6327 results
JACC. Cardiovascular imaging,
8 2 2025, Pages S1936-878X(25)00483-8
Clinical Integration of AI-Enabled Plaque Quantification to Improve Cardiovascular Risk Stratification.
Shaw LJ, Blankstein R, Leipsic JA, Sengupta PP, Nieman K, Bax JJ, Zoghbi WA, Chandrashekhar Y
Abstract
Neurology,
Volume 105, Issue 7, 5 1 2025, Pages e214071
Sensitivity of Different Clinical Outcome Measures in Assessing Adults With Becker Muscular Dystrophy: A 3-Year Natural History Study.
Schrama EJ, Koeks Z, Van De Velde NM, Alleman I, van Benthem JJ, van Weperen PW, Hooijmans MT, Kan HE, Spitali P, Ajmone Marsan N, Atsma DE, van Duyvenvoorde HA, Verschuuren JJGM, Niks EH
Background and objectives: Slow and highly variable disease progression in Becker muscular dystrophy (BMD) stresses the need to develop sensitive outcome measures for clinical trials. We evaluated responsiveness of different outcome measures in adult patients with BMD over 3 years and explored if the sensitivity of outcome measures can be increased by selecting on phenotype or genotype. Methods: Genetically confirmed patients with BMD were recruited via the Dutch Dystrophinopathy Database. Funct...
Abstract
Clinical cancer research : an official journal of the American Association for Cancer Research,
4 1 2025
Prognosis and biological characteristics of ER-low metastatic breast cancer: results from a multicenter cohort and the TONIC trial.
Miglietta F, De Graaf M, Vernieri C, Piacentini F, Cacciatore M, Botticelli A, Vingiani A, Fotia G, Nicolè L, Griguolo G, Giarratano T, Massa D, Pellegrini V, Schiavi F, Porra F, Fassan M, Pruneri G, Dei Tos AP, Guarneri V, Kok M, Dieci MV
Purpose: To assess prognosis of ER-low expression and its dynamics in HER2- metastatic breast cancer (BC) and to compare sensitivity to nivolumab between ER-low and triple-negative (TN) BC. Experimental design: Two cohorts were analyzed: a multicenter cohort of 982 patients with HER2- metastatic BC, and one prospective cohort of 110 patients with ER
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 33, Issue 10, 3 1 2025, Pages 299-306
ENDOCOR: a nationwide consortium of endocarditis teams-initiating a registry for infective endocarditis within the Netherlands Heart Registration.
Peijster AJL, Heinen FJ, Douiyeb S, van der Stoel MD, Selder JL, Watson-de Lepper AGW, Houthuizen P, Meijs MFL, Kampschreur LM, Schalla S, Sinha BNM, Bakker ALM, Kouijzer IJE, Nijland F, Boel CHE, Riezebos RK, Duffels MGJ, Hjortnaes J, Klautz RJM, Verkaik NJ, Post MC, Chamuleau SAJ, Kamp O, Tanis W
Background: Despite advancements in diagnostics and treatment strategies, infective endocarditis continues to carry a substantial morbidity and mortality risk. In addition, the field of infective endocarditis contains many gaps in evidence, as international guidelines are predominantly based on low-level evidence. To improve infective endocarditis care and survival rates in the Netherlands, adequate evaluation of diagnostics, treatment strategies and outcomes is essential. Methods: To address th...
Abstract
Atherosclerosis,
Volume 409, 2 1 2025, Pages 120509
Immunopeptidomics analysis of human atherosclerosis plaques identifies antigenic drivers of atherosclerosis.
Lozano Vigario F, Molenaar J, Simó Vesperinas I, van der Zon M, Crone NSA, de Jong MJM, Hemme E, Depuydt MAC, Delfos L, de Mol J, Bernabé Kleijn MN, Peeters JAHM, Wezel A, Smeets HJ, Tjokrodirijo RTN, de Ru AH, Kros A, Quax PHA, de Vries MR, Kuiper J, Bot I, van Veelen P, Slütter B
Background and aim: Atherosclerosis has an auto-immune component driven by self-reactive T and B cells. Identifying their antigenic drivers may lead to new diagnosis and treatment approaches. Here, we aim to identify immunogenic T cell epitopes derived from atherosclerosis-relevant proteins such as ApoB100 by studying the repertoire of peptides presented by HLA in human plaques. Methods: We used immunopeptidomics to identify peptides presented by HLA-DR molecules from plaques of patients that un...
