9.6 per year)
source: EuropePMC
The American journal of medicine,
Volume 134, Issue 4, 30 5 2020, Pages 482-489
Impact of Coronavirus Disease 2019 (COVID-19) Outbreak on Acute Admissions at the Emergency and Cardiology Departments Across Europe.
Sokolski M, Gajewski P, Zymliński R, Biegus J, Berg JMT, Bor W, Braunschweig F, Caldeira D, Cuculi F, D'Elia E, Edes IF, Garus M, Greenwood JP, Halfwerk FR, Hindricks G, Knuuti J, Kristensen SD, Landmesser U, Lund LH, Lyon A, Mebazaa A, Merkely B, Nawrocka-Millward S, Pinto FJ, Ruschitzka F, Semedo E, Senni M, Sepehri Shamloo A, Sorensen J, Stengaard C, Thiele H, Toggweiler S, Tukiendorf A, Verhorst PM, Wright DJ, Zamorano P, Zuber M, Narula J, Bax JJ, Ponikowski P
Purpose: We evaluated whether the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) pandemic was associated with changes in the pattern of acute cardiovascular admissions across European centers. Methods: We set-up a multicenter, multinational, pan-European observational registry in 15 centers from 12 countries. All consecutive acute admissions to emergency departments and cardiology departments throughout a 1-month period during the COVID-19 outbreak were compared with an equivalent...
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
Cardiology in the young,
Volume 30, Issue 12, 29 5 2020, Pages 1960-1963
Dealing with kinked and swirled pulmonary vessels: surgical treatment of arterial tortuosity syndrome: a case report.
Ricciardi G, Sojak V, Hazekamp MG
We present the case of a child with arterial tortuosity syndrome, describing the operative findings and our surgical technique to address pulmonary arteries stenosis.
Abstract
Cited 16 times since 2020 (3.6 per year)
source: EuropePMC
Arthritis & rheumatology (Hoboken, N.J.),
Volume 72, Issue 11, 29 5 2020, Pages 1897-1904
Association of Anti-Topoisomerase I Antibodies of the IgM Isotype With Disease Progression in Anti-Topoisomerase I-Positive Systemic Sclerosis.
Boonstra M, Bakker JA, Grummels A, Ninaber MK, Ajmone Marsan N, Wortel CM, Huizinga TWJ, Jordan S, Hoffman-Vold AM, Distler O, Toes REM, Scherer HU, de Vries-Bouwstra JK
Objective: Anti-topoisomerase I (anti-topo I) autoantibodies in systemic sclerosis (SSc) are associated with diffuse skin involvement and interstitial lung fibrosis. Thus far, however, the relationship between anti-topo I antibody response and disease course has not yet been fully evaluated. This study was undertaken to gain insight into the association between characteristics of the anti-topo I antibody response and clinical disease course in SSc patients positive for anti-topo I antibodies. Me...
Abstract
Cited 10 times since 2020 (2.2 per year)
source: EuropePMC
Scientific reports,
Volume 10, Issue 1, 29 5 2020, Pages 15968
bFGF blockade reduces intraplaque angiogenesis and macrophage infiltration in atherosclerotic vein graft lesions in ApoE3*Leiden mice.
Parma L, Peters HAB, Sluiter TJ, Simons KH, Lazzari P, de Vries MR, Quax PHA
Intraplaque angiogenesis increases the chance of unstable atherosclerotic plaque rupture and thrombus formation leading to myocardial infarction. Basic Fibroblast Growth Factor (bFGF) plays a key role in angiogenesis and inflammation and is involved in the pathogenesis of atherosclerosis. Therefore, we aim to test K5, a small molecule bFGF-inhibitor, on remodelling of accelerated atherosclerotic vein grafts lesions in ApoE3*Leiden mice. K5-mediated bFGF-signalling blockade strongly decreased int...
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
Journal of vascular surgery cases and innovative techniques,
Volume 6, Issue 4, 25 4 2020, Pages 633-636
Giant true hepatic aneurysm mimicking Mirizzi syndrome.
