6139 results
Cited 8 times since 2017 (1.1 per year)
source: EuropePMC
Journal of internal medicine,
Volume 282, Issue 6, 27 4 2017, Pages 522-536
A protective role of IRF3 and IRF7 signalling downstream TLRs in the development of vein graft disease via type I interferons.
Simons KH, Peters HAB, Jukema JW, de Vries MR, Quax PHA
Background: Toll like receptors (TLR) play an important role in vein graft disease (VGD). Interferon regulatory factors (IRF) 3 and 7 are the transcriptional regulators of type I interferons (IFN) and type I IFN responsive genes and are downstream factors of TLRs. Relatively little is known with regard to the interplay of IRFs and TLRs in VGD development. The aim of this study was to investigate the role of IRF3 and IRF7 signaling downstream TLRs and the effect of IRF3 and IRF7 in VGD. Methods a...
Abstract
Cited 2 times since 2017 (0.3 per year)
source: EuropePMC
Frontiers in aging neuroscience,
Volume 9, 27 4 2017, Pages 307
Lower Performance in Orientation to Time and Place Associates with Greater Risk of Cardiovascular Events and Mortality in the Oldest Old: Leiden 85-Plus Study.
Rostamian S, van Buchem MA, Jukema JW, Gussekloo J, Poortvliet RKE, de Cren AJM, Sabayan B
Background: Impairment in orientation to time and place is commonly observed in community-dwelling older individuals. Nevertheless, the clinical significance of this has been not fully explored. In this study, we investigated the link between performance in orientation domains and future risk of cardiovascular events and mortality in a non-hospital setting of the oldest old adults. Methods: We included 528 subjects free of myocardial infarction (Group A), 477 individuals free of stroke/transient...
Abstract
Cited 1 times since 2017 (0.1 per year)
source: EuropePMC
The Journal of dermatological treatment,
Volume 29, Issue 4, 26 4 2017, Pages 375-382
Thiopurine metabolite levels in patients with atopic dermatitis and/or chronic hand/foot eczema treated with azathioprine.
Garritsen FM, van der Schaft J, Bruijnzeel-Koomen CAF, van Schaik RH, de Graaf M, van den Broek MPH, de Bruin-Weller MS
Background: Azathioprine is frequently used in severe eczema. It is converted in the liver into active metabolites, including 6-thioguanine nucleotide (6-TGN) and methylated 6-methylmercaptopurine (6-MMP). In the past, the therapeutic potential of azathioprine may have not been fully utilized. Recent investigations on inflammatory bowel disease have led to a better understanding of azathioprine metabolism and optimizing treatment. Objective: To investigate whether measuring thiopurine metabolite...
Abstract
Multimedia manual of cardiothoracic surgery : MMCTS,
Volume 2017, 25 4 2017
The Ross reimplantation technique.
Schneider A, Klautz RJM, Hazekamp M
Pulmonary autograft replacement of a diseased aortic valve (the Ross procedure) is effective in children, where growth is essential, and in young patients for whom a biological solution is preferred. Long-term outcomes are generally good. However eventual autograft dilatation may necessitate reoperation. In order to diminish the risk of autograft dilatation, several 'wrapping' techniques have been developed. Here, we present our technique of choice: the reimplantation of the pulmonary...
Abstract
Cited 10 times since 2017 (1.3 per year)
source: EuropePMC
JMIR research protocols,
Volume 6, Issue 9, 22 4 2017, Pages e186
Using Smart Technology to Improve Outcomes in Myocardial Infarction Patients: Rationale and Design of a Protocol for a Randomized Controlled Trial, The Box.
Treskes RW, van Winden LA, van Keulen N, Atsma DE, van der Velde ET, van den Akker-van Marle E, Mertens B, Schalij MJ
Background: Recent evidence suggests that frequent monitoring using smartphone-compatible wearable technologies might improve clinical effectiveness and patient satisfaction of care. Objective: The aim of this study is to investigate the clinical effectiveness and patient satisfaction of a smart technology intervention in patients admitted with a ST elevation myocardial infarction (STEMI) or non-ST acute coronary syndrome (NST-ACS). Methods: In this single center, open, randomized controlled tri...
Abstract
Cited 11 times since 2017 (1.5 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 11, Issue 6, 22 4 2017, Pages 423-428
Coronary lumen volume to myocardial mass ratio in primary microvascular angina.
