Research

Publications

Below you can find a list of our published research.

7971 results

Cited 15 times since 2021 (3.9 per year) source: EuropePMC

Microbiology spectrum, Volume 9, Issue 1, 14 2 2021, Pages e0005821 Spread of Carbapenem-Resistant Klebsiella pneumoniae in an Intensive Care Unit: A Whole-Genome Sequence-Based Prospective Observational Study. Wei L, Wu L, Wen H, Feng Y, Zhu S, Liu Y, Tang L, Doughty E, van Schaik W, McNally A, Zong Z

The aim of this study was to determine the contribution of the contamination of the health care environment in the acquisition of carbapenem-resistant Klebsiella pneumoniae (CRKP) in a CRKP-prevalent setting. We performed a 3-month prospective study in a 20-bed medical intensive care unit (ICU) by collecting rectal/oral swabs from patients within 3 days of ICU admission and weekly thereafter. We also comprehensively sampled the beds and rooms of patients and instruments for patient care every we... Abstract

Cited 7 times since 2021 (1.8 per year) source: EuropePMC

EJVES vascular forum, Volume 52, 14 2 2021, Pages 26-29 Ruptured Aneurysm of the Common Iliac Artery Caused by Brucella melitensis: A Case Report. Willems SA, Buntinx M, Gelinck LBS, van Schaik J, Eefting D

Introduction: Brucella is a genus of aerobic Gram negative bacteria that causes the disease brucellosis. It is considered a zoonotic infection transmitted to humans by ingestion of unpasteurised dairy products. Although aortic involvement is rarely seen, it can be a life threatening complication of this disease. This case report describes a ruptured aneurysm of the common iliac artery (CIA) due to secondary infection by Brucella melitensis. Report: A 79 year old man with a known isolated aneurys... Abstract

Cited 7 times since 2021 (1.8 per year) source: EuropePMC

mSystems, Volume 6, Issue 4, 13 2 2021, Pages e0013721 Metagenome-Wide Analysis of Rural and Urban Surface Waters and Sediments in Bangladesh Identifies Human Waste as a Driver of Antibiotic Resistance. McInnes RS, Uz-Zaman MH, Alam IT, Ho SFS, Moran RA, Clemens JD, Islam MS, van Schaik W

In many low- and middle-income countries, antibiotic-resistant bacteria spread in the environment due to inadequate treatment of wastewater and the poorly regulated use of antibiotics in agri- and aquaculture. Here, we characterized the abundance and diversity of antibiotic-resistant bacteria and antibiotic resistance genes in surface waters and sediments in Bangladesh through quantitative culture of extended-spectrum beta-lactamase (ESBL)-producing coliforms and shotgun metagenomics. Samples we... Abstract

Cited 27 times since 2021 (7 per year) source: EuropePMC

BMJ open, Volume 11, Issue 7, 12 2 2021, Pages e050519 Effectiveness of contact tracing apps for SARS-CoV-2: a rapid systematic review. Jenniskens K, Bootsma MCJ, Damen JAAG, Oerbekke MS, Vernooij RWM, Spijker R, Moons KGM, Kretzschmar MEE, Hooft L

Objective: To systematically review evidence on effectiveness of contact tracing apps (CTAs) for SARS-CoV-2 on epidemiological and clinical outcomes. Design: Rapid systematic review. Data sources: EMBASE (OVID), MEDLINE (PubMed), BioRxiv and MedRxiv were searched up to 28 October 2020. Study selection: Studies, both empirical and model-based, assessing effect of CTAs for SARS-CoV-2 on reproduction number (R), total number of infections, hospitalisation rate, mortality rate, and other epidemiolog... Abstract

Cited 1 times since 2021 (0.3 per year) source: EuropePMC

Transboundary and emerging diseases, Volume 69, Issue 4, 12 2 2021, Pages 2008-2020 The effectiveness of bovine tuberculosis surveillance in Dutch badgers. Orrico M, van Schaik G, Koets A, van den Broek J, Montizaan M, La Haye M, Rijks JM