Corion CLS, Vriens PWHE, Alwayn IPJ, Hamming JF, van Schaik J
Giant true aneurysms of the hepatic arteries are rare. Pseudoaneurysms of the hepatic arteries are more common and are mostly caused by intra-abdominal infection, iatrogenic injury, or trauma. Hepatic or cystic pseudoaneurysms are often successfully treated by embolization owing to their saccular nature as opposed to true aneurysms. We present a case of a patient with a giant true aneurysm of the proper hepatic artery, mimicking Mirizzi syndrome. Open reconstruction was successfully preformed, a...
Abstract
Cited 16 times since 2020 (3.6 per year)
source: EuropePMC
Cells,
Volume 9, Issue 10, 24 4 2020, Pages E2164
Integrative Multi-Omics Analysis in Calcific Aortic Valve Disease Reveals a Link to the Formation of Amyloid-Like Deposits.
Heuschkel MA, Skenteris NT, Hutcheson JD, van der Valk DD, Bremer J, Goody P, Hjortnaes J, Jansen F, Bouten CVC, van den Bogaerdt A, Matic L, Marx N, Goettsch C
Calcific aortic valve disease (CAVD) is the most prevalent valvular heart disease in the developed world, yet no pharmacological therapy exists. Here, we hypothesize that the integration of multiple omic data represents an approach towards unveiling novel molecular networks in CAVD. Databases were searched for CAVD omic studies. Differentially expressed molecules from calcified and control samples were retrieved, identifying 32 micro RNAs (miRNA), 596 mRNAs and 80 proteins. Over-representation p...
Abstract
Cited 3 times since 2020 (0.7 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 15, Issue 2, 23 4 2020, Pages 121-128
The clinical utility of FFR<sub>CT</sub> stratified by age.
Anastasius M, Maggiore P, Huang A, Blanke P, Patel MR, Nørgaard BL, Fairbairn TA, Nieman K, Akasaka T, Berman DS, Raff GL, Hurwitz Koweek LM, Pontone G, Kawasaki T, Rønnow Sand NP, Jensen JM, Amano T, Poon M, Øvrehus KA, Sonck J, Rabbat MG, Mullen S, De Bruyne B, Rogers C, Matsuo H, Bax JJ, Leipsic J
Background: CT coronary angiography (CTA) with Fractional Flow Reserve as determined by CT (FFRCT) is a safe alternative to invasive coronary angiography. A negative FFRCT has been shown to have low cardiac event rates compared to those with a positive FFRCT. However, the clinical utility of FFRCT according to age is not known. Methods: Patients' in the ADVANCE (Assessing Diagnostic Value of Non-invasive FFRCT in Coronary Care) registry, were stratified into those ≥65 or
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
Nature communications,
Volume 11, Issue 1, 21 3 2020, Pages 4760
Straightforward preparation of supramolecular Janus nanorods by hydrogen bonding of end-functionalized polymers.
Han S, Pensec S, Yilmaz D, Lorthioir C, Jestin J, Guigner JM, Niepceron F, Rieger J, Stoffelbach F, Nicol E, Colombani O, Bouteiller L
Janus cylinders are one-dimensional colloids that have two faces with different compositions and functionalities, and are useful as building blocks for advanced functional materials. Such anisotropic objects are difficult to prepare with nanometric dimensions. Here we describe a robust and versatile strategy to form micrometer long Janus nanorods with diameters in the 10-nanometer range, by self-assembly in water of end-functionalized polymers. The Janus topology is not a result of the phase seg...
Abstract
Clinical chemistry and laboratory medicine,
Volume 59, Issue 1, 18 3 2020, Pages e13-e17
Successfully meeting analytical expectations for the fast 0/1-h algorithm for NSTEMI by internal control procedures for cardiac troponin T.
Endlich W, Mensink WJ, den Elzen WPJ, Tops LF, Cobbaert CM
Abstract
Cited 7 times since 2020 (1.6 per year)
source: EuropePMC
The American journal of cardiology,
Volume 136, 15 3 2020, Pages 131-139
Prognostic Implications of Increased Right Ventricular Wall Tension in Secondary Tricuspid Regurgitation.
Fortuni F, Dietz MF, Butcher SC, Prihadi EA, van der Bijl P, Ajmone Marsan N, Delgado V, Bax JJ
Secondary tricuspid regurgitation (TR) imposes a chronic volume overload on the right ventricle (RV) which can increase RV wall tension (RVWT). The aim of this study was to investigate the prognostic implications of increased RVWT in patients with significant secondary TR. A total of 1,142 patients with moderate-to-severe secondary TR were included. Based on the simplified Laplace-Young's law, RVWT was defined as the product between pulmonary artery systolic pressure (PASP) and RV base-to-a...