Grover R, Leipsic JA, Mooney J, Kueh SH, Ohana M, Nørgaard BL, Eftekhari A, Bax JJ, Murphy DT, Hague CJ, Seidman MA, Blanke P, Sedlak T, Sellers SL
Background: Microvascular angina (MVA) is an incompletely understood clinical entity. Computational analysis of coronary Computed Tomography Angiography (CTA) has shown an association between low coronary lumen volume to myocardial mass (V/M) ratio and lower Fractional Flow Reserve values, independent of plaque measures. We hypothesized that low V/M ratio may be present in patients with MVA. Methods: A retrospective case-control analysis was performed using patients fulfilling guideline criteria...
Abstract
Cited 24 times since 2017 (3.2 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 11, Issue 6, 21 3 2017, Pages 462-467
Fractional flow reserve derived from coronary computed tomography angiography reclassification rate using value distal to lesion compared to lowest value.
Kueh SH, Mooney J, Ohana M, Kim U, Blanke P, Grover R, Sellers S, Ellis J, Murphy D, Hague C, Bax JJ, Nørgaard BL, Rabbat M, Leipsic JA
Introduction: A standardised approach to the interpretation of FFRCT data is currently lacking. We evaluated the rate of reclassification of FFRCT positivity using the FFRCT value distal to an anatomical stenoses compared to the lowest FFRCT value. Method: Patients who underwent coronary CTA and FFRCT analysis were eligible. FFRCT value of ≤ 0.80 was considered positive. Positive FFRCT distal to stenosis was defined as those with a stenoses of ≥ 25% with an associated FFRCT value of ≤ 0.80 withi...
Abstract
Cited 7 times since 2017 (0.9 per year)
source: EuropePMC
The American journal of cardiology,
Volume 120, Issue 12, 18 3 2017, Pages 2226-2232
Prevalence and Prognostic Relevance of Ventricular Conduction Disturbances in Patients With Aortic Stenosis.
Prihadi EA, Leung M, Vollema EM, Ng ACT, Ajmone Marsan N, Bax JJ, Delgado V
The prevalence and prognostic implications of ventricular conduction disturbances in aortic stenosis (AS) have not been extensively evaluated. The present retrospective study investigated the prevalence and prognostic implications of ventricular conduction abnormalities (including the QRS morphology and duration) in AS. A total of 1,245 patients (mean age 66 ± 14 years, 62.8% men) with varying AS severity (aortic sclerosis 33.9%, mild AS 11.5%, moderate AS 29.9%, and severe AS 24.7%) were evalua...
Abstract
Cited 23 times since 2017 (3.1 per year)
source: EuropePMC
JACC. Clinical electrophysiology,
Volume 3, Issue 13, 13 2 2017, Pages 1592-1598
Temporal Relationship of Asystole to Onset of Transient Loss of Consciousness in Tilt-Induced Reflex Syncope.
Saal DP, Thijs RD, van Zwet EW, Bootsma M, Brignole M, Benditt DG, van Dijk JG
Objectives: The purpose of this study was to investigate the relationship between the onset of asystole and transient loss of consciousness (TLOC) in tilt-induced reflex syncope and estimate how often asystole was the principal cause of TLOC. Background: The presence of asystole in vasovagal syncope (VVS) may prompt physicians to consider pacemaker therapy for syncope prevention, but the benefit of pacing is limited in VVS. Methods: We evaluated electrocardiography, electroencephalography, blood...
Abstract
Cited 12 times since 2017 (1.6 per year)
source: EuropePMC
Scientific reports,
Volume 7, Issue 1, 12 2 2017, Pages 11303
Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium.
Weng LC, Lunetta KL, Müller-Nurasyid M, Smith AV, Thériault S, Weeke PE, Barnard J, Bis JC, Lyytikäinen LP, Kleber ME, Martinsson A, Lin HJ, Rienstra M, Trompet S, Krijthe BP, Dörr M, Klarin D, Chasman DI, Sinner MF, Waldenberger M, Launer LJ, Harris TB, Soliman EZ, Alonso A, Paré G, Teixeira PL, Denny JC, Shoemaker MB, Van Wagoner DR, Smith JD, Psaty BM, Sotoodehnia N, Taylor KD, Kähönen M, Nikus K, Delgado GE, Melander O, Engström G, Yao J, Guo X, Christophersen IE, Ellinor PT, Geelhoed B, Verweij N, Macfarlane P, Ford I, Heeringa J, Franco OH, Uitterlinden AG, Völker U, Teumer A, Rose LM, Kääb S, Gudnason V, Arking DE, Conen D, Roden DM, Chung MK, Heckbert SR, Benjamin EJ, Lehtimäki T, März W, Smith JG, Rotter JI, van der Harst P, Jukema JW, Stricker BH, Felix SB, Albert CM, Lubitz SA
It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. Study-specific results were combined using meta-analysis (88,383 individuals of European descent, including 7,292 with AF). Variants with nominal interaction associations in the discovery analysis were tested for association in four independent st...