Countries survey wildlife for bovine tuberculosis (bTB) to ensure case detection or to ascertain a high probability of freedom from bTB in wildlife. The Eurasian badger (Meles meles) is a potential bTB reservoir host. Between 2008 and 2019, 282 badgers were examined post-mortem in the context of general wildlife disease and targeted bTB surveillance programmes in the Netherlands, and no bTB cases were detected. However, it was unclear how effective this surveillance effort was to demonstrate fre... Abstract

Cited 30 times since 2021 (7.7 per year) source: EuropePMC

Nature reviews. Cardiology, Volume 18, Issue 12, 12 2 2021, Pages 824-837 Effects of fatty acids on T cell function: role in atherosclerosis. Reilly NA, Lutgens E, Kuiper J, Heijmans BT, Jukema JW

T cells are among the most common cell types present in atherosclerotic plaques and are increasingly being recognized as a central mediator in atherosclerosis development and progression. At the same time, triglycerides and fatty acids have re-emerged as crucial risk factors for atherosclerosis. Triglycerides and fatty acids are important components of the milieu to which the T cell is exposed from the circulation to the plaque, and increasing evidence shows that fatty acids influence T cell fun... Abstract

Cited 10 times since 2021 (2.6 per year) source: EuropePMC

Pharmaceutics, Volume 13, Issue 7, 10 2 2021, Pages 1055 Kinetic and Microhydrodynamic Modeling of Fenofibrate Nanosuspension Production in a Wet Stirred Media Mill. Guner G, Yilmaz D, Bilgili E

This study examined the impact of stirrer speed and bead material loading on fenofibrate particle breakage during wet stirred media milling (WSMM) via three kinetic models and a microhydrodynamic model. Evolution of median particle size was tracked via laser diffraction during WSMM operating at 3000-4000 rpm with 35-50% (v/v) concentration of polystyrene or zirconia beads. Additional experiments were performed at the center points of the above conditions, as well as outside the range of these co... Abstract

Cited 22 times since 2021 (5.7 per year) source: EuropePMC

Brain, behavior and evolution, Volume 96, Issue 1, 9 2 2021, Pages 1-12 A Farewell to the Encephalization Quotient: A New Brain Size Measure for Comparative Primate Cognition. van Schaik CP, Triki Z, Bshary R, Heldstab SA

Both absolute and relative brain sizes vary greatly among and within the major vertebrate lineages. Scientists have long debated how larger brains in primates and hominins translate into greater cognitive performance, and in particular how to control for the relationship between the noncognitive functions of the brain and body size. One solution to this problem is to establish the slope of cognitive equivalence, i.e., the line connecting organisms with an identical bauplan but different body siz... Abstract

Cited 2 times since 2021 (0.5 per year) source: EuropePMC

Microvascular research, Volume 138, 8 2 2021, Pages 104222 Evaluation of gingival microcirculation in patients with gestational diabetes mellitus. Yilmaz D, Altas A

Objective: The aim of this study was to evaluate the possible microcircularity variations at periodontal mucous level in patients with gestational diabetes mellitus (GDM). Material and methods: Overall 55 periodontally healthy and non-smoker participants were enrolled in the study by whom 30 were diagnosed with GDM (26 to 34 weeks pregnant) and 25 were systemically healthy unpregnant controls. The analysis was performed in the masticatory/gingival mucosa of maxillary anterior region and by the o... Abstract

Cited 3 times since 2021 (0.8 per year) source: EuropePMC

Journal of cardiovascular development and disease, Volume 8, Issue 7, 8 2 2021, Pages 79 Superimposed Tissue Formation in Human Aortic Valve Disease: Differences between Regurgitant and Stenotic Valves. Kruithof BPT, van Wijngaarden AL, Mousavi Gourabi B, Hjortnaes J, Palmen M, Ajmone Marsan N

The formation of superimposed tissue (SIT), a layer on top of the original valve leaflet, has been described in patients with mitral regurgitation as a major contributor to valve thickening and possibly as a result of increased mechanical stresses. However, little is known whether SIT formation also occurs in aortic valve disease. We therefore performed histological analyses to assess SIT formation in aortic valve leaflets (n = 31) from patients with aortic stenosis (n = 17) or aortic regurgitat... Abstract

