8684 results
Cited 10 times since 2021 (2.9 per year)
source: EuropePMC
HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues,
Volume 35, Issue 2, 9 2 2021, Pages 139-159
CURA-An Ethics Support Instrument for Nurses in Palliative Care. Feasibility and First Perceived Outcomes.
van Schaik MV, Pasman HR, Widdershoven G, Molewijk B, Metselaar S
Evaluating the feasibility and first perceived outcomes of a newly developed clinical ethics support instrument called CURA. This instrument is tailored to the needs of nurses that provide palliative care and is intended to foster both moral competences and moral resilience. This study is a descriptive cross-sectional evaluation study. Respondents consisted of nurses and nurse assistants (n = 97) following a continuing education program (course participants) and colleagues of these course partic...
Abstract
Cited 521 times since 2021 (149.2 per year)
source: EuropePMC
Nature,
Volume 600, Issue 7890, 9 2 2021, Pages 675-679
The power of genetic diversity in genome-wide association studies of lipids.
Graham SE, Clarke SL, Wu KH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I, Vedantam S, Winkler TW, Locke AE, Marouli E, Hwang MY, Han S, Narita A, Choudhury A, Bentley AR, Ekoru K, Verma A, Trivedi B, Martin HC, Hunt KA, Hui Q, Klarin D, Zhu X, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Ruotsalainen SE, Havulinna AS, Veturi Y, Feng Q, Rosenthal EA, Lingren T, Pacheco JA, Pendergrass SA, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Hindy G, Rasheed A, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Willemsen G, Wood AR, Ji Y, Gao Z, Haworth S, Mitchell RE, Chai JF, Aadahl M, Yao J, Manichaikul A, Warren HR, Ramirez J, Bork-Jensen J, Kårhus LL, Goel A, Sabater-Lleal M, Noordam R, Sidore C, Fiorillo E, McD
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels2, heart disease remains the leading cause of death worldwide3. Genome-wideassociation studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets,...
Abstract
Frontiers in veterinary science,
Volume 8, 8 2 2021, Pages 817576
Corrigendum: Control and Eradication Programs for Six Cattle Diseases in the Netherlands.
Santman-Berends IMGA, Mars MH, Weber MF, van Duijn L, Waldeck HWF, Biesheuvel MM, van den Brink KMJA, Dijkstra T, Hodnik JJ, Strain SAJ, de Roo A, Veldhuis AMB, van Schaik G
[This corrects the article DOI: 10.3389/fvets.2021.670419.].
Abstract
Cited 3 times since 2021 (0.9 per year)
source: EuropePMC
Appetite,
Volume 170, 8 2 2021, Pages 105853
To like or not to like: Negotiating food assessments of children from families with a low socioeconomic position.
van der Heijden A, Te Molder H, Huma B, Jager G
The present study explored how primary school-aged children from families with a low socioeconomic position produce 'likes' and 'dislikes' of foods during everyday family meals, and how these (dis)likes are understood and treated by their parents. It is crucial to understand how food preferences develop in the course of everyday life, as it is known that there are socioeconomic disparities in food preference and consumption, and that children from families with a low socioeco...
Abstract
Cited 14 times since 2021 (4 per year)
source: EuropePMC
Scientific reports,
Volume 11, Issue 1, 7 1 2021, Pages 23555
Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome.
Cammann VL, Scheitz JF, von Rennenberg R, Jäncke L, Nolte CH, Szawan KA, Stengl H, Würdinger M, Endres M, Templin C, Ghadri JR, InterTAK Consortium
Cardiac alterations are frequently observed after acute neurological disorders. Takotsubo syndrome (TTS) represents an acute heart failure syndrome and is increasingly recognized as part of the spectrum of cardiac complications observed after neurological disorders. A systematic investigation of TTS patients with neurological disorders has not been conducted yet. The aim of the study was to expand insights regarding neurological disease entities triggering TTS and to investigate the clinical pro...
