7971 results
Cited 432 times since 2021 (117.7 per year)
source: EuropePMC
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
Volume 73, Issue 7, 1 1 2021, Pages e2005-e2015
Risk Factors for Coronavirus Disease 2019 (COVID-19) Death in a Population Cohort Study from the Western Cape Province, South Africa.
Western Cape Department of Health in collaboration with the National Institute for Communicable Diseases, South Africa
Background: Risk factors for coronavirus disease 2019 (COVID-19) death in sub-Saharan Africa and the effects of human immunodeficiency virus (HIV) and tuberculosis on COVID-19 outcomes are unknown. Methods: We conducted a population cohort study using linked data from adults attending public-sector health facilities in the Western Cape, South Africa. We used Cox proportional hazards models, adjusted for age, sex, location, and comorbidities, to examine the associations between HIV, tuberculosis,...
Abstract
Cited 20 times since 2021 (5.4 per year)
source: EuropePMC
Journal of clinical gastroenterology,
Volume 55, Issue 9, 1 1 2021, Pages 798-809
A Systematic Review With Meta-Analysis of the Efficacy of Cannabis and Cannabinoids for Inflammatory Bowel Disease: What Can We Learn From Randomized and Nonrandomized Studies?
Doeve BH, van de Meeberg MM, van Schaik FDM, Fidder HH
Goal and background: A number of studies have investigated the effectiveness of cannabis or cannabinoids for treatment of inflammatory bowel diseases (IBD). We aimed to systematically analyze their effect in in the treatment of IBD patients. Study: We included randomized controlled trials and nonrandomized studies analyzing IBD patients of any age using cannabi(noid)s. Two reviewers searched 3 databases until August 13, 2019. Primary outcome was clinical remission and secondary outcomes included...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 22, Issue 11, 1 1 2021, Pages 1219-1227
The year 2020 in the European Heart Journal - Cardiovascular Imaging: part I.
Edvardsen T, Donal E, Marsan NA, Maurovich-Horvat P, Dweck MR, Maurer G, Petersen SE, Cosyns B
The European Heart Journal - Cardiovascular Imaging was launched in 2012 and has during these 9 years become one of the leading multimodality cardiovascular imaging journals. The journal is currently ranked as number 20 among all cardiovascular journals. Our journal is well established as one of the top cardiovascular journals and is the most important cardiovascular imaging journal in Europe. The most important studies published in our Journal in 2020 will be highlighted in two reports. Part I...
Abstract
Cited 13 times since 2021 (3.5 per year)
source: EuropePMC
Journal for immunotherapy of cancer,
Volume 9, Issue 10, 1 1 2021, Pages e003671
Primary vulvar squamous cell carcinomas with high T cell infiltration and active immune signaling are potential candidates for neoadjuvant PD-1/PD-L1 immunotherapy.
Kortekaas KE, Santegoets SJ, Tas L, Ehsan I, Charoentong P, van Doorn HC, van Poelgeest MIE, Mustafa DAM, van der Burg SH
Background: A profound insight into the immune landscape of vulvar squamous cell carcinoma (VSCC) is lacking. Here, an in-depth interrogation of T cell infiltration, local immune contexture, signaling pathways and checkpoint molecule expression was performed in early-stage and late-stage VSCC. Methods: The type, location, and infiltration pattern of T cells were studied in 109 patients with primary VSCC FIGO stage I-III. RNA expression of genes involved in immune oncology and oncogenic signaling...
Abstract
Cited 7 times since 2021 (1.9 per year)
source: EuropePMC
European heart journal. Quality of care & clinical outcomes,
Volume 7, Issue 6, 1 1 2021, Pages 583-590
Utilization of diagnostic resources and costs in patients with suspected cardiac chest pain.
Vester MPM, Eindhoven DC, Bonten TN, Wagenaar H, Holthuis HJ, Schalij MJ, de Grooth GJ, van Dijkman PRM
Aims: Non-acute chest pain is a common complaint and can be caused by various conditions. With the rising healthcare expenditures of today, it is necessary to use our healthcare resources effectively. This study aims to give insight into the diagnostic effort and costs for patients with non-acute chest pain. Methods and results: Financial data of patients without a cardiac history from four hospitals (January 2012-October 2018), who were registered with the national diagnostic code 'no card...