Abstract
Cited 22 times since 2017 (2.9 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 67, Issue 6, 11 2 2017, Pages 1891-1900.e4
Adventitial adipogenic degeneration is an unidentified contributor to aortic wall weakening in the abdominal aortic aneurysm.
Doderer SA, Gäbel G, Kokje VBC, Northoff BH, Holdt LM, Hamming JF, Lindeman JHN
Objective: The processes driving human abdominal aortic aneurysm (AAA) progression are not fully understood. Although antiinflammatory and proteolytic strategies effectively quench aneurysm progression in preclinical models, so far all clinical interventions failed. These observations hint at an incomplete understanding of the processes involved in AAA progression and rupture. Interestingly, strong clinical and molecular associations exist between popliteal artery aneurysms (PAAs) and AAAs; howe...
Abstract
Cited 4 times since 2017 (0.5 per year)
source: EuropePMC
European journal of heart failure,
Volume 19, Issue 12, 7 1 2017, Pages 1732-1735
Risk stratification of Asian patients with heart failure and reduced ejection fraction: the effectiveness of the Echo Heart Failure Score.
Bosch L, Carluccio E, Coiro S, Gong L, Sim D, Yeo D, Jaufeerally F, Leong KTG, Ong HY, Pin NT, Richards AM, Arslan F, Ling LH, Lam CSP, Ambrosio G
Abstract
Cited 159 times since 2017 (21.1 per year)
source: EuropePMC
Nature genetics,
Volume 49, Issue 10, 4 1 2017, Pages 1450-1457
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
Zhao W, Rasheed A, Tikkanen E, Lee JJ, Butterworth AS, Howson JMM, Assimes TL, Chowdhury R, Orho-Melander M, Damrauer S, Small A, Asma S, Imamura M, Yamauch T, Chambers JC, Chen P, Sapkota BR, Shah N, Jabeen S, Surendran P, Lu Y, Zhang W, Imran A, Abbas S, Majeed F, Trindade K, Qamar N, Mallick NH, Yaqoob Z, Saghir T, Rizvi SNH, Memon A, Rasheed SZ, Memon FU, Mehmood K, Ahmed N, Qureshi IH, Tanveer-Us-Salam, Iqbal W, Malik U, Mehra N, Kuo JZ, Sheu WH, Guo X, Hsiung CA, Juang JJ, Taylor KD, Hung YJ, Lee WJ, Quertermous T, Lee IT, Hsu CC, Bottinger EP, Ralhan S, Teo YY, Wang TD, Alam DS, Di Angelantonio E, Epstein S, Nielsen SF, Nordestgaard BG, Tybjaerg-Hansen A, Young R, CHD Exome+ Consortium, Benn M, Frikke-Schmidt R, Kamstrup PR, EPIC-CVD Consortium, EPIC-Interact Consortium, Michigan Biobank, Jukema JW, Sattar N, Smit R, Chung RH, Liang KW, Anand S, Sanghera DK, Ripatti S, Loos RJF, Kooner JS, Tai ES, Rotter JI, Chen YI, Frossard P, Maeda S, Kadowaki T, Reilly M, Pare G, Melander O, Salomaa V, Rader DJ, Da
To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLA-DRB5 (odds ratio (OR) = 1.29). We show that genetically mediated increase in T2D risk also confers higher CHD risk. J...
Abstract
Cited 1 times since 2017 (0.1 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 70, Issue 13, 1 1 2017, Pages 1681-1682
Patients With an ICD Remain at Risk for Painful Shocks in Last Moments of Life.