Abstract
Cited 16 times since 2021 (4.6 per year)
source: EuropePMC
Cell reports. Medicine,
Volume 2, Issue 12, 6 1 2021, Pages 100461
Soluble antigens derived from <i>Coxiella burnetii</i> elicit protective immunity in three animal models without inducing hypersensitivity.
Gregory AE, van Schaik EJ, Fratzke AP, Russell-Lodrigue KE, Farris CM, Samuel JE
Q fever is caused by the intracellular bacterium Coxiella burnetii, for which there is no approved vaccine in the United States. A formalin-inactivated whole-cell vaccine (WCV) from virulent C. burnetii NMI provides single-dose long-lived protection, but concerns remain over vaccine reactogenicity. We therefore sought an alternate approach by purifying native C. burnetii antigens from the clonally derived avirulent NMII strain. A soluble bacterial extract, termed Sol II, elicits high-titer, high...
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
Epilepsy & behavior : E&B,
Volume 126, 2 1 2021, Pages 108456
Infantile spasms: Knowledge, attitude, and practice of pediatricians in Turkey.
Yılmaz D, Yayıcı Köken Ö, Gürkaş E, Ceylan N, Çıtak Kurt AN
Background: Infantile Spasms Syndrome (ISS) encompasses both West syndrome (WS), comprising epileptic spasms, psychomotor stagnation or regression and hypsarrhythmia, and also infants presenting with epileptic spasms who do not fulfill the triad of WS. Objective: To investigate the knowledge, attitude, and practice regarding ISS among Turkish pediatricians and pediatric residents. Methods: A cross-sectional study was conducted among pediatricians and pediatric residents from all regions of Turke...
Abstract
Cited 2 times since 2021 (0.6 per year)
source: EuropePMC
Indian heart journal,
Volume 74, Issue 1, 2 1 2021, Pages 76-78
Acute aortic syndromes in India: The need for a nationwide program to increase awareness.
Shetty V, Shetty D, Grewal N
Acute aortic dissection is a rare, but potentially life-threatening and time-critical condition that is frequently misdiagnosed. Therefore, its prompt and proper diagnosis is vital to increase a patient's chance of survival and to prevent grievous complications. Raising awareness and educating the general population and healthcare professionals about an aortic dissection is mandatory, for early diagnosis and improving the chances of survival.
Abstract
European heart journal. Cardiovascular Imaging,
Volume 23, Issue 1, 1 1 2021, Pages 113-114
Atrial positron emission tomography in atrial fibrillation: predicting radiofrequency catheter ablation success.
van der Bijl P, van Rosendael A, Bax JJ
Abstract
The Journal of invasive cardiology,
Volume 33, Issue 12, 1 1 2021, Pages E1004
Delayed Iatrogenic Left Ventricular Apex Perforation Sealed With an Amplatzer Septal Occluder Device Under Transthoracic Echocardiography Guidance.
Montero-Cabezas JM, Delgado V, van der Kley F
High rates of spontaneous rupture and death have been described when the pseudoaneurysm is left untreated. Percutaneous closure has emerged as an alternative to surgery in patients with unacceptable surgical risk. In this case, transthoracic echocardiography allowed optimal characterization of the defect and successful procedure guidance, avoiding risks derived from more invasive intraprocedural imaging techniques.
Abstract
Annals of surgery,
Volume 274, Issue 6, 1 1 2021, Pages e858
Response to the Comment on "Long-term Prognosis After Elective Abdominal Aortic Aneurysm Repair is Poor in Women and Men".
Bulder RMA, Talvitie M, Bastiaannet E, Hamming JF, Hultgren R, Lindeman JHN
Abstract
Cited 18 times since 2021 (5.1 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 23, Issue 12, 1 1 2021, Pages 1989-1997
Accuracy of electroanatomical mapping-guided cardiac radiotherapy for ventricular tachycardia: pitfalls and solutions.