Abstract
Cited 299 times since 2021 (81.5 per year)
source: EuropePMC
European heart journal,
Volume 42, Issue 40, 1 1 2021, Pages 4194
Corrigendum to: 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC.
Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, Boriani G, Castella M, Dan GA, Dilaveris PE, Fauchier L, Filippatos G, Kalman JM, La Meir M, Lane DA, Lebeau JP, Lettino M, Lip GYH, Pinto FJ, Thomas GN, Valgimigli M, Van Gelder IC, Van Putte BP, Watkins CL
Abstract
European heart journal. Cardiovascular Imaging,
Volume 22, Issue 11, 1 1 2021, Pages 1255-1256
Haemodynamic response to COVID-19 and its outcome implications.
van der Bijl P, Bax JJ
Abstract
Cited 9 times since 2021 (2.4 per year)
source: EuropePMC
Environmental science & technology,
Volume 55, Issue 20, 30 5 2021, Pages 13770-13782
Optical Properties of Water for Prediction of Wastewater Contamination, Human-Associated Bacteria, and Fecal Indicator Bacteria in Surface Water at Three Watershed Scales.
Corsi SR, De Cicco LA, Hansen AM, Lenaker PL, Bergamaschi BA, Pellerin BA, Dila DK, Bootsma MJ, Spencer SK, Borchardt MA, McLellan SL
Relations between spectral absorbance and fluorescence properties of water and human-associated and fecal indicator bacteria were developed for facilitating field sensor applications to estimate wastewater contamination in waterways. Leaking wastewater conveyance infrastructure commonly contaminates receiving waters. Methods to quantify such contamination can be time consuming, expensive, and often nonspecific. Human-associated bacteria are wastewater specific but require discrete sampling and l...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
The Journal of social psychology,
Volume 164, Issue 1, 30 5 2021, Pages 12-26
No evidence for modulation of facial mimicry by attachment tendencies in adulthood: an EMG investigation.
Vacaru SV, van Schaik JE, Spiess L, Hunnius S
Mimicking another individual functions as a social glue: it smoothens the interaction and fosters affiliation. Here, we investigated whether the intrinsic motivation to affiliate with others, stemming from attachment relationships, modulates individuals' engagement in facial mimicry (FM). Participants (N = 100; MAge = 24.54 years, SDAge = 3.90 years) observed faces with happy, sad, and neutral expressions, while their facial muscle activity was recorded with electromyography. Attachment was...
Abstract
Cited 10 times since 2021 (2.7 per year)
source: EuropePMC
Journal of pharmaceutical sciences,
Volume 111, Issue 3, 30 5 2021, Pages 734-742
Caffeic Acid Phenethyl Ester Loaded Electrospun Nanofibers for Wound Dressing Application.
Kaya S, Yilmaz DE, Akmayan I, Egri O, Arasoglu T, Derman S
Electrospinning is an advantageous method with a wide usage area, which enables the production of materials consisting of nano-thickness fibers. In this study, caffeic acid phenethyl ester (CAPE) molecule was loaded onto the poly(lactic-co-glycolic acid) (PLGA) nanofibers and obtained nanofibers were physicochemically and biologically investigated for the first time in the literature. The existence of CAPE molecules, loaded on PLGA membranes by dropping and spraying methods, was evaluated by a c...
Abstract
Cited 3 times since 2021 (0.8 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 8, Issue 10, 28 4 2021, Pages 121
Deficient Myocardial Organization and Pathological Fibrosis in Fetal Aortic Stenosis-Association of Prenatal Ultrasound with Postmortem Histology.
Zwanenburg F, DeRuiter MC, Wisse LJ, van Munsteren CJ, Bartelings MM, Goumans MJ, Ten Harkel ADJ, Jongbloed MRM, Haak MC
In fetal aortic stenosis (AS), it remains challenging to predict left ventricular development over the course of pregnancy. Myocardial organization, differentiation and fibrosis could be potential biomarkers relevant for biventricular outcome. We present four cases of fetal AS with varying degrees of severity and associate myocardial deformation on fetal ultrasound with postmortem histopathological characteristics. During routine fetal echocardiography, speckle tracking recordings of the cardiac...