Abstract
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society,
Volume 33, Issue 5, 1 1 2025, Pages e70092
H<sub>2</sub>O<sub>2</sub>-Producing Electrochemical Bandages Are Active Using Off-the-Shelf Hydrogels.
Dagsuyu E, Kies P, Patel R, Beyenal H
An electrochemical bandage (e-bandage) that generates hydrogen peroxide (H2O2) through a combination of working, counter and reference electrodes used with an electrolyte-providing hydrogel is being developed for wound infection management. e-Bandage biocidal activity was previously demonstrated using Xanthan gum hydrogel. For clinical use, clinically used hydrogels would be ideal, but their use with the described e-bandage has not been shown. The goal of this work was to evaluate the biocidal a...
Abstract
Cited 2 times since 2025 (17 per year)
source: EuropePMC
JAMA cardiology,
Volume 10, Issue 9, 1 1 2025, Pages 896-903
Location of LMNA Variants and Clinical Outcomes in Cardiomyopathy.
Bhaskaran A, Ben Yaou R, Helms AS, Fayssoil A, Richard P, Stojkovic T, Anselme F, Labombarda F, Chikhaoui C, De Sandre-Giovannoli A, Jeru I, Leturcq F, Vigouroux C, Dembele M, Elliott P, Savvatis K, Zeppenfeld K, Bouguerra H, Charron P, Kumar S, Bonne G, Wahbi K, Lakdawala NK
Importance: Prior studies have suggested that patients with nonmissense (ie, truncating) variants causing LMNA cardiomyopathy have worse arrhythmic outcomes compared to those with missense variants. However, the effect of the spatial distribution of missense and truncating variants on clinical outcomes remains poorly understood. Objective: To determine the association of the spatial distribution of missense and truncating LMNA variants with cardiac outcomes. Design, setting, and participants: Th...
Abstract
Cells,
Volume 14, Issue 17, 31 5 2025, Pages 1357
Heart Failure Impacts Endothelial Cell Responses to Cardiac Surgery on Cardiopulmonary Bypass.
Papazisi O, Postma RJ, Dirven RJ, Beeres SLMA, Berendsen RR, Arbous SM, Klautz RJM, van Vessem ME, Bijkerk R, Lindeman JHN, Palmen M, van Zonneveld AJ
Patients with heart failure with a reduced ejection fraction (HFrEF) are at an increased risk of developing postoperative hemodynamic instability and vasoplegia after surgery on cardiopulmonary bypass (CPB). Potentially pre-existing endothelial cell (EC) alterations due to chronic HF influence EC responses to cardiac surgery and might be responsible for the altered vascular responsiveness observed postoperatively. In this study, well-described EC activation markers were measured in blood samples...
Abstract
European journal of heart failure,
30 5 2025
Left ventricular ejection fraction and benefit of tricuspid valve interventions - insights from the international TRIGISTRY.
Heitzinger G, Dreyfus J, Dannenberg V, Topilsky Y, Benfari G, Marsan NA, Taramasso M, Russo G, Bohbot Y, Iliadis C, Weber M, Nombela-Franco L, Eixerés-Esteve A, Bazire B, Iung B, Obadia JF, Loureiro RE, Riant E, Donal E, Habib G, Lavie-Badie Y, Hausleiter J, Stolz L, Badano L, Le Tourneau T, Coisne A, Modine T, Praz F, Zamorano JL, von Bardeleben RS, Hahn RT, Fam N, Sievert H, Muraru D, Adamo M, Heuts S, Nejjari M, Chan V, De Bonis M, Carnero-Alcazar M, Rudolph V, Crestanello J, Lurz P, Bax J, Gauda R, Bernick J, Wells GA, Maisano F, Enriquez-Sarano M, Bartko P, Messika-Zeitoun D, TRIGISTRY Investigators
Aims: The impact of treatment for tricuspid regurgitation (TR) across different levels of left ventricular ejection fraction (LVEF) remains uncertain. This study aimed to compare the outcomes of surgical and transcatheter tricuspid valve interventions (TTVI) to conservative (medical) management across LVEF categories. Methods and results: Patients with severe isolated TR from the TRIGISTRY, a multicentre international registry, were categorized based on LVEF (preserved ejection fraction [pEF]: ≥...