Abdel-Kafi S, Sramko M, Omara S, de Riva M, Cvek J, Peichl P, Kautzner J, Zeppenfeld K, Zeppenfeld K
Aims: To analyse and optimize the interobserver agreement for gross target volume (GTV) delineation on cardiac computed tomography (CCT) based on electroanatomical mapping (EAM) data acquired to guide radiotherapy for ventricular tachycardia (VT). Methods and results: Electroanatomical mapping data were exported and merged with the segmented CCT using manual registration by two observers. A GTV was created by both observers for predefined left ventricular (LV) areas based on preselected endocard...
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
Medical mycology,
Volume 60, Issue 1, 1 1 2021, Pages myab060
Implementation of a clinical decision rule for selecting empiric treatment for invasive aspergillosis in a setting with high triazole resistance.
van de Peppel RJ, van Grootveld R, Hendriks BJC, van Paassen J, Bernards S, Jolink H, Koopmans JG, von dem Borne PA, van der Beek MT, de Boer MGJ
World-wide, emerging triazole resistance increasingly complicates treatment of invasive aspergillosis (IA). In settings with substantial (>10%) prevalence of triazole resistance, empiric combination therapy with both a triazole and liposomal amphotericin B (LAmB) can be considered because of the low yields of susceptibility testing. To avoid toxicity while optimizing outcome, a strategy with monotherapy would be preferable. A newly designed treatment algorithm based on literature and expert c...
Abstract
Cited 5 times since 2021 (1.4 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 23, Issue 1, 1 1 2021, Pages 95-101
Comparison of left atrial strain measured by feature tracking computed tomography and speckle tracking echocardiography in patients with aortic stenosis.
Hirasawa K, Kuneman JH, Singh GK, Gegenava T, Hautemann D, Reiber JHC, Ajmone Marsan N, Bax JJ, Delgado V
Aims: Peak left atrial longitudinal strain (PALS) is a marker of the left atrial (LA) reservoir function. Novel feature tracking (FT) software allows assessment of LA strain from multidetector computed tomography (MDCT) data. This study aimed at evaluating the agreement between speckle tracking echocardiography (STE) and FT MDCT for the measurement of PALS in patients with sinus rhythm (SR) and with atrial fibrillation (AF). Methods and results: The current study included 318 patients (80 ± 7 ye...
Abstract
Cited 64 times since 2021 (18.2 per year)
source: EuropePMC
Nature,
Volume 600, Issue 7890, 1 1 2021, Pages 748-753
Activation of homologous recombination in G1 preserves centromeric integrity.
Yilmaz D, Furst A, Meaburn K, Lezaja A, Wen Y, Altmeyer M, Reina-San-Martin B, Soutoglou E
Centromeric integrity is key for proper chromosome segregation during cell division1. Centromeres have unique chromatin features that are essential for centromere maintenance2. Although they are intrinsically fragile and represent hotspots for chromosomal rearrangements3, little is known about how centromere integrity in response to DNA damage is preserved. DNA repair by homologous recombination requires the presence of the sister chromatid and is suppressed in the G1 phase of the cell cycle4. H...
Abstract
Cited 8 times since 2021 (2.3 per year)
source: EuropePMC
Pediatric emergency care,
Volume 37, Issue 12, 1 1 2021, Pages e1075-e1081
Integration of Physical Examination, Old and New Biomarkers, and Ultrasonography by Using Neural Networks for Pediatric Appendicitis.
Akgül F, Er A, Ulusoy E, Çağlar A, Çitlenbik H, Keskinoğlu P, Şişman AR, Karakuş OZ, Özer E, Duman M, Yılmaz D
Objective: The objective of this study was to evaluate physical examinations, imaging, and laboratory analyses individually and combined using innovative statistical analysis methods for the accurate diagnosis of pediatric appendicitis. Methods: Patients admitted to hospital with symptoms of abdominal pain whose pediatric appendicitis scores greater than 3 were included in the study. Clinical, radiologic, and laboratory findings and as a new biomarker calprotectin (CPT) concentrations were evalu...