Abstract
Cited 10 times since 2021 (2.7 per year)
source: EuropePMC
ESC heart failure,
Volume 8, Issue 6, 28 4 2021, Pages 4425-4443
HFA of the ESC position paper on the management of LVAD-supported patients for the non-LVAD specialist healthcare provider Part 3: at the hospital and discharge.
Gustafsson F, Ben Avraham B, Chioncel O, Hasin T, Grupper A, Shaul A, Nalbantgil S, Hammer Y, Mullens W, Tops LF, Elliston J, Tsui S, Milicic D, Altenberger J, Abuhazira M, Winnik S, Lavee J, Piepoli MF, Hill L, Hamdan R, Ruhparwar A, Anker S, Crespo-Leiro MG, Coats AJS, Filippatos G, Metra M, Rosano G, Seferovic P, Ruschitzka F, Adamopoulos S, Barac Y, De Jonge N, Frigerio M, Goncalvesova E, Gotsman I, Itzhaki Ben Zadok O, Ponikowski P, Potena L, Ristic A, Jaarsma T, Ben Gal T
The growing population of left ventricular assist device (LVAD)-supported patients increases the probability of an LVAD- supported patient hospitalized in the internal or surgical wards with certain expected device related, and patient-device interaction complication as well as with any other comorbidities requiring hospitalization. In this third part of the trilogy on the management of LVAD-supported patients for the non-LVAD specialist healthcare provider, definitions and structured approach t...
Abstract
Cited 30 times since 2021 (8.2 per year)
source: EuropePMC
BMJ (Clinical research ed.),
Volume 374, 28 4 2021, Pages n2134
Performance of prediction models for nephropathy in people with type 2 diabetes: systematic review and external validation study.
Slieker RC, van der Heijden AAWA, Siddiqui MK, Langendoen-Gort M, Nijpels G, Herings R, Feenstra TL, Moons KGM, Bell S, Elders PJ, 't Hart LM, Beulens JWJ
Objectives: To identify and assess the quality and accuracy of prognostic models for nephropathy and to validate these models in external cohorts of people with type 2 diabetes. Design: Systematic review and external validation. Data sources: PubMed and Embase. Eligibility criteria: Studies describing the development of a model to predict the risk of nephropathy, applicable to people with type 2 diabetes. Methods: Screening, data extraction, and risk of bias assessment were done in duplicate. El...
Abstract
Cited 6 times since 2021 (1.6 per year)
source: EuropePMC
Peptides,
Volume 146, 28 4 2021, Pages 170664
Mendelian randomization study of the relation between adiponectin and heart function, unravelling the paradox.
Christen T, de Mutsert R, Lamb HJ, van Dijk KW, le Cessie S, Rosendaal FR, Jukema JW, Trompet S
High adiponectin concentrations are generally regarded as beneficial with regard to cardiometabolic health, but have been paradoxically associated with increased cardiovascular disease risk, specifically heart failure, in individuals at high cardiovascular risk. We aimed to investigate the association between adiponectin and heart function parameters, and inversely, we estimated the effect of genetically-determined heart function and NT-proBNP as the main marker of heart failure on adiponectin u...
Abstract
Cited 13 times since 2021 (3.5 per year)
source: EuropePMC
Scientific reports,
Volume 11, Issue 1, 22 4 2021, Pages 18797
Derivation and characterisation of endothelial cells from patients with chronic thromboembolic pulmonary hypertension.
Tura-Ceide O, Smolders VFED, Aventin N, Morén C, Guitart-Mampel M, Blanco I, Piccari L, Osorio J, Rodríguez C, Rigol M, Solanes N, Malandrino A, Kurakula K, Goumans MJ, Quax PHA, Peinado VI, Castellà M, Barberà JA
Pulmonary endarterectomy (PEA) resected material offers a unique opportunity to develop an in vitro endothelial cell model of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to comprehensively analyze the endothelial function, molecular signature, and mitochondrial profile of CTEPH-derived endothelial cells to better understand the pathophysiological mechanisms of endothelial dysfunction behind CTEPH, and to identify potential novel targets for the prevention and treatment of the...