Abstract
European heart journal,
29 5 2025, Pages ehaf194
2025 ESC/EACTS Guidelines for the management of valvular heart disease.
Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo M, Ajmone Marsan N, Barili F, Bonaros N, Cosyns B, De Paulis R, Gamra H, Jahangiri M, Jeppsson A, Klautz RJM, Mores B, Pérez-David E, Pöss J, Prendergast BD, Rocca B, Rossello X, Suzuki M, Thiele H, Tribouilloy CM, Wojakowski W, ESC/EACTS Scientific Document Group
Abstract
The Annals of thoracic surgery,
29 5 2025, Pages S0003-4975(25)00805-7
Mitral Valve Repair in Infective Endocarditis: A Patient-Tailored Approach.
Tomšič A, Palmen M
Abstract
Journal of the American College of Cardiology,
27 4 2025, Pages S0735-1097(25)07551-5
Lipoprotein(a) Levels and Time to Cardiovascular Benefit With Alirocumab in Patients With Recent Acute Coronary Syndrome.
Ray KK, Szarek M, Bhatt DL, Bittner VA, Fazio S, Goodman SG, Harrington RA, Jukema JW, White HD, Steg PG, Schwartz GG
Abstract
Scientific reports,
Volume 15, Issue 1, 21 3 2025, Pages 30672
Metagenomic analysis and genomic characterization of enterovirus A76 and Norovirus GI.6[P11] co-infection in a patient with acute gastroenteritis in Thailand.
Chuchaona W, Izquierdo-Lara RW, Schapendonk CME, Khongwichit S, Koopmans MPG, de Graaf M, Poovorawan Y
Acute gastroenteritis (AGE) remains a significant global health concern, with noroviruses among the most prevalent viral pathogens. However, other enteric viruses also contribute substantially to the public health burden. This study provides the first molecular characterization of a co-infection involving a rarely reported enterovirus A76 (EV-A76) and a norovirus GI.6[P11] in a patient from Thailand. Metagenomic sequencing successfully identified complete viral genomes, revealing unique genetic...
Abstract
JACC. Basic to translational science,
Volume 10, Issue 9, 21 3 2025, Pages 101359
Triglycerides and T Cells in Cardiovascular Risk: Inflammatory Transcriptomic Profile in Hypertriglyceridemia Patients' T Cells.
Reilly NA, Mulder JWCM, Dekkers KF, Kuipers TB, van Vark-van der Zee LC, Mulder MT, Roeters van Lennep JE, Jukema JW, Heijmans BT
Triglycerides and T cells play a key role in atherosclerosis, the leading cause of cardiovascular disease (CVD). Moderately elevated triglycerides have emerged as a causal risk factor, and T cells are a prominent component of atherosclerotic plaques. This cross-sectional study examined transcriptomic differences in T cells among patients with varying triglyceride levels via RNA sequencing. We analyzed CD4+ and CD8+ T cells from 49 participants, including those with primary (genetic) and secondar...
Abstract
JMIR cardio,
Volume 9, 18 3 2025, Pages e56236
Adherence Patterns of Patients Using Remote Patient Management After Myocardial Infarction: Mixed Methods Persona Approach.
Hondmann SM, Schrauwen L, Reijnders T, Stoop E, Evers AW, Visch VT, Atsma DE, Janssen VR
Background: Remote patient management (RPM) using smartphone-enabled health monitoring devices (SHMDs) can be an effective, value-added part of cardiovascular care. However, cardiac patients' adherence to RPM is variable. Personas are fictional representations of users with common behaviors, needs, and motivation and can thereby help guide tailoring of interventions to be meaningful and possibly more effective. Personas can be used to understand the needs of the patient group and guide tail...
Abstract
American journal of physiology. Renal physiology,
Volume 329, Issue 4, 18 3 2025, Pages F453-F464
The impact of chronic kidney disease on arteriovenous fistula remodeling: studies in a murine model of autosomal dominant polycystic kidney disease.