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 34, Issue 1, 10 2 2020, Pages 20-29
The Obesity Paradox in Patients with Significant Tricuspid Regurgitation: Effects of Obesity on Right Ventricular Remodeling and Long-Term Prognosis.
Dietz MF, Prihadi EA, van der Bijl P, Ajmone Marsan N, Bax JJ, Delgado V
Background: Obesity may cause right ventricular (RV) remodeling due to volume overload. However, obesity is also associated with better prognosis compared with normal weight in patients with various cardiac diseases. The aim of this study was to assess the impact of obesity on RV remodeling and long-term prognosis in patients with significant (moderate and severe) tricuspid regurgitation (TR). Methods: A total of 951 patients with significant TR (median age, 70 years; interquartile range, 61-77 ...
Abstract
Cited 36 times since 2020 (8 per year)
source: EuropePMC
Neurology,
Volume 95, Issue 24, 10 2 2020, Pages e3331-e3343
Association of common genetic variants with brain microbleeds: A genome-wide association study.
Knol MJ, Lu D, Traylor M, Adams HHH, Romero JRJ, Smith AV, Fornage M, Hofer E, Liu J, Hostettler IC, Luciano M, Trompet S, Giese AK, Hilal S, van den Akker EB, Vojinovic D, Li S, Sigurdsson S, van der Lee SJ, Jack CR, Wilson D, Yilmaz P, Satizabal CL, Liewald DCM, van der Grond J, Chen C, Saba Y, van der Lugt A, Bastin ME, Windham BG, Cheng CY, Pirpamer L, Kantarci K, Himali JJ, Yang Q, Morris Z, Beiser AS, Tozer DJ, Vernooij MW, Amin N, Beekman M, Koh JY, Stott DJ, Houlden H, Schmidt R, Gottesman RF, MacKinnon AD, DeCarli C, Gudnason V, Deary IJ, van Duijn CM, Slagboom PE, Wong TY, Rost NS, Jukema JW, Mosley TH, Werring DJ, Schmidt H, Wardlaw JM, Ikram MA, Seshadri S, Launer LJ, Markus HS, Alzheimer's Disease Neuroimaging Initiative
Objective: To identify common genetic variants associated with the presence of brain microbleeds (BMBs). Methods: We performed genome-wide association studies in 11 population-based cohort studies and 3 case-control or case-only stroke cohorts. Genotypes were imputed to the Haplotype Reference Consortium or 1000 Genomes reference panel. BMBs were rated on susceptibility-weighted or T2*-weighted gradient echo MRI sequences, and further classified as lobar or mixed (including strictly deep and inf...
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
Radiology case reports,
Volume 15, Issue 11, 7 1 2020, Pages 2205-2207
Antegrade common femoral artery access site closure using the MANTA vascular closure device.
Stomp W, Eefting D, van Schaik J, Sudiono DR, van der Meer RW
In antegrade peripheral endovascular procedures, the use of covered stents may require a large sheath size, which precludes the use of regular closure devices. The MANTA vascular closure device is a collagen plug-based vascular closure device for large bore percutaneous arterial interventions, which is normally used to close retrograde vascular access sites. We describe successful antegrade common femoral access site closure with the MANTA vascular closure device in 2 patients, a 68-year-old mal...
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
Annals of vascular surgery,
Volume 71, 3 1 2020, Pages 411-418
Stent Graft Sizing for Endovascular Abdominal Aneurysm Repair Using Open Source Image Processing Software.
Knöps E, van Schaik J, van der Bogt KEA, Veger HTC, Putter H, Waasdorp EJ, van der Vorst JR
Introduction: An important step to reach a favorable outcome of abdominal endovascular aneurysm repair (EVAR) is preoperative sizing of the stent graft using computed tomography angiography (CTA) images of the abdominal aorta. A variety of costly image processing software options is available to obtain the necessary aortic measurements. A package that can be used for EVAR sizing is OsiriX Lite®-an open source, freely downloadable image processing option. This study assesses the concurrent validi...
Abstract