Abstract
Cited 22 times since 2021 (6.2 per year)
source: EuropePMC
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases,
Volume 28, Issue 6, 24 4 2021, Pages 880.e1-880.e8
Alcaligenes faecalis metallo-β-lactamase in extensively drug-resistant Pseudomonas aeruginosa isolates.
Li Y, Zhu Y, Zhou W, Chen Z, Moran RA, Ke H, Feng Y, van Schaik W, Shen H, Ji J, Ruan Z, Hua X, Yu Y
Objectives: To characterize Alcaligenes faecalis metallo-β-lactamase (MBL) AFM-2 and AFM-3 from clinical Pseudomonas aeruginosa isolates NDTH10366, NDTH9845 and WTJH17. Methods: Clinical isolates were whole-genome sequenced using the Illumina and Oxford Nanopore platforms. MICs of clinical isolates and transformants containing MBL genes were determined using broth microdilution methods. Kinetic parameters of purified AFM and NDM-1 were measured using a spectrophotometer. The AFM structure was mo...
Abstract
Cited 7 times since 2021 (2 per year)
source: EuropePMC
International journal of molecular sciences,
Volume 22, Issue 23, 24 4 2021, Pages 12678
Cold-Inducible RNA-Binding Protein but Not Its Antisense lncRNA Is a Direct Negative Regulator of Angiogenesis In Vitro and In Vivo via Regulation of the 14q32 angiomiRs-microRNA-329-3p and microRNA-495-3p.
Goossens EAC, Zhang L, de Vries MR, Jukema JW, Quax PHA, Nossent AY
Inhibition of the 14q32 microRNAs, miR-329-3p and miR-495-3p, improves post-ischemic neovascularization. Cold-inducible RNA-binding protein (CIRBP) facilitates maturation of these microRNAs. We hypothesized that CIRBP deficiency improves post-ischemic angiogenesis via downregulation of 14q32 microRNA expression. We investigated these regulatory mechanisms both in vitro and in vivo. We induced hindlimb ischemia in Cirp-/- and C57Bl/6-J mice, monitored blood flow recovery with laser Doppler perfus...
Abstract
Cited 4 times since 2021 (1.1 per year)
source: EuropePMC
Biomicrofluidics,
Volume 15, Issue 6, 22 4 2021, Pages 064103
Nucleation kinetics of calcium oxalate monohydrate as a function of pH, magnesium, and osteopontin concentration quantified with droplet microfluidics.
Ibis F, Yu TW, Penha FM, Ganguly D, Nuhu MA, van der Heijden AEDM, Kramer HJM, Eral HB
A droplet-based microfluidic platform is presented to study the nucleation kinetics of calcium oxalate monohydrate (COM), the most common constituent of kidney stones, while carefully monitoring the pseudo-polymorphic transitions. The precipitation kinetics of COM is studied as a function of supersaturation and pH as well as in the presence of inhibitors of stone formation, magnesium ions (Mg2+), and osteopontin (OPN). We rationalize the trends observed in the measured nucleation rates leveragin...
Abstract
Cited 12 times since 2021 (3.4 per year)
source: EuropePMC
Journal of clinical medicine,
Volume 10, Issue 22, 20 3 2021, Pages 5426
Inaccurate Risk Assessment by the ACS NSQIP Risk Calculator in Aortic Surgery.
Hers TM, Van Schaik J, Keekstra N, Putter H, Hamming JF, Van Der Vorst JR
Objectives: The aim of this retrospective study was to assess the predictive performance of the American College of Surgeons (ACS) risk calculator for aortic aneurysm repair for the patient population of a Dutch tertiary referral hospital. Methods: This retrospective study included all patients who underwent elective endovascular or open aortic aneurysm repair at our institution between the years 2013 and 2019. Preoperative patient demographics and postoperative complication data were collected,...
Abstract