Yilmaz D, van der Heijden AC, Thijssen J, Schalij MJ, van Erven L
Abstract
Cited 2171 times since 2017 (287.9 per year)
source: EuropePMC
European heart journal,
Volume 38, Issue 36, 1 1 2017, Pages 2739-2791
2017 ESC/EACTS Guidelines for the management of valvular heart disease.
Baumgartner H, Falk V, Bax JJ, De Bonis M, Hamm C, Holm PJ, Iung B, Lancellotti P, Lansac E, Rodriguez Muñoz D, Rosenhek R, Sjögren J, Tornos Mas P, Vahanian A, Walther T, Wendler O, Windecker S, Zamorano JL, ESC Scientific Document Group
Abstract
Cited 6 times since 2017 (0.8 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 52, Issue 3, 1 1 2017, Pages 418-424
Standards defining a 'Heart Valve Centre': ESC Working Group on Valvular Heart Disease and European Association for Cardiothoracic Surgery Viewpoint.
Chambers JB, Prendergast B, Iung B, Rosenhek R, Zamorano JL, Piérard LA, Modine T, Falk V, Kappetein AP, Pibarot P, Sundt T, Baumgartner H, Bax JJ, Lancellotti P
Abstract
Cited 9 times since 2017 (1.2 per year)
source: EuropePMC
Journal of applied oral science : revista FOB,
Volume 25, Issue 5, 1 1 2017, Pages 515-522
Effects of Syzygium aromaticum, Cinnamomum zeylanicum, and Salvia triloba extracts on proliferation and differentiation of dental pulp stem cells.
Mendi A, Yağci BG, Kiziloğlu M, Saraç N, Yilmaz D, Uğur A, Uçkan D
Introduction: Hypersensitivity, local irritative and cytotoxic effects are known for the chemical components of Syzygium aromaticum and Cinnamomum zeylanicum contained in dental materials. However, there is no intimate data in dentistry using the whole extracts of these plants and introducing new ones. Salvia triloba is a well-known anti-inflammatory plant that correspondingly could be used in several dental traumas. Objectives: We aimed to show and compare the effect of S. aromaticum, C. zeylan...
Abstract
Cited 4 times since 2017 (0.5 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 18, Issue 9, 1 1 2017, Pages 1041-1048
Three-dimensional transoesophageal echocardiography of the aortic valve and root: changes in aortic root dilation and aortic regurgitation.
Regeer MV, Kamperidis V, Versteegh MIM, Schalij MJ, Marsan NA, Bax JJ, Delgado V
Aims: It has been hypothesized that in response to dilation of the aortic root, the aortic valve cusps may remodel to prevent aortic regurgitation (AR). The aim of the present study was to evaluate the association between aortic cusp dimensions and aortic root geometry. Methods and results: Three-dimensional transoesophageal echocardiography was performed in 40 patients with aortic root dilation (mean age 57 ± 12 years, 75% men, 35% bicuspid aortic valve) and 20 controls with a normal aortic roo...
Abstract
Cited 17 times since 2017 (2.3 per year)
source: EuropePMC
Current treatment options in cardiovascular medicine,
Volume 19, Issue 9, 1 1 2017, Pages 71
Current Challenges in Translating Tissue-Engineered Heart Valves.
Stassen OMJA, Muylaert DEP, Bouten CVC, Hjortnaes J
Opinion statement: Heart valve disease is a major health burden, treated by either valve repair or valve replacement, depending on the affected valve. Nearly 300,000 valve replacements are performed worldwide per year. Valve replacement is lifesaving, but not without complications. The in situ tissue-engineered heart valve is a promising alternative to current treatments, but the translation of this novel technology to the clinic still faces several challenges. These challenges originate from th...
Abstract
Cited 10 times since 2017 (1.3 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 18, Issue 9, 1 1 2017, Pages 969-977
Impact of computed tomography myocardial perfusion following computed tomography coronary angiography on downstream referral for invasive coronary angiography, revascularization and, outcome at 12 months.
van Rosendael AR, Dimitriu-Leen AC, de Graaf MA, van Zwet EW, Jukema JW, Bax JJ, Kroft LJ, Scholte AJ
Aims: The aim of this study was to assess the impact of adding stress computed tomography (CT) myocardial perfusion (CTP) to coronary CT angiography (CTA) on downstream referral for invasive coronary angiography (ICA), revascularization, and outcome in patients presenting with new-onset chest pain. Methods and results: Three hundred and eighty-four patients were referred for cardiac CT. Patients with lesions ≥50% stenosis underwent subsequently stress CTP. Perfusion scans were considered abnorma...
Abstract