Cited 32 times since 2021 (8.2 per year) source: EuropePMC

Frontiers in genetics, Volume 12, 8 2 2021, Pages 711943 CYP3A4∗22 Genotyping in Clinical Practice: Ready for Implementation? Mulder TAM, van Eerden RAG, de With M, Elens L, Hesselink DA, Matic M, Bins S, Mathijssen RHJ, van Schaik RHN

Cytochrome P450 3A4 (CYP3A4) is the most important drug metabolizing enzyme in the liver, responsible for the oxidative metabolism of ∼50% of clinically prescribed drugs. Therefore, genetic variation in CYP3A4 could potentially affect the pharmacokinetics, toxicity and clinical outcome of drug treatment. Thus far, pharmacogenetics for CYP3A4 has not received much attention. However, the recent discovery of the intron 6 single-nucleotide polymorphism (SNP) rs35599367C > T, encoding the CYP3A4∗... Abstract

Cited 18 times since 2021 (4.6 per year) source: EuropePMC

Frontiers in veterinary science, Volume 8, 8 2 2021, Pages 620998 Assessment of Evaluation Tools for Integrated Surveillance of Antimicrobial Use and Resistance Based on Selected Case Studies. Sandberg M, Hesp A, Aenishaenslin C, Bordier M, Bennani H, Bergwerff U, Chantziaras I, De Meneghi D, Ellis-Iversen J, Filippizi ME, Mintiens K, Nielsen LR, Norström M, Tomassone L, van Schaik G, Alban L

Regular evaluation of integrated surveillance for antimicrobial use (AMU) and resistance (AMR) in animals, humans, and the environment is needed to ensure system effectiveness, but the question is how. In this study, six different evaluation tools were assessed after being applied to AMU and AMR surveillance in eight countries: (1) ATLASS: the Assessment Tool for Laboratories and AMR Surveillance Systems developed by the Food and Agriculture Organization (FAO) of the United Nations, (2) ECoSur:... Abstract

Cited 11 times since 2021 (2.8 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 29, Issue 11, 7 1 2021, Pages 557-565 2020 ESC Guidelines on acute coronary syndrome without ST-segment elevation : Recommendations and critical appraisal from the Dutch ACS and Interventional Cardiology working groups. Arslan F, Damman P, Zwart B, Appelman Y, Voskuil M, de Vos A, van Royen N, Jukema JW, Waalewijn R, Hermanides RS, Woudstra P, Ten Cate T, Lemkes JS, Vink MA, Balder W, van der Wielen MLJ, Vlaar PJ, van der Heijden DJ, Assa S, van 't Hof AW, Ten Berg JM

Recently, the European Society of Cardiology (ESC) has updated its guidelines for the management of patients with acute coronary syndrome (ACS) without ST-segment elevation. The current consensus document of the Dutch ACS working group and the Working Group of Interventional Cardiology of the Netherlands Society of Cardiology aims to put the 2020 ESC Guidelines into the Dutch perspective and to provide practical recommendations for Dutch cardiologists, focusing on antiplatelet therapy, risk asse... Abstract

Cited 4 times since 2021 (1 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 8, 7 1 2021, Pages 699492 Prognostic Value of Natriuretic Peptides for All-Cause Mortality, Right Ventricular Failure, Major Adverse Events, and Myocardial Recovery in Advanced Heart Failure Patients Receiving a Left Ventricular Assist Device: A Systematic Review. Janssen E, Jukema JW, Beeres SLMA, Schalij MJ, Tops LF

Aims: Major adverse event (MAE) rates during left ventricular assist device (LVAD) therapy in advanced heart failure (HF) patients are high, and impair quality of life and survival. Prediction and risk stratification of MAEs in order to improve patient selection and thereby outcome during LVAD therapy is therefore warranted. Circulating natriuretic peptides (NPs) are strong predictors of MAEs and mortality in chronic HF patients. However, whether NPs can identify patients who are at risk of MAEs... Abstract

Heart, lung & circulation, Volume 30, Issue 12, 7 1 2021, Pages e129-e130 Reversal of Femoral Vein Pulsatility Due to Severe Tricuspid Regurgitation After Transcatheter Tricuspid Valve-in-Valve Implantation: A "Wave Dissipation" Effect. Pereira AR, van der Kley F, Montero-Cabezas JM, de Weger A, Delgado V