Laboyrie SL, Peters DJM, Bijkerk R, de Winter EP, Duijs JMGJ, de Klerk JA, de Vries MR, Rotmans JI
The arteriovenous fistula (AVF) is the gold standard for hemodialysis vascular access, although inadequate vascular remodeling and intimal hyperplasia pose a major limitation. It is essential to study this in a clinically relevant model. We used an autosomal dominant polycystic kidney disease (ADPKD) model, the most common hereditary cause of chronic kidney disease (CKD), to study the effect of CKD on AVFs. Jugular-carotid AVFs were created in adult B6OlaPkd1nl/nl (ADPKD) mice and B6OlaPkd1+/+ l...
Abstract
The American journal of cardiology,
Volume 255, 16 3 2025, Pages 116-125
Diagnosis and Treatment of Unrecognized Spontaneous Coronary Artery Dissection in Young Women Presenting With an Acute Coronary Syndrome.
Al-Gully J, Montero-Cabezas JM, Eikenboom J, den Exter PL, van der Kley F, Jukema W, Bingen BO, Al Amri I
Spontaneous coronary artery dissection (SCAD) is often overlooked as a cause of acute coronary syndrome (ACS), particularly in young women. SCAD requires distinct management, underscoring the importance of its timely and accurate diagnosis for effective treatment. This study aims to evaluate the frequency of SCAD underdiagnosis in young women with ACS and pinpoints potential SCAD indicators. All consecutive women ≤55 years with ACS who underwent coronary angiography (CAG) at our tertiary center...
Abstract
JACC. Advances,
Volume 4, Issue 9, 13 2 2025, Pages 102063
Ventricular Tachycardia Predicts All-Cause Mortality and Nonsudden Cardiac Death in Nonischemic Cardiomyopathy.
Omara S, Jensen TN, Koeber L, Thune JJ, Pehrson S, Mertens B, Tedrow UB, Hindricks G, Ebert M, Carbucicchio C, Berruezo A, Vaseghi M, Shivkumar K, Deneke T, Wijnmaalen AP, Stevenson WG, Nielsen JC, Zeppenfeld K
Background: Patients with nonischemic cardiomyopathies (NICMs) are at a risk for end-stage heart failure and death from ventricular arrhythmias. Implanted defibrillators (ICDs) protect against sudden arrhythmic death, but several studies suggest that ventricular arrhythmias are associated with worse outcomes despite ICDs. Objectives: This study evaluated the relationship of ventricular tachycardia (VT) with total mortality and nonsudden cardiovascular death (NSCVD) in NICM patients with ICDs enr...
Abstract
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
Volume 225, 13 2 2025, Pages 112097
Investigation of structural and radiation shielding properties of natural granite, clay, natural cement, and quartz supplied from Hakkâri region.
Kabamakli E, Yalcin S, Aktas B, Yilmaz D
This study aims to investigate the physical, structural, and radiation shielding properties of four rock types commonly used in natural cement, including clay, granite, and quartz originating from the Hakkâri region of Turkey. Structural characterization was performed using ICP-MS, XRD, and FT-IR analyses. At the same time, radiation shielding effectiveness was determined through measurements of mass attenuation coefficient (MAC), linear attenuation coefficient (LAC), half-value layer (HVL), mea...
Abstract
Acta dermato-venereologica,
Volume 105, 12 2 2025, Pages adv44209
Topical Steroid Withdrawal: Perspectives of Dutch Healthcare Professionals.
Vroman F, Schimmel CS, Van der Rijst LP, De Graaf M, De Bruin-Weller M, Kemperman PMJH, Hijnen DJ, Haeck IM
Topical steroid withdrawal (TSW) is a highly controversial condition, typically reported following prolonged and/or frequent use of topical corticosteroids. Despite growing public awareness, knowledge of topical steroid withdrawal remains limited. Therefore, this study aimed to explore the perspectives of Dutch healthcare professionals (HCPs) on topical steroid withdrawal. A web-based survey was conducted among 168 Dutch HCPs. The results show that erythema (64.1%) and a burning sensation (60.3%...
Abstract