Abstract
Cited 11 times since 2021 (3 per year)
source: EuropePMC
NPJ genomic medicine,
Volume 6, Issue 1, 21 3 2021, Pages 76
Predicting cancer drug TARGETS - TreAtment Response Generalized Elastic-neT Signatures.
Rydzewski NR, Peterson E, Lang JM, Yu M, Laura Chang S, Sjöström M, Bakhtiar H, Song G, Helzer KT, Bootsma ML, Chen WS, Shrestha RM, Zhang M, Quigley DA, Aggarwal R, Small EJ, Wahl DR, Feng FY, Zhao SG
We are now in an era of molecular medicine, where specific DNA alterations can be used to identify patients who will respond to specific drugs. However, there are only a handful of clinically used predictive biomarkers in oncology. Herein, we describe an approach utilizing in vitro DNA and RNA sequencing and drug response data to create TreAtment Response Generalized Elastic-neT Signatures (TARGETS). We trained TARGETS drug response models using Elastic-Net regression in the publicly available G...
Abstract
Cited 5 times since 2021 (1.4 per year)
source: EuropePMC
International journal of cardiology,
Volume 344, 21 3 2021, Pages 1-7
Comparison of guidelines for diagnosing suspected stable angina and the additional value of the calcium score.
Rijlaarsdam-Hermsen D, van Domburg RT, Deckers JW, Kuijpers D, van Dijkman PRM
Background The performance of current diagnostic algorithms of the American College of Cardiology/American Heart Association (ACC/AHA), National Institute for Health and Care Excellence (NICE) and European Society of Cardiology (ESC) in patients with stable chest pain and coronary artery calcium (CAC) remains a matter of debate. We compared their merits in patients with CAC and investigated the additional value of the CAC score to improve diagnostic accuracy and risk stratification. Methods and...
Abstract
Cited 16 times since 2021 (4.3 per year)
source: EuropePMC
Frontiers in immunology,
Volume 12, 20 3 2021, Pages 754712
<i>Coxiella burnetii</i> Whole Cell Vaccine Produces a Th1 Delayed-Type Hypersensitivity Response in a Novel Sensitized Mouse Model.
Fratzke AP, Gregory AE, van Schaik EJ, Samuel JE
Q-VAX®, a whole cell, formalin-inactivated vaccine, is the only vaccine licensed for human use to protect against Coxiella burnetii, the cause of Q fever. Although this vaccine provides long-term protection, local and systemic reactogenic responses are common in previously sensitized individuals which prevents its use outside of Australia. Despite the importance of preventing these adverse reactions to develop widely accepted, novel vaccines against C. burnetii, little is understood about the un...
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
Journal of visualized experiments : JoVE,
Issue 175, 17 3 2021
Automated, High-Throughput Detection of Bacterial Adherence to Host Cells.
Yang J, Qin QM, Van Schaik E, Samuel JE, de Figueiredo P
Identification of emerging bacterial pathogens is critical for human health and security. Bacterial adherence to host cells is an essential step in bacterial infections and constitutes a hallmark of potential threat. Therefore, examining the adherence of bacteria to host cells can be used as a component of bacterial threat assessment. A standard method for enumerating bacterial adherence to host cells is to co-incubate bacteria with host cells, harvest the adherent bacteria, plate the harvested...
Abstract
Cited 40 times since 2021 (10.8 per year)
source: EuropePMC
Frontiers in physiology,
Volume 12, 16 3 2021, Pages 665298
Asymmetry and Heterogeneity: Part and Parcel in Cardiac Autonomic Innervation and Function.
Zandstra TE, Notenboom RGE, Wink J, Kiès P, Vliegen HW, Egorova AD, Schalij MJ, De Ruiter MC, Jongbloed MRM
The cardiac autonomic nervous system (cANS) regulates cardiac adaptation to different demands. The heart is an asymmetrical organ, and in the selection of adequate treatment of cardiac diseases it may be relevant to take into account that the cANS also has sidedness as well as regional differences in anatomical, functional, and molecular characteristics. The left and right ventricles respond differently to adrenergic stimulation. Isoforms of nitric oxide synthase, which plays an important role i...
Abstract