Abstract

Cited 21 times since 2021 (5.4 per year) source: EuropePMC

The Journal of allergy and clinical immunology, Volume 149, Issue 1, 6 1 2021, Pages 125-134 Unraveling heterogeneity in pediatric atopic dermatitis: Identification of serum biomarker based patient clusters. Bakker DS, de Graaf M, Nierkens S, Delemarre EM, Knol E, van Wijk F, de Bruin-Weller MS, Drylewicz J, Thijs JL

Background: Increasing evidence shows that pediatric atopic dermatitis (AD) differs from adult AD on a biologic level. Broad biomarker profiling across a wide range of ages of pediatric patients with AD is lacking. Objective: Our aim was to identify serum biomarker profiles in children with AD aged 0 to 17 years and compare these profiles with those previously found in adults with AD. Methods: Luminex multiplex immunoassays were used to measure 145 biomarkers in serum from 240 children with AD (... Abstract

Cited 8 times since 2021 (2 per year) source: EuropePMC

The American journal of cardiology, Volume 154, 4 1 2021, Pages 92-98 Prognostic Value of Maximal and Submaximal Exercise Performance in Fontan Patients < 15 Years of Age. Terol Espinosa de Los Monteros C, Harteveld LM, Kuipers IM, Rammeloo L, Hazekamp MG, Blom NA, Ten Harkel ADJ

In patients after Fontan completion exercise capacity is significantly reduced. Although peak oxygen consumption (VO2peak) is a strong prognostic factor in many cardiovascular diseases, it requires the achievement of a maximal effort. Therefore, submaximal exercise parameters such as oxygen uptake efficiency slope (OUES) may be of value. In the present observational study we evaluated the exercise capacity with maximal and submaximal parameters in a group of Fontan patients with an extracardiac... Abstract

Cited 1 times since 2021 (0.3 per year) source: EuropePMC

Complementary therapies in clinical practice, Volume 44, 4 1 2021, Pages 101437 Effect of reflexology on ankle brachial index, diabetic peripheral neuropathy, and glycemic control in older adults with diabetes: A randomized controlled trial. Cicek SC, Demir S, Yilmaz D, Yildiz S

Objective: The purpose of this study was to determine the effect of foot reflexology on ankle brachial index, diabetic peripheral neuropathy and glycemic control in older adults with diabetes. Methods: A randomized controlled, parallel-group trial study was conducted at the outpatient elderly health center in Bolu, Turkey. 48 adults aged 65 and over enrolled in the elderly health center were randomized into two groups in a ratio of 1:1 (experimental, n = 24; control, n = 24). Foot reflexology wa... Abstract

Cited 25 times since 2021 (6.4 per year) source: EuropePMC

Journal of neurology, Volume 269, Issue 3, 3 1 2021, Pages 1375-1385 The natural history of primary progressive aphasia: beyond aphasia. Ulugut H, Stek S, Wagemans LEE, Jutten RJ, Keulen MA, Bouwman FH, Prins ND, Lemstra AW, Krudop W, Teunissen CE, van Berckel BNM, Ossenkoppele R, Barkhof F, van der Flier WM, Scheltens P, Pijnenburg YAL

Introduction: Primary progressive aphasia (PPA) is divided into three prototypical subtypes that are all characterized by their single core symptom of aphasia. Although later in their course, other cognitive, behavioral, and motor domains may become involved, little is known about the progression profile of each subtype relative to the other subtypes. Methods: In this longitudinal retrospective cohort study, based on the recent biomarker-supported diagnostic criteria, 24 subjects diagnosed with... Abstract

Cited 628 times since 2021 (160.5 per year) source: EuropePMC

European heart journal, Volume 42, Issue 25, 1 1 2021, Pages 2439-2454 SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. SCORE2 working group and ESC Cardiovascular risk collaboration

Aims: The aim of this study was to develop, validate, and illustrate an updated prediction model (SCORE2) to estimate 10-year fatal and non-fatal cardiovascular disease (CVD) risk in individuals without previous CVD or diabetes aged 40-69 years in Europe. Methods and results: We derived risk prediction models using individual-participant data from 45 cohorts in 13 countries (677 684 individuals, 30 121 CVD events). We used sex-specific and competing risk-adjusted models, including age, smoking s... Abstract